Differential expression of genes related to drug responsiveness between sparsely and densely granulated somatotroph adenomas.

abstract：:There are differences in the susceptibility of rat strains to pituitary growth and lactotroph proliferation caused by long-term treatment with estrogens. To investigate the pituitary mechanism for this strain difference in estrogen-induced lactotroph proliferation, we compared the abilities of 17-β estradiol (E2) and ...

journal_title：Endocrine journal

authors： Mitsui T,Ishida M,Izawa M,Arita J

更新日期：2013-01-01 00:00:00

abstract：:In an attempt to define the hypothalamic-pituitary-adrenal (HPA) axis in non-insulin dependent diabetic rats (WBN/Kob), we measured plasma corticotropin releasing factor (CRF), as well as arginine vasopressin (AVP), ACTH, and corticosterone (B), CRF concentrations in the median eminence (ME), the remainder of the hypo...

journal_title：Endocrine journal

authors： Tojo C,Takao T,Nishioka T,Numata Y,Suemaru S,Hashimoto K

更新日期：1996-04-01 00:00:00

abstract：:The neurohypophysial hormone, oxytocin, is involved in the regulation of energy metabolism. Adiponectin (APN) is an adipose tissue-specific serum protein that inversely associates with metabolic syndrome (MetS). High-molecular-weight adiponectin (HMW APN) is considered the active form. In the present study, we aimed t...

journal_title：Endocrine journal

authors： Yuan G,Qian W,Pan R,Jia J,Jiang D,Yang Q,Wang S,Liu Y,Yu S,Hu H,Sun W,Ye J,Mao C,Zhuang R,Zhou L

更新日期：2016-07-30 00:00:00

abstract：:Sexual differentiation of the rodent brain is recognized to involve transcriptional activation of multiple genes induced by gonadal steroids at developmental stages. To identify the genes differing in expression level between sexes, we analyzed gene expression in male and female rat hypothalami at postnatal day 5 by m...

journal_title：Endocrine journal

authors： Yonehara K,Suzuki M,Nishihara M

更新日期：2002-04-01 00:00:00

abstract：:The syndrome of McCune-Albright syndrome (MAS) is clasically defined as a triad presentation with the findings of polyostotic fibrous dysplasia, café-au-lait spots, and sexual precocity. However, not all patients present with complete symptoms. A 52-year-old man was diagnosed as having a variant of McCune-Albright syn...

journal_title：Endocrine journal

authors： Sargin H,Gozu H,Bircan R,Sargin M,Avsar M,Ekinci G,Yayla A,Gulec I,Bozbuga M,Cirakoglu B,Tanakol R

更新日期：2006-02-01 00:00:00

abstract：:A series of chimeric TSH-LH/CG receptors were constructed by substituting homologous segments of the extracellular domain of the rat TSH receptor with corresponding segments of rat LH/CG receptor: C1 (amino acids 37-123 substituted), C2 (91-112), C3 (173-234), C4 (233-266), C5 (268-304), C6 (112-305) and C7 (36-404). ...

journal_title：Endocrine journal

authors： Akamizu T,Inoue D,Kosugi S,Ban T,Kohn LD,Imura H,Mori T

更新日期：1993-06-01 00:00:00

abstract：:Patients with growth hormone (GH) deficiency (GHD) have a clinical feature of visceral adiposity and it has been reported that these patients have an increased active cortisol (F)/inactive cortisone (E) metabolite ratio. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an enzyme expressed in liver and adipo...

journal_title：Endocrine journal

authors： Morita J,Hakuno F,Hizuka N,Takahashi S,Takano K

更新日期：2009-01-01 00:00:00

abstract：:Age is an important prognostic factor in papillary thyroid carcinoma (PTC). In this study, we investigated the difference in prognosis of 7 subsets of PTC patients without distant metastasis at presentation or a history of radiation exposure (20 years or younger, 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kihara M,Takamura Y,Kobayashi K,Miya A

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH. Fifty patients with PCOS, ...

journal_title：Endocrine journal

authors： Bayraktar F,Dereli D,Ozgen AG,Yilmaz C

更新日期：2004-12-01 00:00:00

abstract：:Parathyroidectomy (PTX) is the standard treatment for secondary hyperparathyroidism (SHPT); however, the administration of cinacalcet has gained prominence as a noninvasive treatment. We aimed to determine whether PTX or cinacalcet is more effective in preventing morbidity and mortality through reviewing follow-up dat...

journal_title：Endocrine journal

authors： Kim WW,Rhee Y,Kim BS,Kim K,Lee CR,Kang SW,Lee J,Jeong JJ,Nam KH,Chung WY

更新日期：2019-10-28 00:00:00

abstract：:Fructose 2,6-bisphosphate (F2,6BP) is a powerful allosteric activator of 6-phosphofructo-1-kinase, which is the rate-limiting enzyme for glycolysis. Mitogenic stimulation of lymphocytes is related to an enhanced rate of glucose utilization and F2,6BP mediated activation of glycolysis. To determine the effect of hyperg...

journal_title：Endocrine journal

authors： Atsumi T,Chiba H,Yoshioka N,Bucala R,Koike T

更新日期：2007-08-01 00:00:00

abstract：:Growth hormone (GH) is known to accelerate spermatogenesis and maintain gonadal function. In this study, we evaluated the effect of GH on recovery from testicular damage induced by cyclophosphamide (CP). Eleven- to fourteen-week-old GH-deficient Lewis rats (dw/dw) were divided into 4 groups (n = 10 each), with one gro...

journal_title：Endocrine journal

authors： Satoh K,Ohyama K,Nakagomi Y,Ohta M,Shimura Y,Sano T,Ishikawa H,Amemiya S,Nakazawa S

更新日期：2002-12-01 00:00:00

abstract：:Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...

journal_title：Endocrine journal

authors： Kawashima Sonoyama Y,Tajima T,Fujimoto M,Hasegawa A,Miyahara N,Nishimura R,Hashida Y,Hayashi A,Hanaki K,Kanzaki S

更新日期：2017-01-30 00:00:00

abstract：:Carcinoma showing thymic-like differentiation (CASTLE) is a rare tumour of the thyroid, which arises from ectopic thymic tissue or remnants of branchial pouches. A systematic review of English literature evidences less than thirty cases; from them, it clearly appears that CASTLE is considered an indolent slow-growing ...

journal_title：Endocrine journal

authors： Cappelli C,Tironi A,Marchetti GP,Pirola I,De Martino E,Delbarba A,Castellano M,Rosei EA

更新日期：2008-08-01 00:00:00

abstract：:Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amyl...

journal_title：Endocrine journal

authors： Miyagawa J,Hanafusa O,Sasada R,Yamamoto K,Igarashi K,Yamamori K,Seno M,Tada H,Nammo T,Li M,Yamagata K,Nakajima H,Namba M,Kuwajima M,Matsuzawa Y

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:Surgical removal of growth hormone-producing pituitary adenomas (GHomas) becomes difficult when they invade the cavernous sinus (CS). We investigated the relation among tumor proliferative potential, tumor volume and invasion of GHomas to CS. MATERIALS & METHODS:15 patients with GHoma aged 20-59 years were enr...

journal_title：Endocrine journal

authors： Iuchi S,Saeki N,Uchino Y,Higuchi Y,Tatsuno I,Nakamura S,Yasuda T,Yamaura A

更新日期：2000-03-01 00:00:00

abstract：:The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

journal_title：Endocrine journal

authors： Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

更新日期：2005-10-01 00:00:00

abstract：:The islets of Langerhans is the endocrine function region of pancreas, which exist in five cell types. The majority of endocrine cells are insulin-secreting β cells, mixed up with glucagon-secreting α-cells. The islets of Langerhans are highly vascularized, and the capillary network around the islet is about five time...

journal_title：Endocrine journal

authors： Cao Z,Wang X

更新日期：2014-01-01 00:00:00

abstract：:Our previous studies have revealed that protein malnutrition enhances insulin signaling in rat liver and muscle in response to a bolus insulin injection. However, it has not been established whether protein malnutrition up-regulates insulin signaling under physiological conditions, such as feeding. Here, we studied th...

journal_title：Endocrine journal

authors： Toyoshima Y,Tokita R,Taguchi Y,Akiyama-Akanishi N,Takenaka A,Kato H,Chida K,Hakuno F,Minami S,Takahashi S

更新日期：2014-01-01 00:00:00

abstract：:Thyrotropin levels are outside normal reference range in subclinical thyroid disease. Metabolic syndrome (MetS) involves clustered cardiovascular risk factors, including abnormal lipids, insulin resistance, and hypertension. This study aimed to investigate associations between subclinical thyroid disease, thyrotropi...

journal_title：Endocrine journal

authors： Wang CY,Chang TC,Chen MF

更新日期：2012-01-01 00:00:00

abstract：:X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

journal_title：Endocrine journal

authors： Miyamoto J,Koto S,Hasegawa Y

更新日期：2000-04-01 00:00:00

abstract：:To evaluate the usefulness of monitoring serum sialic acid (SA) levels for diagnosis and follow-up of subacute granulomatous thyroiditis (SAT), 43 patients were studied at our clinic. In the acute phase of the disease their SA levels averaged 104.9 +/- 19.7 mg/dl (normal 44-69 mg/dl). In the recovery phase SA levels r...

journal_title：Endocrine journal

authors： Tajiri J,Noguchi S,Morita M,Tamaru M,Murakami T,Murakami N

更新日期：1993-02-01 00:00:00

abstract：:Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

journal_title：Endocrine journal

authors： Luo J,Yang X,Liang J,Li W

更新日期：2015-01-01 00:00:00

abstract：:We report herein the case of a 1-year-old boy with McCune-Albright syndrome (MAS) who presented with infantile-onset Cushing' s syndrome caused by ACTH independent macronodular adrenal hyperplasia (AIMAH). Abdominal CT, MRI, and adrenal scintigraphy with (131)I-adosterol identified bilateral adrenal involvement with t...

journal_title：Endocrine journal

authors： Hamajima T,Maruwaka K,Homma K,Matsuo K,Fujieda K,Hasegawa T

更新日期：2010-01-01 00:00:00

abstract：:Glucagon dysfunction as well as insulin dysfunction is associated with the pathogenesis of type 2 diabetes (T2DM). However, it is still unclear whether the measurement of plasma glucagon levels is useful in understanding the pathophysiology of T2DM. We recently reported that sandwich ELISA provides more accurate plasm...

journal_title：Endocrine journal

authors： Kobayashi M,Satoh H,Matsuo T,Kusunoki Y,Tokushima M,Watada H,Namba M,Kitamura T

更新日期：2020-09-28 00:00:00

abstract：:Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation....

journal_title：Endocrine journal

authors： Yamamuro T,Inoue K,Nagai Y,Azuma D,Yamamoto A,Hara K,Kohara M,Iwata T,Nakatsuka S,Morii E,Yamamoto T

更新日期：2018-12-28 00:00:00

abstract：:To examine the specific changes in gene expression in thyroid carcinomas, we performed sequence specific-differential display (SS-DD) analysis by using a specific degenerate primer for the superfamily of the small G protein. After subcloning and sequencing analysis, one of the genes that showed decreased expression in...

journal_title：Endocrine journal

authors： Liu G,Takano T,Matsuzuka F,Higashiyama T,Kuma K,Amino N

更新日期：1999-06-01 00:00:00

abstract：:The common phenotype of nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene mutations in 46,XY is gonadal dysgenesis without adrenal deficiency. Though the phenotype of gonadal dysgenesis is variable, ranging from complete female to normal male genitalia, an asymptomatic 46,XY male is rare. Preserved fertil...

journal_title：Endocrine journal

authors： Yagi H,Takagi M,Kon M,Igarashi M,Fukami M,Hasegawa Y

更新日期：2015-01-01 00:00:00

abstract：:Sodium-glucose co-transporter-2 inhibitors are newly established anti-diabetic agents with a unique glucose-lowering mechanism. In the present study, we investigated the efficacy and safety of the sodium-glucose co-transporter-2 inhibitor ipragliflozin (Ipra) for metabolic markers and cardiovascular parameters in Japa...

journal_title：Endocrine journal

authors： Nomiyama T,Shimono D,Horikawa T,Fujimura Y,Ohsako T,Terawaki Y,Fukuda T,Motonaga R,Tanabe M,Yanase T,Collaborators of Fukuoka Study of Ipragliflozin (FUSION) trial.

更新日期：2018-08-27 00:00:00

abstract：:A 19-year-old girl presented at our emergency room with hypokalemic periodic paralysis. She had a thyrotoxic goiter and had experienced three paralytic attacks during the previous 2 years on occasions when she stopped taking antithyroid drugs. In addition to thyrotoxic periodic paralysis (TPP), she had metabolic acido...

journal_title：Endocrine journal

authors： Im EJ,Lee JM,Kim JH,Chang SA,Moon SD,Ahn YB,Son HS,Cha BY,Lee KW,Son HY

更新日期：2010-01-01 00:00:00