Abstract:
:Sexual differentiation of the rodent brain is recognized to involve transcriptional activation of multiple genes induced by gonadal steroids at developmental stages. To identify the genes differing in expression level between sexes, we analyzed gene expression in male and female rat hypothalami at postnatal day 5 by means of a cDNA microarray consisting of 2352 genes. By comparing the expression pattern between sexes, we identified 12 male-enriched genes and 20 female-enriched genes. Among them, the expression pattern of 1 male-enriched gene, jagged homolog 1, and those of 2 female-enriched genes, p27Kip1 and p130, were confirmed to be consistent with microarray data by RT-PCR. Investigation of these genes should help to elucidate the molecular and cellular mechanisms underlying sexual differentiation of the rodent central nervous system.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Yonehara K,Suzuki M,Nishihara Mdoi
10.1507/endocrj.49.131subject
Has Abstractpub_date
2002-04-01 00:00:00pages
131-7issue
2eissn
0918-8959issn
1348-4540journal_volume
49pub_type
杂志文章abstract::In this study, nine patients with Graves' ophthalmopathy with positive clinical activity score (CAS), who were either unresponsive or not suitable for glucocorticoid treatment, were given 100 microg of octreotide three times daily, subcutaneously, for three months. The mean age was 49+/-13 years. All patients were und...
journal_title:Endocrine journal
pub_type: 杂志文章
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journal_title:Endocrine journal
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:
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abstract::To determine whether patients with medullary thyroid carcinoma (MTC) develop other endocrine neoplasms or their relatives develop MTC, we investigated the mutations in the RET proto-oncogene in patients with multiple endocrine neoplasia type 2B (MEN 2B, N = 1) and sporadic MTC (N = 6). DNA from MTC tissue and the peri...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0577
更新日期:2020-11-18 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2018-08-27 00:00:00
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journal_title:Endocrine journal
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更新日期:2020-08-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.557
更新日期:2001-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07e-020
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2000-06-01 00:00:00
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journal_title:Endocrine journal
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更新日期:1996-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-008
更新日期:2010-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
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