Abstract:
:Prostaglandin E2 (PGE2) has a potent bone resorbing activity in vitro, but some recent studies have shown that PGE2 stimulates bone formation in vivo. The effects of PGE2 on the bone are therefore still controversial. We attempted to reveal the effects of PGE2 on bone in vivo more directly; we injected PGE2 continuously into the bone marrow and onto the periosteum and examined the local effects of PGE2 histologically or by bone densitometry. Following PGE2 infusion into the bone marrow, new bone was formed in the bone marrow around the infused site and following PGE2 infusion onto the periosteum, extensive periosteal bone formation was observed. Bone mineral content was also increased significantly in the PGE2 infused bones. The administration of cyclic AMP did not mimic the effects of PGE2. In contrast to in vitro experiments, the in vivo effect of PGE2 is predominantly to produce bone.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Takada M,Yamamoto I,Yuu I,Kigami Y,Ohnaka Y,Morita Rdoi
10.1507/endocrj.42.323subject
Has Abstractpub_date
1995-06-01 00:00:00pages
323-30issue
3eissn
0918-8959issn
1348-4540journal_volume
42pub_type
杂志文章abstract::Tumor necrosis factor-alpha (TNF-alpha) in placenta is believed to be involved in pathogenesis of intrauterine growth restriction. In contrast, insulin-like growth factors (IGFs) are believed to be important for stimulation of fetal and placental growth. IGF-I stimulates metabolic and growth-promoting actions directly...
journal_title:Endocrine journal
pub_type: 杂志文章
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abstract::Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...
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doi:10.1507/endocrj.EJ16-0280
更新日期:2017-01-30 00:00:00
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journal_title:Endocrine journal
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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doi:10.1507/endocrj.EJ19-0036
更新日期:2019-10-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1993-08-01 00:00:00
abstract::Late-night salivary cortisol (NSC) has been recognized as a sensitive and easy-to-perform screening test for the diagnosis of overt Cushing's syndrome (CS). However, there have been few reports on the diagnostic utility of salivary cortisol (SC) measurement in the diagnosis of subclinical Cushing's syndrome (SCS). T...
journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2011-01-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2009-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.42.405
更新日期:1995-06-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0033
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1995-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
abstract::Aerobic (sub lactate threshold; sub-LT) exercise training facilitates oxidative phosphorylation and glycolysis of skeletal muscle. Thyroid hormone (TH) also facilitates such metabolic events. Thus, we studied whether TH signaling pathway is activated by treadmill training. Male adult rats received 30 min/day treadmill...
journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2016-08-31 00:00:00
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journal_title:Endocrine journal
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更新日期:2014-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1507/endocrj.EJ15-0500
更新日期:2016-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2020-09-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,随机对照试验
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更新日期:2006-04-01 00:00:00
abstract::Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.207
更新日期:2002-04-01 00:00:00
abstract::The identification of unique point mutations in patients with pseudohypoparathyroidism (PHP) with Albright's hereditary osteodystrophy (AHO) in different ethnic backgrounds has proved that defects within the Gs alpha gene account for Gs alpha deficiency in those patients. To search a mutation hot spot of the Gs alpha ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.621
更新日期:1997-08-01 00:00:00