Intraventricular injection of melatonin inhibits naloxone-induced, but not NMDA- or LHRH-induced LH release in ovariectomized estrogen-primed rats.

abstract：:Some categories of drugs are known for causing hyperglycemia or diabetes such as steroids, antipsychotics, and immunosuppressant. However, there has been little evidence from studies about the proportion of each drug in the context of drug-induced diabetes. In this study, we used data from the Japanese Adverse Drug Ev...

journal_title：Endocrine journal

authors： Konishi H,Shirakawa J,Arai M,Terauchi Y

更新日期：2019-06-28 00:00:00

abstract：:We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide po...

journal_title：Endocrine journal

authors： Zheng J,Chen LL,Xiao F,Hu X,Deng X,Li H

更新日期：2012-01-01 00:00:00

abstract：:Transsphenoidal adenomectomy is currently the first choice for treatment of patients with pituitary ACTH-dependent Cushing's syndrome. However, pharmacotherapy is prescribed for some patients, e.g., unsuccessful surgery. We treated a woman in whom pituitary Cushing's syndrome was improved while she was on antimuscarin...

journal_title：Endocrine journal

authors： Shimizu C,Yamane Y,Ishizuka T,Kijima H,Takano K,Takano A,Kubo M,Koike T

更新日期：2001-06-01 00:00:00

abstract：:von Hippel-Lindau (VHL) disease (VHLD) is a hereditary autosomal dominant syndrome that causes various benign and malignant tumors. VHLD is caused by mutations in the VHL tumor suppressor gene. Here, we report a mutation in the VHL gene in a Japanese family with VHLD type 2A, characterized by pheochromocytoma (PHE), a...

journal_title：Endocrine journal

authors： Imanaka M,Iida K,Takahashi K,Tsuji K,Nishizawa H,Fukuoka H,Takeno R,Takahashi Y,Okimura Y,Kaji H,Chihara K

更新日期：2006-12-01 00:00:00

abstract：:Growth hormone (GH) is known to accelerate spermatogenesis and maintain gonadal function. In this study, we evaluated the effect of GH on recovery from testicular damage induced by cyclophosphamide (CP). Eleven- to fourteen-week-old GH-deficient Lewis rats (dw/dw) were divided into 4 groups (n = 10 each), with one gro...

journal_title：Endocrine journal

authors： Satoh K,Ohyama K,Nakagomi Y,Ohta M,Shimura Y,Sano T,Ishikawa H,Amemiya S,Nakazawa S

更新日期：2002-12-01 00:00:00

abstract：:Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. To date, while GH deficiency (GHD) has been reported in multiple patients with PHP-Ia caused by mutations on the maternally expressed GNAS coding regions a...

journal_title：Endocrine journal

authors： Sano S,Iwata H,Matsubara K,Fukami M,Kagami M,Ogata T

更新日期：2015-01-01 00:00:00

abstract：:The mechanism of onset of hypoglycemia in patients with carnitine deficiency has yet to be determined. Using mice with systemic carnitine deficiency (JVS mice), we examined this mechanism, focusing on the weaning period (days 14-28 postpartum). For normal mice, the survival rate was 100%, and no hypoglycemia was obser...

journal_title：Endocrine journal

authors： Kuwajima M,Fujihara H,Sei H,Umehara A,Sei M,Tsuda TT,Sukeno A,Okamoto T,Inubushi A,Ueta Y,Doi T,Kido H

更新日期：2007-12-01 00:00:00

abstract：:Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gl...

journal_title：Endocrine journal

authors： Nakahara R,Tsunekawa K,Yabe S,Nara M,Seki K,Kasahara T,Ogiwara T,Nishino M,Kobayashi I,Murakami M

更新日期：2005-12-01 00:00:00

abstract：:Circulating human GH (hGH) consists of several molecular isoforms. It was previously reported that the proportion of 20 kilodalton hGH (20K-hGH) was elevated in the serum of patients with active acromegaly. In this study, we investigated the effects of octreotide and transsphenoidal adenomectomy on the proportion of 2...

journal_title：Endocrine journal

authors： Murakami Y,Shimizu T,Yamamoto M,Kato Y

更新日期：2004-06-01 00:00:00

abstract：:Postprandial hyperglycemia and/or hyperlipidemia can contribute to development of atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The objective of this study was to compare the effects of miglitol and sitagliptin on postprandial glucose and lipid metabolism in patients with T2DM. Thirty-five patients...

journal_title：Endocrine journal

authors： Okada K,Yagyu H,Kotani K,Yamazaki H,Ozaki K,Takahashi M,Nagashima S,Osuga J,Ishibashi S

更新日期：2013-01-01 00:00:00

abstract：:To evaluate the usefulness of monitoring serum sialic acid (SA) levels for diagnosis and follow-up of subacute granulomatous thyroiditis (SAT), 43 patients were studied at our clinic. In the acute phase of the disease their SA levels averaged 104.9 +/- 19.7 mg/dl (normal 44-69 mg/dl). In the recovery phase SA levels r...

journal_title：Endocrine journal

authors： Tajiri J,Noguchi S,Morita M,Tamaru M,Murakami T,Murakami N

更新日期：1993-02-01 00:00:00

abstract：:We describe here a patient with primary hyperparathyroidism who had high serum intact PTH levels for over 16 months after parathyroidectomy without signs of recurrence or persistence of the disease. The patient was a 48-year-old female who appeared well nourished (body mass index, 23.7). She was received subtotal gast...

journal_title：Endocrine journal

authors： Mimura Y,Kanauchi H,Ogawa T,Ohkura F,Kaminishi M

更新日期：1998-10-01 00:00:00

abstract：:Immunoglobulin G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 levels, IgG4-positive plasmacytes, and lymphocyte infiltration into multiple organs. IgG4 thyroiditis is a subset of patients with Hashimoto's thyroiditis (HT) who exhibited histopathological features of IgG4-RD; its source of serum Ig...

journal_title：Endocrine journal

authors： Takeshima K,Ariyasu H,Inaba H,Inagaki Y,Yamaoka H,Furukawa Y,Doi A,Furuta H,Nishi M,Akamizu T

更新日期：2015-01-01 00:00:00

abstract：:The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...

journal_title：Endocrine journal

authors： Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.

更新日期：2015-01-01 00:00:00

abstract：:Immunoreactive activin A (ir-activin A) release from cultured rat anterior pituitary cells was examined by measuring ir-activin A in culture medium by a specific radioimmunoassay. Ir-activin A release into the medium increased over 1-18 days, and reached a maximal level at 12-15 days. The basal levels of ir-activin A ...

journal_title：Endocrine journal

authors： Liu ZH,Shintani Y,Wakatsuki M,Sakamoto Y,Harada K,Zhang CY,Saito S

更新日期：1996-02-01 00:00:00

abstract：:Plasma CRH levels were measured in patients with non-insulin dependent diabetes mellitus (NIDDM) as the pituitary-adrenal abnormalities have been reported in NIDDM. They were also measured after oral administration of 75 g glucose to examine whether glucose increased plasma CRH along with insulin secretion. The baseli...

journal_title：Endocrine journal

authors： Hashimoto K,Nishioka T,Takao T,Numata Y

更新日期：1993-12-01 00:00:00

abstract：:Late-night salivary cortisol (NSC) has been recognized as a sensitive and easy-to-perform screening test for the diagnosis of overt Cushing's syndrome (CS). However, there have been few reports on the diagnostic utility of salivary cortisol (SC) measurement in the diagnosis of subclinical Cushing's syndrome (SCS). T...

journal_title：Endocrine journal

authors： Tateishi Y,Kouyama R,Mihara M,Doi M,Yoshimoto T,Hirata Y

更新日期：2012-01-01 00:00:00

abstract：:Sarpogrelate, a selective 5-HT(2) receptor antagonist, is known to have a significant effect on antiplatelet action. This study was a double-blinded, randomized, paralleled multicenter trial to compare the effects of sarpogrelate and aspirin on preventing macrovascular complications in patients with type 2 diabetes. T...

journal_title：Endocrine journal

authors： Park SY,Rhee SY,Oh S,Kwon HS,Cha BY,Lee HJ,Lee HC,Kim YS

更新日期：2012-01-01 00:00:00

abstract：:There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control d...

journal_title：Endocrine journal

authors： Abbas JM,Chakraborty J,Akanji AO,Doi SA

更新日期：2008-05-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are important for fetal and postnatal development, but the regulation of circulating IGFs and IGFBPs has not been as thoroughly investigated in the maternal/fetal unit as in the adult animal where nutrition status plays a regulatory role. We used t...

journal_title：Endocrine journal

authors： Lee WH,Gaylord TD,Bowsher RR,Hlaing M,Moorehead H,Liechty EA

更新日期：1997-02-01 00:00:00

abstract：:The antidiabetic effects of Lactobacillus casei (LC) on a non-insulin-dependent diabetes mellitus (NIDDM) model, KK-Ay mice, were investigated. The oral administration of LC to male 4-week-old KK-Ay mice, or raising the mice on a 0.05% LC-containing diet significantly decreased the plasma glucose at 8 to 10 weeks of a...

journal_title：Endocrine journal

authors： Matsuzaki T,Yamazaki R,Hashimoto S,Yokokura T

更新日期：1997-06-01 00:00:00

abstract：:The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According t...

journal_title：Endocrine journal

authors： Fu Q,Sun M,Wang Z,He W,Duan Y,Yang T

更新日期：2018-01-30 00:00:00

abstract：:The renin-angiotensin system (RAS) has been unequivocally implicated as a mediator of diabetic complications. The present study was designed to evaluate the RAS in non-insulin dependent diabetic patients with diabetic nephropathy. Plasma renin activity, plasma angiotensin II and serum angiotensin-converting enzyme (AC...

journal_title：Endocrine journal

authors： Nicola W,Sidhom G,El Khyat Z,Ibrahim S,Salah A,El Sayed A

更新日期：2001-02-01 00:00:00

abstract：:Circulating anti-islet autoantibodies in sera are used as a predictive marker for type 1 diabetes (T1D). We here report two Japanese patients with autoimmune thyroid disease complicated with T1D in whom the time course of anti-islet autoantibodies were observed before the clinical onset of diabetes. Case 1: A woman wh...

journal_title：Endocrine journal

authors： Horie I,Kawasaki E,Shimomura A,Satoh T,Ueki I,Kuwahara H,Ando T,Abiru N,Usa T,Eguchi K

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH. Fifty patients with PCOS, ...

journal_title：Endocrine journal

authors： Bayraktar F,Dereli D,Ozgen AG,Yilmaz C

更新日期：2004-12-01 00:00:00

abstract：:Our previous studies have revealed that protein malnutrition enhances insulin signaling in rat liver and muscle in response to a bolus insulin injection. However, it has not been established whether protein malnutrition up-regulates insulin signaling under physiological conditions, such as feeding. Here, we studied th...

journal_title：Endocrine journal

authors： Toyoshima Y,Tokita R,Taguchi Y,Akiyama-Akanishi N,Takenaka A,Kato H,Chida K,Hakuno F,Minami S,Takahashi S

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study is to investigate glucose metabolism longitudinally during pregnancy to explore mechanisms underlying gestational diabetes mellitus (GDM). We reviewed a total of 62 pregnant Japanese women who underwent a 75g oral glucose tolerance test (OGTT) twice during pregnancy (median: early, 13; late, 28 w...

journal_title：Endocrine journal

authors： Saisho Y,Miyakoshi K,Ikenoue S,Kasuga Y,Matsumoto T,Minegishi K,Yoshimura Y,Itoh H

更新日期：2013-01-01 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is a skeletal disorder with progressive heterotopic ossification in skeletal muscle. A mutation causing constitutive activation in a bone morphogenetic protein (BMP) type 1 receptor [ALK2(R206H)] is found in most patients with FOP. However, the details in the heterotopic oss...

journal_title：Endocrine journal

authors： Mao L,Yano M,Kawao N,Tamura Y,Okada K,Kaji H

更新日期：2013-01-01 00:00:00

abstract：:Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether t...

journal_title：Endocrine journal

authors： Botelho IMB,Moura Neto A,Silva CA,Tambascia MA,Alegre SM,Zantut-Wittmann DE

更新日期：2018-10-29 00:00:00

abstract：:This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for init...

journal_title：Endocrine journal

authors： Kawanabe S,Nagai Y,Nakamura Y,Nishine A,Nakagawa T,Tanaka Y

更新日期：2019-01-28 00:00:00