Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia.

abstract：:We measured serum levels of the carboxy-terminal propeptide of type 1 procollagen (P1CP) as a marker of bone formation and the carboxy-terminal telopeptide of type 1 collagen (1CTP) as a marker of bone resorption by RIA in sera from 40 Graves' disease patients and 14 Hashimoto's disease patients before and during trea...

journal_title：Endocrine journal

authors： Miyakawa M,Tsushima T,Demura H

更新日期：1996-12-01 00:00:00

abstract：:The octanoylation of Ser3 is essential for the biological function of ghrelin. We examined the concentrations of the n-octanoylated active-form ghrelin in cord and neonatal blood using an RIA system that specifically recognized n-octanoylated ghrelin, as well as a system that measured the total ghrelin concentration. ...

journal_title：Endocrine journal

authors： Yokota I,Kitamura S,Hosoda H,Kotani Y,Kangawa K

更新日期：2005-04-01 00:00:00

abstract：:Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively. We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation. In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells. Ce...

journal_title：Endocrine journal

authors： Kitamura R,Ogata T,Tanaka Y,Motoyoshi K,Seno M,Takei I,Umezawa K,Kojima I

更新日期：2007-04-01 00:00:00

abstract：:Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented wit...

journal_title：Endocrine journal

authors： Advani A,Johnson SJ,Nicol MR,Papacleovoulou G,Evans DB,Vaikkakara S,Mason JI,Quinton R

更新日期：2010-01-01 00:00:00

abstract：:Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPA...

journal_title：Endocrine journal

authors： Kurosawa H,Saisho Y,Fukunaga K,Haraguchi M,Yamasawa W,Kurihara I,Betsuyaku T,Itoh H

更新日期：2018-01-30 00:00:00

abstract：:The gene responsible for multiple endocrine neoplasia type 1 (MEN1) has recently been cloned, and its germline mutations were identified in patients with this syndrome. The majority of the mutations, frameshift or nonsense mutations, are expected to result in a loss of function of the gene product menin. Since the con...

journal_title：Endocrine journal

authors： Miyauchi A,Sato M,Matsubara S,Ohye H,Kihara M,Matsusaka K,Nishitani A,Takahara J

更新日期：1998-12-01 00:00:00

abstract：:Guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), are primarily present in the intestine and maintain homeostasis in body fluids. Recently, rats whose macrophages overexpress Gn and GC-C were found to be resistant to diet-induced obesity. Considering that obesity is strongly related to a...

journal_title：Endocrine journal

authors： Hasegawa K,Akieda-Asai S,Fujii Y,Bae CR,Yasuda M,Date Y

更新日期：2015-01-01 00:00:00

abstract：:Insulin and insulin-like growth factor-1 (IGF-1) are two structurally related hormones which produce similar biological activities such as metabolic and growth promoting actions. Their receptors, insulin and IGF-1 receptors, also share similarities in both structure and functions such as tyrosine-specific protein kina...

journal_title：Endocrine journal

authors： Kadowaki T,Tobe K,Honda-Yamamoto R,Tamemoto H,Kaburagi Y,Momomura K,Ueki K,Takahashi Y,Yamauchi T,Akanuma Y,Yazaki Y

更新日期：1996-10-01 00:00:00

abstract：:In hope of understanding possible roles of estrogen during early embryogenesis, we examined the expression of both estrogen receptor alpha (ER alpha) and ER beta, a recently cloned novel subtype, in mouse oocytes and preimplantation embryos by means of reverse transcription polymerase chain reaction (RT-PCR). To inves...

journal_title：Endocrine journal

authors： Hiroi H,Momoeda M,Inoue S,Tsuchiya F,Matsumi H,Tsutsumi O,Muramatsu M,Taketani Y

更新日期：1999-02-01 00:00:00

abstract：:Since there is increasing evidence that postprandial hyperglycemia is a risk factor for the development of macrovascular complications, it is important to predict postprandial hyperglycemia in the early stages of glucose intolerance, and routine medical checkups provide a good opportunity to do so. The aim of this stu...

journal_title：Endocrine journal

authors： Goto M,Yamamoto-Honda R,Shimbo T,Goto A,Terauchi Y,Kanazawa Y,Noda M

更新日期：2011-01-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH)-stimulated thyroid stimulating hormone (TSH) response in normal subjects is suppressed by oral glucose administration. Pharmacologic studies indicate that this suppressive action of glucose is mediated by an increase in hypothalamic somatostatin (SRIH) tone. Since activation of the ...

journal_title：Endocrine journal

authors： Park C,Kim E,Sohn S,Yang I,Koh G,Oh S,Woo J,Kim S,Kim J,Kim Y,Oh K,Park S,Park S

更新日期：2005-02-01 00:00:00

abstract：:The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...

journal_title：Endocrine journal

authors： Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.

更新日期：2015-01-01 00:00:00

abstract：:A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pitu...

journal_title：Endocrine journal

authors： Tanaka S,Tatsumi KI,Takano T,Murakami Y,Takao T,Yamakita N,Tahara S,Teramoto A,Hashimoto K,Kato Y,Amino N

更新日期：2003-12-01 00:00:00

abstract：:As a rare condition characterized by inflammation of the pituitary gland, hypophysitis usually results in hypopituitarism and pituitary enlargement. The most critical outcome of hypopituitarism is caused by secondary adrenal insufficiency. Glucocorticoid deficiency is a life-threatening condition, and patients who dev...

journal_title：Endocrine journal

authors： Aikawa E,Horie I,Naganobu K,Nozaki A,Kamada A,Abiru N,Kawakami A

更新日期：2020-11-28 00:00:00

abstract：:There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control d...

journal_title：Endocrine journal

authors： Abbas JM,Chakraborty J,Akanji AO,Doi SA

更新日期：2008-05-01 00:00:00

abstract：:Synchronous associations of Cushing's syndrome (CS) and primary aldosteronism (PA) with multiple adrenocortical adenomas secreting each hormone independently have rarely been reported. Herein, we describe a unique case of PA associated with CS with detailed clinical and pathological investigations. Bilateral adrenal m...

journal_title：Endocrine journal

authors： Onoda N,Ishikawa T,Nishio K,Tahara H,Inaba M,Wakasa K,Sumi T,Yamazaki T,Shigematsu K,Hirakawa K

更新日期：2009-01-01 00:00:00

abstract：:Metabolic disorders, such as PCOS (polycystic ovarian syndrome) and T2DM (type 2 diabetes mellitus), are associated with menstrual dysfunction, anovulation, infertility, and early pregnancy loss. Ovarian dysfunction is not only related to low pregnancy rates but also to the increased risk of miscarriage. Women with PC...

journal_title：Endocrine journal

authors： Su Y,Wu J,He J,Liu X,Chen X,Ding Y,Zhang C,Chen W,Wang Y,Gao R

更新日期：2017-06-29 00:00:00

abstract：:This study aimed to assess the relationship between the metabolic effect after laparoscopic sleeve gastrectomy (LSG) in morbidly obese Japanese patients, with or without type 2 diabetes mellitus (T2DM), and improved pancreatic steatosis (PS). The study enrolled 27 morbidly obese Japanese patients who were undergoing L...

journal_title：Endocrine journal

authors： Umemura A,Sasaki A,Nitta H,Baba S,Ando T,Kajiwara T,Ishigaki Y

更新日期：2017-05-30 00:00:00

abstract：:The purpose of this study was to determine whether treatment using the active form of vitamin D (1,25(OH)2D3) could protect against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats and ameliorate oxidative stress. Male Sprague-Dawley rats were divided into three groups and treated with sta...

journal_title：Endocrine journal

authors： Zhu CG,Liu YX,Wang H,Wang BP,Qu HQ,Wang BL,Zhu M

更新日期：2017-07-28 00:00:00

abstract：:Growth hormone (GH) secreted from the pituitary is essential for postnatal growth in animals. GH exerts its actions by a direct effect on target organs and by stimulating insulin-like growth factor I (IGF-I) production. In the human pituitary, there is a naturally occurring variant protein which has a molecular mass o...

journal_title：Endocrine journal

authors： Yoshizato H,Tanaka M,Fujikawa T,Higashimoto Y,Shimizu A,Nakashima K

更新日期：2000-03-01 00:00:00

abstract：:Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...

journal_title：Endocrine journal

authors： Kawashima Sonoyama Y,Tajima T,Fujimoto M,Hasegawa A,Miyahara N,Nishimura R,Hashida Y,Hayashi A,Hanaki K,Kanzaki S

更新日期：2017-01-30 00:00:00

abstract：:To assess the total daily inulin dose (TDD) and contribution of basal insulin to TDD and to identify the predictive factors for insulin requirement profiles in subjects with type 2 diabetes, we retrospectively examined insulin requirement profiles of 275 hospitalized subjects treated with basal-bolus insulin therapy (...

journal_title：Endocrine journal

authors： Shimoda S,Okubo M,Koga K,Sekigami T,Kawashima J,Kukidome D,Igata M,Ishii N,Shimakawa A,Matsumura T,Motoshima H,Furukawa N,Nishida K,Araki E

更新日期：2015-01-01 00:00:00

abstract：:PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

journal_title：Endocrine journal

authors： Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

更新日期：1997-02-01 00:00:00

abstract：:This study investigates whether the plasma brain natriuretic peptide (BNP) level is increased by the clinical traits of diabetes, including its complications, and whether these levels are affected by the presence of other combined diseases such as hypertension, hyperlipidemia, and coronary heart disease (CHD) in patie...

journal_title：Endocrine journal

authors： Igarashi M,Jimbu Y,Hirata A,Tominaga M

更新日期：2005-06-01 00:00:00

abstract：:Immunoglobulin G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 levels, IgG4-positive plasmacytes, and lymphocyte infiltration into multiple organs. IgG4 thyroiditis is a subset of patients with Hashimoto's thyroiditis (HT) who exhibited histopathological features of IgG4-RD; its source of serum Ig...

journal_title：Endocrine journal

authors： Takeshima K,Ariyasu H,Inaba H,Inagaki Y,Yamaoka H,Furukawa Y,Doi A,Furuta H,Nishi M,Akamizu T

更新日期：2015-01-01 00:00:00

abstract：:Late-night salivary cortisol (NSC) has been recognized as a sensitive and easy-to-perform screening test for the diagnosis of overt Cushing's syndrome (CS). However, there have been few reports on the diagnostic utility of salivary cortisol (SC) measurement in the diagnosis of subclinical Cushing's syndrome (SCS). T...

journal_title：Endocrine journal

authors： Tateishi Y,Kouyama R,Mihara M,Doi M,Yoshimoto T,Hirata Y

更新日期：2012-01-01 00:00:00

abstract：:Thyroid hormone plays an important role in growth hormone (GH) synthesis and secretion. To study the relationship between thyroid function and urinary GH secretion in the hyperthyroid and hypothyroid states, we measured thyroid hormones, simultaneously with serum and urinary GH levels, in 54 patients with thyroid dise...

journal_title：Endocrine journal

authors： Murao K,Takahara J,Sato M,Tamaki M,Niimi M,Ishida T

更新日期：1994-10-01 00:00:00

abstract：:Sarcopenia is an emerging risk factor for metabolic disorders. No study of the association of sarcopenia with insulin resistance, diabetes, and metabolic syndrome (MS) according to age group and obesity status in the general population has been reported. We investigated these associations in the Korean population. Par...

journal_title：Endocrine journal

authors： Moon SS

更新日期：2014-01-01 00:00:00

abstract：:Thyrotoxic periodic paralysis (TPP) is mainly associated with Graves' disease but rarely with autonomously functioning thyroid nodule (AFTN). We herein report a case of AFTN associated with TPP in which the latter resolved after (131) I therapy for the former. We analyzed the genes encoding thyrotropin receptor (TSHR)...

journal_title：Endocrine journal

authors： Ozaki H,Mori K,Nakagawa Y,Hoshikawa S,Ito S,Yoshida K

更新日期：2008-03-01 00:00:00

abstract：:The purpose of the study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) levels and PAI-1 activity in young and lean women with PCOS and to compare with controls matched for age and weight. Thirty two women with PCOS and 25 weight and age-matched healthy controls participated in this study. Patients were...

journal_title：Endocrine journal

authors： Tarkun I,Cantürk Z,Arslan BC,Türemen E,Tarkun P

更新日期：2004-10-01 00:00:00