Increase in Pit-1 mRNA is not required for the estrogen-induced expression of prolactin gene and lactotroph proliferation.

abstract：:Insulin and insulin-like growth factor-1 (IGF-1) are two structurally related hormones which produce similar biological activities such as metabolic and growth promoting actions. Their receptors, insulin and IGF-1 receptors, also share similarities in both structure and functions such as tyrosine-specific protein kina...

journal_title：Endocrine journal

authors： Kadowaki T,Tobe K,Honda-Yamamoto R,Tamemoto H,Kaburagi Y,Momomura K,Ueki K,Takahashi Y,Yamauchi T,Akanuma Y,Yazaki Y

更新日期：1996-10-01 00:00:00

abstract：:Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. It has recently been reported that this syndrome is caused by mutations in the AAAS gene. In the present study, we analyzed the AAAS gene in a Japanese patient with...

journal_title：Endocrine journal

authors： Katsumata N,Hirose H,Kagami M,Tanaka T

更新日期：2002-02-01 00:00:00

abstract：:To determine whether patients with medullary thyroid carcinoma (MTC) develop other endocrine neoplasms or their relatives develop MTC, we investigated the mutations in the RET proto-oncogene in patients with multiple endocrine neoplasia type 2B (MEN 2B, N = 1) and sporadic MTC (N = 6). DNA from MTC tissue and the peri...

journal_title：Endocrine journal

authors： Migita M,Hiromatsu Y,Sato M,Yang D,Kameo J,Jimi A,Nonaka K

更新日期：1997-08-01 00:00:00

abstract：:We assessed the incidence of elderly patients in Japanese acromegalics and the characteristics of their clinical presentation. We also evaluated the safety and efficacy of transsphenoidal surgery (TSS) in this patient group. During the 28-year period from 1980 to 2007 we treated 290 patients with acromegaly at our hos...

journal_title：Endocrine journal

authors： Arita K,Hirano H,Yunoue S,Fujio S,Tominaga A,Sakoguchi T,Sugiyama K,Kurisu K

更新日期：2008-10-01 00:00:00

abstract：:The objective of this study was to assess the potential predictive factors for follicle growth, ovulation, and pregnancy rate in patients with primary ovarian insufficiency/premature ovarian failure (POI/POF). We enrolled 25 POI patients with desired fertility who were treated and monitored for a minimum of 7 months b...

journal_title：Endocrine journal

authors： Miyazaki K,Miki F,Uchida S,Masuda H,Uchida H,Maruyama T

更新日期：2015-01-01 00:00:00

abstract：:The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

journal_title：Endocrine journal

authors： Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

更新日期：2005-10-01 00:00:00

abstract：:We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...

journal_title：Endocrine journal

authors： Oita M,Miyoshi H,Ono K,Nakamura A,Cho KY,Nomoto H,Yamamoto K,Omori K,Manda N,Kurihara Y,Aoki S,Atsumi T

更新日期：2018-02-26 00:00:00

abstract：:An open-label prospective cross-over trial was performed to compare the efficacy and adverse effects of nateglinide with those of voglibose on Japanese early type 2 diabetes (who were oral hypoglycemic agent naïve and whose HbA(1C) levels were between 7.0 and 7.9% before treatment). Fourteen patients received 270 mg/d...

journal_title：Endocrine journal

authors： Kurebayashi S,Watada H,Tanaka Y,Kawasumi M,Kawamori R,Hirose T

更新日期：2006-04-01 00:00:00

abstract：:The tissue-specific circulating markers of thyroid hormone action on cardiac function have not been established. Although the relationship between thyroid function and plasma brain natriuretic peptide (BNP) levels has been evaluated in patients with thyroid disorders, the relationship between these parameters in the g...

journal_title：Endocrine journal

authors： Ohba K,Okada E,Goto Y,Suzuki S,Machii M,Nonaka D,Matsushita A,Sasaki S,Suda T,Oki Y,Takase H

更新日期：2020-04-28 00:00:00

abstract：:We saw a 57-yr-old female non-insulin dependent diabetes mellitus (NIDDM) patient with antiinsulin antibody, in whom insulin-like growth factor-I (IGF-I) was shown to be effective as a blood glucose-lowering agent. Due to the presence of the antibody, the patient suffered from postprandial hyperglycemia and frequent h...

journal_title：Endocrine journal

authors： Kajimoto Y,Kawamori R,Fujitani Y,Kishimoto M,Kubota M,Yamasaki Y,Morishima T,Kamada T

更新日期：1995-02-01 00:00:00

abstract：:The management of occult small thyroid nodules found by ultrasonography is sometimes problematic. Self-palpation may be utilized in the follow-up of these nodules. We developed a method of thyroid self-examination (TSE). We examined the size of the nodules palpable by this method by ultrasonography. In 78 patients exa...

journal_title：Endocrine journal

authors： Takano T,Hasegawa Y,Amino N

更新日期：2000-10-01 00:00:00

abstract：:Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...

journal_title：Endocrine journal

authors： Yamamoto T,Matsuo S,Ueshima Y,Inoue F,Kinugasa A,Sawada T

更新日期：1993-08-01 00:00:00

abstract：:We describe a patient with right adrenal tumor detected incidentally. The tumor was diagnosed as pheochromocytoma by endocrinological and radiological studies, and was removed surgically. Graves' disease, which had been in remission for more than two decades after discontinuation of antithyroid drug treatment, relapse...

journal_title：Endocrine journal

authors： Abe M,Mori K,Nagai K,Ito S

更新日期：2003-12-01 00:00:00

abstract：:Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completel...

journal_title：Endocrine journal

authors： Fukumoto S,Ozono K,Michigami T,Minagawa M,Okazaki R,Sugimoto T,Takeuchi Y,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab for malignant melanoma that was approved earlier than ni...

journal_title：Endocrine journal

authors： Okano Y,Satoh T,Horiguchi K,Toyoda M,Osaki A,Matsumoto S,Tomaru T,Nakajima Y,Ishii S,Ozawa A,Shibusawa N,Shimada T,Higuchi T,Chikamatsu K,Yamada M

更新日期：2016-10-29 00:00:00

abstract：:In vitro studies in isolated pancreas and islets have shown that glucagon-like peptide-1 (GLP-1) promotes insulin release in a typical concentration-dependent manner. In contrast, the relationship between plasma GLP-1 and insulin concentrations in vivo is complicated, because GLP-1-promoted insulin release lowers bloo...

journal_title：Endocrine journal

authors： Eiki J,Yada T

更新日期：2011-01-01 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is a skeletal disorder with progressive heterotopic ossification in skeletal muscle. A mutation causing constitutive activation in a bone morphogenetic protein (BMP) type 1 receptor [ALK2(R206H)] is found in most patients with FOP. However, the details in the heterotopic oss...

journal_title：Endocrine journal

authors： Mao L,Yano M,Kawao N,Tamura Y,Okada K,Kaji H

更新日期：2013-01-01 00:00:00

abstract：:While patients with large goitrous thyroid diseases often have a relatively high serum free triiodothyronine (FT3)/free thyroxine (FT4) ratio, athyreotic patients have a relatively low FT3/FT4 ratio. Here we investigated the relationship between thyroid hormone status and thyroid volume (TV) among a large number of eu...

journal_title：Endocrine journal

authors： Kawasaki M,Ito M,Danno H,Kousaka K,Nakamura T,Yoshioka W,Kasahara T,Kudo T,Nishihara E,Fukata S,Nishikawa M,Nakamura H,Toyoda N,Miyauchi A

更新日期：2019-09-28 00:00:00

abstract：:The measurement of TSH receptor antibody (TRAb) has been recommended to predict the risk of neonatal hyperthyroidism (NH) in pregnant women with Graves' disease (GD). For the first generation TRAb (TRAb1) assay with commercial kit (Brahms, Berlin, Germany; or Cosmic co., Tokyo, Japan) an arbitrary limit of 40 U/l or 5...

journal_title：Endocrine journal

authors： Kamijo K

更新日期：2007-08-01 00:00:00

abstract：:Musk is a secreted external hormone or information compound that is stored in musk scent glands of the males of species within the family Moschidae, such as Moschus berezovskii. The secretion of musk changes periodically during the courtship and reproduction periods, with the early stage of secretion occurring from Ma...

journal_title：Endocrine journal

authors： Fan M,Zhang M,Shi M,Zhang T,Qi L,Yu J,Li X,Lin S,Huang Z,Yang S,Zhou J,Li Y,Sun X,Cha M,Xu S,Liu Y,Guo X,Hu D,Liu S

更新日期：2018-11-29 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is rarely reported in Japanese and other oriental populations. To examine if there is a racial difference in the prevalence of MEN 1, we initiated extensive work on patients with endocrine tumors for additional lesions, and annual screening of family members of affected pati...

journal_title：Endocrine journal

authors： Katai M,Sakurai A,Itakura Y,Ikeo Y,Nakajima K,Hara M,Iijima S,Kaneko T,Kobayashi M,Ichikawa K,Aizawa T,Hashizume K

更新日期：1997-12-01 00:00:00

abstract：:Although gonadal estrogens are known to facilitate the development of skeletal lesion in SHOX haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly...

journal_title：Endocrine journal

authors： Fukami M,Nishi Y,Hasegawa Y,Miyoshi Y,Okabe T,Haga N,Nagai T,Tanaka T,Ogata T

更新日期：2004-04-01 00:00:00

abstract：:Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. To date, while GH deficiency (GHD) has been reported in multiple patients with PHP-Ia caused by mutations on the maternally expressed GNAS coding regions a...

journal_title：Endocrine journal

authors： Sano S,Iwata H,Matsubara K,Fukami M,Kagami M,Ogata T

更新日期：2015-01-01 00:00:00

abstract：:Parathyroidectomy (PTX) is the standard treatment for secondary hyperparathyroidism (SHPT); however, the administration of cinacalcet has gained prominence as a noninvasive treatment. We aimed to determine whether PTX or cinacalcet is more effective in preventing morbidity and mortality through reviewing follow-up dat...

journal_title：Endocrine journal

authors： Kim WW,Rhee Y,Kim BS,Kim K,Lee CR,Kang SW,Lee J,Jeong JJ,Nam KH,Chung WY

更新日期：2019-10-28 00:00:00

abstract：:Atrial and brain natriuretic peptides (ANP and BNP, respectively) are cardiac hormones. During cardiac development, their expression is a maker of cardiomyocyte differentiation and is under tight spatiotemporal regulation. After birth, however, their ventricular expression is only up-regulated in response to various c...

journal_title：Endocrine journal

authors： Kuwahara K,Nakao K

更新日期：2010-01-01 00:00:00

abstract：:Immunoreactive activin A (ir-activin A) release from cultured rat anterior pituitary cells was examined by measuring ir-activin A in culture medium by a specific radioimmunoassay. Ir-activin A release into the medium increased over 1-18 days, and reached a maximal level at 12-15 days. The basal levels of ir-activin A ...

journal_title：Endocrine journal

authors： Liu ZH,Shintani Y,Wakatsuki M,Sakamoto Y,Harada K,Zhang CY,Saito S

更新日期：1996-02-01 00:00:00

abstract：:This is a case report of an 18-year-old man with central diabetes incipidus (DI). An MRI done three months after the onset of the DI did not disclose a responsible lesion. Four months later, a second MRI showed the location of the tumor origin at the upper pituitary stalk and median eminence. Eight months later, the t...

journal_title：Endocrine journal

authors： Saeki N,Uchida D,Tatsuno I,Saito Y,Yamaura A

更新日期：1999-04-01 00:00:00

abstract：:We previously identified an approximately 200 bp "minimal promoter" of the rat TSH receptor (TSHR) gene which is essential for the promoter activity. In the present study, we have cloned and characterized an upstream region of the TSHR promoter to disclose additional functional element(s). We screened a rat genomic li...

journal_title：Endocrine journal

authors： Ikuyama S,Ohe K,Takayanagi R,Kohn LD,Nawata H

更新日期：1997-04-01 00:00:00

abstract：:Nesfatin-1 is a polypeptide derived from the posttranslational processing of the N-terminal fragment of nucleobindin 2 (NUCB2), that was originally identified as an anorexigenic hypothalamic neuropeptide. A number of reports have recently shown that NUCB2/nesfatin-1 is widely expressed in various peripheral tissues, i...

journal_title：Endocrine journal

authors： Cao X,Liu XM,Zhou LH

更新日期：2013-01-01 00:00:00

abstract：:In hope of understanding possible roles of estrogen during early embryogenesis, we examined the expression of both estrogen receptor alpha (ER alpha) and ER beta, a recently cloned novel subtype, in mouse oocytes and preimplantation embryos by means of reverse transcription polymerase chain reaction (RT-PCR). To inves...

journal_title：Endocrine journal

authors： Hiroi H,Momoeda M,Inoue S,Tsuchiya F,Matsumi H,Tsutsumi O,Muramatsu M,Taketani Y

更新日期：1999-02-01 00:00:00