Abstract:
:There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control design to evaluate differences in lipid parameters between cases and controls. Univariate analysis revealed that many factors were associated with LDL particle size. Binary logistic regression however revealed that only thyroid status and serum triglyceride (TG) levels were independently associated with LDL particle size. Results from this study support an independent association between LDL particle size phenotype and both plasma TG concentrations and thyroid status. After adjusting for TG levels, other insulin resistance syndrome (IRS) traits were not associated with LDL size phenotype, suggesting that the IRS related sdLDL is linked most strongly to alterations in TG levels.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Abbas JM,Chakraborty J,Akanji AO,Doi SAdoi
10.1507/endocrj.k07e-065subject
Has Abstractpub_date
2008-05-01 00:00:00pages
381-9issue
2eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K07E-065journal_volume
55pub_type
杂志文章abstract::Angiopoietin-like protein 8 (ANGPTL8) is a newly discovered adipokine plays an important role in energy homoeostasis, obesity and type 2 diabetes (T2D). Although lifestyle modification in obesity and T2D is known to offer metabolic benefits, there is paucity of comprehensive data on change in ANGPTL8. We investigated ...
journal_title:Endocrine journal
pub_type: 杂志文章,随机对照试验
doi:10.1507/endocrj.EJ18-0191
更新日期:2019-01-28 00:00:00
abstract::Patients with growth hormone (GH) deficiency (GHD) have a clinical feature of visceral adiposity and it has been reported that these patients have an increased active cortisol (F)/inactive cortisone (E) metabolite ratio. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an enzyme expressed in liver and adipo...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k08e-311
更新日期:2009-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.131
更新日期:2002-04-01 00:00:00
abstract::To determine whether patients with medullary thyroid carcinoma (MTC) develop other endocrine neoplasms or their relatives develop MTC, we investigated the mutations in the RET proto-oncogene in patients with multiple endocrine neoplasia type 2B (MEN 2B, N = 1) and sporadic MTC (N = 6). DNA from MTC tissue and the peri...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
doi:10.1507/endocrj.44.559
更新日期:1997-08-01 00:00:00
abstract::Insulin and insulin-like growth factor-1 (IGF-1) are two structurally related hormones which produce similar biological activities such as metabolic and growth promoting actions. Their receptors, insulin and IGF-1 receptors, also share similarities in both structure and functions such as tyrosine-specific protein kina...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.43.suppl_s33
更新日期:1996-10-01 00:00:00
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journal_title:Endocrine journal
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doi:10.1507/endocrj.ej11-0157
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abstract::The identification of unique point mutations in patients with pseudohypoparathyroidism (PHP) with Albright's hereditary osteodystrophy (AHO) in different ethnic backgrounds has proved that defects within the Gs alpha gene account for Gs alpha deficiency in those patients. To search a mutation hot spot of the Gs alpha ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.621
更新日期:1997-08-01 00:00:00
abstract::This is a case report of an 18-year-old man with central diabetes incipidus (DI). An MRI done three months after the onset of the DI did not disclose a responsible lesion. Four months later, a second MRI showed the location of the tumor origin at the upper pituitary stalk and median eminence. Eight months later, the t...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.263
更新日期:1999-04-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.459
更新日期:1999-06-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,评审
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更新日期:2016-07-30 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0112
更新日期:2016-10-29 00:00:00
abstract::The aim of this study is to investigate glucose metabolism longitudinally during pregnancy to explore mechanisms underlying gestational diabetes mellitus (GDM). We reviewed a total of 62 pregnant Japanese women who underwent a 75g oral glucose tolerance test (OGTT) twice during pregnancy (median: early, 13; late, 28 w...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.95
更新日期:1997-02-01 00:00:00
abstract::A 77-year-old man was diagnosed as having hypothyroidism. An electrocardiogram obtained at the time of the first examination revealed Brugada electrocardiographic waveforms in leads V1 to V3. When pilsicainide hydrochloride loading changed the waveforms of the electrocardiographic ST segment, this result suggested an ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07e-024
更新日期:2008-07-01 00:00:00
abstract::Diabetes mellitus complicated with insulin antibodies is rare in clinical practice but usually difficult to control. A high amount of insulin antibodies, especially with low affinity and high binding capacity, leads to unstable glycemic control characterized by hyperglycemia unresponsive to large volume of insulin and...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0523
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.511
更新日期:1996-10-01 00:00:00
abstract::Recent studies indicate that succinate dehydrogenase (SDH) genes B, C, or D are, at least partly, involved in the pathogenesis of pheochromocytoma or paraganglioma. Of these three genes, the SDHD gene mutation is most closely related with paragangliomas of the neck. Here we describe a case of an SDHD-related paragangl...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k09e-111
更新日期:2009-01-01 00:00:00
abstract::We report on two siblings with classic simple virilizing 21-hydroxylase deficiency whose neonatal screening for serum 17alpha-hydroxyprogesterone (17-OHP) gave normal results. The proband, a girl with clitoromegaly whose screening 17-OHP value had been 9.2 ng/ml, was diagnosed at the age of 6 months, and her elder bro...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.45.427
更新日期:1998-06-01 00:00:00
abstract::Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented wit...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-046
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.655
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0541
更新日期:2021-01-21 00:00:00
abstract::The syndrome of inappropriate secretion of thyrotropin (SITSH) is defined as the inappropriate non-suppression of serum TSH in the presence of elevated free thyroid hormone; TSH-secreting pituitary adenomas and the syndrome of resistance to thyroid hormone are the main etiologies of SITSH. In addition, erroneous thyro...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej12-0089
更新日期:2012-01-01 00:00:00
abstract::Growth hormone (GH) secreted from the pituitary is essential for postnatal growth in animals. GH exerts its actions by a direct effect on target organs and by stimulating insulin-like growth factor I (IGF-I) production. In the human pituitary, there is a naturally occurring variant protein which has a molecular mass o...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.supplmarch_s37
更新日期:2000-03-01 00:00:00
abstract::The aim of the study was to explore the relationship between daily glycemic variability (GV) and visit-to-visit glycemic variability (VVV) in patients with type 2 diabetes (T2DM). A total of 156 outpatients with T2DM who had undergone continuous glucose monitoring (CGM) for 5 days were included in this study. Indices ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0012
更新日期:2020-08-28 00:00:00
abstract::Ghrelin is a peptide hormone with a unique structure comprising a medium chain fatty acid modification. Ghrelin cells are known to be abundantly localized in the gastric mucosa and are released into the blood stream to exert their multifunctional physiological effects. To elucidate the regulatory mechanisms of ghrelin...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.64.S27
更新日期:2017-01-01 00:00:00
abstract::This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.61
更新日期:2003-02-01 00:00:00
abstract::Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism and anosmia, for which three modes of transmission have been described: X-linked, autosomal recessive and autosomal dominant. The KAL1 gene, responsible for the X-linked form of the disease, has been isolated and its intron-exon organizat...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.651
更新日期:1999-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1507/endocrj.EJ17-0303
更新日期:2018-02-26 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the rate of malignancy in thyroid nodules incidentally detected at sonography and to determine the diagnostic value of ultrasonography-guided fine needle aspiration cytology (USgFNAC) in thyroid nodules. METHODS:Five hundred patients (84 men and 416 women) who had thyr...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07-120
更新日期:2008-03-01 00:00:00