SIADH closely associated with non-functioning pituitary adenoma.

abstract：:Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

journal_title：Endocrine journal

authors： Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

更新日期：2016-07-30 00:00:00

abstract：OBJECTIVE:This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients. MATERIAL AND METHODS:Thirty type 2 di...

journal_title：Endocrine journal

authors： Akalin A,Temiz G,Akcar N,Sensoy B

更新日期：2008-10-01 00:00:00

abstract：:The effect of add-on therapy with sitagliptin on glycemic control was prospectively investigated in patients with type 2 diabetes mellitus (T2DM) receiving insulin alone or insulin combined with oral antidiabetic drugs. Seventy-one patients were evaluated (38 men and 33 women aged 63.9 ± 10.2 years). They were divided...

journal_title：Endocrine journal

authors： Katsuno T,Ikeda H,Ida K,Miyagawa J,Namba M

更新日期：2013-01-01 00:00:00

abstract：:Impaired secretion of glucagon-like peptide 1 (GLP-1) has been suggested to contribute to the deficient incretin effect in patients with type 2 diabetes mellitus (T2DM). Recent studies, however, have not always supported this notion. Since Japanese patients with T2DM usually have severe impairment in the earlyphase of...

journal_title：Endocrine journal

authors： Lee S,Yabe D,Nohtomi K,Takada M,Morita R,Seino Y,Hirano T

更新日期：2010-01-01 00:00:00

abstract：:This study assessed the dose-dependent efficacy and safety of exenatide over 12 weeks in Japanese patients with type 2 diabetes suboptimally controlled despite therapeutic doses of sulfonylurea (SU), SU plus biguanide, or SU plus thiazolidinedione. Patients were randomly assigned to placebo (N = 40), 2.5 microg (N = 3...

journal_title：Endocrine journal

authors： Kadowaki T,Namba M,Yamamura A,Sowa H,Wolka AM,Brodows RG

更新日期：2009-01-01 00:00:00

abstract：:The objective of this study was to assess the potential predictive factors for follicle growth, ovulation, and pregnancy rate in patients with primary ovarian insufficiency/premature ovarian failure (POI/POF). We enrolled 25 POI patients with desired fertility who were treated and monitored for a minimum of 7 months b...

journal_title：Endocrine journal

authors： Miyazaki K,Miki F,Uchida S,Masuda H,Uchida H,Maruyama T

更新日期：2015-01-01 00:00:00

abstract：:The inflammatory biomarkers that fully characterize the metabolically unhealthy (MU) state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggest follistatin-like protein 1 (FSTL1) could be used as a biomarker for inflammation and CVD, however there is little information on FSTL...

journal_title：Endocrine journal

authors： Lee SY,Kim DY,Kyung Kwak M,Hee Ahn S,Kim H,Kim BJ,Koh JM,Rhee Y,Hwa Kim C,Hyun Baek K,Min YK,Hun Lee S,Kang MI

更新日期：2019-03-28 00:00:00

abstract：:We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...

journal_title：Endocrine journal

authors： Oita M,Miyoshi H,Ono K,Nakamura A,Cho KY,Nomoto H,Yamamoto K,Omori K,Manda N,Kurihara Y,Aoki S,Atsumi T

更新日期：2018-02-26 00:00:00

abstract：:Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...

journal_title：Endocrine journal

authors： Yamamoto T,Matsuo S,Ueshima Y,Inoue F,Kinugasa A,Sawada T

更新日期：1993-08-01 00:00:00

abstract：:Diabetes mellitus complicated with insulin antibodies is rare in clinical practice but usually difficult to control. A high amount of insulin antibodies, especially with low affinity and high binding capacity, leads to unstable glycemic control characterized by hyperglycemia unresponsive to large volume of insulin and...

journal_title：Endocrine journal

authors： Hayashi A,Takano K,Kawai S,Shichiri M

更新日期：2016-01-01 00:00:00

abstract：:Fatigue is a common symptom in patients visiting the clinic of psychosomatic medicine. A 250-μg synthetic ACTH (1-24) test (rapid ACTH test) and Beck depression inventory (BDI) were performed for 62 patients presenting with fatigue who visited the Department of Psychosomatic Medicine at Fukuoka Tokushukai Hospital. Pa...

journal_title：Endocrine journal

authors： Matsubayashi S,Nakatake N,Hara T

更新日期：2020-01-28 00:00:00

abstract：:Geographic differences have been reported to affect the morphological and molecular features of papillary thyroid carcinomas (PTCs). The area around Chernobyl is well-known to be iodine-deficient in contrast to Japan, an iodine-rich country. We reviewed histological differences in adult PTC between Ukraine and Japan. ...

journal_title：Endocrine journal

authors： Ito M,Bogdanova T,Zurnadzhy L,Saenko V,Rogounovitch T,Mitsutake N,Kondo H,Maeda S,Nakashima M,Tronko M,Yamashita S

更新日期：2014-01-01 00:00:00

abstract：:We measured serum levels of the carboxy-terminal propeptide of type 1 procollagen (P1CP) as a marker of bone formation and the carboxy-terminal telopeptide of type 1 collagen (1CTP) as a marker of bone resorption by RIA in sera from 40 Graves' disease patients and 14 Hashimoto's disease patients before and during trea...

journal_title：Endocrine journal

authors： Miyakawa M,Tsushima T,Demura H

更新日期：1996-12-01 00:00:00

abstract：:Components of cyclinD1/cyclin-dependent kinase 4 (CDK4)/p16INK4a/pRb pathway are the frequent target of many tumor types. We examined the role of retinoblastoma susceptibility gene (RB1) and the CDK4 gene in human pituitary tumorigenesis. For the RB1 gene, pRb expression and loss of heterozygosity (LOH) on 13q in pitu...

journal_title：Endocrine journal

authors： Honda S,Tanaka-Kosugi C,Yamada S,Sano T,Matsumoto T,Itakura M,Yoshimoto K

更新日期：2003-06-01 00:00:00

abstract：:21-hydroxylase deficiency (21-OHD) is the most common type of congenital adrenal hyperplasia. In addition to the clinical problems caused by adrenal insufficiency and androgen excess, a risk for obesity and metabolic syndrome during young adulthood is a major ramification of the disease. Although glucocorticoid therap...

journal_title：Endocrine journal

authors： Takishima S,Nakajima K,Nomura R,Tsuji-Hosokawa A,Matsuda N,Matsubara Y,Ono M,Miyai K,Takasawa K,Morio T,Hasegawa Y,Kashimada K

更新日期：2016-11-30 00:00:00

abstract：:Since 1989, neonatal mass screening for congenital adrenal hyperplasia (CAH) has been carried out in Japan. The mass screening has detected not only the patients with the classic form of steroid 21-hydroxylase deficiency (21-OHD), but also those with the nonclassic (NC) form of 21-OHD, and the molecular basis in these...

journal_title：Endocrine journal

authors： Shinagawa T,Horikawa R,Isojima T,Naiki Y,Tanaka T,Katsumata N

更新日期：2007-12-01 00:00:00

abstract：:We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (N...

journal_title：Endocrine journal

authors： Watanabe K,Iwatani Y,Hidaka Y,Watanabe M,Amino N

更新日期：1995-10-01 00:00:00

abstract：:It has been suggested that metabolic syndrome (MetS) overlaps prediabetes and type 2 diabetes and that it is not necessary to consider it as a separate clinical entity. In the present study, patients with normoglycemia and dysglycemia were compared in terms of MetS frequency and MetS criteria characteristics, in order...

journal_title：Endocrine journal

authors： Uzunlulu M,Oguz A

更新日期：2007-12-01 00:00:00

abstract：:Synchronous associations of Cushing's syndrome (CS) and primary aldosteronism (PA) with multiple adrenocortical adenomas secreting each hormone independently have rarely been reported. Herein, we describe a unique case of PA associated with CS with detailed clinical and pathological investigations. Bilateral adrenal m...

journal_title：Endocrine journal

authors： Onoda N,Ishikawa T,Nishio K,Tahara H,Inaba M,Wakasa K,Sumi T,Yamazaki T,Shigematsu K,Hirakawa K

更新日期：2009-01-01 00:00:00

abstract：:Parathyroidectomy (PTX) is the standard treatment for secondary hyperparathyroidism (SHPT); however, the administration of cinacalcet has gained prominence as a noninvasive treatment. We aimed to determine whether PTX or cinacalcet is more effective in preventing morbidity and mortality through reviewing follow-up dat...

journal_title：Endocrine journal

authors： Kim WW,Rhee Y,Kim BS,Kim K,Lee CR,Kang SW,Lee J,Jeong JJ,Nam KH,Chung WY

更新日期：2019-10-28 00:00:00

abstract：:The purpose of this study is to evaluate the impact of insulin secretion-sensitivity index-2 (ISSI-2) in the identification of the role of pancreatic iron deposition on beta-cell function in thalassemia major. Tissue iron stores were measured with magnetic resonance imaging (MRI) in the liver (R2), pancreas (R2*), and...

journal_title：Endocrine journal

authors： Karadas N,Yurekli B,Bayraktaroglu S,Aydinok Y

更新日期：2019-12-25 00:00:00

abstract：:In anovulatory patients ovulation is usually induced by clomiphene citrate (CC) or gonadotropin therapy, but in the case of polycystic ovary syndrome (PCOS), diagnosed by the presence of several micropolycysts in the ovaries and a high LH/FSH ratio in the serum, CC is only minimally effective, and side effects are oft...

journal_title：Endocrine journal

authors： Sakai A,Kondo Z,Kamei K,Izumi S,Sumi K

更新日期：1999-02-01 00:00:00

abstract：:Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance. The aim of the present study was to determine the relationship between serum irisin concentration and ...

journal_title：Endocrine journal

authors： Adamska A,Karczewska-Kupczewska M,Lebkowska A,Milewski R,Górska M,Otziomek E,Nikolajuk A,Wolczynski S,Kowalska I

更新日期：2016-12-30 00:00:00

abstract：:We examined 13 patients with euthyroid Graves' disease suspected ophthalmologically, by comparing them with 20 patients with untreated Graves' disease and by following them up for 5 to 10 years. They had Graves' ophthalmopathy (NOSPECS class II-IV) without other ocular diseases, normal levels of serum thyroid hormones...

journal_title：Endocrine journal

authors： Kashiwai T,Tada H,Asahi K,Hidaka Y,Tamaki H,Iwatani Y,Amino N

更新日期：1995-06-01 00:00:00

abstract：:The effect of prolonged diabetes on epinephrine-induced adenosine 3',5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1 microM epinephrine-induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with preserved adipose tissue....

journal_title：Endocrine journal

authors： Yamatani K,Saito K,Ohnuma H,Ikezawa Y,Seino T,Manaka Y,Daimon M,Takahashi K,Sasaki H

更新日期：1997-10-01 00:00:00

abstract：:In hope of understanding possible roles of estrogen during early embryogenesis, we examined the expression of both estrogen receptor alpha (ER alpha) and ER beta, a recently cloned novel subtype, in mouse oocytes and preimplantation embryos by means of reverse transcription polymerase chain reaction (RT-PCR). To inves...

journal_title：Endocrine journal

authors： Hiroi H,Momoeda M,Inoue S,Tsuchiya F,Matsumi H,Tsutsumi O,Muramatsu M,Taketani Y

更新日期：1999-02-01 00:00:00

abstract：:Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case of a 52-year-old female doctor suffering from breast cancer having metastasized to the lung...

journal_title：Endocrine journal

authors： Okahata S,Sakamoto K,Mitsumatsu T,Kondo Y,Noso S,Ikegami H,Shiba T

更新日期：2019-04-25 00:00:00

abstract：:Sexual differentiation of the rodent brain is recognized to involve transcriptional activation of multiple genes induced by gonadal steroids at developmental stages. To identify the genes differing in expression level between sexes, we analyzed gene expression in male and female rat hypothalami at postnatal day 5 by m...

journal_title：Endocrine journal

authors： Yonehara K,Suzuki M,Nishihara M

更新日期：2002-04-01 00:00:00

abstract：:The management of occult small thyroid nodules found by ultrasonography is sometimes problematic. Self-palpation may be utilized in the follow-up of these nodules. We developed a method of thyroid self-examination (TSE). We examined the size of the nodules palpable by this method by ultrasonography. In 78 patients exa...

journal_title：Endocrine journal

authors： Takano T,Hasegawa Y,Amino N

更新日期：2000-10-01 00:00:00

abstract：:Primary granulomatous hypophysitis (PGH) is a rarely occurred inflammatory disease of unknown etiology. We retrospective review a case of PGH treated by microsurgical transsphenoidal approach and review the appropriately documented cases of PGH collected from the literatures. The patient was a 56-year-old female who p...

journal_title：Endocrine journal

authors： Su SB,Zhang DJ,Yue SY,Zhang JN

更新日期：2011-01-01 00:00:00