Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation.

abstract：:Breast cancer in young women younger than 35 years old is rare, aggressive and associated with a poor prognosis. Endocrine therapy is a preferred treatment modality in hormone receptor-positive early stage and advanced breast cancer, combined therapy of goserelin and letrozole presents an option for premenopausal wome...

journal_title：Endocrine journal

authors： Liu X,Qu H,Cao W,Wang Y,Ma Z,Li F,Wang H

更新日期：2013-01-01 00:00:00

abstract：:This study assessed the dose-dependent efficacy and safety of exenatide over 12 weeks in Japanese patients with type 2 diabetes suboptimally controlled despite therapeutic doses of sulfonylurea (SU), SU plus biguanide, or SU plus thiazolidinedione. Patients were randomly assigned to placebo (N = 40), 2.5 microg (N = 3...

journal_title：Endocrine journal

authors： Kadowaki T,Namba M,Yamamura A,Sowa H,Wolka AM,Brodows RG

更新日期：2009-01-01 00:00:00

abstract：:Treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia with normothyroxinemia) has not been established. In this study, changes in thyroid function after discontinuation of low-dose L-thyroxine (L-T4) supplement in infants with the condition were evaluated. Fourteen infants with hy...

journal_title：Endocrine journal

authors： Tomita Y,Ishiguro H,Shinagawa T,Kubota C,Shinohara O

更新日期：2003-08-01 00:00:00

abstract：:The purpose of this prospective study was to characterize the changes in serum levels of two proteins produced during the synthesis and degradation of type I collagen, i.e., the carboxyterminal propeptide of type I procollagen (PICP) and the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICT...

journal_title：Endocrine journal

authors： Yasumizu T,Fukada Y,Hoshi K

更新日期：1999-04-01 00:00:00

abstract：:To measure thyroid-stimulating antibody (TSAb) in sera from patients with Graves' disease, we developed a new assay system with using frozen stocks of CHO-K1 cells. CHO-K1 cells transfected with cloned thyrotropin (TSH) receptor on a 96 well plate were frozen in Cell Banker and stored at -70 degrees C. Three days befo...

journal_title：Endocrine journal

authors： Takano T,Sumizaki H,Amino N

更新日期：1997-06-01 00:00:00

abstract：:Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing's syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among vari...

journal_title：Endocrine journal

authors： Uehara M,Yamazaki H,Yoshikawa N,Kuribara-Souta A,Tanaka H

更新日期：2020-01-28 00:00:00

abstract：:Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance. The aim of the present study was to determine the relationship between serum irisin concentration and ...

journal_title：Endocrine journal

authors： Adamska A,Karczewska-Kupczewska M,Lebkowska A,Milewski R,Górska M,Otziomek E,Nikolajuk A,Wolczynski S,Kowalska I

更新日期：2016-12-30 00:00:00

abstract：:A series of chimeric TSH-LH/CG receptors were constructed by substituting homologous segments of the extracellular domain of the rat TSH receptor with corresponding segments of rat LH/CG receptor: C1 (amino acids 37-123 substituted), C2 (91-112), C3 (173-234), C4 (233-266), C5 (268-304), C6 (112-305) and C7 (36-404). ...

journal_title：Endocrine journal

authors： Akamizu T,Inoue D,Kosugi S,Ban T,Kohn LD,Imura H,Mori T

更新日期：1993-06-01 00:00:00

abstract：:We here describe two patients with empty sella syndrome who had variable and abnormal ACTH and cortisol secretory profiles. The patients are a 58-year old male and a 41-year old female, both of whom were neurotic. In both cases, low-dose dexamethasone suppression tests (1 mg, p.o., overnight) caused variable responses...

journal_title：Endocrine journal

authors： Sakaguchi H,Inoue D,Kataoka K,Koshiyama H,Aoki N,Nakao K

更新日期：1996-08-01 00:00:00

abstract：:Some categories of drugs are known for causing hyperglycemia or diabetes such as steroids, antipsychotics, and immunosuppressant. However, there has been little evidence from studies about the proportion of each drug in the context of drug-induced diabetes. In this study, we used data from the Japanese Adverse Drug Ev...

journal_title：Endocrine journal

authors： Konishi H,Shirakawa J,Arai M,Terauchi Y

更新日期：2019-06-28 00:00:00

abstract：:To assess the total daily inulin dose (TDD) and contribution of basal insulin to TDD and to identify the predictive factors for insulin requirement profiles in subjects with type 2 diabetes, we retrospectively examined insulin requirement profiles of 275 hospitalized subjects treated with basal-bolus insulin therapy (...

journal_title：Endocrine journal

authors： Shimoda S,Okubo M,Koga K,Sekigami T,Kawashima J,Kukidome D,Igata M,Ishii N,Shimakawa A,Matsumura T,Motoshima H,Furukawa N,Nishida K,Araki E

更新日期：2015-01-01 00:00:00

abstract：:The physiology of insulin signaling under normal and disease conditions is well studied in classical insulin target tissues, but not in podocytes. To examine insulin stimulation of podocyte GLUT4 translocation, we established a protocol involving treatment with the PPARα agonist fenofibrate to induce E11 podocyte diff...

journal_title：Endocrine journal

authors： Saito T,Yamada E,Okada S,Shimoda Y,Tagaya Y,Hashimoto K,Satoh T,Mori M,Okada J,Pessin JE,Yamada M

更新日期：2014-01-01 00:00:00

abstract：:We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide po...

journal_title：Endocrine journal

authors： Zheng J,Chen LL,Xiao F,Hu X,Deng X,Li H

更新日期：2012-01-01 00:00:00

abstract：:We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...

journal_title：Endocrine journal

authors： Oita M,Miyoshi H,Ono K,Nakamura A,Cho KY,Nomoto H,Yamamoto K,Omori K,Manda N,Kurihara Y,Aoki S,Atsumi T

更新日期：2018-02-26 00:00:00

abstract：:Pathogenesis of pseudohypoparathyroidism type 1b (PHP-1b) is related to the loss of methylation at the GNAS exon A/B region, which is combined with epigenetic defects at other differentially methylated GNAS regions in most sporadic cases. In this study, we established a method for evaluating the methylation status of...

journal_title：Endocrine journal

authors： Kinoshita K,Minagawa M,Takatani T,Takatani R,Ohashi M,Kohno Y

更新日期：2011-01-01 00:00:00

abstract：:PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

journal_title：Endocrine journal

authors： Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

更新日期：1997-02-01 00:00:00

abstract：:The human endometrium undergoes cyclical changes including proliferation, differentiation, tissue breakdown, and shedding (menstruation) throughout a woman's reproductive life. The postovulatory rise in ovarian progesterone induces profound remodeling and differentiation of the estradiol-primed endometrium. This chang...

journal_title：Endocrine journal

authors： Maruyama T,Yoshimura Y

更新日期：2008-10-01 00:00:00

abstract：:Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented wit...

journal_title：Endocrine journal

authors： Advani A,Johnson SJ,Nicol MR,Papacleovoulou G,Evans DB,Vaikkakara S,Mason JI,Quinton R

更新日期：2010-01-01 00:00:00

abstract：:Long-term management of patients with differentiated thyroid cancer (DTC) commonly includes TSH-suppressive therapy with L-T4 and, in case of postsurgical hypoparathyroidism, Calcium-D3 supplementation, both of which may affect skeletal health. Experience with female patients treated for DTC at a young age and who wer...

journal_title：Endocrine journal

authors： Leonova TA,Drozd VM,Saenko VA,Mine M,Biko J,Rogounovitch TI,Takamura N,Reiners C,Yamashita S

更新日期：2015-01-01 00:00:00

abstract：:The aims of this study were to: 1) determine the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism, and 2) investigate the change in PRL levels with treatment. In this observational study, patients with a new diagnosis of hypothyroidism in our endocrinology clinic ...

journal_title：Endocrine journal

authors： Hekimsoy Z,Kafesçiler S,Güçlü F,Ozmen B

更新日期：2010-01-01 00:00:00

abstract：:We report a de novo heterozygous 5,013,940 bp terminal deletion of chromosome 15q26 in a 13 9/12 -year-old Japanese girl with short stature (-3.9 SD), mild mental retardation, and ventricular septal defect (VSD). This terminal deletion involved IGF1R but not NR2F2, and was associated with an addition of telomere repea...

journal_title：Endocrine journal

authors： Dateki S,Fukami M,Tanaka Y,Sasaki G,Moriuchi H,Ogata T

更新日期：2011-01-01 00:00:00

abstract：:The common phenotype of nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene mutations in 46,XY is gonadal dysgenesis without adrenal deficiency. Though the phenotype of gonadal dysgenesis is variable, ranging from complete female to normal male genitalia, an asymptomatic 46,XY male is rare. Preserved fertil...

journal_title：Endocrine journal

authors： Yagi H,Takagi M,Kon M,Igarashi M,Fukami M,Hasegawa Y

更新日期：2015-01-01 00:00:00

abstract：:Carcinoma showing thymic-like differentiation (CASTLE) is a rare tumour of the thyroid, which arises from ectopic thymic tissue or remnants of branchial pouches. A systematic review of English literature evidences less than thirty cases; from them, it clearly appears that CASTLE is considered an indolent slow-growing ...

journal_title：Endocrine journal

authors： Cappelli C,Tironi A,Marchetti GP,Pirola I,De Martino E,Delbarba A,Castellano M,Rosei EA

更新日期：2008-08-01 00:00:00

abstract：:Inflammatory lesions of the pituitary gland are rarely encountered. Recently, the concept of immunoglobulin G4 (IgG4)-related systemic disease was proposed in Japan, and more than 20 cases have been reported as possibly associated with infundibulo-hypophysitis since 2000. We herein review such case reports in the publ...

journal_title：Endocrine journal

authors： Shimatsu A,Oki Y,Fujisawa I,Sano T

更新日期：2009-01-01 00:00:00

abstract：:Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

journal_title：Endocrine journal

authors： Luo J,Yang X,Liang J,Li W

更新日期：2015-01-01 00:00:00

abstract：:The present study was undertaken to determine pathophysiology of body water control in hypernatremic subjects with hypothalamic space-occupying lesions. Eight subjects with hypothalamic space-occupying lesions were divided into two groups of hypernatremia in the presence or absence of body water deficit. In 5 dehydrat...

journal_title：Endocrine journal

authors： Hayashi T,Murata M,Saito T,Ikoma A,Tamemoto H,Kawakami M,Ishikawa SE

更新日期：2008-08-01 00:00:00

abstract：:Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis. Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes. We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected...

journal_title：Endocrine journal

authors： Ito Y,Higashiyama T,Hirokawa M,Fukushima M,Inoue H,Yabuta T,Tomoda C,Uruno T,Kihara M,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi A

更新日期：2008-12-01 00:00:00

abstract：:The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...

journal_title：Endocrine journal

authors： Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.

更新日期：2015-01-01 00:00:00

abstract：:In this study, nine patients with Graves' ophthalmopathy with positive clinical activity score (CAS), who were either unresponsive or not suitable for glucocorticoid treatment, were given 100 microg of octreotide three times daily, subcutaneously, for three months. The mean age was 49+/-13 years. All patients were und...

journal_title：Endocrine journal

authors： Uysal AR,Corapçioğlu D,Tonyukuk VC,Güllü S,Sav H,Kamel N,Erdoğan G

更新日期：1999-08-01 00:00:00

abstract：:Circulating human GH (hGH) consists of several molecular isoforms. It was previously reported that the proportion of 20 kilodalton hGH (20K-hGH) was elevated in the serum of patients with active acromegaly. In this study, we investigated the effects of octreotide and transsphenoidal adenomectomy on the proportion of 2...

journal_title：Endocrine journal

authors： Murakami Y,Shimizu T,Yamamoto M,Kato Y

更新日期：2004-06-01 00:00:00