Mechanisms of TRH-induced GH release (paradoxical response) in human somatotroph adenoma cells.

Abstract:

:The mechanisms of paradoxical TRH response in human somatotroph adenoma cells were investigated using intracellular calcium measurement and static incubation assay. Intracellular calcium measurement revealed that TRH induces a biphasic response: a transient increase followed by a sustained plateau. The transient phase was due to the calcium release from IP(3)-regulated intracellular calcium store and the subsequent sustained phase was due to the calcium influx through the voltage-gated calcium channels. The signal transduction mechanism of the calcium plateau involved protein kinase C. These calcium responses, especially the second phase, was responsible for the TRH-induced GH release.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Okinaga H,Takano K,Hayashi S,Yasufuku-Takano J,Teramoto A,Fujita T

doi

10.1507/endocrj.52.763

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

763-7

issue

6

eissn

0918-8959

issn

1348-4540

pii

JST.JSTAGE/endocrj/52.763

journal_volume

52

pub_type

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