Pathogenesis of chronic hypernatremia with dehydrated and non-dehydrated states in hypothalamic space-occupying lesions.

abstract：:We previously reported that IA-2 autoantibodies (Ab) facilitated the diagnosis of Japanese insulin-dependent diabetes mellitus (IDDM), but the number tested was not large enough to investigate whether IA-2Ab can improve the diagnostic accuracy. In this report, sera from 78 patients with less than 2 year-disease durati...

journal_title：Endocrine journal

authors： Kasuga A,Ozawa Y,Maruyama T,Ishihara T,Amemiya S,Saruta T

更新日期：1997-08-01 00:00:00

abstract：:Somatostatin is well known to inhibit the hormone secretion of various peptides. This action has been considered to be generally mediated via six different specific somatostatin receptors (sstr), sstr1, sstr2A, sstr2B, sstr3, sstr4, and sstr5. It then becomes very important to demonstrate the localization of these sst...

journal_title：Endocrine journal

authors： Taniyama Y,Suzuki T,Mikami Y,Moriya T,Satomi S,Sasano H

更新日期：2005-10-01 00:00:00

abstract：:In cases of thyroid papillary carcinoma, a less aggressive cancer, surgeons may hesitate to perform total thyroidectomy on patients with poor general condition because these may experience longer survival without undergoing surgery. To investigate the influence of general patient condition on the patients' survival wh...

journal_title：Endocrine journal

authors： Shinohara S,Kikuchi M,Harada H,Takebayashi S,Yunoki K,Yamazaki K

更新日期：2016-11-30 00:00:00

abstract：:Metabolic syndrome is a common disorder in Taiwan. For this study 431 subjects were randomly selected from visitors to the Department of Health Management. Blood pressure, blood glucose, lipid, uric acid levels and anthropometric measurements with immunoreactive insulin (IRI) and leptin levels were all correlated. We ...

journal_title：Endocrine journal

authors： Chiou WK,Lin JD,Weng HF,Ou YC,Liu TH,Fang JT

更新日期：2005-02-01 00:00:00

abstract：:Sirtuin1 (SIRT1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. These findings suggest that SIRT1 may play a role in the pathophysiology of visceral obesity. Therefore, we investigated the relationship between SIRT1 gene ex...

journal_title：Endocrine journal

authors： Lee H,Chu SH,Park JY,Park HK,Im JA,Lee JW

更新日期：2013-01-01 00:00:00

abstract：:Atrial and brain natriuretic peptides (ANP and BNP, respectively) are cardiac hormones. During cardiac development, their expression is a maker of cardiomyocyte differentiation and is under tight spatiotemporal regulation. After birth, however, their ventricular expression is only up-regulated in response to various c...

journal_title：Endocrine journal

authors： Kuwahara K,Nakao K

更新日期：2010-01-01 00:00:00

abstract：:The aims of this study were to: 1) determine the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism, and 2) investigate the change in PRL levels with treatment. In this observational study, patients with a new diagnosis of hypothyroidism in our endocrinology clinic ...

journal_title：Endocrine journal

authors： Hekimsoy Z,Kafesçiler S,Güçlü F,Ozmen B

更新日期：2010-01-01 00:00:00

abstract：:The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These fact...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kobayashi K,Kihara M,Miya A

更新日期：2014-01-01 00:00:00

abstract：:Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase (21-OH) deficiency (21-OHD) is an autosomal recessive disorder, in which CYP21A2 mutations or deletions result in underproduction of glucocorticoid and mineralocorticoid, and overproduction of androgens. Patients with CAH are treated with oral steroid ...

journal_title：Endocrine journal

authors： Naiki Y,Miyado M,Horikawa R,Katsumata N,Onodera M,Pang S,Ogata T,Fukami M

更新日期：2016-10-29 00:00:00

abstract：:von Hippel-Lindau (VHL) disease (VHLD) is a hereditary autosomal dominant syndrome that causes various benign and malignant tumors. VHLD is caused by mutations in the VHL tumor suppressor gene. Here, we report a mutation in the VHL gene in a Japanese family with VHLD type 2A, characterized by pheochromocytoma (PHE), a...

journal_title：Endocrine journal

authors： Imanaka M,Iida K,Takahashi K,Tsuji K,Nishizawa H,Fukuoka H,Takeno R,Takahashi Y,Okimura Y,Kaji H,Chihara K

更新日期：2006-12-01 00:00:00

abstract：:Long-term management of patients with differentiated thyroid cancer (DTC) commonly includes TSH-suppressive therapy with L-T4 and, in case of postsurgical hypoparathyroidism, Calcium-D3 supplementation, both of which may affect skeletal health. Experience with female patients treated for DTC at a young age and who wer...

journal_title：Endocrine journal

authors： Leonova TA,Drozd VM,Saenko VA,Mine M,Biko J,Rogounovitch TI,Takamura N,Reiners C,Yamashita S

更新日期：2015-01-01 00:00:00

abstract：:Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively. We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation. In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells. Ce...

journal_title：Endocrine journal

authors： Kitamura R,Ogata T,Tanaka Y,Motoyoshi K,Seno M,Takei I,Umezawa K,Kojima I

更新日期：2007-04-01 00:00:00

abstract：:The gene responsible for multiple endocrine neoplasia type 1 (MEN1) has recently been cloned, and its germline mutations were identified in patients with this syndrome. The majority of the mutations, frameshift or nonsense mutations, are expected to result in a loss of function of the gene product menin. Since the con...

journal_title：Endocrine journal

authors： Miyauchi A,Sato M,Matsubara S,Ohye H,Kihara M,Matsusaka K,Nishitani A,Takahara J

更新日期：1998-12-01 00:00:00

abstract：:This paper reports the case of an infant presenting with sexual ambiguity at birth. The child presented with labia majora synechia, thready genital tubercle and perineal hypospadias. The karyotype was 46,XY. Low testosterone levels with no response to hCG administration, associated with high LH level for her age, h...

journal_title：Endocrine journal

authors： Richard N,Leprince C,Gruchy N,Pigny P,Andrieux J,Mittre H,Manouvrier S,Lahlou N,Weill J,Kottler ML

更新日期：2011-01-01 00:00:00

abstract：:Since there is increasing evidence that postprandial hyperglycemia is a risk factor for the development of macrovascular complications, it is important to predict postprandial hyperglycemia in the early stages of glucose intolerance, and routine medical checkups provide a good opportunity to do so. The aim of this stu...

journal_title：Endocrine journal

authors： Goto M,Yamamoto-Honda R,Shimbo T,Goto A,Terauchi Y,Kanazawa Y,Noda M

更新日期：2011-01-01 00:00:00

abstract：:We demonstrated severe hyponatremia in a 68 year-old man who had pituitary tumor. He had poor appetite and was disoriented. Tests revealed hyponatremia of 110 mmol/l, and he was admitted to Jichi Medical School Omiya Medical Center to undergo further tests. Physical findings revealed disturbance of consciousness with ...

journal_title：Endocrine journal

authors： Kanda M,Omori Y,Shinoda S,Yamauchi T,Tamemoto H,Kawakami M,Ishikawa SE

更新日期：2004-08-01 00:00:00

abstract：:Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

journal_title：Endocrine journal

authors： Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

更新日期：2016-07-30 00:00:00

abstract：:Ketoconazole is an imidazole derivative used to treat systemic and superficial mycoses by inhibiting sterol synthesis in fungi. The drug impairs steroid hormone synthesis by blocking mitochondrial P450-dependent enzyme systems. Because of its potent inhibitory effects on adrenal steroidogenesis, ketoconazole is valuab...

journal_title：Endocrine journal

authors： Chou SC,Lin JD

更新日期：2000-08-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) and its agonists have been known to directly affect steroid hormone production in human granulosa cells. In this study, we examined effects of GnRH on Ca2+ mobilization, protein kinase C activity and steroidogenesis of human granulosa cells. Human granulosa cells were harvested by...

journal_title：Endocrine journal

authors： Hori H,Uemura T,Minaguchi H

更新日期：1998-04-01 00:00:00

abstract：:Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether t...

journal_title：Endocrine journal

authors： Botelho IMB,Moura Neto A,Silva CA,Tambascia MA,Alegre SM,Zantut-Wittmann DE

更新日期：2018-10-29 00:00:00

abstract：:We recently reported three cases of severe hypertriglyceridemia caused by tamoxifen-treatment after breast cancer surgery. In that report we showed that one of the three patients had apo E3/3 and another had E4/2 phenotype. There are few data about the relationship between apoprotein E phenotype, one of modifiers of l...

journal_title：Endocrine journal

authors： Hozumi Y,Kawano M,Saito T,Miyata M

更新日期：1998-04-01 00:00:00

abstract：:Thyroid hormone plays an important role in growth hormone (GH) synthesis and secretion. To study the relationship between thyroid function and urinary GH secretion in the hyperthyroid and hypothyroid states, we measured thyroid hormones, simultaneously with serum and urinary GH levels, in 54 patients with thyroid dise...

journal_title：Endocrine journal

authors： Murao K,Takahara J,Sato M,Tamaki M,Niimi M,Ishida T

更新日期：1994-10-01 00:00:00

abstract：:Immunocytochemical staining and cell immunoblot assay (CIBA) were performed in adenoma tissue from five patients with Cushing's disease and three patients with clinically silent corticotroph adenomas. All five patients with Cushing's disease showed hypersecretion of ACTH (130, 190, 331, 120, and 130 pg/ml), high level...

journal_title：Endocrine journal

authors： Kojima Y,Suzuki S,Yamamura K,Ohhashi G,Yamamoto I

更新日期：2002-06-01 00:00:00

abstract：:Geographic differences have been reported to affect the morphological and molecular features of papillary thyroid carcinomas (PTCs). The area around Chernobyl is well-known to be iodine-deficient in contrast to Japan, an iodine-rich country. We reviewed histological differences in adult PTC between Ukraine and Japan. ...

journal_title：Endocrine journal

authors： Ito M,Bogdanova T,Zurnadzhy L,Saenko V,Rogounovitch T,Mitsutake N,Kondo H,Maeda S,Nakashima M,Tronko M,Yamashita S

更新日期：2014-01-01 00:00:00

abstract：:This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...

journal_title：Endocrine journal

authors： Daimon M,Sugiyama K,Kameda W,Saitoh T,Oizumi T,Hirata A,Yamaguchi H,Ohnuma H,Igarashi M,Kato T

更新日期：2003-02-01 00:00:00

abstract：:Cushing's disease is primarily caused by adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. Pituitary tumor-transforming gene 1 (PTTG1) expression, a hallmark of pituitary tumors, stimulates pituitary cell proliferation. Histone deacetylases (HDACs) play an important role in regulating gene transcription...

journal_title：Endocrine journal

authors： Nakada Y,Kageyama K,Sugiyama A,Desaki R,Takayasu S,Niioka K,Murasawa S,Ishigame N,Asari Y,Iwasaki Y,Daimon M

更新日期：2015-01-01 00:00:00

abstract：:We had a patient with asymptomatic hyper-immunoreactive glucagonemia and with no evidence of pancreatic tumor detected by radiological examinations. The glucagon level was not decreased by the administration of glucose or somatosatin analogue (SMS 201-995). Gel filtration studies revealed that most glucagon immunoreac...

journal_title：Endocrine journal

authors： Hattori N,Saiki Y,Kajikawa M,Ishihara T,Moridera K,Hino M,Ikekubo K,Kurahachi H

更新日期：1995-08-01 00:00:00

abstract：:Exercise is a fundamental component of diabetes management. However, choosing inappropriate type or timing of exercise is associated with mild or severe hypoglycemia either during exercise or several hours after exercise. Several studies have shown that impaired counterregulatory responses triggers hypoglycemia. There...

journal_title：Endocrine journal

authors： Mao Y,Wen S,Zhou M,Zhu S,Zhou L

更新日期：2019-09-28 00:00:00

abstract：:To evaluate the prevalence of lymphocytic infiltrate in a large series of pituitary adenomas, we retrospectively studied tumor tissues from 1400 patients. Based on immunocytochemical data, tumors were classified as PRL (n=411), multihormonal (n=310), immunonegative (n=275), ACTH (n=166), GH (n=137), alpha subunit (n=4...

journal_title：Endocrine journal

authors： Heshmati HM,Kujas M,Casanova S,Wollan PC,Racadot J,Van Effenterre R,Derome PJ,Turpin G

更新日期：1998-06-01 00:00:00

abstract：:The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, ...

journal_title：Endocrine journal

authors： Ogawa M,Moriya N,Ikeda H,Tanae A,Tanaka T,Ohyama K,Mori O,Yazawa T,Fujita K,Seino Y,Kubo T,Tanaka H,Nishi Y,Yoshimoto M

更新日期：2004-02-01 00:00:00