Histopathological improvement of acromegalic cardiomyopathy by intermittent subcutaneous infusion of octreotide.

abstract：:The neurohypophysial hormone, oxytocin, is involved in the regulation of energy metabolism. Adiponectin (APN) is an adipose tissue-specific serum protein that inversely associates with metabolic syndrome (MetS). High-molecular-weight adiponectin (HMW APN) is considered the active form. In the present study, we aimed t...

journal_title：Endocrine journal

authors： Yuan G,Qian W,Pan R,Jia J,Jiang D,Yang Q,Wang S,Liu Y,Yu S,Hu H,Sun W,Ye J,Mao C,Zhuang R,Zhou L

更新日期：2016-07-30 00:00:00

abstract：:Guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), are primarily present in the intestine and maintain homeostasis in body fluids. Recently, rats whose macrophages overexpress Gn and GC-C were found to be resistant to diet-induced obesity. Considering that obesity is strongly related to a...

journal_title：Endocrine journal

authors： Hasegawa K,Akieda-Asai S,Fujii Y,Bae CR,Yasuda M,Date Y

更新日期：2015-01-01 00:00:00

abstract：:There are two main subtypes of GH-producing pituitary adenoma: densely granulated (DG-type) and sparsely granulated (SG-type). Despite the difference in drug responsiveness between the two subtypes, their molecular mechanisms remain unknown. The aim of this study is to evaluate the differential expression of genes r...

journal_title：Endocrine journal

authors： Kato M,Inoshita N,Sugiyama T,Tani Y,Shichiri M,Sano T,Yamada S,Hirata Y

更新日期：2012-01-01 00:00:00

abstract：:PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

journal_title：Endocrine journal

authors： Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

更新日期：1997-02-01 00:00:00

abstract：:The purpose of this study is to evaluate the impact of insulin secretion-sensitivity index-2 (ISSI-2) in the identification of the role of pancreatic iron deposition on beta-cell function in thalassemia major. Tissue iron stores were measured with magnetic resonance imaging (MRI) in the liver (R2), pancreas (R2*), and...

journal_title：Endocrine journal

authors： Karadas N,Yurekli B,Bayraktaroglu S,Aydinok Y

更新日期：2019-12-25 00:00:00

abstract：:Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...

journal_title：Endocrine journal

authors： Kabalak T,Ozgen AG

更新日期：2002-04-01 00:00:00

abstract：:A 43-year-old woman was admitted to our hospital for further treatment of acromegaly with high plasma GH and IGF-I levels after transsphenoidal adenomectomy and subsequent treatment with bromocriptine. Physical examination and magnetic resonance imaging (MRI) showed an active acromegalic appearance with residual pitui...

journal_title：Endocrine journal

authors： Matsuno M,Sohmiya M,Yamamoto H,Kato Y

更新日期：1998-10-01 00:00:00

abstract：:Expression of activin A in fetal rat pancreas was studied immunohistochemically by using anti-activin A antibody. On embryonic day 12 (E12), cells in cap-like pancreatic anlage were stained with anti-activin A antibody. In these sections, no immunoreactive insulin or glucagon was observed. On E13.5, cells containing i...

journal_title：Endocrine journal

authors： Furukawa M,Eto Y,Kojima I

更新日期：1995-02-01 00:00:00

abstract：:Exercise is a fundamental component of diabetes management. However, choosing inappropriate type or timing of exercise is associated with mild or severe hypoglycemia either during exercise or several hours after exercise. Several studies have shown that impaired counterregulatory responses triggers hypoglycemia. There...

journal_title：Endocrine journal

authors： Mao Y,Wen S,Zhou M,Zhu S,Zhou L

更新日期：2019-09-28 00:00:00

abstract：:Metabolic syndrome is a common disorder in Taiwan. For this study 431 subjects were randomly selected from visitors to the Department of Health Management. Blood pressure, blood glucose, lipid, uric acid levels and anthropometric measurements with immunoreactive insulin (IRI) and leptin levels were all correlated. We ...

journal_title：Endocrine journal

authors： Chiou WK,Lin JD,Weng HF,Ou YC,Liu TH,Fang JT

更新日期：2005-02-01 00:00:00

abstract：:A preoperative molecular-based diagnostic technique for thyroid papillary and anaplastic carcinomas was recently developed to detect oncofetal fibronectin (onfFN) messenger RNA (mRNA) in fine needle aspiration biopsy (FNAB) by means of reverse transcription-polymerase chain reaction (RT-PCR). We report two cases of th...

journal_title：Endocrine journal

authors： Takano T,Shiba E,Tada H,Yoshimura H,Yoshida K,Doi R,Amino N

更新日期：2000-06-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) and its agonists have been known to directly affect steroid hormone production in human granulosa cells. In this study, we examined effects of GnRH on Ca2+ mobilization, protein kinase C activity and steroidogenesis of human granulosa cells. Human granulosa cells were harvested by...

journal_title：Endocrine journal

authors： Hori H,Uemura T,Minaguchi H

更新日期：1998-04-01 00:00:00

abstract：:Proliferative response of peripheral blood mononuclear cells (PBMC) to glutamic acid decarboxylase (GAD), which has been reported in patients with type 1 diabetes, was measured in type 2 diabetes, especially in patients with antibodies to GAD initially diagnosed as having type 2 diabetes (anti-GAD+ type 2 diabetes). W...

journal_title：Endocrine journal

authors： Fukui M,Nakamura N,Nakano K,Kajiyama S,Matsuo S,Obayashi H,Ohta M,Shigeta M,Shigeta H,Kitagawa Y,Kondo M

更新日期：2000-12-01 00:00:00

abstract：:We propose a new classification of thyroid follicular cell tumors which is correlated with patient's prognosis. It is unique as to two new categories: borderline malignancy between benign and malignant, and moderately differentiated adenocarcinoma (MDA) as a differentiation classification to stratify tumor aggressive...

journal_title：Endocrine journal

authors： Kakudo K,Bai Y,Liu Z,Li Y,Ito Y,Ozaki T

更新日期：2012-01-01 00:00:00

abstract：:The mechanisms of paradoxical TRH response in human somatotroph adenoma cells were investigated using intracellular calcium measurement and static incubation assay. Intracellular calcium measurement revealed that TRH induces a biphasic response: a transient increase followed by a sustained plateau. The transient phase...

journal_title：Endocrine journal

authors： Okinaga H,Takano K,Hayashi S,Yasufuku-Takano J,Teramoto A,Fujita T

更新日期：2005-12-01 00:00:00

abstract：:To assess the total daily inulin dose (TDD) and contribution of basal insulin to TDD and to identify the predictive factors for insulin requirement profiles in subjects with type 2 diabetes, we retrospectively examined insulin requirement profiles of 275 hospitalized subjects treated with basal-bolus insulin therapy (...

journal_title：Endocrine journal

authors： Shimoda S,Okubo M,Koga K,Sekigami T,Kawashima J,Kukidome D,Igata M,Ishii N,Shimakawa A,Matsumura T,Motoshima H,Furukawa N,Nishida K,Araki E

更新日期：2015-01-01 00:00:00

abstract：:To address the effects of ezetimibe on high-density lipoprotein (HDL) metabolism, the HDL subclasses, cholesteryl ester transfer protein (CETP), and lecithin-cholesterol acyltransferase (LCAT) were measured in patients with type 2 diabetes mellitus (T2DM). Twenty-three hypercholesterolemic patients with T2DM were tre...

journal_title：Endocrine journal

authors： Yagyu H,Nagashima S,Takahashi M,Miyamoto M,Okada K,Osuga J,Ishibashi S

更新日期：2012-01-01 00:00:00

abstract：:We report a rare case of ACTH-independent macronodular adrenal hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT). A 57-year-old woman was admitted to our hospital for further examination of secondary hypertension and bilateral adrenal macrotumors. Midnight serum cortisol elevation with undetectable plasma AC...

journal_title：Endocrine journal

authors： Sato M,Soma M,Nakayama T,Kosuge K,Suzuki R,Okada K,Komatsu K,Sugitani M,Matsumoto K

更新日期：2006-02-01 00:00:00

abstract：:The aim of this study is to explore beta cell dysfunction and its clinical significance in gestational diabetes mellitus (GDM). We assessed insulin sensitivity and insulin secretion in a total of 277 Japanese women between 24 and 27 weeks of pregnancy who underwent a 2 h, 75 g oral glucose tolerance test (OGTT) becaus...

journal_title：Endocrine journal

authors： Saisho Y,Miyakoshi K,Tanaka M,Shimada A,Ikenoue S,Kadohira I,Yoshimura Y,Itoh H

更新日期：2010-01-01 00:00:00

abstract：:Pathogenesis of pseudohypoparathyroidism type 1b (PHP-1b) is related to the loss of methylation at the GNAS exon A/B region, which is combined with epigenetic defects at other differentially methylated GNAS regions in most sporadic cases. In this study, we established a method for evaluating the methylation status of...

journal_title：Endocrine journal

authors： Kinoshita K,Minagawa M,Takatani T,Takatani R,Ohashi M,Kohno Y

更新日期：2011-01-01 00:00:00

abstract：:Recent studies indicate that succinate dehydrogenase (SDH) genes B, C, or D are, at least partly, involved in the pathogenesis of pheochromocytoma or paraganglioma. Of these three genes, the SDHD gene mutation is most closely related with paragangliomas of the neck. Here we describe a case of an SDHD-related paragangl...

journal_title：Endocrine journal

authors： Yamashita R,Usui T,Hashimoto S,Suzuki H,Takahashi M,Honkura K,Iwamoto K,Kodama E,Tagami T,Naruse M,Shimatsu A,Kaise K

更新日期：2009-01-01 00:00:00

abstract：:Angiotensin II (Ang II) is a well-known peptide that maintains the balance of electrolytes in the higher vertebrates. Ang II stimulation in the adrenal gland induces the synthesis of mineralocorticoids, mainly aldosterone, through the up-regulation of aldosterone synthase (CYP11B2) gene expression. Additionally, it ha...

journal_title：Endocrine journal

authors： Ito R,Shima H,Masuda K,Sato I,Shimada H,Yokoyama A,Shirahige K,Igarashi K,Sugawara A

更新日期：2020-12-26 00:00:00

abstract：:The aim of this study was to assess the changes in insulin secretion and insulin sensitivity in relation to fasting and 2-hour plasma glucose (PG) levels and to assess the independent contributions of their impairments to non-diabetic hyperglycemia. A total of 2157 Japanese workers (mean age 52.6±7.3 years and mean B...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Sakurai M,Nakamura K,Moriuchi T,Miyamoto S,Nohara A,Kawashiri MA,Takeda Y,Yamagishi M

更新日期：2012-01-01 00:00:00

abstract：:To determine whether patients with medullary thyroid carcinoma (MTC) develop other endocrine neoplasms or their relatives develop MTC, we investigated the mutations in the RET proto-oncogene in patients with multiple endocrine neoplasia type 2B (MEN 2B, N = 1) and sporadic MTC (N = 6). DNA from MTC tissue and the peri...

journal_title：Endocrine journal

authors： Migita M,Hiromatsu Y,Sato M,Yang D,Kameo J,Jimi A,Nonaka K

更新日期：1997-08-01 00:00:00

abstract：:Erythropoietin (EPO) is known to stimulate erythropoiesis after binding with its specific receptor. In clinics, EPO is widely used in hemodialyzed patients with diabetes. However, changes in the expression of the erythropoietin receptor (EPOR) under diabetic conditions are still unclear. Therefore, we investigated EPO...

journal_title：Endocrine journal

authors： Kuo SC,Li Y,Cheng KC,Niu CS,Cheng JT,Niu HS

更新日期：2018-02-26 00:00:00

abstract：:Primary granulomatous hypophysitis (PGH) is a rarely occurred inflammatory disease of unknown etiology. We retrospective review a case of PGH treated by microsurgical transsphenoidal approach and review the appropriately documented cases of PGH collected from the literatures. The patient was a 56-year-old female who p...

journal_title：Endocrine journal

authors： Su SB,Zhang DJ,Yue SY,Zhang JN

更新日期：2011-01-01 00:00:00

abstract：:Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completel...

journal_title：Endocrine journal

authors： Fukumoto S,Ozono K,Michigami T,Minagawa M,Okazaki R,Sugimoto T,Takeuchi Y,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-ol...

journal_title：Endocrine journal

authors： Aoyama M,Takizawa H,Tsuboi M,Nakagawa Y,Tangoku A

更新日期：2017-12-28 00:00:00

abstract：:This study aims to investigate the prevalence of islet autoantibodies and other organ-specific autoantibodies in type 1 diabetes mellitus (T1DM) patients and characterize their clinical features. Glutamic acid decarboxylase antibody (GADA), insulinoma antigen 2 antibody (IA-2A), zinc transporter 8 antibody (ZnT8A) and...

journal_title：Endocrine journal

authors： Pan S,Wu T,Shi X,Xie Z,Huang G,Zhou Z

更新日期：2020-07-28 00:00:00

abstract：:Effects of reserpine treatment, not associated with pituitary irradiation, on the pituitary-adrenocortical axis in a total of 37 untreated patients with Cushing's disease were evaluated. With short-term treatment (2 mg daily for 2 weeks, n = 36), basal excretion of urinary 17-OHCS significantly decreased from 11.2 +/-...

journal_title：Endocrine journal

authors： Minamori Y,Yasuda K,Murayama M,Morita H,Yamakita N,Miura K

更新日期：1993-10-01 00:00:00