A case of factitious adrenal insufficiency after vascular graft surgery caused by spurious immunometric assays.


:A 70-year-old man with abdominal aortic aneurysm underwent surgical repair with Hemashield vascular graft. Postoperatively, he was found to have very low plasma cortisol levels, which failed to increase after stimulation with ACTH. A tentative diagnosis of adrenal insufficiency was made despite the lack of its clinical manifestations and a replacement therapy with hydrocortisone was started. He had also elevated plasma levels of TSH, thyroid hormones and estrogen without any clinical manifestations. Such abnormal hormone levels were spontaneously normalized three months after operation, which was later proven to be factitious by different immunometric assays (IMA). Since the vascular graft coated with bovine type I collagen has been reported to induce a transient immune response in some patients after surgery, we speculated that certain antibodies generated against heterologous collagen and/or yet-unknown components derived from the graft may have caused such factitious data; exogenous addition of bovine type I collagen and albumin to patient's serum, however, failed to affect the assay results. Whatever the cause, caution must be paid that some patients with surgical repair using heterologous materials may have such factitious hormone data by IMAs.


Endocr J


Endocrine journal


Sakai H,Matsumoto K,Sugiyama M,Yoshimoto T,Doi M,Izumiyama H,Hirata Y




Has Abstract


2006-06-01 00:00:00














  • The ratio of glycated albumin to hemoglobin A1c measured in IFCC units accurately represents the glycation gap.

    abstract::The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究


    authors: Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.

    更新日期:2015-01-01 00:00:00

  • Glucose-lowering effects of 7-day treatment with SGLT2 inhibitor confirmed by intermittently scanned continuous glucose monitoring in outpatients with type 1 diabetes. A pilot study.

    abstract::The present study used intermittently scanned continuous glucose monitoring (isCGM) in 10 patients with type 1 diabetes mellitus (T1DM) to evaluate the efficacy and safety of 7-day outpatient treatment with the combination of intensive insulin therapy and sodium-glucose transporter 2 inhibitor (SGLT2-I). All participa...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kurozumi A,Okada Y,Tanaka Y

    更新日期:2020-11-18 00:00:00

  • Short term effects of atorvastatin on endothelial functions and oxidized LDL levels in patients with type 2 diabetes.

    abstract:OBJECTIVE:This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients. MATERIAL AND METHODS:Thirty type 2 di...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Akalin A,Temiz G,Akcar N,Sensoy B

    更新日期:2008-10-01 00:00:00

  • A novel heterozygous mutation of steroidogenic factor-1 (SF-1/Ad4BP) gene (NR5A1) in a 46, XY disorders of sex development (DSD) patient without adrenal failure.

    abstract::Steroidogenic factor-1 [(SF-1/Ad4BP) (MIM184757)] is a nuclear receptor that regulates multiple genes involved in adrenal and gonadal development, steroidogenesis, reproduction, and other metabolic functions. Initially, mutations of SF-1/Ad4BP gene (NR5A1) in humans were identified in two 46, XY female patients with a...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Tajima T,Fujiwara F,Fujieda K

    更新日期:2009-01-01 00:00:00

  • Clinical evaluation of the iodide/creatinine ratio of casual urine samples as an index of daily iodide excretion in a population study.

    abstract::To assess the daily iodine intake in a population study, we have compared the validity and degree of reliability of the urine iodide/creatinine ratios and iodide concentrations of casual samples as a representative index of daily urine iodide excretion. The morning urine samples were obtained from apparently healthy 2...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章


    authors: Konno N,Yuri K,Miura K,Kumagai M,Murakami S

    更新日期:1993-02-01 00:00:00

  • TSH-receptor antibodies determined by the first, second and third generation assays and thyroid-stimulating antibody in pregnant patients with Graves' disease.

    abstract::The measurement of TSH receptor antibody (TRAb) has been recommended to predict the risk of neonatal hyperthyroidism (NH) in pregnant women with Graves' disease (GD). For the first generation TRAb (TRAb1) assay with commercial kit (Brahms, Berlin, Germany; or Cosmic co., Tokyo, Japan) an arbitrary limit of 40 U/l or 5...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kamijo K

    更新日期:2007-08-01 00:00:00

  • Effect of treatment with epoprostenol and endothelin receptor antagonists on the development of thyrotoxicosis in patients with pulmonary arterial hypertension.

    abstract::Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HP...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Satoh M,Aso K,Nakayama T,Saji T

    更新日期:2017-12-28 00:00:00

  • Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells.

    abstract::Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amyl...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Miyagawa J,Hanafusa O,Sasada R,Yamamoto K,Igarashi K,Yamamori K,Seno M,Tada H,Nammo T,Li M,Yamagata K,Nakajima H,Namba M,Kuwajima M,Matsuzawa Y

    更新日期:1999-12-01 00:00:00

  • Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.

    abstract::To address the effects of ezetimibe on high-density lipoprotein (HDL) metabolism, the HDL subclasses, cholesteryl ester transfer protein (CETP), and lecithin-cholesterol acyltransferase (LCAT) were measured in patients with type 2 diabetes mellitus (T2DM). Twenty-three hypercholesterolemic patients with T2DM were tre...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章


    authors: Yagyu H,Nagashima S,Takahashi M,Miyamoto M,Okada K,Osuga J,Ishibashi S

    更新日期:2012-01-01 00:00:00

  • Chronic intramedullary infusion of prostaglandin E2 stimulates bone formation both in the bone marrow and in the periosteum.

    abstract::Prostaglandin E2 (PGE2) has a potent bone resorbing activity in vitro, but some recent studies have shown that PGE2 stimulates bone formation in vivo. The effects of PGE2 on the bone are therefore still controversial. We attempted to reveal the effects of PGE2 on bone in vivo more directly; we injected PGE2 continuous...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Takada M,Yamamoto I,Yuu I,Kigami Y,Ohnaka Y,Morita R

    更新日期:1995-06-01 00:00:00

  • Sodium bicarbonate infusion test: a new method for evaluating parathyroid function.

    abstract::We have developed a new test for estimating the secretory capacity of parathyroid hormone (PTH) from the parathyroid gland. Sodium bicarbonate solution [8.4% (w/v); 35 ml/m(2) body surface area] was infused for 2 min, and blood samples for the determination of plasma ionized calcium, plasma PTH (intact, midregion, car...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章


    authors: Iwasaki Y,Mutsuga N,Yamamori E,Kakita A,Oiso Y,Imai T,Funahashi H,Tanaka Y,Kondo K,Nakashima N

    更新日期:2003-10-01 00:00:00

  • Effects of growth hormone on testicular dysfunction induced by cyclophosphamide (CP) in GH-deficient rats.

    abstract::Growth hormone (GH) is known to accelerate spermatogenesis and maintain gonadal function. In this study, we evaluated the effect of GH on recovery from testicular damage induced by cyclophosphamide (CP). Eleven- to fourteen-week-old GH-deficient Lewis rats (dw/dw) were divided into 4 groups (n = 10 each), with one gro...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Satoh K,Ohyama K,Nakagomi Y,Ohta M,Shimura Y,Sano T,Ishikawa H,Amemiya S,Nakazawa S

    更新日期:2002-12-01 00:00:00

  • A somatotropin-producing pituitary adenoma with an isolated adrenocorticotropin-producing pituitary adenoma in a female patient with acromegaly, subclinical Cushing's disease and a left adrenal tumor.

    abstract::A 67-year-old female with hypertension and impaired glucose tolerance was admitted to our hospital because of a typical acromegalic appearance, including large, thickened bulky hands and feet, and a large prominent forehead and tongue. She did not have a Cushingoid appearance, such as a moon-face, buffalo hump, purple...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kobayashi Y,Takei M,Ohkubo Y,Kakizawa Y,Matoba H,Kumagai M,Takeda T,Suzuki S,Komatsu M

    更新日期:2014-01-01 00:00:00

  • Multiple endocrine neoplasia type 1 is not rare in Japan.

    abstract::Multiple endocrine neoplasia type 1 (MEN 1) is rarely reported in Japanese and other oriental populations. To examine if there is a racial difference in the prevalence of MEN 1, we initiated extensive work on patients with endocrine tumors for additional lesions, and annual screening of family members of affected pati...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Katai M,Sakurai A,Itakura Y,Ikeo Y,Nakajima K,Hara M,Iijima S,Kaneko T,Kobayashi M,Ichikawa K,Aizawa T,Hashizume K

    更新日期:1997-12-01 00:00:00

  • Prolactin and bromocriptine induced changes in liver, adipose tissue and blood lipids of mature male bonnet monkeys, Macaca radiata (Geoffroy).

    abstract::Effects of prolactin and bromocriptine on neutral and phospholipids of liver, adipose tissue and serum were studied in mature male bonnet monkeys. Hyperprolactinemia (ovine prolactin, 250 micrograms/kg body weight/day, i.p. for 30 days) elevated hepatic total lipids and phospholipids and decreased total and free chole...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Aruldhas MM,Thampi LT,Kumari TM,Govindarajulu P

    更新日期:1994-04-01 00:00:00

  • Nutritional regulation of circulating insulin-like growth factors (IGFs) and their binding proteins in the ovine fetus.

    abstract::Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are important for fetal and postnatal development, but the regulation of circulating IGFs and IGFBPs has not been as thoroughly investigated in the maternal/fetal unit as in the adult animal where nutrition status plays a regulatory role. We used t...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Lee WH,Gaylord TD,Bowsher RR,Hlaing M,Moorehead H,Liechty EA

    更新日期:1997-02-01 00:00:00

  • Masked type 1 diabetes mellitus (T1DM) unveiled by glucocorticoid replacement: a case of simultaneous development of T1DM and hypophysitis in an elderly woman.

    abstract::As a rare condition characterized by inflammation of the pituitary gland, hypophysitis usually results in hypopituitarism and pituitary enlargement. The most critical outcome of hypopituitarism is caused by secondary adrenal insufficiency. Glucocorticoid deficiency is a life-threatening condition, and patients who dev...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Aikawa E,Horie I,Naganobu K,Nozaki A,Kamada A,Abiru N,Kawakami A

    更新日期:2020-11-28 00:00:00

  • Satisfaction and efficacy of switching from daily dipeptidyl peptidase-4 inhibitors to weekly trelagliptin in patients with type 2 diabetes-Randomized controlled study.

    abstract::We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Oita M,Miyoshi H,Ono K,Nakamura A,Cho KY,Nomoto H,Yamamoto K,Omori K,Manda N,Kurihara Y,Aoki S,Atsumi T

    更新日期:2018-02-26 00:00:00

  • Influence of thyroid dysfunction on brain natriuretic peptide level in health examination participants.

    abstract::The tissue-specific circulating markers of thyroid hormone action on cardiac function have not been established. Although the relationship between thyroid function and plasma brain natriuretic peptide (BNP) levels has been evaluated in patients with thyroid disorders, the relationship between these parameters in the g...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Ohba K,Okada E,Goto Y,Suzuki S,Machii M,Nonaka D,Matsushita A,Sasaki S,Suda T,Oki Y,Takase H

    更新日期:2020-04-28 00:00:00

  • Chimeric studies of the extracellular domain of the rat thyrotropin (TSH) receptor: amino acids (268-304) in the TSH receptor are involved in ligand high affinity binding, but not in TSH receptor-specific signal transduction.

    abstract::A series of chimeric TSH-LH/CG receptors were constructed by substituting homologous segments of the extracellular domain of the rat TSH receptor with corresponding segments of rat LH/CG receptor: C1 (amino acids 37-123 substituted), C2 (91-112), C3 (173-234), C4 (233-266), C5 (268-304), C6 (112-305) and C7 (36-404). ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Akamizu T,Inoue D,Kosugi S,Ban T,Kohn LD,Imura H,Mori T

    更新日期:1993-06-01 00:00:00

  • Thyroid function and internal carotid artery stenosis in ischemic stroke.

    abstract::Thyroid dysfunction has been known to be closely associated with increased vascular events. The aims of the present study included determining the prevalence of subclinical thyroid disease and relationships between normal ranges of thyroid function and internal carotid artery steno-occlusion (ICS) in patients with isc...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Jeong SK,Seo JY,Nam HS,Park HK

    更新日期:2010-01-01 00:00:00

  • Random urinary gonadotropins as a useful initial test for girls with central precocious puberty.

    abstract::Recent evidence indicates that urinary gonadotropins may be an alternative method for detecting pubertal disorders. The aim of this study was to evaluate the associations of first morning voided (FMV) and random urinary gonadotropins with the pubertal response to a gonadotropin-releasing hormone (GnRH) stimulation tes...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Shim YS,An SH,Lee HJ,Kang MJ,Yang S,Hwang IT

    更新日期:2019-10-28 00:00:00

  • Drug-induced hyperglycemia in the Japanese Adverse Drug Event Report database: association of evelolimus use with diabetes.

    abstract::Some categories of drugs are known for causing hyperglycemia or diabetes such as steroids, antipsychotics, and immunosuppressant. However, there has been little evidence from studies about the proportion of each drug in the context of drug-induced diabetes. In this study, we used data from the Japanese Adverse Drug Ev...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Konishi H,Shirakawa J,Arai M,Terauchi Y

    更新日期:2019-06-28 00:00:00

  • Prolactin expresses differential effects on apoptotic cell death of luteal cells in vivo and in vitro.

    abstract::PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

    更新日期:1997-02-01 00:00:00

  • Individualization of recommendations from the international consensus on continuous glucose monitoring-derived metrics in Japanese children and adolescents with type 1 diabetes.

    abstract::We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Urakami T,Yoshida K,Kuwabara R,Mine Y,Aoki M,Suzuki J,Morioka I

    更新日期:2020-10-28 00:00:00

  • Long-term effects of ketoconazole in the treatment of residual or recurrent Cushing's disease.

    abstract::Ketoconazole is an imidazole derivative used to treat systemic and superficial mycoses by inhibiting sterol synthesis in fungi. The drug impairs steroid hormone synthesis by blocking mitochondrial P450-dependent enzyme systems. Because of its potent inhibitory effects on adrenal steroidogenesis, ketoconazole is valuab...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Chou SC,Lin JD

    更新日期:2000-08-01 00:00:00

  • Preoperative diagnosis of thyroid carcinomas by aspiration biopsy-reverse transcription-polymerase chain reaction (ABRP): a report of two cases.

    abstract::A preoperative molecular-based diagnostic technique for thyroid papillary and anaplastic carcinomas was recently developed to detect oncofetal fibronectin (onfFN) messenger RNA (mRNA) in fine needle aspiration biopsy (FNAB) by means of reverse transcription-polymerase chain reaction (RT-PCR). We report two cases of th...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Takano T,Shiba E,Tada H,Yoshimura H,Yoshida K,Doi R,Amino N

    更新日期:2000-06-01 00:00:00

  • Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma.

    abstract::The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab for malignant melanoma that was approved earlier than ni...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Okano Y,Satoh T,Horiguchi K,Toyoda M,Osaki A,Matsumoto S,Tomaru T,Nakajima Y,Ishii S,Ozawa A,Shibusawa N,Shimada T,Higuchi T,Chikamatsu K,Yamada M

    更新日期:2016-10-29 00:00:00

  • Diurnal variation in growth hormone receptor messenger ribonucleic acid in liver and skeletal muscle of lit/+ and lit/lit mice.

    abstract::The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Itoh E,Iida K,del Rincon JP,Kim DS,Thorner MO

    更新日期:2004-12-01 00:00:00

  • Octreotide treatment results in the inhibition of GH gene expression in the adenoma of the patients with acromegaly.

    abstract::Seven patients with growth hormone (GH)-secreting pituitary adenoma were treated preoperatively with octreotide (Sandostatin or SMS 201-995; a somatostatin analogue), and were compared with 18 non-treated patients in their clinical courses and adenoma analyses. Octreotide treatment improved the endocrinological data i...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Tsukamoto N,Nagaya T,Kuwayama A,Takano K,Shizume K,Sugita K,Seo H

    更新日期:1994-08-01 00:00:00