Involvement of the cholinergic pathway in the pathogenesis of pituitary Cushing's syndrome.

abstract：:A 43-year-old woman was admitted to our hospital for further treatment of acromegaly with high plasma GH and IGF-I levels after transsphenoidal adenomectomy and subsequent treatment with bromocriptine. Physical examination and magnetic resonance imaging (MRI) showed an active acromegalic appearance with residual pitui...

journal_title：Endocrine journal

authors： Matsuno M,Sohmiya M,Yamamoto H,Kato Y

更新日期：1998-10-01 00:00:00

abstract：:Sarpogrelate, a selective 5-HT(2) receptor antagonist, is known to have a significant effect on antiplatelet action. This study was a double-blinded, randomized, paralleled multicenter trial to compare the effects of sarpogrelate and aspirin on preventing macrovascular complications in patients with type 2 diabetes. T...

journal_title：Endocrine journal

authors： Park SY,Rhee SY,Oh S,Kwon HS,Cha BY,Lee HJ,Lee HC,Kim YS

更新日期：2012-01-01 00:00:00

abstract：:The effects of an aqueous extract of Ferula hormonis on social aggression, fertility and some physiological and biochemical parameters were investigated in male mice. The ingestion of 3 mg/kg of aqueous extract of F. hormonis for six weeks clearly inhibited social aggression. Body wet weight and other sex accessory or...

journal_title：Endocrine journal

authors： Khleifat K,Homady MH,Tarawneh KA,Shakhanbeh J

更新日期：2001-08-01 00:00:00

abstract：:The aim of this study is to investigate glucose metabolism longitudinally during pregnancy to explore mechanisms underlying gestational diabetes mellitus (GDM). We reviewed a total of 62 pregnant Japanese women who underwent a 75g oral glucose tolerance test (OGTT) twice during pregnancy (median: early, 13; late, 28 w...

journal_title：Endocrine journal

authors： Saisho Y,Miyakoshi K,Ikenoue S,Kasuga Y,Matsumoto T,Minegishi K,Yoshimura Y,Itoh H

更新日期：2013-01-01 00:00:00

abstract：:Seven patients with growth hormone (GH)-secreting pituitary adenoma were treated preoperatively with octreotide (Sandostatin or SMS 201-995; a somatostatin analogue), and were compared with 18 non-treated patients in their clinical courses and adenoma analyses. Octreotide treatment improved the endocrinological data i...

journal_title：Endocrine journal

authors： Tsukamoto N,Nagaya T,Kuwayama A,Takano K,Shizume K,Sugita K,Seo H

更新日期：1994-08-01 00:00:00

abstract：:An early thirties man diagnosed with Erdheim-Chester disease (ECD) was simultaneously disclosed to have hypogonadotropic hypogonadism, central adrenal insufficiency, and GH deficiency in addition to central diabetes insipidus (CDI). Pituitary magnetic resonance imaging (MRI) showed swelling in the stalk, enlargement o...

journal_title：Endocrine journal

authors： Manaka K,Makita N,Iiri T

更新日期：2014-01-01 00:00:00

abstract：:To measure thyroid-stimulating antibody (TSAb) in sera from patients with Graves' disease, we developed a new assay system with using frozen stocks of CHO-K1 cells. CHO-K1 cells transfected with cloned thyrotropin (TSH) receptor on a 96 well plate were frozen in Cell Banker and stored at -70 degrees C. Three days befo...

journal_title：Endocrine journal

authors： Takano T,Sumizaki H,Amino N

更新日期：1997-06-01 00:00:00

abstract：:Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation....

journal_title：Endocrine journal

authors： Yamamuro T,Inoue K,Nagai Y,Azuma D,Yamamoto A,Hara K,Kohara M,Iwata T,Nakatsuka S,Morii E,Yamamoto T

更新日期：2018-12-28 00:00:00

abstract：:Triptolide, a major active component of Tripterygium wilfordii Hook F (TWHF), is known to have multiple pharmacological activities. However, studies have also shown that triptolide is highly toxic to the reproductive system by disrupting normal androgen and estrogen signaling. In the present study, we investigated the...

journal_title：Endocrine journal

authors： Zhang J,Liu L,Mu X,Jiang Z,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:We have developed a new test for estimating the secretory capacity of parathyroid hormone (PTH) from the parathyroid gland. Sodium bicarbonate solution [8.4% (w/v); 35 ml/m(2) body surface area] was infused for 2 min, and blood samples for the determination of plasma ionized calcium, plasma PTH (intact, midregion, car...

journal_title：Endocrine journal

authors： Iwasaki Y,Mutsuga N,Yamamori E,Kakita A,Oiso Y,Imai T,Funahashi H,Tanaka Y,Kondo K,Nakashima N

更新日期：2003-10-01 00:00:00

abstract：:Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gl...

journal_title：Endocrine journal

authors： Nakahara R,Tsunekawa K,Yabe S,Nara M,Seki K,Kasahara T,Ogiwara T,Nishino M,Kobayashi I,Murakami M

更新日期：2005-12-01 00:00:00

abstract：:Continuous subcutaneous insulin infusion (CSII) therapy using insulin pumps has become widely used in the treatment of type 1 diabetes mellitus (T1DM). This retrospective study aimed to assess the efficacy and safety of long-term insulin pump treatment in patients with T1DM aged ≥50 years. The study included patients ...

journal_title：Endocrine journal

authors： Matejko B,Krzyżowska S,Kieć-Wilk B,Malecki MT,Klupa T

更新日期：2020-03-28 00:00:00

abstract：:It has been indicated that some subsets of clinically nonfunctioning pituitary adenoma exhibit immunohistochemical and ultrastructural features of somatotroph or corticotroph cells, which are described as silent somatotroph and corticotroph adenomas, respectively. We here describe a 70-year-old woman with nonfunctioni...

journal_title：Endocrine journal

authors： Sakaguchi H,Koshiyama H,Sano T,Inoue D,Hashimoto N,Aoki N,Nakao K

更新日期：1997-04-01 00:00:00

abstract：:The cytologic localization and cellular levels of insulin-like growth factor binding protein-4 (IGFBP-4) in follicular and stromal compartments of normal and polycystic ovary syndrome (PCOS) ovaries during follicular growth and regression were investigated by the avidin/biotin immunoperoxidase method with a polyclonal...

journal_title：Endocrine journal

authors： Peng X,Maruo T,Samoto T,Mochizuki M

更新日期：1996-06-01 00:00:00

abstract：:The relative concentrations of total insulin receptor (IR) mRNA were measured in the epididymal adipose tissue and liver of intact untreated rats, dexamethasone-treated rats, adrenalectomized rats and adrenalectomized rats treated with dexamethasone, using RNA blot assays and a specific IR cDNA probe. Northern blot as...

journal_title：Endocrine journal

authors： Leal MA,Aller P,Mas A,Carranza MC,Calle C

更新日期：1994-12-01 00:00:00

abstract：:Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-ol...

journal_title：Endocrine journal

authors： Aoyama M,Takizawa H,Tsuboi M,Nakagawa Y,Tangoku A

更新日期：2017-12-28 00:00:00

abstract：:Although several authors have reported single cases illustrative of some ultrasonographic characteristic of parathyroid carcinoma, the value of ultrasonography for diagnosing this entity remains to be determined. The purpose of our study was to investigate the ultrasonographic features of parathyroid carcinoma in a la...

journal_title：Endocrine journal

authors： Hara H,Igarashi A,Yano Y,Yashiro T,Ueno E,Aiyoshi Y,Ito K,Obara T

更新日期：2001-04-01 00:00:00

abstract：:The islets of Langerhans is the endocrine function region of pancreas, which exist in five cell types. The majority of endocrine cells are insulin-secreting β cells, mixed up with glucagon-secreting α-cells. The islets of Langerhans are highly vascularized, and the capillary network around the islet is about five time...

journal_title：Endocrine journal

authors： Cao Z,Wang X

更新日期：2014-01-01 00:00:00

abstract：:Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension. The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium...

journal_title：Endocrine journal

authors： Ohtsuka H,Komiya I,Aizawa T,Yamada T

更新日期：1995-12-01 00:00:00

abstract：:Pituitary adrenocorticotropic hormone (ACTH)-secreting tumor presents with a variety of clinical features. We outlined the features of ACTH release and characteristics of corticotroph adenoma cells. We especially focused on the corticotroph adenomas in patients with no clinical features of Cushing's disease. Subclinic...

journal_title：Endocrine journal

authors： Kageyama K,Oki Y,Nigawara T,Suda T,Daimon M

更新日期：2014-01-01 00:00:00

abstract：:The present study was aimed to examine the possible functional relationship between melatonin and hypothalamic transmitters, endogenous opioids and excitatory amino acids in controlling gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous injection of naloxone (mu opioid receptor antagonist), ...

journal_title：Endocrine journal

authors： Akema T,Ikeda T,Chiba A,Sugiyama H,Sato I,Kimura F,Toyoda J

更新日期：1999-12-01 00:00:00

abstract：:The onset of physical signs in infants with hypophosphatemic vitamin D resistant rickets (HDRR) has generally been considered to be at the age of 12 months, but the time of appearance of hypophosphatemia and rachitic signs on radiographs remains unclear. We report a prospective study in three neonates whose mothers we...

journal_title：Endocrine journal

authors： Minamitani K,Minagawa M,Yasuda T,Niimi H

更新日期：1996-06-01 00:00:00

abstract：:Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity...

journal_title：Endocrine journal

authors： Iwasaki T,Nakajima A,Yoneda M,Terauchi Y

更新日期：2006-06-01 00:00:00

abstract：:This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...

journal_title：Endocrine journal

authors： Daimon M,Sugiyama K,Kameda W,Saitoh T,Oizumi T,Hirata A,Yamaguchi H,Ohnuma H,Igarashi M,Kato T

更新日期：2003-02-01 00:00:00

abstract：:Thyroid nodules (TN) are common in the general population, and the clinical importance of diagnosing thyroid nodules is based on excluding the possibility of thyroid cancer, which occurs in 7-15% of cases. The thyroid gland, owing to its superficial location, is easily accessible via thermography, a noninvasive method...

journal_title：Endocrine journal

authors： Damião CP,Montero JRG,Moran MBH,de Oliveira Marçal E Silva Carvalho ME,de Farias CG,Brito IB,Saad MAN,Fontes CAP,Fainstein C,Rodrigues MFO,Palombo A,Conci A,da Cruz Filho RA,Lima GAB

更新日期：2021-01-21 00:00:00

abstract：:PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

journal_title：Endocrine journal

authors： Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

更新日期：1997-02-01 00:00:00

abstract：:In this study, nine patients with Graves' ophthalmopathy with positive clinical activity score (CAS), who were either unresponsive or not suitable for glucocorticoid treatment, were given 100 microg of octreotide three times daily, subcutaneously, for three months. The mean age was 49+/-13 years. All patients were und...

journal_title：Endocrine journal

authors： Uysal AR,Corapçioğlu D,Tonyukuk VC,Güllü S,Sav H,Kamel N,Erdoğan G

更新日期：1999-08-01 00:00:00

abstract：:The effect of add-on therapy with sitagliptin on glycemic control was prospectively investigated in patients with type 2 diabetes mellitus (T2DM) receiving insulin alone or insulin combined with oral antidiabetic drugs. Seventy-one patients were evaluated (38 men and 33 women aged 63.9 ± 10.2 years). They were divided...

journal_title：Endocrine journal

authors： Katsuno T,Ikeda H,Ida K,Miyagawa J,Namba M

更新日期：2013-01-01 00:00:00

abstract：:Sexual differentiation of the rodent brain is recognized to involve transcriptional activation of multiple genes induced by gonadal steroids at developmental stages. To identify the genes differing in expression level between sexes, we analyzed gene expression in male and female rat hypothalami at postnatal day 5 by m...

journal_title：Endocrine journal

authors： Yonehara K,Suzuki M,Nishihara M

更新日期：2002-04-01 00:00:00

abstract：:Plasma CRH levels were measured in patients with non-insulin dependent diabetes mellitus (NIDDM) as the pituitary-adrenal abnormalities have been reported in NIDDM. They were also measured after oral administration of 75 g glucose to examine whether glucose increased plasma CRH along with insulin secretion. The baseli...

journal_title：Endocrine journal

authors： Hashimoto K,Nishioka T,Takao T,Numata Y

更新日期：1993-12-01 00:00:00