Abstract:
:The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycohemoglobin Standardization Program units (A1C-NGSP; %) and using glycated albumin (GA) level instead of fructosamine level for calculating the G-gap, we investigated whether the G-gap is better represented by GA/A1C ratio if expressed in SI units (GA/A1C-SI ratio) rather than in NGSP units (GA/A1C-% ratio). We examined 749 Japanese children with type 1 diabetes using simultaneous GA and A1C measurements. Of these, 369 patients were examined more than five times to assess the consistency of the G-gap and the GA/A1C ratio within individuals. The relationship of GA/A1C-% ratio to the corresponding A1C-NGSP was stronger than that of GA/A1C-SI ratio to A1C-IFCC. At enrollment, the inverse relationship between the GA/A1C-SI ratio and G-gap was highly significant (R(2) = 0.95) compared with that between the GA/A1C-% ratio and G-gap (R(2) = 0.69). A highly significant inverse relationship was also observed between the mean GA/A1C-SI ratio and the mean G-gaps obtained individually over time (R(2) = 0.95) compared with that using the corresponding A1C-NGSP (R(2) = 0.67). We conclude that the G-gap is better represented by the GA/A1C-SI ratio. We propose the use of mean GA/A1C-SI ratios easily obtained individually over time as reference values in Japanese children with type 1 diabetes (6.75 ± 0.60 [means ± SD]).
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.doi
10.1507/endocrj.EJ14-0066subject
Has Abstractpub_date
2015-01-01 00:00:00pages
161-72issue
2eissn
0918-8959issn
1348-4540pii
DN/JST.JSTAGE/endocrj/EJ14-0066journal_volume
62pub_type
杂志文章,多中心研究abstract::Age is an important prognostic factor in papillary thyroid carcinoma (PTC). In this study, we investigated the difference in prognosis of 7 subsets of PTC patients without distant metastasis at presentation or a history of radiation exposure (20 years or younger, 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej12-0044
更新日期:2012-01-01 00:00:00
abstract::Sodium-glucose co-transporter-2 inhibitors are newly established anti-diabetic agents with a unique glucose-lowering mechanism. In the present study, we investigated the efficacy and safety of the sodium-glucose co-transporter-2 inhibitor ipragliflozin (Ipra) for metabolic markers and cardiovascular parameters in Japa...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1507/endocrj.EJ18-0022
更新日期:2018-08-27 00:00:00
abstract::Plasma CRH levels were measured in patients with non-insulin dependent diabetes mellitus (NIDDM) as the pituitary-adrenal abnormalities have been reported in NIDDM. They were also measured after oral administration of 75 g glucose to examine whether glucose increased plasma CRH along with insulin secretion. The baseli...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.40.705
更新日期:1993-12-01 00:00:00
abstract::Although gonadal estrogens are known to facilitate the development of skeletal lesion in SHOX haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.197
更新日期:2004-04-01 00:00:00
abstract::A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ19-0183
更新日期:2019-12-25 00:00:00
abstract::Treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia with normothyroxinemia) has not been established. In this study, changes in thyroid function after discontinuation of low-dose L-thyroxine (L-T4) supplement in infants with the condition were evaluated. Fourteen infants with hy...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.379
更新日期:2003-08-01 00:00:00
abstract::Thyrotropin-releasing hormone (TRH)-stimulated thyroid stimulating hormone (TSH) response in normal subjects is suppressed by oral glucose administration. Pharmacologic studies indicate that this suppressive action of glucose is mediated by an increase in hypothalamic somatostatin (SRIH) tone. Since activation of the ...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1507/endocrj.52.69
更新日期:2005-02-01 00:00:00
abstract::Sarpogrelate, a selective 5-HT(2) receptor antagonist, is known to have a significant effect on antiplatelet action. This study was a double-blinded, randomized, paralleled multicenter trial to compare the effects of sarpogrelate and aspirin on preventing macrovascular complications in patients with type 2 diabetes. T...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1507/endocrj.ej12-0047
更新日期:2012-01-01 00:00:00
abstract::von Hippel-Lindau (VHL) disease (VHLD) is a hereditary autosomal dominant syndrome that causes various benign and malignant tumors. VHLD is caused by mutations in the VHL tumor suppressor gene. Here, we report a mutation in the VHL gene in a Japanese family with VHLD type 2A, characterized by pheochromocytoma (PHE), a...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-046
更新日期:2006-12-01 00:00:00
abstract::Bartter syndrome (BS) type 1, also referred to antenatal BS, is a genetic tubulopathy with hypokalemic metabolic alkalosis and prenatal onset of polyuria leading to polyhydramnios. It has been shown that BS type 1 is caused by mutations in the SLC12A1 gene encoding bumetanide-sensitive Na-K-2Cl (-) cotransporter (NKCC...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-204
更新日期:2007-12-01 00:00:00
abstract::Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HP...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ17-0155
更新日期:2017-12-28 00:00:00
abstract::Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension. The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium...
journal_title:Endocrine journal
pub_type: 历史文章,杂志文章
doi:10.1507/endocrj.42.781
更新日期:1995-12-01 00:00:00
abstract::Insulin and insulin-like growth factor-1 (IGF-1) are two structurally related hormones which produce similar biological activities such as metabolic and growth promoting actions. Their receptors, insulin and IGF-1 receptors, also share similarities in both structure and functions such as tyrosine-specific protein kina...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.43.suppl_s33
更新日期:1996-10-01 00:00:00
abstract::In order to compare the bone aging process in Werner's syndrome, a disease characterized by premature aging, and that in natural aging, we have assessed the bone status in a total of 19 cases (11 males and eight postmenopausal females) with Werner's syndrome. The spinal deformity index was determined for a total of 87...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.45.505
更新日期:1998-08-01 00:00:00
abstract::Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented wit...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-046
更新日期:2010-01-01 00:00:00
abstract::We previously developed a radioreceptor assay which is presumably specific for detection of blocking-type anti-TSH receptor (TSHR) antibodies using unsolubilized porcine TSHR. Employing this assay, we measured blocking TSH-binding inhibitory immunoglobulin (TBII) in the sera from 30 untreated Graves' patients and comp...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.703
更新日期:2001-12-01 00:00:00
abstract::Sixteen sporadic pheochromocytomas, 3 pheochromocytomas in neurofibromatosis 1, and 4 pheochromocytomas in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations at codon 768 of the RET proto-oncogene by AluI digestion of polymerase chain reaction PCR products and mutations in exon 13 by PCR-single st...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.109
更新日期:1996-02-01 00:00:00
abstract::The effect of luteinizing hormone releasing hormone (LHRH) on the neuronal activity of CA1 and CA3 regions of the hippocampus was studied by means of extracellular recordings in the castrated male, intact male, castrated female, and castrated female injected s.c. with 20 micrograms estradiol benzoate (EB) for 3 days. ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.42.251
更新日期:1995-04-01 00:00:00
abstract::The present study was undertaken to determine pathophysiology of body water control in hypernatremic subjects with hypothalamic space-occupying lesions. Eight subjects with hypothalamic space-occupying lesions were divided into two groups of hypernatremia in the presence or absence of body water deficit. In 5 dehydrat...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07e-132
更新日期:2008-08-01 00:00:00
abstract::In anovulatory patients ovulation is usually induced by clomiphene citrate (CC) or gonadotropin therapy, but in the case of polycystic ovary syndrome (PCOS), diagnosed by the presence of several micropolycysts in the ovaries and a high LH/FSH ratio in the serum, CC is only minimally effective, and side effects are oft...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.217
更新日期:1999-02-01 00:00:00
abstract::A fasting triglyceridemia >10 mmol/L is associated with chylomicronemia (CM) and an increased recurrent acute pancreatitis (RAP) risk. The number of pancreatitis episodes varies significantly between patients with CM. The objective of this study was to investigate gene expression profiles of RAP in patients with CM. A...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0123
更新日期:2020-11-28 00:00:00
abstract::Pathogenesis of pseudohypoparathyroidism type 1b (PHP-1b) is related to the loss of methylation at the GNAS exon A/B region, which is combined with epigenetic defects at other differentially methylated GNAS regions in most sporadic cases. In this study, we established a method for evaluating the methylation status of...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-364
更新日期:2011-01-01 00:00:00
abstract::A nationwide epidemiologic survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases was conducted in 2010 to clarify the prevalence and the clinical presentations of the disorders. A questionnaire inquiring the experience of patients with these diseases was sent to randomly selected hospitals th...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0275
更新日期:2015-01-01 00:00:00
abstract::Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.EJ16-0064
更新日期:2016-07-30 00:00:00
abstract::Insulin-like growth factor-I activates a calcium-permeable cation channel GRC (growth factor-regulated channel). In the present study, we investigated the immunohistochemical localization of GRC in human tissues using a polyclonal anti-GRC antibody. Immunoreactive GRC was detected in the stomach, duodenum, large intes...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.349
更新日期:2002-06-01 00:00:00
abstract::Endothelial dysfunction is considered to be an early event in the development of atherosclerosis. The present study was undertaken to evaluate endothelial function and biochemical markers in type 2 diabetes mellitus (T2DM) patients before and after treatment with or without pioglitazone (PIO). Forty-one T2DM patients ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k08e-308
更新日期:2009-01-01 00:00:00
abstract::Proliferative response of peripheral blood mononuclear cells (PBMC) to glutamic acid decarboxylase (GAD), which has been reported in patients with type 1 diabetes, was measured in type 2 diabetes, especially in patients with antibodies to GAD initially diagnosed as having type 2 diabetes (anti-GAD+ type 2 diabetes). W...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.753
更新日期:2000-12-01 00:00:00
abstract::Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. To date, while GH deficiency (GHD) has been reported in multiple patients with PHP-Ia caused by mutations on the maternally expressed GNAS coding regions a...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0033
更新日期:2015-01-01 00:00:00
abstract::The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These fact...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.EJ14-0303
更新日期:2014-01-01 00:00:00
abstract::Thyrotropin levels are outside normal reference range in subclinical thyroid disease. Metabolic syndrome (MetS) involves clustered cardiovascular risk factors, including abnormal lipids, insulin resistance, and hypertension. This study aimed to investigate associations between subclinical thyroid disease, thyrotropi...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej12-0076
更新日期:2012-01-01 00:00:00