Abstract:
OBJECTIVE:This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients. MATERIAL AND METHODS:Thirty type 2 diabetic and 11 healthy subjects with LDL levels between 100-160 mg/dl. without a history of cardiovascular event were included in the study. Both groups were matched with respect to age, gender, body mass indices and lipid levels. Flow- mediated dilatation (endothelium dependent, FMD) and nitroglycerine-induced dilatation (endothelium independent, NID) were measured in the brachial artery using high-resolution ultrasound in all participants and carotid artery intima media thickness (IMT) were also evaluated. OxLDL levels, lipid parameters, blood glucose, C-peptide, HbA1c and inflammatory markers including C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR) were studied. Type 2 diabetic patients received 10 mg. Atorvastatin for 6 weeks and FMD and NID were reevaluated and oxLDL levels and inflammatory markers remeasured. RESULTS:Basal FMD, NID, IMT and oxLDL levels besides inflammatory markers were not significantly different between patients and controls. No correlation was found between inflammatory markers and FMD and NID. Only IMT correlated with fibrinogen levels obtained before treatment. In non-diabetics, IMT also correlated with oxLDL levels (p: 0.013). FMD and NID significantly improved after atorvastatin therapy ((7.62 +/- 7.6 vs. 12.65 +/- 7.8, p<0.001 and 18.22 +/- 9.57 vs. 21.43 +/- 9.6, p: 0.007, respectively). Atorvastatin significantly reduced oxLDL levels (57.85 +/- 10.33 vs. 44.36 +/- 6.34, p<0.001). CONCLUSION:Atorvastatin improves endothelial functions and reduces oxLDL levels in type 2 diabetics with average lipid levels in the short term and may have beneficial effects in the prevention of early atherosclerotic changes.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Akalin A,Temiz G,Akcar N,Sensoy Bdoi
10.1507/endocrj.k07e-121subject
Has Abstractpub_date
2008-10-01 00:00:00pages
861-6issue
5eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K07E-121journal_volume
55pub_type
杂志文章abstract::We propose a new classification of thyroid follicular cell tumors which is correlated with patient's prognosis. It is unique as to two new categories: borderline malignancy between benign and malignant, and moderately differentiated adenocarcinoma (MDA) as a differentiation classification to stratify tumor aggressive...
journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.ej11-0184
更新日期:2012-01-01 00:00:00
abstract::The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established. Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT). Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with t...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej13-0359
更新日期:2014-01-01 00:00:00
abstract::The effect of a synthetic steroidal anti-androgen, TZP-4238, on steroid-induced rat prostatic hyperplasia was investigated. Male Wistar rats were divided into four experimental groups. Group 1 consisted of intact controls. The other animals were castrated. The castrated animals were treated for 7 weeks with 1) testost...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.40.479
更新日期:1993-08-01 00:00:00
abstract::Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.207
更新日期:2002-04-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-222
更新日期:2007-04-01 00:00:00
abstract::We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0193
更新日期:2020-10-28 00:00:00
abstract::This study assessed the dose-dependent efficacy and safety of exenatide over 12 weeks in Japanese patients with type 2 diabetes suboptimally controlled despite therapeutic doses of sulfonylurea (SU), SU plus biguanide, or SU plus thiazolidinedione. Patients were randomly assigned to placebo (N = 40), 2.5 microg (N = 3...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-01-01 00:00:00
abstract::The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According t...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ17-0325
更新日期:2018-01-30 00:00:00
abstract::In order to investigate the immunological aspects of silent thyroiditis, T lymphocyte subsets were analyzed by two-color flow cytometry in 10 patients with silent thyroiditis in the thyrotoxic phase, 12 patients with silent thyroiditis in the recovery phase, and 11 healthy volunteers as a control. The percentages of C...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.41.663
更新日期:1994-12-01 00:00:00
abstract::Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...
journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1993-08-01 00:00:00
abstract::Recent studies indicate that succinate dehydrogenase (SDH) genes B, C, or D are, at least partly, involved in the pathogenesis of pheochromocytoma or paraganglioma. Of these three genes, the SDHD gene mutation is most closely related with paragangliomas of the neck. Here we describe a case of an SDHD-related paragangl...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k09e-111
更新日期:2009-01-01 00:00:00
abstract::This paper reports the case of an infant presenting with sexual ambiguity at birth. The child presented with labia majora synechia, thready genital tubercle and perineal hypospadias. The karyotype was 46,XY. Low testosterone levels with no response to hCG administration, associated with high LH level for her age, h...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k11e-119
更新日期:2011-01-01 00:00:00
abstract::The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron stat...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-010
更新日期:2006-10-01 00:00:00
abstract::The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究
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更新日期:2015-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0126
更新日期:2016-08-31 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07-120
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1507/endocrj.50.61
更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0387
更新日期:2018-05-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.651
更新日期:1999-10-01 00:00:00
abstract::Thyroid hormone plays an important role in growth hormone (GH) synthesis and secretion. To study the relationship between thyroid function and urinary GH secretion in the hyperthyroid and hypothyroid states, we measured thyroid hormones, simultaneously with serum and urinary GH levels, in 54 patients with thyroid dise...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.41.517
更新日期:1994-10-01 00:00:00
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doi:10.1507/endocrj.EJ15-0137
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.163
更新日期:1997-02-01 00:00:00
abstract::We report herein the case of a 1-year-old boy with McCune-Albright syndrome (MAS) who presented with infantile-onset Cushing' s syndrome caused by ACTH independent macronodular adrenal hyperplasia (AIMAH). Abdominal CT, MRI, and adrenal scintigraphy with (131)I-adosterol identified bilateral adrenal involvement with t...
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pub_type: 杂志文章
doi:10.1507/endocrj.k10e-003
更新日期:2010-01-01 00:00:00
abstract::The presence of human progesterone receptor (PR) mRNA variants has been demonstrated in uterine endometrium and breast tissues as well as in cancer cells of these tissues. While exon deletions by the alternative splicing in these variants have been reported, there are few reports available on the PR mRNA variants with...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.473
更新日期:2002-08-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.40.545
更新日期:1993-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,评审
doi:10.1507/endocrj.ej13-0419
更新日期:2014-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.329
更新日期:1997-04-01 00:00:00