Abstract:
:A 70-year-old man with abdominal aortic aneurysm underwent surgical repair with Hemashield vascular graft. Postoperatively, he was found to have very low plasma cortisol levels, which failed to increase after stimulation with ACTH. A tentative diagnosis of adrenal insufficiency was made despite the lack of its clinical manifestations and a replacement therapy with hydrocortisone was started. He had also elevated plasma levels of TSH, thyroid hormones and estrogen without any clinical manifestations. Such abnormal hormone levels were spontaneously normalized three months after operation, which was later proven to be factitious by different immunometric assays (IMA). Since the vascular graft coated with bovine type I collagen has been reported to induce a transient immune response in some patients after surgery, we speculated that certain antibodies generated against heterologous collagen and/or yet-unknown components derived from the graft may have caused such factitious data; exogenous addition of bovine type I collagen and albumin to patient's serum, however, failed to affect the assay results. Whatever the cause, caution must be paid that some patients with surgical repair using heterologous materials may have such factitious hormone data by IMAs.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Sakai H,Matsumoto K,Sugiyama M,Yoshimoto T,Doi M,Izumiyama H,Hirata Ydoi
10.1507/endocrj.k06-006subject
Has Abstractpub_date
2006-06-01 00:00:00pages
415-9issue
3eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K06-006journal_volume
53pub_type
杂志文章abstract::Thyroid hormone plays an important role in growth hormone (GH) synthesis and secretion. To study the relationship between thyroid function and urinary GH secretion in the hyperthyroid and hypothyroid states, we measured thyroid hormones, simultaneously with serum and urinary GH levels, in 54 patients with thyroid dise...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.41.517
更新日期:1994-10-01 00:00:00
abstract::Patients with growth hormone (GH) deficiency (GHD) have a clinical feature of visceral adiposity and it has been reported that these patients have an increased active cortisol (F)/inactive cortisone (E) metabolite ratio. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an enzyme expressed in liver and adipo...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k08e-311
更新日期:2009-01-01 00:00:00
abstract::Although curcumin was widely applied as a functional food for different diseases, it was found to reduce serum testosterone level and fertility in male animals by unknown molecular mechanisms. Here in our study, we investigated the possible mechanisms of curcumin-suppressed testosterone production in Leydig cells. Our...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ18-0010
更新日期:2018-08-27 00:00:00
abstract::The antidiabetic effects of Lactobacillus casei (LC) on a non-insulin-dependent diabetes mellitus (NIDDM) model, KK-Ay mice, were investigated. The oral administration of LC to male 4-week-old KK-Ay mice, or raising the mice on a 0.05% LC-containing diet significantly decreased the plasma glucose at 8 to 10 weeks of a...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.357
更新日期:1997-06-01 00:00:00
abstract::We describe a case of diabetes insipidus (DI) due to a pituitary tumor in a 33-year-old pregnant woman who developed a sudden onset of polyuria (over 8 l/day) and polydipsia at 30 weeks of gestation. Her plasma concentration of vasopressin (AVP) was low compared with high serum osmolality (298 mOsm/kg), and her urine ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.577
更新日期:1996-10-01 00:00:00
abstract::It has been indicated that some subsets of clinically nonfunctioning pituitary adenoma exhibit immunohistochemical and ultrastructural features of somatotroph or corticotroph cells, which are described as silent somatotroph and corticotroph adenomas, respectively. We here describe a 70-year-old woman with nonfunctioni...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.329
更新日期:1997-04-01 00:00:00
abstract::The effects of an aqueous extract of Ferula hormonis on social aggression, fertility and some physiological and biochemical parameters were investigated in male mice. The ingestion of 3 mg/kg of aqueous extract of F. hormonis for six weeks clearly inhibited social aggression. Body wet weight and other sex accessory or...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.473
更新日期:2001-08-01 00:00:00
abstract::The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, ...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
doi:10.1507/endocrj.51.61
更新日期:2004-02-01 00:00:00
abstract::Metabolic syndrome (MetS) is the occurrence of diabetes mellitus/glucose intolerance, arterial hypertension, central obesity, dyslipidemia, and microalbuminuria in the same patient (definition by WHO). Presence of metabolic syndrome is associated with larger myocardial infarction size and complications following acut...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej12-0131
更新日期:2012-01-01 00:00:00
abstract::We here describe two patients with empty sella syndrome who had variable and abnormal ACTH and cortisol secretory profiles. The patients are a 58-year old male and a 41-year old female, both of whom were neurotic. In both cases, low-dose dexamethasone suppression tests (1 mg, p.o., overnight) caused variable responses...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.417
更新日期:1996-08-01 00:00:00
abstract::In this study we confirmed our previous findings on the importance of IgE in Graves' disease and further investigated the relationships existing among Graves' disease, IgE, and interleukin-4. Two hundred and thirty-two newly diagnosed Graves' disease patients were treated with methimazole for 2 years, and were classif...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-054
更新日期:2006-12-01 00:00:00
abstract::An open-label prospective cross-over trial was performed to compare the efficacy and adverse effects of nateglinide with those of voglibose on Japanese early type 2 diabetes (who were oral hypoglycemic agent naïve and whose HbA(1C) levels were between 7.0 and 7.9% before treatment). Fourteen patients received 270 mg/d...
journal_title:Endocrine journal
pub_type: 杂志文章,随机对照试验
doi:10.1507/endocrj.53.213
更新日期:2006-04-01 00:00:00
abstract::Pituitary adrenocorticotropic hormone (ACTH)-secreting tumor presents with a variety of clinical features. We outlined the features of ACTH release and characteristics of corticotroph adenoma cells. We especially focused on the corticotroph adenomas in patients with no clinical features of Cushing's disease. Subclinic...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.ej14-0120
更新日期:2014-01-01 00:00:00
abstract::We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1507/endocrj.EJ17-0303
更新日期:2018-02-26 00:00:00
abstract::In anovulatory patients ovulation is usually induced by clomiphene citrate (CC) or gonadotropin therapy, but in the case of polycystic ovary syndrome (PCOS), diagnosed by the presence of several micropolycysts in the ovaries and a high LH/FSH ratio in the serum, CC is only minimally effective, and side effects are oft...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.217
更新日期:1999-02-01 00:00:00
abstract::In recent times, the role of fibroblast growth factor 21 (FGF21) in patients with gestational diabetes mellitus (GDM) has been increasingly investigated. However, to our knowledge, no systematic analysis has been conducted yet to evaluate the relationship between FGF21 levels and GDM. Confirmed studies related to circ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0481
更新日期:2020-11-06 00:00:00
abstract::Although gonadal estrogens are known to facilitate the development of skeletal lesion in SHOX haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.197
更新日期:2004-04-01 00:00:00
abstract::This study aimed to assess the relationship between the metabolic effect after laparoscopic sleeve gastrectomy (LSG) in morbidly obese Japanese patients, with or without type 2 diabetes mellitus (T2DM), and improved pancreatic steatosis (PS). The study enrolled 27 morbidly obese Japanese patients who were undergoing L...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0321
更新日期:2017-05-30 00:00:00
abstract::Ghrelin is a peptide hormone with a unique structure comprising a medium chain fatty acid modification. Ghrelin cells are known to be abundantly localized in the gastric mucosa and are released into the blood stream to exert their multifunctional physiological effects. To elucidate the regulatory mechanisms of ghrelin...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.64.S27
更新日期:2017-01-01 00:00:00
abstract::Reactive oxygen species (ROS) are induced under diabetic conditions and are likely associated with the development of type 2 diabetes. It is also known that ROS production is facilitated in the presence of copper ion through the Fenton reaction. The aim of this study was to examine the involvement of copper ion in the...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k09e-051
更新日期:2009-01-01 00:00:00
abstract::To evaluate the prevalence of lymphocytic infiltrate in a large series of pituitary adenomas, we retrospectively studied tumor tissues from 1400 patients. Based on immunocytochemical data, tumors were classified as PRL (n=411), multihormonal (n=310), immunonegative (n=275), ACTH (n=166), GH (n=137), alpha subunit (n=4...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究
doi:10.1507/endocrj.45.357
更新日期:1998-06-01 00:00:00
abstract::Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented wit...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-046
更新日期:2010-01-01 00:00:00
abstract::Angiopoietin-like protein 8 (ANGPTL8) is a newly discovered adipokine plays an important role in energy homoeostasis, obesity and type 2 diabetes (T2D). Although lifestyle modification in obesity and T2D is known to offer metabolic benefits, there is paucity of comprehensive data on change in ANGPTL8. We investigated ...
journal_title:Endocrine journal
pub_type: 杂志文章,随机对照试验
doi:10.1507/endocrj.EJ18-0191
更新日期:2019-01-28 00:00:00
abstract::Guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), are primarily present in the intestine and maintain homeostasis in body fluids. Recently, rats whose macrophages overexpress Gn and GC-C were found to be resistant to diet-induced obesity. Considering that obesity is strongly related to a...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0193
更新日期:2015-01-01 00:00:00
abstract::The present study was aimed to examine the possible functional relationship between melatonin and hypothalamic transmitters, endogenous opioids and excitatory amino acids in controlling gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous injection of naloxone (mu opioid receptor antagonist), ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.831
更新日期:1999-12-01 00:00:00
abstract::Obesity consists of hypertrophy and hyperplasia of adipocytes. Although the number of adipocytes is influenced by anatomical location, nutritional environment, hormone and genetic variation, it has been thought to be determined by the proliferation of precursor cells and subsequent differentiation. However, our recent...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej13-0053
更新日期:2013-01-01 00:00:00
abstract::Sera from 30 Japanese insulin-dependent diabetes mellitus (IDDM) patients of short duration were examined to determine whether they had antibodies to proteolytic fragments of islet antigen, the molecular weights of which were 37,000 and/or 40,000 Mr (37KAb). The median age and disease duration of the patients were 13 ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.615
更新日期:1996-12-01 00:00:00
abstract::The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary thyroid carcinoma (PTC) is significantly lower in Asian countries than Western countries; however, the difference remains unexplained. This study aimed to evaluate the incidence of NIFTP in tumors diagnos...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0198
更新日期:2020-10-28 00:00:00
abstract::Aerobic (sub lactate threshold; sub-LT) exercise training facilitates oxidative phosphorylation and glycolysis of skeletal muscle. Thyroid hormone (TH) also facilitates such metabolic events. Thus, we studied whether TH signaling pathway is activated by treadmill training. Male adult rats received 30 min/day treadmill...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0126
更新日期:2016-08-31 00:00:00
abstract::Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.207
更新日期:2002-04-01 00:00:00