Fulminant type 1 diabetes associated with Isolated ACTH deficiency induced by anti-programmed cell death 1 antibody-insight into the pathogenesis of autoimmune endocrinopathy.

abstract：:A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and still showed impaired water diuresis during glucocorticoid replacement therapy is reported. A 45-year-old woman was initially admitted for nausea, vomiting, and general malaise. Her serum sodium and plasma osmolality, ACTH and cort...

journal_title：Endocrine journal

authors： Kageyama Y

更新日期：2000-12-01 00:00:00

abstract：:This study aims to investigate the prevalence of islet autoantibodies and other organ-specific autoantibodies in type 1 diabetes mellitus (T1DM) patients and characterize their clinical features. Glutamic acid decarboxylase antibody (GADA), insulinoma antigen 2 antibody (IA-2A), zinc transporter 8 antibody (ZnT8A) and...

journal_title：Endocrine journal

authors： Pan S,Wu T,Shi X,Xie Z,Huang G,Zhou Z

更新日期：2020-07-28 00:00:00

abstract：:To address the effects of ezetimibe on high-density lipoprotein (HDL) metabolism, the HDL subclasses, cholesteryl ester transfer protein (CETP), and lecithin-cholesterol acyltransferase (LCAT) were measured in patients with type 2 diabetes mellitus (T2DM). Twenty-three hypercholesterolemic patients with T2DM were tre...

journal_title：Endocrine journal

authors： Yagyu H,Nagashima S,Takahashi M,Miyamoto M,Okada K,Osuga J,Ishibashi S

更新日期：2012-01-01 00:00:00

abstract：:The measurement of TSH receptor antibody (TRAb) has been recommended to predict the risk of neonatal hyperthyroidism (NH) in pregnant women with Graves' disease (GD). For the first generation TRAb (TRAb1) assay with commercial kit (Brahms, Berlin, Germany; or Cosmic co., Tokyo, Japan) an arbitrary limit of 40 U/l or 5...

journal_title：Endocrine journal

authors： Kamijo K

更新日期：2007-08-01 00:00:00

abstract：:The mechanisms of paradoxical TRH response in human somatotroph adenoma cells were investigated using intracellular calcium measurement and static incubation assay. Intracellular calcium measurement revealed that TRH induces a biphasic response: a transient increase followed by a sustained plateau. The transient phase...

journal_title：Endocrine journal

authors： Okinaga H,Takano K,Hayashi S,Yasufuku-Takano J,Teramoto A,Fujita T

更新日期：2005-12-01 00:00:00

abstract：:Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism and anosmia, for which three modes of transmission have been described: X-linked, autosomal recessive and autosomal dominant. The KAL1 gene, responsible for the X-linked form of the disease, has been isolated and its intron-exon organizat...

journal_title：Endocrine journal

authors： Izumi Y,Tatsumi K,Okamoto S,Hosokawa A,Ueno S,Fukui H,Amino N

更新日期：1999-10-01 00:00:00

abstract：:Ghrelin is a peptide hormone with a unique structure comprising a medium chain fatty acid modification. Ghrelin cells are known to be abundantly localized in the gastric mucosa and are released into the blood stream to exert their multifunctional physiological effects. To elucidate the regulatory mechanisms of ghrelin...

journal_title：Endocrine journal

authors： Sakata I,Gong Z,Ikenoya C,Takemi S,Sakai T

更新日期：2017-01-01 00:00:00

abstract：:Cushing's disease rarely appears as a consequence of hereditary disease. However, familial diseases with diminished glucocorticoid feedback are associated with secondary hypercorticotropinism and have been shown to give rise to pituitary adenomas. We here describe the rare case of a 30-year old female patient with con...

journal_title：Endocrine journal

authors： Haase M,Schott M,Kaminsky E,Lüdecke DK,Saeger W,Fritzen R,Schinner S,Scherbaum WA,Willenberg HS

更新日期：2011-01-01 00:00:00

abstract：:Pituitary adrenocorticotropic hormone (ACTH)-secreting tumor presents with a variety of clinical features. We outlined the features of ACTH release and characteristics of corticotroph adenoma cells. We especially focused on the corticotroph adenomas in patients with no clinical features of Cushing's disease. Subclinic...

journal_title：Endocrine journal

authors： Kageyama K,Oki Y,Nigawara T,Suda T,Daimon M

更新日期：2014-01-01 00:00:00

abstract：:The renin-angiotensin system (RAS) has been unequivocally implicated as a mediator of diabetic complications. The present study was designed to evaluate the RAS in non-insulin dependent diabetic patients with diabetic nephropathy. Plasma renin activity, plasma angiotensin II and serum angiotensin-converting enzyme (AC...

journal_title：Endocrine journal

authors： Nicola W,Sidhom G,El Khyat Z,Ibrahim S,Salah A,El Sayed A

更新日期：2001-02-01 00:00:00

abstract：:The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

journal_title：Endocrine journal

authors： Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

更新日期：2005-10-01 00:00:00

abstract：:Patients with growth hormone (GH) deficiency (GHD) have a clinical feature of visceral adiposity and it has been reported that these patients have an increased active cortisol (F)/inactive cortisone (E) metabolite ratio. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an enzyme expressed in liver and adipo...

journal_title：Endocrine journal

authors： Morita J,Hakuno F,Hizuka N,Takahashi S,Takano K

更新日期：2009-01-01 00:00:00

abstract：:This study aimed to assess the relationship between the metabolic effect after laparoscopic sleeve gastrectomy (LSG) in morbidly obese Japanese patients, with or without type 2 diabetes mellitus (T2DM), and improved pancreatic steatosis (PS). The study enrolled 27 morbidly obese Japanese patients who were undergoing L...

journal_title：Endocrine journal

authors： Umemura A,Sasaki A,Nitta H,Baba S,Ando T,Kajiwara T,Ishigaki Y

更新日期：2017-05-30 00:00:00

abstract：:The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron stat...

journal_title：Endocrine journal

authors： Ikeda Y,Suehiro T,Yamanaka S,Kumon Y,Takata H,Inada S,Ogami N,Osaki F,Inoue M,Arii K,Hashimoto K

更新日期：2006-10-01 00:00:00

abstract：:A preoperative molecular-based diagnostic technique for thyroid papillary and anaplastic carcinomas was recently developed to detect oncofetal fibronectin (onfFN) messenger RNA (mRNA) in fine needle aspiration biopsy (FNAB) by means of reverse transcription-polymerase chain reaction (RT-PCR). We report two cases of th...

journal_title：Endocrine journal

authors： Takano T,Shiba E,Tada H,Yoshimura H,Yoshida K,Doi R,Amino N

更新日期：2000-06-01 00:00:00

abstract：:Estrogen has been shown to stimulate lactotroph proliferation and expression of the prolactin (PRL) gene. Recently it has been established that Pit-1, a pituitary-specific transcription factor, is required for lactotroph proliferation. Furthermore, in vitro studies showed that an increase in the PRL promoter activity ...

journal_title：Endocrine journal

authors： Tsukahara S,Kambe F,Suganuma N,Tomoda Y,Seo H

更新日期：1994-10-01 00:00:00

abstract：:Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

journal_title：Endocrine journal

authors： Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

更新日期：2016-07-30 00:00:00

abstract：:Exercise is a fundamental component of diabetes management. However, choosing inappropriate type or timing of exercise is associated with mild or severe hypoglycemia either during exercise or several hours after exercise. Several studies have shown that impaired counterregulatory responses triggers hypoglycemia. There...

journal_title：Endocrine journal

authors： Mao Y,Wen S,Zhou M,Zhu S,Zhou L

更新日期：2019-09-28 00:00:00

abstract：:An open-label prospective cross-over trial was performed to compare the efficacy and adverse effects of nateglinide with those of voglibose on Japanese early type 2 diabetes (who were oral hypoglycemic agent naïve and whose HbA(1C) levels were between 7.0 and 7.9% before treatment). Fourteen patients received 270 mg/d...

journal_title：Endocrine journal

authors： Kurebayashi S,Watada H,Tanaka Y,Kawasumi M,Kawamori R,Hirose T

更新日期：2006-04-01 00:00:00

abstract：:We report a rare case of ACTH-independent macronodular adrenal hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT). A 57-year-old woman was admitted to our hospital for further examination of secondary hypertension and bilateral adrenal macrotumors. Midnight serum cortisol elevation with undetectable plasma AC...

journal_title：Endocrine journal

authors： Sato M,Soma M,Nakayama T,Kosuge K,Suzuki R,Okada K,Komatsu K,Sugitani M,Matsumoto K

更新日期：2006-02-01 00:00:00

abstract：:Patients with adrenal insufficiency require appropriate glucocorticoid replacement therapy; however, reliable biological parameters for optimizing glucocorticoid supplementation are limited. The physician has to rely primarily on clinical judgment, carefully taking into account signs and symptoms potentially suggestiv...

journal_title：Endocrine journal

authors： Watanabe T,Ozawa A,Ishii S,Tomaru T,Shibusawa N,Saito T,Yamada E,Horiguchi K,Nakajima Y,Matsumoto S,Yoshino S,Katano-Toki A,Hashimoto K,Mori M,Okada S,Satoh T,Yamada M

更新日期：2018-05-28 00:00:00

abstract：:Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...

journal_title：Endocrine journal

authors： Yamamoto T,Matsuo S,Ueshima Y,Inoue F,Kinugasa A,Sawada T

更新日期：1993-08-01 00:00:00

abstract：:The extent of thyroidectomy in Graves' disease remains controversial. In our institution, long-term euthyroidism without thyroxin replacement therapy has been the aim, and it has long been the standard surgical procedure used to treat Graves' disease in many institutions, including our hospital. Based our several clin...

journal_title：Endocrine journal

authors： Sugino K,Nagahama M,Kitagawa W,Ohkuwa K,Uruno T,Matsuzu K,Suzuki A,Tomoda C,Y Hames K,Akaishi J,Masaki C,Ogimi Y,Yabuta T,Ito K

更新日期：2019-02-28 00:00:00

abstract：:To determine whether patients with medullary thyroid carcinoma (MTC) develop other endocrine neoplasms or their relatives develop MTC, we investigated the mutations in the RET proto-oncogene in patients with multiple endocrine neoplasia type 2B (MEN 2B, N = 1) and sporadic MTC (N = 6). DNA from MTC tissue and the peri...

journal_title：Endocrine journal

authors： Migita M,Hiromatsu Y,Sato M,Yang D,Kameo J,Jimi A,Nonaka K

更新日期：1997-08-01 00:00:00

abstract：:Genetic linkage analyses have traced the loci for multiple endocrine neoplasia type 2A (MEN 2A) to an interval on chromosome 10q11.2. This region encompasses the RET proto-oncogene, a receptor tyrosine kinase gene expressed in medullary thyroid carcinoma (MTC) and pheochromocytoma. By means of genomic polymerase chain...

journal_title：Endocrine journal

authors： Oishi S,Sato T,Takiguchi-Shirahama S,Nakamura Y

更新日期：1995-08-01 00:00:00

abstract：:Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...

journal_title：Endocrine journal

authors： Kabalak T,Ozgen AG

更新日期：2002-04-01 00:00:00

abstract：:KRN568 is a calcimimetic compound which acts on the calcium sensing receptors (CaR) on the parathyroid gland to suppress secretion of PTH. A recent report has demonstrated that CaRs are expressed on cultured human antral gastrin cells and that gastrin secretion is stimulated by an increase in extracellular calcium lev...

journal_title：Endocrine journal

authors： Igarashi T,Ogata E,Maruyama K,Fukuda T

更新日期：2000-10-01 00:00:00

abstract：:Atrial and brain natriuretic peptides (ANP and BNP, respectively) are cardiac hormones. During cardiac development, their expression is a maker of cardiomyocyte differentiation and is under tight spatiotemporal regulation. After birth, however, their ventricular expression is only up-regulated in response to various c...

journal_title：Endocrine journal

authors： Kuwahara K,Nakao K

更新日期：2010-01-01 00:00:00

abstract：:Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity...

journal_title：Endocrine journal

authors： Iwasaki T,Nakajima A,Yoneda M,Terauchi Y

更新日期：2006-06-01 00:00:00

abstract：:We previously identified an approximately 200 bp "minimal promoter" of the rat TSH receptor (TSHR) gene which is essential for the promoter activity. In the present study, we have cloned and characterized an upstream region of the TSHR promoter to disclose additional functional element(s). We screened a rat genomic li...

journal_title：Endocrine journal

authors： Ikuyama S,Ohe K,Takayanagi R,Kohn LD,Nawata H

更新日期：1997-04-01 00:00:00