Prevalence of lymphocytic infiltrate in 1400 pituitary adenomas.

abstract：:It has been indicated that some subsets of clinically nonfunctioning pituitary adenoma exhibit immunohistochemical and ultrastructural features of somatotroph or corticotroph cells, which are described as silent somatotroph and corticotroph adenomas, respectively. We here describe a 70-year-old woman with nonfunctioni...

journal_title：Endocrine journal

authors： Sakaguchi H,Koshiyama H,Sano T,Inoue D,Hashimoto N,Aoki N,Nakao K

更新日期：1997-04-01 00:00:00

abstract：:Since 1989, neonatal mass screening for congenital adrenal hyperplasia (CAH) has been carried out in Japan. The mass screening has detected not only the patients with the classic form of steroid 21-hydroxylase deficiency (21-OHD), but also those with the nonclassic (NC) form of 21-OHD, and the molecular basis in these...

journal_title：Endocrine journal

authors： Shinagawa T,Horikawa R,Isojima T,Naiki Y,Tanaka T,Katsumata N

更新日期：2007-12-01 00:00:00

abstract：:Guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), are primarily present in the intestine and maintain homeostasis in body fluids. Recently, rats whose macrophages overexpress Gn and GC-C were found to be resistant to diet-induced obesity. Considering that obesity is strongly related to a...

journal_title：Endocrine journal

authors： Hasegawa K,Akieda-Asai S,Fujii Y,Bae CR,Yasuda M,Date Y

更新日期：2015-01-01 00:00:00

abstract：:Interferon-tau (IFNtau) is produced by the trophectoderm of ruminant ungulates and its gene transactivation in vitro has so far been achieved only in human choriocarcinoma cells, JAR and JEG3. To examine if ovine IFNtau gene transactivation could be induced in cells other than JAR or JEG3 cells and its activation coul...

journal_title：Endocrine journal

authors： Yamaguchi H,Ikeda Y,Taylor A,Katsumura M,Miyazawa T,Takahashi E,Imakawa K,Sakai S

更新日期：1999-06-01 00:00:00

abstract：:We examined 13 patients with euthyroid Graves' disease suspected ophthalmologically, by comparing them with 20 patients with untreated Graves' disease and by following them up for 5 to 10 years. They had Graves' ophthalmopathy (NOSPECS class II-IV) without other ocular diseases, normal levels of serum thyroid hormones...

journal_title：Endocrine journal

authors： Kashiwai T,Tada H,Asahi K,Hidaka Y,Tamaki H,Iwatani Y,Amino N

更新日期：1995-06-01 00:00:00

abstract：:The synthesis of nitric oxide (NO) has been demonstrated in the vascular endothelial cells and other tissues including in rat and bovine adrenal gland. To determine whether NO mediates aldosterone production in the adrenals, we evaluated the basal production of aldosterone, and the ACTH or angiotensin II (A II)-stimul...

journal_title：Endocrine journal

authors： Nakayama T,Izumi Y,Soma M,Kanmatsuse K

更新日期：1996-04-01 00:00:00

abstract：:Circulating anti-islet autoantibodies in sera are used as a predictive marker for type 1 diabetes (T1D). We here report two Japanese patients with autoimmune thyroid disease complicated with T1D in whom the time course of anti-islet autoantibodies were observed before the clinical onset of diabetes. Case 1: A woman wh...

journal_title：Endocrine journal

authors： Horie I,Kawasaki E,Shimomura A,Satoh T,Ueki I,Kuwahara H,Ando T,Abiru N,Usa T,Eguchi K

更新日期：2010-01-01 00:00:00

abstract：:Some categories of drugs are known for causing hyperglycemia or diabetes such as steroids, antipsychotics, and immunosuppressant. However, there has been little evidence from studies about the proportion of each drug in the context of drug-induced diabetes. In this study, we used data from the Japanese Adverse Drug Ev...

journal_title：Endocrine journal

authors： Konishi H,Shirakawa J,Arai M,Terauchi Y

更新日期：2019-06-28 00:00:00

abstract：:In hope of understanding possible roles of estrogen during early embryogenesis, we examined the expression of both estrogen receptor alpha (ER alpha) and ER beta, a recently cloned novel subtype, in mouse oocytes and preimplantation embryos by means of reverse transcription polymerase chain reaction (RT-PCR). To inves...

journal_title：Endocrine journal

authors： Hiroi H,Momoeda M,Inoue S,Tsuchiya F,Matsumi H,Tsutsumi O,Muramatsu M,Taketani Y

更新日期：1999-02-01 00:00:00

abstract：:We measured serum levels of the carboxy-terminal propeptide of type 1 procollagen (P1CP) as a marker of bone formation and the carboxy-terminal telopeptide of type 1 collagen (1CTP) as a marker of bone resorption by RIA in sera from 40 Graves' disease patients and 14 Hashimoto's disease patients before and during trea...

journal_title：Endocrine journal

authors： Miyakawa M,Tsushima T,Demura H

更新日期：1996-12-01 00:00:00

abstract：:Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

journal_title：Endocrine journal

authors： Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

更新日期：2016-07-30 00:00:00

abstract：:Somatostatin is well known to inhibit the hormone secretion of various peptides. This action has been considered to be generally mediated via six different specific somatostatin receptors (sstr), sstr1, sstr2A, sstr2B, sstr3, sstr4, and sstr5. It then becomes very important to demonstrate the localization of these sst...

journal_title：Endocrine journal

authors： Taniyama Y,Suzuki T,Mikami Y,Moriya T,Satomi S,Sasano H

更新日期：2005-10-01 00:00:00

abstract：:To assess the daily iodine intake in a population study, we have compared the validity and degree of reliability of the urine iodide/creatinine ratios and iodide concentrations of casual samples as a representative index of daily urine iodide excretion. The morning urine samples were obtained from apparently healthy 2...

journal_title：Endocrine journal

authors： Konno N,Yuri K,Miura K,Kumagai M,Murakami S

更新日期：1993-02-01 00:00:00

abstract：:The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established. Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT). Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with t...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Hayashi K,Kawashiri MA,Yamagishi M,Yamada M,Fumisawa Y,Yamauchi K,Aizawa T

更新日期：2014-01-01 00:00:00

abstract：:It is known that endoplasmic reticulum (ER) stress is provoked under diabetic conditions and is possibly involved in the development of insulin resistance. In this study, using ER stress-activated indicator (ERAI) transgenic mice which express green fluorescent protein under ER stress conditions, we directly evaluated...

journal_title：Endocrine journal

authors： Yoshiuchi K,Kaneto H,Matsuoka TA,Kasami R,Kohno K,Iwawaki T,Nakatani Y,Yamasaki Y,Shimomura I,Matsuhisa M

更新日期：2009-01-01 00:00:00

abstract：:Pituitary adrenocorticotropic hormone (ACTH)-secreting tumor presents with a variety of clinical features. We outlined the features of ACTH release and characteristics of corticotroph adenoma cells. We especially focused on the corticotroph adenomas in patients with no clinical features of Cushing's disease. Subclinic...

journal_title：Endocrine journal

authors： Kageyama K,Oki Y,Nigawara T,Suda T,Daimon M

更新日期：2014-01-01 00:00:00

abstract：:The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...

journal_title：Endocrine journal

authors： Itoh E,Iida K,del Rincon JP,Kim DS,Thorner MO

更新日期：2004-12-01 00:00:00

abstract：:A nationwide epidemiologic survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases was conducted in 2010 to clarify the prevalence and the clinical presentations of the disorders. A questionnaire inquiring the experience of patients with these diseases was sent to randomly selected hospitals th...

journal_title：Endocrine journal

authors： Endo I,Fukumoto S,Ozono K,Namba N,Inoue D,Okazaki R,Yamauchi M,Sugimoto T,Minagawa M,Michigami T,Nagai M,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:The presence of human progesterone receptor (PR) mRNA variants has been demonstrated in uterine endometrium and breast tissues as well as in cancer cells of these tissues. While exon deletions by the alternative splicing in these variants have been reported, there are few reports available on the PR mRNA variants with...

journal_title：Endocrine journal

authors： Yamanaka T,Hirata S,Shoda T,Hoshi K

更新日期：2002-08-01 00:00:00

abstract：:A 19-year-old girl presented at our emergency room with hypokalemic periodic paralysis. She had a thyrotoxic goiter and had experienced three paralytic attacks during the previous 2 years on occasions when she stopped taking antithyroid drugs. In addition to thyrotoxic periodic paralysis (TPP), she had metabolic acido...

journal_title：Endocrine journal

authors： Im EJ,Lee JM,Kim JH,Chang SA,Moon SD,Ahn YB,Son HS,Cha BY,Lee KW,Son HY

更新日期：2010-01-01 00:00:00

abstract：:Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

journal_title：Endocrine journal

authors： Luo J,Yang X,Liang J,Li W

更新日期：2015-01-01 00:00:00

abstract：:A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and...

journal_title：Endocrine journal

authors： Naito Y,Mori J,Tazoe J,Tomida A,Yagyu S,Nakajima H,Iehara T,Tatsuzawa K,Mukai T,Hosoi H

更新日期：2019-12-25 00:00:00

abstract：:Prostaglandin E2 (PGE2) has a potent bone resorbing activity in vitro, but some recent studies have shown that PGE2 stimulates bone formation in vivo. The effects of PGE2 on the bone are therefore still controversial. We attempted to reveal the effects of PGE2 on bone in vivo more directly; we injected PGE2 continuous...

journal_title：Endocrine journal

authors： Takada M,Yamamoto I,Yuu I,Kigami Y,Ohnaka Y,Morita R

更新日期：1995-06-01 00:00:00

abstract：:A preoperative molecular-based diagnostic technique for thyroid papillary and anaplastic carcinomas was recently developed to detect oncofetal fibronectin (onfFN) messenger RNA (mRNA) in fine needle aspiration biopsy (FNAB) by means of reverse transcription-polymerase chain reaction (RT-PCR). We report two cases of th...

journal_title：Endocrine journal

authors： Takano T,Shiba E,Tada H,Yoshimura H,Yoshida K,Doi R,Amino N

更新日期：2000-06-01 00:00:00

abstract：:Metabolic syndrome (MetS) is the occurrence of diabetes mellitus/glucose intolerance, arterial hypertension, central obesity, dyslipidemia, and microalbuminuria in the same patient (definition by WHO). Presence of metabolic syndrome is associated with larger myocardial infarction size and complications following acut...

journal_title：Endocrine journal

authors： Kranjcec D,Altabas V

更新日期：2012-01-01 00:00:00

abstract：:Decreased circulating levels of adiponectin, a novel adipose-derived adipocytokine, in obesity possibly contribute to the development of insulin resistance which is a major factor in the pathogenesis of type 2 diabetes. The present study was conducted to examine whether circulating and adipose tissue adiponectin level...

journal_title：Endocrine journal

authors： Fujita H,Fujishima H,Koshimura J,Hosoba M,Yoshioka N,Shimotomai T,Morii T,Narita T,Kakei M,Ito S

更新日期：2005-08-01 00:00:00

abstract：:Expression of activin A in fetal rat pancreas was studied immunohistochemically by using anti-activin A antibody. On embryonic day 12 (E12), cells in cap-like pancreatic anlage were stained with anti-activin A antibody. In these sections, no immunoreactive insulin or glucagon was observed. On E13.5, cells containing i...

journal_title：Endocrine journal

authors： Furukawa M,Eto Y,Kojima I

更新日期：1995-02-01 00:00:00

abstract：:Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively. We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation. In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells. Ce...

journal_title：Endocrine journal

authors： Kitamura R,Ogata T,Tanaka Y,Motoyoshi K,Seno M,Takei I,Umezawa K,Kojima I

更新日期：2007-04-01 00:00:00

abstract：:The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...

journal_title：Endocrine journal

authors： Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.

更新日期：2015-01-01 00:00:00

abstract：:Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. It has recently been reported that this syndrome is caused by mutations in the AAAS gene. In the present study, we analyzed the AAAS gene in a Japanese patient with...

journal_title：Endocrine journal

authors： Katsumata N,Hirose H,Kagami M,Tanaka T

更新日期：2002-02-01 00:00:00