Efficacy and safety of sodium-glucose cotransporter 2 inhibitor ipragliflozin on glycemic control and cardiovascular parameters in Japanese patients with type 2 diabetes mellitus; Fukuoka Study of Ipragliflozin (FUSION).

abstract：:The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH. Fifty patients with PCOS, ...

journal_title：Endocrine journal

authors： Bayraktar F,Dereli D,Ozgen AG,Yilmaz C

更新日期：2004-12-01 00:00:00

abstract：:The physiology of insulin signaling under normal and disease conditions is well studied in classical insulin target tissues, but not in podocytes. To examine insulin stimulation of podocyte GLUT4 translocation, we established a protocol involving treatment with the PPARα agonist fenofibrate to induce E11 podocyte diff...

journal_title：Endocrine journal

authors： Saito T,Yamada E,Okada S,Shimoda Y,Tagaya Y,Hashimoto K,Satoh T,Mori M,Okada J,Pessin JE,Yamada M

更新日期：2014-01-01 00:00:00

abstract：:Treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia with normothyroxinemia) has not been established. In this study, changes in thyroid function after discontinuation of low-dose L-thyroxine (L-T4) supplement in infants with the condition were evaluated. Fourteen infants with hy...

journal_title：Endocrine journal

authors： Tomita Y,Ishiguro H,Shinagawa T,Kubota C,Shinohara O

更新日期：2003-08-01 00:00:00

abstract：:Effects of reserpine treatment, not associated with pituitary irradiation, on the pituitary-adrenocortical axis in a total of 37 untreated patients with Cushing's disease were evaluated. With short-term treatment (2 mg daily for 2 weeks, n = 36), basal excretion of urinary 17-OHCS significantly decreased from 11.2 +/-...

journal_title：Endocrine journal

authors： Minamori Y,Yasuda K,Murayama M,Morita H,Yamakita N,Miura K

更新日期：1993-10-01 00:00:00

abstract：:Recent evidence indicates that urinary gonadotropins may be an alternative method for detecting pubertal disorders. The aim of this study was to evaluate the associations of first morning voided (FMV) and random urinary gonadotropins with the pubertal response to a gonadotropin-releasing hormone (GnRH) stimulation tes...

journal_title：Endocrine journal

authors： Shim YS,An SH,Lee HJ,Kang MJ,Yang S,Hwang IT

更新日期：2019-10-28 00:00:00

abstract：:To assess the total daily inulin dose (TDD) and contribution of basal insulin to TDD and to identify the predictive factors for insulin requirement profiles in subjects with type 2 diabetes, we retrospectively examined insulin requirement profiles of 275 hospitalized subjects treated with basal-bolus insulin therapy (...

journal_title：Endocrine journal

authors： Shimoda S,Okubo M,Koga K,Sekigami T,Kawashima J,Kukidome D,Igata M,Ishii N,Shimakawa A,Matsumura T,Motoshima H,Furukawa N,Nishida K,Araki E

更新日期：2015-01-01 00:00:00

abstract：:A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pitu...

journal_title：Endocrine journal

authors： Tanaka S,Tatsumi KI,Takano T,Murakami Y,Takao T,Yamakita N,Tahara S,Teramoto A,Hashimoto K,Kato Y,Amino N

更新日期：2003-12-01 00:00:00

abstract：:A preoperative molecular-based diagnostic technique for thyroid papillary and anaplastic carcinomas was recently developed to detect oncofetal fibronectin (onfFN) messenger RNA (mRNA) in fine needle aspiration biopsy (FNAB) by means of reverse transcription-polymerase chain reaction (RT-PCR). We report two cases of th...

journal_title：Endocrine journal

authors： Takano T,Shiba E,Tada H,Yoshimura H,Yoshida K,Doi R,Amino N

更新日期：2000-06-01 00:00:00

abstract：:We previously identified an approximately 200 bp "minimal promoter" of the rat TSH receptor (TSHR) gene which is essential for the promoter activity. In the present study, we have cloned and characterized an upstream region of the TSHR promoter to disclose additional functional element(s). We screened a rat genomic li...

journal_title：Endocrine journal

authors： Ikuyama S,Ohe K,Takayanagi R,Kohn LD,Nawata H

更新日期：1997-04-01 00:00:00

abstract：:Proliferative response of peripheral blood mononuclear cells (PBMC) to glutamic acid decarboxylase (GAD), which has been reported in patients with type 1 diabetes, was measured in type 2 diabetes, especially in patients with antibodies to GAD initially diagnosed as having type 2 diabetes (anti-GAD+ type 2 diabetes). W...

journal_title：Endocrine journal

authors： Fukui M,Nakamura N,Nakano K,Kajiyama S,Matsuo S,Obayashi H,Ohta M,Shigeta M,Shigeta H,Kitagawa Y,Kondo M

更新日期：2000-12-01 00:00:00

abstract：:The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These fact...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kobayashi K,Kihara M,Miya A

更新日期：2014-01-01 00:00:00

abstract：:The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...

journal_title：Endocrine journal

authors： Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.

更新日期：2015-01-01 00:00:00

abstract：:Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case of a 52-year-old female doctor suffering from breast cancer having metastasized to the lung...

journal_title：Endocrine journal

authors： Okahata S,Sakamoto K,Mitsumatsu T,Kondo Y,Noso S,Ikegami H,Shiba T

更新日期：2019-04-25 00:00:00

abstract：:To evaluate the clinical usefulness of serum soluble Fas (sFas) and sFas ligand as a prognostic factor and for monitoring the regression and progression of metastatic prostate cancer treated with endocrine therapy, sFas and sFas ligand were measured in sera collected from 30 patients with untreated metastatic prostate...

journal_title：Endocrine journal

authors： Furuya Y,Nagakawa O,Fuse H

更新日期：2003-10-01 00:00:00

abstract：:A fasting triglyceridemia >10 mmol/L is associated with chylomicronemia (CM) and an increased recurrent acute pancreatitis (RAP) risk. The number of pancreatitis episodes varies significantly between patients with CM. The objective of this study was to investigate gene expression profiles of RAP in patients with CM. A...

journal_title：Endocrine journal

authors： Tremblay K,Brisson D,Gaudet D

更新日期：2020-11-28 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is common in obese women with insulin resistant type 2 diabetes for which metformin treatment is getting established in addition to clomiphene. However, lean PCOS patients are sometimes accompanied with type 1 diabetes. It remains unclear whether these patients are insulin resistant an...

journal_title：Endocrine journal

authors： Shigiyama F,Kumashiro N,Rikitake T,Usui S,Saegusa M,Kitamura M,Uchino H,Hirose T

更新日期：2016-01-01 00:00:00

abstract：:Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-rel...

journal_title：Endocrine journal

authors： Irie J,Inagaki E,Fujita M,Nakaya H,Mitsuishi M,Yamaguchi S,Yamashita K,Shigaki S,Ono T,Yukioka H,Okano H,Nabeshima YI,Imai SI,Yasui M,Tsubota K,Itoh H

更新日期：2020-02-28 00:00:00

abstract：:The effects of an aqueous extract of Ferula hormonis on social aggression, fertility and some physiological and biochemical parameters were investigated in male mice. The ingestion of 3 mg/kg of aqueous extract of F. hormonis for six weeks clearly inhibited social aggression. Body wet weight and other sex accessory or...

journal_title：Endocrine journal

authors： Khleifat K,Homady MH,Tarawneh KA,Shakhanbeh J

更新日期：2001-08-01 00:00:00

abstract：:This study aims to investigate the prevalence of islet autoantibodies and other organ-specific autoantibodies in type 1 diabetes mellitus (T1DM) patients and characterize their clinical features. Glutamic acid decarboxylase antibody (GADA), insulinoma antigen 2 antibody (IA-2A), zinc transporter 8 antibody (ZnT8A) and...

journal_title：Endocrine journal

authors： Pan S,Wu T,Shi X,Xie Z,Huang G,Zhou Z

更新日期：2020-07-28 00:00:00

abstract：:Primary granulomatous hypophysitis (PGH) is a rarely occurred inflammatory disease of unknown etiology. We retrospective review a case of PGH treated by microsurgical transsphenoidal approach and review the appropriately documented cases of PGH collected from the literatures. The patient was a 56-year-old female who p...

journal_title：Endocrine journal

authors： Su SB,Zhang DJ,Yue SY,Zhang JN

更新日期：2011-01-01 00:00:00

abstract：:We have developed a new test for estimating the secretory capacity of parathyroid hormone (PTH) from the parathyroid gland. Sodium bicarbonate solution [8.4% (w/v); 35 ml/m(2) body surface area] was infused for 2 min, and blood samples for the determination of plasma ionized calcium, plasma PTH (intact, midregion, car...

journal_title：Endocrine journal

authors： Iwasaki Y,Mutsuga N,Yamamori E,Kakita A,Oiso Y,Imai T,Funahashi H,Tanaka Y,Kondo K,Nakashima N

更新日期：2003-10-01 00:00:00

abstract：:A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and...

journal_title：Endocrine journal

authors： Naito Y,Mori J,Tazoe J,Tomida A,Yagyu S,Nakajima H,Iehara T,Tatsuzawa K,Mukai T,Hosoi H

更新日期：2019-12-25 00:00:00

abstract：:Seven patients with growth hormone (GH)-secreting pituitary adenoma were treated preoperatively with octreotide (Sandostatin or SMS 201-995; a somatostatin analogue), and were compared with 18 non-treated patients in their clinical courses and adenoma analyses. Octreotide treatment improved the endocrinological data i...

journal_title：Endocrine journal

authors： Tsukamoto N,Nagaya T,Kuwayama A,Takano K,Shizume K,Sugita K,Seo H

更新日期：1994-08-01 00:00:00

abstract：:Immunoreactive activin A (ir-activin A) release from cultured rat anterior pituitary cells was examined by measuring ir-activin A in culture medium by a specific radioimmunoassay. Ir-activin A release into the medium increased over 1-18 days, and reached a maximal level at 12-15 days. The basal levels of ir-activin A ...

journal_title：Endocrine journal

authors： Liu ZH,Shintani Y,Wakatsuki M,Sakamoto Y,Harada K,Zhang CY,Saito S

更新日期：1996-02-01 00:00:00

abstract：:We previously developed a radioreceptor assay which is presumably specific for detection of blocking-type anti-TSH receptor (TSHR) antibodies using unsolubilized porcine TSHR. Employing this assay, we measured blocking TSH-binding inhibitory immunoglobulin (TBII) in the sera from 30 untreated Graves' patients and comp...

journal_title：Endocrine journal

authors： Tada H,Izumi Y,Watanabe Y,Takano T,Fukata S,Kuma K,Hidaka Y,Amino N

更新日期：2001-12-01 00:00:00

abstract：:Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension. The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium...

journal_title：Endocrine journal

authors： Ohtsuka H,Komiya I,Aizawa T,Yamada T

更新日期：1995-12-01 00:00:00

abstract：:Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. Howe...

journal_title：Endocrine journal

authors： Shu X,Shu S,Tang S,Yang L,Liu D,Li K,Dong Z,Ma Z,Zhu Z,Din J

更新日期：2018-04-26 00:00:00

abstract：:Pathogenesis of pseudohypoparathyroidism type 1b (PHP-1b) is related to the loss of methylation at the GNAS exon A/B region, which is combined with epigenetic defects at other differentially methylated GNAS regions in most sporadic cases. In this study, we established a method for evaluating the methylation status of...

journal_title：Endocrine journal

authors： Kinoshita K,Minagawa M,Takatani T,Takatani R,Ohashi M,Kohno Y

更新日期：2011-01-01 00:00:00

abstract：:The syndrome of McCune-Albright syndrome (MAS) is clasically defined as a triad presentation with the findings of polyostotic fibrous dysplasia, café-au-lait spots, and sexual precocity. However, not all patients present with complete symptoms. A 52-year-old man was diagnosed as having a variant of McCune-Albright syn...

journal_title：Endocrine journal

authors： Sargin H,Gozu H,Bircan R,Sargin M,Avsar M,Ekinci G,Yayla A,Gulec I,Bozbuga M,Cirakoglu B,Tanakol R

更新日期：2006-02-01 00:00:00

abstract：:This study investigates whether the plasma brain natriuretic peptide (BNP) level is increased by the clinical traits of diabetes, including its complications, and whether these levels are affected by the presence of other combined diseases such as hypertension, hyperlipidemia, and coronary heart disease (CHD) in patie...

journal_title：Endocrine journal

authors： Igarashi M,Jimbu Y,Hirata A,Tominaga M

更新日期：2005-06-01 00:00:00