Abstract:
:Proliferative response of peripheral blood mononuclear cells (PBMC) to glutamic acid decarboxylase (GAD), which has been reported in patients with type 1 diabetes, was measured in type 2 diabetes, especially in patients with antibodies to GAD initially diagnosed as having type 2 diabetes (anti-GAD+ type 2 diabetes). We studied 12 patients with type 1 diabetes, 22 with anti-GAD+ type 2 diabetes, 31 with type 2 diabetes who were negative for anti-GAD (anti-GAD+ type 2 diabetes), and 30 healthy control subjects for cellular responses in vitro to GAD. The mean stimulation index (SI) in response to GAD was significantly higher in type 1 diabetes than in anti-GAD+ type 2 diabetes or healthy controls (1.47+/-0.35 vs. 1.11+/-0.35, P<0.05, and 1.06+/-0.07, P<0.05, respectively). The mean
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Fukui M,Nakamura N,Nakano K,Kajiyama S,Matsuo S,Obayashi H,Ohta M,Shigeta M,Shigeta H,Kitagawa Y,Kondo Mdoi
10.1507/endocrj.47.753subject
Has Abstractpub_date
2000-12-01 00:00:00pages
753-61issue
6eissn
0918-8959issn
1348-4540journal_volume
47pub_type
杂志文章abstract::Decreased circulating levels of adiponectin, a novel adipose-derived adipocytokine, in obesity possibly contribute to the development of insulin resistance which is a major factor in the pathogenesis of type 2 diabetes. The present study was conducted to examine whether circulating and adipose tissue adiponectin level...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.427
更新日期:2005-08-01 00:00:00
abstract::In vitro studies in isolated pancreas and islets have shown that glucagon-like peptide-1 (GLP-1) promotes insulin release in a typical concentration-dependent manner. In contrast, the relationship between plasma GLP-1 and insulin concentrations in vivo is complicated, because GLP-1-promoted insulin release lowers bloo...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k11e-096
更新日期:2011-01-01 00:00:00
abstract::Lipopolysaccharide (LPS) is known to stimulate the synthesis and secretion of various proinflammatory cytokines in both the peripheral immune cells and the brain. Yet, the relative contribution of peripheral and central cytokines to the LPS-induced activation of the hypothalamo-pituitary-adrenal axis is still poorly u...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.487
更新日期:1999-08-01 00:00:00
abstract::The measurement of TSH receptor antibody (TRAb) has been recommended to predict the risk of neonatal hyperthyroidism (NH) in pregnant women with Graves' disease (GD). For the first generation TRAb (TRAb1) assay with commercial kit (Brahms, Berlin, Germany; or Cosmic co., Tokyo, Japan) an arbitrary limit of 40 U/l or 5...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-196
更新日期:2007-08-01 00:00:00
abstract::Adrenocortical carcinoma (ACC) is a rare aggressive tumor originating from adrenocortical parenchymal cells and its incidence is approximately 1 per million population per year. An oncocytic ACC is a recently identified entity among the several known histopathological variants of ACC, which is characterized by oncocyt...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0024
更新日期:2020-08-28 00:00:00
abstract::The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary thyroid carcinoma (PTC) is significantly lower in Asian countries than Western countries; however, the difference remains unexplained. This study aimed to evaluate the incidence of NIFTP in tumors diagnos...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0198
更新日期:2020-10-28 00:00:00
abstract::Endothelial dysfunction is considered to be an early event in the development of atherosclerosis. The present study was undertaken to evaluate endothelial function and biochemical markers in type 2 diabetes mellitus (T2DM) patients before and after treatment with or without pioglitazone (PIO). Forty-one T2DM patients ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k08e-308
更新日期:2009-01-01 00:00:00
abstract::Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells are necessary to comprehend its range of diverse and contradictory effects. In this study, we examined the anti-obesity effects of resveratrol on high-fat diet (HFD)-induced obese mice at dosages ranging from 1 to 30 mg/kg treatme...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0545
更新日期:2016-01-01 00:00:00
abstract::There are two main subtypes of GH-producing pituitary adenoma: densely granulated (DG-type) and sparsely granulated (SG-type). Despite the difference in drug responsiveness between the two subtypes, their molecular mechanisms remain unknown. The aim of this study is to evaluate the differential expression of genes r...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej11-0177
更新日期:2012-01-01 00:00:00
abstract::Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amyl...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.755
更新日期:1999-12-01 00:00:00
abstract::It has been reported that there is an inverse relationship between serum sodium (Na) and potassium (K) levels in patients with diabetic coma. The present study was undertaken to determine whether such an inverse relation depends upon plasma glucose levels in diabetic patients for their glycemic control. We examined tw...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.75
更新日期:1999-02-01 00:00:00
abstract::A nationwide epidemiologic survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases was conducted in 2010 to clarify the prevalence and the clinical presentations of the disorders. A questionnaire inquiring the experience of patients with these diseases was sent to randomly selected hospitals th...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0275
更新日期:2015-01-01 00:00:00
abstract::Sodium-glucose co-transporter-2 inhibitors are newly established anti-diabetic agents with a unique glucose-lowering mechanism. In the present study, we investigated the efficacy and safety of the sodium-glucose co-transporter-2 inhibitor ipragliflozin (Ipra) for metabolic markers and cardiovascular parameters in Japa...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1507/endocrj.EJ18-0022
更新日期:2018-08-27 00:00:00
abstract::This paper reports the case of an infant presenting with sexual ambiguity at birth. The child presented with labia majora synechia, thready genital tubercle and perineal hypospadias. The karyotype was 46,XY. Low testosterone levels with no response to hCG administration, associated with high LH level for her age, h...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k11e-119
更新日期:2011-01-01 00:00:00
abstract::In order to investigate the immunological aspects of silent thyroiditis, T lymphocyte subsets were analyzed by two-color flow cytometry in 10 patients with silent thyroiditis in the thyrotoxic phase, 12 patients with silent thyroiditis in the recovery phase, and 11 healthy volunteers as a control. The percentages of C...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.41.663
更新日期:1994-12-01 00:00:00
abstract::Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gl...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.691
更新日期:2005-12-01 00:00:00
abstract::Sera from 30 Japanese insulin-dependent diabetes mellitus (IDDM) patients of short duration were examined to determine whether they had antibodies to proteolytic fragments of islet antigen, the molecular weights of which were 37,000 and/or 40,000 Mr (37KAb). The median age and disease duration of the patients were 13 ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.615
更新日期:1996-12-01 00:00:00
abstract::Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-rel...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
doi:10.1507/endocrj.EJ19-0313
更新日期:2020-02-28 00:00:00
abstract::Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.40.461
更新日期:1993-08-01 00:00:00
abstract::We measured serum levels of the carboxy-terminal propeptide of type 1 procollagen (P1CP) as a marker of bone formation and the carboxy-terminal telopeptide of type 1 collagen (1CTP) as a marker of bone resorption by RIA in sera from 40 Graves' disease patients and 14 Hashimoto's disease patients before and during trea...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.701
更新日期:1996-12-01 00:00:00
abstract::Following the accident at the Fukushima Daiichi Nuclear Power Station which occurred on March 11, 2011 due to the Eastern Japan Great Earthquake (the Accident), there have been concerns over elevation of the risk of thyroid cancer among children due to internal exposure to radioactive iodine. In Fukushima Prefecture, ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej14-0032
更新日期:2014-01-01 00:00:00
abstract::Age is an important prognostic factor in papillary thyroid carcinoma (PTC). In this study, we investigated the difference in prognosis of 7 subsets of PTC patients without distant metastasis at presentation or a history of radiation exposure (20 years or younger, 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej12-0044
更新日期:2012-01-01 00:00:00
abstract::We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1507/endocrj.EJ17-0303
更新日期:2018-02-26 00:00:00
abstract::Effects of prolactin and bromocriptine on neutral and phospholipids of liver, adipose tissue and serum were studied in mature male bonnet monkeys. Hyperprolactinemia (ovine prolactin, 250 micrograms/kg body weight/day, i.p. for 30 days) elevated hepatic total lipids and phospholipids and decreased total and free chole...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.41.207
更新日期:1994-04-01 00:00:00
abstract::The purpose of this study was to review the phenotypic and endocrine features or a series of patients with ambiguous genitalia or sex-reversal due to gonadal dysgenesis (GD) and to analyse the impact of these on the decision about sex of rearing. This study is a retrospective analysis of 22 patients with GD treated be...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.95
更新日期:1997-02-01 00:00:00
abstract::We report a rare case of ACTH-independent macronodular adrenal hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT). A 57-year-old woman was admitted to our hospital for further examination of secondary hypertension and bilateral adrenal macrotumors. Midnight serum cortisol elevation with undetectable plasma AC...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.53.111
更新日期:2006-02-01 00:00:00
abstract::A preoperative molecular-based diagnostic technique for thyroid papillary and anaplastic carcinomas was recently developed to detect oncofetal fibronectin (onfFN) messenger RNA (mRNA) in fine needle aspiration biopsy (FNAB) by means of reverse transcription-polymerase chain reaction (RT-PCR). We report two cases of th...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.271
更新日期:2000-06-01 00:00:00
abstract::It has been indicated that some subsets of clinically nonfunctioning pituitary adenoma exhibit immunohistochemical and ultrastructural features of somatotroph or corticotroph cells, which are described as silent somatotroph and corticotroph adenomas, respectively. We here describe a 70-year-old woman with nonfunctioni...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.329
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients. MATERIAL AND METHODS:Thirty type 2 di...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07e-121
更新日期:2008-10-01 00:00:00
abstract::Angiopoietin-like protein 8 (ANGPTL8) is a newly discovered adipokine plays an important role in energy homoeostasis, obesity and type 2 diabetes (T2D). Although lifestyle modification in obesity and T2D is known to offer metabolic benefits, there is paucity of comprehensive data on change in ANGPTL8. We investigated ...
journal_title:Endocrine journal
pub_type: 杂志文章,随机对照试验
doi:10.1507/endocrj.EJ18-0191
更新日期:2019-01-28 00:00:00