Abstract:
:We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide polymorphisms. The rs10509291AA and rs10823116GG genotypes were associated with high body mass index (BMI) > 23 Kg/m(2), and the rs7894483TT genotype was associated with lower BMI (< 23 Kg/m(2)). The rs10509291AT genotype was associated with a modestly higher risk of being overweight, consistent with the presence of an rs10509291A being a dominant or semi-dominant allele. The ATAA (rs7894483/rs10823116) and ATAG haplotypes were associated with a higher risk of being overweight (OR: 17.11 and 5.12) compared with the AAAG haplotype (P <0.01). Thus, the rs10509291, rs7894483, and rs10823116 alleles were associated with a high BMI (> 23 Kg/m(2)) and with overweight in this non-diabetic Chinese population.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Zheng J,Chen LL,Xiao F,Hu X,Deng X,Li Hdoi
10.1507/endocrj.ej11-0234subject
Has Abstractpub_date
2012-01-01 00:00:00pages
229-37issue
3eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/EJ11-0234journal_volume
59pub_type
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