TSH-receptor antibodies determined by the first, second and third generation assays and thyroid-stimulating antibody in pregnant patients with Graves' disease.

abstract：:The objective of this study was to assess the potential predictive factors for follicle growth, ovulation, and pregnancy rate in patients with primary ovarian insufficiency/premature ovarian failure (POI/POF). We enrolled 25 POI patients with desired fertility who were treated and monitored for a minimum of 7 months b...

journal_title：Endocrine journal

authors： Miyazaki K,Miki F,Uchida S,Masuda H,Uchida H,Maruyama T

更新日期：2015-01-01 00:00:00

abstract：:Effects of reserpine treatment, not associated with pituitary irradiation, on the pituitary-adrenocortical axis in a total of 37 untreated patients with Cushing's disease were evaluated. With short-term treatment (2 mg daily for 2 weeks, n = 36), basal excretion of urinary 17-OHCS significantly decreased from 11.2 +/-...

journal_title：Endocrine journal

authors： Minamori Y,Yasuda K,Murayama M,Morita H,Yamakita N,Miura K

更新日期：1993-10-01 00:00:00

abstract：:There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control d...

journal_title：Endocrine journal

authors： Abbas JM,Chakraborty J,Akanji AO,Doi SA

更新日期：2008-05-01 00:00:00

abstract：:Although curcumin was widely applied as a functional food for different diseases, it was found to reduce serum testosterone level and fertility in male animals by unknown molecular mechanisms. Here in our study, we investigated the possible mechanisms of curcumin-suppressed testosterone production in Leydig cells. Our...

journal_title：Endocrine journal

authors： Lin YC,Chiu CH,Liu HC,Wang JY

更新日期：2018-08-27 00:00:00

abstract：:Our previous studies have revealed that protein malnutrition enhances insulin signaling in rat liver and muscle in response to a bolus insulin injection. However, it has not been established whether protein malnutrition up-regulates insulin signaling under physiological conditions, such as feeding. Here, we studied th...

journal_title：Endocrine journal

authors： Toyoshima Y,Tokita R,Taguchi Y,Akiyama-Akanishi N,Takenaka A,Kato H,Chida K,Hakuno F,Minami S,Takahashi S

更新日期：2014-01-01 00:00:00

abstract：:The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

journal_title：Endocrine journal

authors： Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

更新日期：2005-10-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) is a form of non-Langerhans histiocytosis. In this report, we show a case of ECD presenting diabetes insipidus and multiple xanthogranulomas received glucocorticoid treatment over a year. During this period, xanthogranulomas improved in response to the glucocorticoid therapy. Furthermore,...

journal_title：Endocrine journal

authors： Taguchi T,Iwasaki Y,Asaba K,Yoshida T,Takao T,Ikeno F,Nakajima H,Kodama H,Hashimoto K

更新日期：2008-03-01 00:00:00

abstract：:The present study was undertaken to determine clinical features of hypopituitarism in elderly subjects. Thirty-one elderly patients with hypopituitarism were enrolled. They were 19 males and 12 females, with the ages of 70.7±5.4 years ranging from 62 to 80 years. High prevalence of hyponatremia (80.6%) and hypoglyc...

journal_title：Endocrine journal

authors： Asano T,Aoki A,Sasaki M,Ikoma A,Kakei M,Kawakami M,Ishikawa SE

更新日期：2012-01-01 00:00:00

abstract：:Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completel...

journal_title：Endocrine journal

authors： Fukumoto S,Ozono K,Michigami T,Minagawa M,Okazaki R,Sugimoto T,Takeuchi Y,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:We have developed a new test for estimating the secretory capacity of parathyroid hormone (PTH) from the parathyroid gland. Sodium bicarbonate solution [8.4% (w/v); 35 ml/m(2) body surface area] was infused for 2 min, and blood samples for the determination of plasma ionized calcium, plasma PTH (intact, midregion, car...

journal_title：Endocrine journal

authors： Iwasaki Y,Mutsuga N,Yamamori E,Kakita A,Oiso Y,Imai T,Funahashi H,Tanaka Y,Kondo K,Nakashima N

更新日期：2003-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) are induced under diabetic conditions and are likely associated with the development of type 2 diabetes. It is also known that ROS production is facilitated in the presence of copper ion through the Fenton reaction. The aim of this study was to examine the involvement of copper ion in the...

journal_title：Endocrine journal

authors： Tanaka A,Kaneto H,Miyatsuka T,Yamamoto K,Yoshiuchi K,Yamasaki Y,Shimomura I,Matsuoka TA,Matsuhisa M

更新日期：2009-01-01 00:00:00

abstract：:Familial hypocalciuric hypercalcemia (FHH) is a benign syndrome with elevated levels of serum calcium, relative hypocalciuria, and non-suppressed serum parathyroid hormone (PTH) levels. FHH usually occurs by a heterozygous mutation of the calcium sensing receptor (Casr), but some FHH patients show no mutations of the ...

journal_title：Endocrine journal

authors： Kanazawa H,Tanaka H,Kodama S,Moriwake A,Kobayashi M,Seino Y

更新日期：2000-02-01 00:00:00

abstract：:Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...

journal_title：Endocrine journal

authors： Kawashima Sonoyama Y,Tajima T,Fujimoto M,Hasegawa A,Miyahara N,Nishimura R,Hashida Y,Hayashi A,Hanaki K,Kanzaki S

更新日期：2017-01-30 00:00:00

abstract：:A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and...

journal_title：Endocrine journal

authors： Naito Y,Mori J,Tazoe J,Tomida A,Yagyu S,Nakajima H,Iehara T,Tatsuzawa K,Mukai T,Hosoi H

更新日期：2019-12-25 00:00:00

abstract：:Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes. And tumor necrosis factor alpha (TNF-α) is one of the ...

journal_title：Endocrine journal

authors： Wu S,Dong K,Wang J,Bi Y

更新日期：2018-06-27 00:00:00

abstract：:In each estrous cycle not all follicles recruited grow to ovulate, as some degenerate through the process of atresia. Apoptosis is the mechanism underlying follicle atresia. TGF-beta1 has been implicated in the induction and promotion of apoptosis in many cell types and it is expressed in the ovary. In this study immu...

journal_title：Endocrine journal

authors： Christopher B

更新日期：2000-08-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase plays an important role in folate metabolism. Individuals who are type 2 diabetes mellitus have greatest risk for the development of vascular complications. The results of studies which assessed the association between MTHFR C677T polymorphism and T2DM with vascular complications we...

journal_title：Endocrine journal

authors： Zhang D,Zhou Y,Han L,Ji H,Li J

更新日期：2014-01-01 00:00:00

abstract：:The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron stat...

journal_title：Endocrine journal

authors： Ikeda Y,Suehiro T,Yamanaka S,Kumon Y,Takata H,Inada S,Ogami N,Osaki F,Inoue M,Arii K,Hashimoto K

更新日期：2006-10-01 00:00:00

abstract：:The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab for malignant melanoma that was approved earlier than ni...

journal_title：Endocrine journal

authors： Okano Y,Satoh T,Horiguchi K,Toyoda M,Osaki A,Matsumoto S,Tomaru T,Nakajima Y,Ishii S,Ozawa A,Shibusawa N,Shimada T,Higuchi T,Chikamatsu K,Yamada M

更新日期：2016-10-29 00:00:00

abstract：:A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and still showed impaired water diuresis during glucocorticoid replacement therapy is reported. A 45-year-old woman was initially admitted for nausea, vomiting, and general malaise. Her serum sodium and plasma osmolality, ACTH and cort...

journal_title：Endocrine journal

authors： Kageyama Y

更新日期：2000-12-01 00:00:00

abstract：:X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

journal_title：Endocrine journal

authors： Miyamoto J,Koto S,Hasegawa Y

更新日期：2000-04-01 00:00:00

abstract：:A 70-year-old man with abdominal aortic aneurysm underwent surgical repair with Hemashield vascular graft. Postoperatively, he was found to have very low plasma cortisol levels, which failed to increase after stimulation with ACTH. A tentative diagnosis of adrenal insufficiency was made despite the lack of its clinica...

journal_title：Endocrine journal

authors： Sakai H,Matsumoto K,Sugiyama M,Yoshimoto T,Doi M,Izumiyama H,Hirata Y

更新日期：2006-06-01 00:00:00

abstract：:The effect of a synthetic steroidal anti-androgen, TZP-4238, on steroid-induced rat prostatic hyperplasia was investigated. Male Wistar rats were divided into four experimental groups. Group 1 consisted of intact controls. The other animals were castrated. The castrated animals were treated for 7 weeks with 1) testost...

journal_title：Endocrine journal

authors： Murakoshi M,Tagawa M,Inada R,Suzuki M,Mizokami A,Watanabe K

更新日期：1993-08-01 00:00:00

abstract：:The effect of add-on therapy with sitagliptin on glycemic control was prospectively investigated in patients with type 2 diabetes mellitus (T2DM) receiving insulin alone or insulin combined with oral antidiabetic drugs. Seventy-one patients were evaluated (38 men and 33 women aged 63.9 ± 10.2 years). They were divided...

journal_title：Endocrine journal

authors： Katsuno T,Ikeda H,Ida K,Miyagawa J,Namba M

更新日期：2013-01-01 00:00:00

abstract：:To examine the specific changes in gene expression in thyroid carcinomas, we performed sequence specific-differential display (SS-DD) analysis by using a specific degenerate primer for the superfamily of the small G protein. After subcloning and sequencing analysis, one of the genes that showed decreased expression in...

journal_title：Endocrine journal

authors： Liu G,Takano T,Matsuzuka F,Higashiyama T,Kuma K,Amino N

更新日期：1999-06-01 00:00:00

abstract：:Following the accident at the Fukushima Daiichi Nuclear Power Station which occurred on March 11, 2011 due to the Eastern Japan Great Earthquake (the Accident), there have been concerns over elevation of the risk of thyroid cancer among children due to internal exposure to radioactive iodine. In Fukushima Prefecture, ...

journal_title：Endocrine journal

authors： Iwaku K,Noh JY,Sasaki E,Suzuki N,Kameda T,Kobayashi S,Yoshihara A,Ohye H,Watanabe N,Suzuki M,Matsumoto M,Kunii Y,Mukasa K,Sugino K,Ito K

更新日期：2014-01-01 00:00:00

abstract：:Triptolide, a major active component of Tripterygium wilfordii Hook F (TWHF), is known to have multiple pharmacological activities. However, studies have also shown that triptolide is highly toxic to the reproductive system by disrupting normal androgen and estrogen signaling. In the present study, we investigated the...

journal_title：Endocrine journal

authors： Zhang J,Liu L,Mu X,Jiang Z,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:The antidiabetic effects of Lactobacillus casei (LC) on a non-insulin-dependent diabetes mellitus (NIDDM) model, KK-Ay mice, were investigated. The oral administration of LC to male 4-week-old KK-Ay mice, or raising the mice on a 0.05% LC-containing diet significantly decreased the plasma glucose at 8 to 10 weeks of a...

journal_title：Endocrine journal

authors： Matsuzaki T,Yamazaki R,Hashimoto S,Yokokura T

更新日期：1997-06-01 00:00:00

abstract：:The synthesis of nitric oxide (NO) has been demonstrated in the vascular endothelial cells and other tissues including in rat and bovine adrenal gland. To determine whether NO mediates aldosterone production in the adrenals, we evaluated the basal production of aldosterone, and the ACTH or angiotensin II (A II)-stimul...

journal_title：Endocrine journal

authors： Nakayama T,Izumi Y,Soma M,Kanmatsuse K

更新日期：1996-04-01 00:00:00

abstract：:The purpose of this study was to review the phenotypic and endocrine features or a series of patients with ambiguous genitalia or sex-reversal due to gonadal dysgenesis (GD) and to analyse the impact of these on the decision about sex of rearing. This study is a retrospective analysis of 22 patients with GD treated be...

journal_title：Endocrine journal

authors： Cameron FJ,Montalto J,Byrt EA,Sinclair AH,Warne GL

更新日期：1997-02-01 00:00:00