Abstract:
:The purpose of the study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) levels and PAI-1 activity in young and lean women with PCOS and to compare with controls matched for age and weight. Thirty two women with PCOS and 25 weight and age-matched healthy controls participated in this study. Patients were evaluated clinically and by pelvic ultrasound and fasting blood samples were taken for hematological and biochemical tests. Fasting insulin, glucose, lipid profile, FSH, LH, PRL, testosterone, SHBG, 17-hydroxyprogesterone, androstenedione, PAI-1 antigen; PAI-1 activity, insulin sensitivity indices (HOMA and QUICKI) were measured. PAI-1 Ag and activity were significantly higher in PCOS women than healthy control group. PAI-1 levels were directly correlated with BMI, insulin levels and insulin sensitivity indices. PAI-1 activity was also correlated with insulin levels and insulin resistance. As a conclusion PAI-1 Ag levels and activity were increased in lean PCOS women and these were directly correlated with insulin resistance. The finding may contribute to evidence of increase risk of cardiovascular disease and anovulatory infertility in PCOS women.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Tarkun I,Cantürk Z,Arslan BC,Türemen E,Tarkun Pdoi
10.1507/endocrj.51.467subject
Has Abstractpub_date
2004-10-01 00:00:00pages
467-72issue
5eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/51.467journal_volume
51pub_type
杂志文章abstract::Synchronous associations of Cushing's syndrome (CS) and primary aldosteronism (PA) with multiple adrenocortical adenomas secreting each hormone independently have rarely been reported. Herein, we describe a unique case of PA associated with CS with detailed clinical and pathological investigations. Bilateral adrenal m...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k08e-268
更新日期:2009-01-01 00:00:00
abstract::The aim of this study was to assess the effect of the long-term different diabetic therapies on the plasma leptin level in type 2 diabetic subjects. We measured plasma leptin, body fat and fasting plasma insulin in 96 type 2 diabetic male subjects. They had received the same treatment regimen for more than one year (3...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.377
更新日期:2001-06-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2016-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.841
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journal_title:Endocrine journal
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doi:10.1507/endocrj.EJ19-0063
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journal_title:Endocrine journal
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doi:10.1507/endocrj.EJ20-0144
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.supplmarch_s125
更新日期:2000-03-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.41.663
更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1507/endocrj.k11e-119
更新日期:2011-01-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2003-08-01 00:00:00
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journal_title:Endocrine journal
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doi:10.1507/endocrj.EJ20-0193
更新日期:2020-10-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0078
更新日期:2016-07-30 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.k08e-067
更新日期:2008-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0126
更新日期:2016-08-31 00:00:00
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doi:10.1507/endocrj.EJ15-0033
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journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.EJ16-0064
更新日期:2016-07-30 00:00:00
abstract::Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. It has recently been reported that this syndrome is caused by mutations in the AAAS gene. In the present study, we analyzed the AAAS gene in a Japanese patient with...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.49
更新日期:2002-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ17-0140
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journal_title:Endocrine journal
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journal_title:Endocrine journal
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journal_title:Endocrine journal
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更新日期:2003-10-01 00:00:00
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.131
更新日期:2002-04-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07-028
更新日期:2007-12-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2019-10-28 00:00:00