Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes.

abstract：:Estrogen plays pivotal roles in body weight regulation through its effects on central estrogen receptor-α (ERα) expression. ERα is found on neurons that express the hypothalamic anorexigenic factors steroidogenic factor-1 (SF-1) and pro-opiomelanocortin (POMC) mediate these effects of estrogen. As the gonadal hormonal...

journal_title：Endocrine journal

authors： Iwasa T,Matsuzaki T,Mayila Y,Yano K,Irahara M

更新日期：2017-12-28 00:00:00

abstract：:Geographic differences have been reported to affect the morphological and molecular features of papillary thyroid carcinomas (PTCs). The area around Chernobyl is well-known to be iodine-deficient in contrast to Japan, an iodine-rich country. We reviewed histological differences in adult PTC between Ukraine and Japan. ...

journal_title：Endocrine journal

authors： Ito M,Bogdanova T,Zurnadzhy L,Saenko V,Rogounovitch T,Mitsutake N,Kondo H,Maeda S,Nakashima M,Tronko M,Yamashita S

更新日期：2014-01-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are important for fetal and postnatal development, but the regulation of circulating IGFs and IGFBPs has not been as thoroughly investigated in the maternal/fetal unit as in the adult animal where nutrition status plays a regulatory role. We used t...

journal_title：Endocrine journal

authors： Lee WH,Gaylord TD,Bowsher RR,Hlaing M,Moorehead H,Liechty EA

更新日期：1997-02-01 00:00:00

abstract：:Ovarian 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which converts progesterone to a derivative devoid of biological activity, plays a crucial role in achieving the short estrous cycle in rats. Although 20alpha-HSD activity has also been demonstrated in the thymus, its molecular nature, function, and regulatio...

journal_title：Endocrine journal

authors： Hirabayashi K,Suzuki M,Takahashi M,Nishihara M

更新日期：2001-10-01 00:00:00

abstract：:The aim of this study was to assess the effect of the long-term different diabetic therapies on the plasma leptin level in type 2 diabetic subjects. We measured plasma leptin, body fat and fasting plasma insulin in 96 type 2 diabetic male subjects. They had received the same treatment regimen for more than one year (3...

journal_title：Endocrine journal

authors： Huang CC,Lin JD,Chang HY

更新日期：2001-06-01 00:00:00

abstract：:Growth hormone (GH) secreted from the pituitary is essential for postnatal growth in animals. GH exerts its actions by a direct effect on target organs and by stimulating insulin-like growth factor I (IGF-I) production. In the human pituitary, there is a naturally occurring variant protein which has a molecular mass o...

journal_title：Endocrine journal

authors： Yoshizato H,Tanaka M,Fujikawa T,Higashimoto Y,Shimizu A,Nakashima K

更新日期：2000-03-01 00:00:00

abstract：:We here describe two patients with empty sella syndrome who had variable and abnormal ACTH and cortisol secretory profiles. The patients are a 58-year old male and a 41-year old female, both of whom were neurotic. In both cases, low-dose dexamethasone suppression tests (1 mg, p.o., overnight) caused variable responses...

journal_title：Endocrine journal

authors： Sakaguchi H,Inoue D,Kataoka K,Koshiyama H,Aoki N,Nakao K

更新日期：1996-08-01 00:00:00

abstract：:The aim of the study was to explore the relationship between daily glycemic variability (GV) and visit-to-visit glycemic variability (VVV) in patients with type 2 diabetes (T2DM). A total of 156 outpatients with T2DM who had undergone continuous glucose monitoring (CGM) for 5 days were included in this study. Indices ...

journal_title：Endocrine journal

authors： Tsuchiya T,Saisho Y,Murakami R,Watanabe Y,Inaishi J,Itoh H

更新日期：2020-08-28 00:00:00

abstract：:As 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is becoming a common imaging modality, the number of thyroid incidentalomas identified by FDG-PET (PET incidentaloma) is increasing. The purpose of this study was to elucidate the risk of cancer in focal thyroid PET incidentaloma in healthy subjects of...

journal_title：Endocrine journal

authors： Ohba K,Nishizawa S,Matsushita A,Inubushi M,Nagayama K,Iwaki H,Matsunaga H,Suzuki S,Sasaki S,Oki Y,Okada H,Nakamura H

更新日期：2010-01-01 00:00:00

abstract：:Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. It has recently been reported that this syndrome is caused by mutations in the AAAS gene. In the present study, we analyzed the AAAS gene in a Japanese patient with...

journal_title：Endocrine journal

authors： Katsumata N,Hirose H,Kagami M,Tanaka T

更新日期：2002-02-01 00:00:00

abstract：:Metabolic disorders, such as PCOS (polycystic ovarian syndrome) and T2DM (type 2 diabetes mellitus), are associated with menstrual dysfunction, anovulation, infertility, and early pregnancy loss. Ovarian dysfunction is not only related to low pregnancy rates but also to the increased risk of miscarriage. Women with PC...

journal_title：Endocrine journal

authors： Su Y,Wu J,He J,Liu X,Chen X,Ding Y,Zhang C,Chen W,Wang Y,Gao R

更新日期：2017-06-29 00:00:00

abstract：:The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab for malignant melanoma that was approved earlier than ni...

journal_title：Endocrine journal

authors： Okano Y,Satoh T,Horiguchi K,Toyoda M,Osaki A,Matsumoto S,Tomaru T,Nakajima Y,Ishii S,Ozawa A,Shibusawa N,Shimada T,Higuchi T,Chikamatsu K,Yamada M

更新日期：2016-10-29 00:00:00

abstract：:The islets of Langerhans is the endocrine function region of pancreas, which exist in five cell types. The majority of endocrine cells are insulin-secreting β cells, mixed up with glucagon-secreting α-cells. The islets of Langerhans are highly vascularized, and the capillary network around the islet is about five time...

journal_title：Endocrine journal

authors： Cao Z,Wang X

更新日期：2014-01-01 00:00:00

abstract：:The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established. Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT). Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with t...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Hayashi K,Kawashiri MA,Yamagishi M,Yamada M,Fumisawa Y,Yamauchi K,Aizawa T

更新日期：2014-01-01 00:00:00

abstract：:Metabolic syndrome (MetS) is the occurrence of diabetes mellitus/glucose intolerance, arterial hypertension, central obesity, dyslipidemia, and microalbuminuria in the same patient (definition by WHO). Presence of metabolic syndrome is associated with larger myocardial infarction size and complications following acut...

journal_title：Endocrine journal

authors： Kranjcec D,Altabas V

更新日期：2012-01-01 00:00:00

abstract：:Adult growth hormone deficiency (GHD) is a well defined clinical condition, which is characterized by abnormal body composition, impaired physical activity and decreased quality of life. In addition, in recent years, growing interest has been shown towards cardiovascular risks in adult patients affected by GHD. In thi...

journal_title：Endocrine journal

authors： Giovannini L,Tirabassi G,Muscogiuri G,Di Somma C,Colao A,Balercia G

更新日期：2015-01-01 00:00:00

abstract：:Recent studies indicate that succinate dehydrogenase (SDH) genes B, C, or D are, at least partly, involved in the pathogenesis of pheochromocytoma or paraganglioma. Of these three genes, the SDHD gene mutation is most closely related with paragangliomas of the neck. Here we describe a case of an SDHD-related paragangl...

journal_title：Endocrine journal

authors： Yamashita R,Usui T,Hashimoto S,Suzuki H,Takahashi M,Honkura K,Iwamoto K,Kodama E,Tagami T,Naruse M,Shimatsu A,Kaise K

更新日期：2009-01-01 00:00:00

abstract：:Atrial and brain natriuretic peptides (ANP and BNP, respectively) are cardiac hormones. During cardiac development, their expression is a maker of cardiomyocyte differentiation and is under tight spatiotemporal regulation. After birth, however, their ventricular expression is only up-regulated in response to various c...

journal_title：Endocrine journal

authors： Kuwahara K,Nakao K

更新日期：2010-01-01 00:00:00

abstract：:We measured serum levels of the carboxy-terminal propeptide of type 1 procollagen (P1CP) as a marker of bone formation and the carboxy-terminal telopeptide of type 1 collagen (1CTP) as a marker of bone resorption by RIA in sera from 40 Graves' disease patients and 14 Hashimoto's disease patients before and during trea...

journal_title：Endocrine journal

authors： Miyakawa M,Tsushima T,Demura H

更新日期：1996-12-01 00:00:00

abstract：:Recent evidence indicates that urinary gonadotropins may be an alternative method for detecting pubertal disorders. The aim of this study was to evaluate the associations of first morning voided (FMV) and random urinary gonadotropins with the pubertal response to a gonadotropin-releasing hormone (GnRH) stimulation tes...

journal_title：Endocrine journal

authors： Shim YS,An SH,Lee HJ,Kang MJ,Yang S,Hwang IT

更新日期：2019-10-28 00:00:00

abstract：:Age is an important prognostic factor in papillary thyroid carcinoma (PTC). In this study, we investigated the difference in prognosis of 7 subsets of PTC patients without distant metastasis at presentation or a history of radiation exposure (20 years or younger, 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kihara M,Takamura Y,Kobayashi K,Miya A

更新日期：2012-01-01 00:00:00

abstract：:To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyrotropin (TSH), fasti...

journal_title：Endocrine journal

authors： Lai Y,Wang J,Jiang F,Wang B,Chen Y,Li M,Liu H,Li C,Xue H,Li N,Yu J,Shi L,Bai X,Hou X,Zhu L,Lu L,Wang S,Xing Q,Teng X,Teng W,Shan Z

更新日期：2011-01-01 00:00:00

abstract：:Our previous studies have revealed that protein malnutrition enhances insulin signaling in rat liver and muscle in response to a bolus insulin injection. However, it has not been established whether protein malnutrition up-regulates insulin signaling under physiological conditions, such as feeding. Here, we studied th...

journal_title：Endocrine journal

authors： Toyoshima Y,Tokita R,Taguchi Y,Akiyama-Akanishi N,Takenaka A,Kato H,Chida K,Hakuno F,Minami S,Takahashi S

更新日期：2014-01-01 00:00:00

abstract：:We studied functional and histopathological changes in acromegalic cardiomyopathy following intermittent subcutaneous infusion of octreotide. A 68-year-old female patient with acromegaly associated with congestive heart failure due to dilated cardiomyopathy was initially treated with cardioactive medication for three ...

journal_title：Endocrine journal

authors： Nishiki M,Murakami Y,Sohmiya M,Koshimura K,Inoue K,Goto Y,Nakamura N,Kato Y

更新日期：1997-10-01 00:00:00

abstract：:Primary granulomatous hypophysitis (PGH) is a rarely occurred inflammatory disease of unknown etiology. We retrospective review a case of PGH treated by microsurgical transsphenoidal approach and review the appropriately documented cases of PGH collected from the literatures. The patient was a 56-year-old female who p...

journal_title：Endocrine journal

authors： Su SB,Zhang DJ,Yue SY,Zhang JN

更新日期：2011-01-01 00:00:00

abstract：:We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...

journal_title：Endocrine journal

authors： Urakami T,Yoshida K,Kuwabara R,Mine Y,Aoki M,Suzuki J,Morioka I

更新日期：2020-10-28 00:00:00

abstract：:We describe a patient with right adrenal tumor detected incidentally. The tumor was diagnosed as pheochromocytoma by endocrinological and radiological studies, and was removed surgically. Graves' disease, which had been in remission for more than two decades after discontinuation of antithyroid drug treatment, relapse...

journal_title：Endocrine journal

authors： Abe M,Mori K,Nagai K,Ito S

更新日期：2003-12-01 00:00:00

abstract：:Clinical studies have shown that hyperhomocysteinemia is associated with bone fragility. Homocysteine (Hcy) induces apoptosis of osteoblastic cell lineage by increasing oxidative stress, which may contribute to Hcy-induced bone fragility. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ameliorate ...

journal_title：Endocrine journal

authors： Takeno A,Kanazawa I,Tanaka K,Notsu M,Yokomoto-Umakoshi M,Sugimoto T

更新日期：2016-04-25 00:00:00

abstract：:The aims of this study were to: 1) determine the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism, and 2) investigate the change in PRL levels with treatment. In this observational study, patients with a new diagnosis of hypothyroidism in our endocrinology clinic ...

journal_title：Endocrine journal

authors： Hekimsoy Z,Kafesçiler S,Güçlü F,Ozmen B

更新日期：2010-01-01 00:00:00

abstract：:Estrogen has been shown to stimulate lactotroph proliferation and expression of the prolactin (PRL) gene. Recently it has been established that Pit-1, a pituitary-specific transcription factor, is required for lactotroph proliferation. Furthermore, in vitro studies showed that an increase in the PRL promoter activity ...

journal_title：Endocrine journal

authors： Tsukahara S,Kambe F,Suganuma N,Tomoda Y,Seo H

更新日期：1994-10-01 00:00:00