Abstract:
:Thyrotoxic periodic paralysis (TPP) is mainly associated with Graves' disease but rarely with autonomously functioning thyroid nodule (AFTN). We herein report a case of AFTN associated with TPP in which the latter resolved after (131) I therapy for the former. We analyzed the genes encoding thyrotropin receptor (TSHR), the alpha-subunit of the stimulatory G protein (Gsalpha), calcium channel CACNA1S and potassium channel KCNE3, and found that the patient does not carry the known mutations in these genes. Whereas the pathogenesis of TPP and AFTN remains to be understood, the present case suggests that ion channel defects responsible for familial hypokalemic periodic paralysis may not be associated with TPP, and that mutations in TSHR and Gs alpha genes may be less frequent in AFTN patients in the Japanese population.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Ozaki H,Mori K,Nakagawa Y,Hoshikawa S,Ito S,Yoshida Kdoi
10.1507/endocrj.k07e-017subject
Has Abstractpub_date
2008-03-01 00:00:00pages
113-9issue
1eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K07E-017journal_volume
55pub_type
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