Inhibition of steroid-induced prostatic hyperplasia in rats by treatment with anti-androgen (TZP-4238).

abstract：:In this study we confirmed our previous findings on the importance of IgE in Graves' disease and further investigated the relationships existing among Graves' disease, IgE, and interleukin-4. Two hundred and thirty-two newly diagnosed Graves' disease patients were treated with methimazole for 2 years, and were classif...

journal_title：Endocrine journal

authors： Yamada T,Komiya I,Miyahara Y,Komatsu M,Shima I,Inazawa T,Aizawa T

更新日期：2006-12-01 00:00:00

abstract：:Hypophysitis, which is often accompanied by pituitary dysfunction, is classified into several subtypes based on the cause, histology, and the location of inflammation in the pituitary gland. A definitive diagnosis requires pituitary biopsy, which is invasive, and the process is limited to specialized clinical settings...

journal_title：Endocrine journal

authors： Takagi H,Iwama S,Sugimura Y,Takahashi Y,Oki Y,Akamizu T,Arima H

更新日期：2020-04-28 00:00:00

abstract：:Adult patients with hypopituitarism are treated by the replacement of deficient hormones, although GH has not been substituted until March 2006 in Japan except for clinical trial. This study examines which hormonal status influences the prevalence of vascular risk disorders in hypopituitary adults. A sample of 263 adu...

journal_title：Endocrine journal

authors： Kaji H,Iida K,Takahashi Y,Okimura Y,Chihara K

更新日期：2007-04-01 00:00:00

abstract：:We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (N...

journal_title：Endocrine journal

authors： Watanabe K,Iwatani Y,Hidaka Y,Watanabe M,Amino N

更新日期：1995-10-01 00:00:00

abstract：:Angiotensin II (Ang II) is a well-known peptide that maintains the balance of electrolytes in the higher vertebrates. Ang II stimulation in the adrenal gland induces the synthesis of mineralocorticoids, mainly aldosterone, through the up-regulation of aldosterone synthase (CYP11B2) gene expression. Additionally, it ha...

journal_title：Endocrine journal

authors： Ito R,Shima H,Masuda K,Sato I,Shimada H,Yokoyama A,Shirahige K,Igarashi K,Sugawara A

更新日期：2020-12-26 00:00:00

abstract：:Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity...

journal_title：Endocrine journal

authors： Iwasaki T,Nakajima A,Yoneda M,Terauchi Y

更新日期：2006-06-01 00:00:00

abstract：:A nationwide epidemiologic survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases was conducted in 2010 to clarify the prevalence and the clinical presentations of the disorders. A questionnaire inquiring the experience of patients with these diseases was sent to randomly selected hospitals th...

journal_title：Endocrine journal

authors： Endo I,Fukumoto S,Ozono K,Namba N,Inoue D,Okazaki R,Yamauchi M,Sugimoto T,Minagawa M,Michigami T,Nagai M,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:We studied functional and histopathological changes in acromegalic cardiomyopathy following intermittent subcutaneous infusion of octreotide. A 68-year-old female patient with acromegaly associated with congestive heart failure due to dilated cardiomyopathy was initially treated with cardioactive medication for three ...

journal_title：Endocrine journal

authors： Nishiki M,Murakami Y,Sohmiya M,Koshimura K,Inoue K,Goto Y,Nakamura N,Kato Y

更新日期：1997-10-01 00:00:00

abstract：:Growth hormone (GH) is known to accelerate spermatogenesis and maintain gonadal function. In this study, we evaluated the effect of GH on recovery from testicular damage induced by cyclophosphamide (CP). Eleven- to fourteen-week-old GH-deficient Lewis rats (dw/dw) were divided into 4 groups (n = 10 each), with one gro...

journal_title：Endocrine journal

authors： Satoh K,Ohyama K,Nakagomi Y,Ohta M,Shimura Y,Sano T,Ishikawa H,Amemiya S,Nakazawa S

更新日期：2002-12-01 00:00:00

abstract：:This randomized, placebo-controlled, double-blind, parallel study assessed the safety, tolerability, pharmacokinetics, and pharmacodynamics of exenatide once weekly (QW) in 30 Japanese patients with type 2 diabetes (T2D) suboptimally controlled by diet and exercise alone or combined with biguanide, sulfonylurea, thiaz...

journal_title：Endocrine journal

authors： Iwamoto K,Nasu R,Yamamura A,Kothare PA,Mace K,Wolka AM,Linnebjerg H

更新日期：2009-01-01 00:00:00

abstract：:Recent evidence indicates that urinary gonadotropins may be an alternative method for detecting pubertal disorders. The aim of this study was to evaluate the associations of first morning voided (FMV) and random urinary gonadotropins with the pubertal response to a gonadotropin-releasing hormone (GnRH) stimulation tes...

journal_title：Endocrine journal

authors： Shim YS,An SH,Lee HJ,Kang MJ,Yang S,Hwang IT

更新日期：2019-10-28 00:00:00

abstract：:Diabetes mellitus complicated with insulin antibodies is rare in clinical practice but usually difficult to control. A high amount of insulin antibodies, especially with low affinity and high binding capacity, leads to unstable glycemic control characterized by hyperglycemia unresponsive to large volume of insulin and...

journal_title：Endocrine journal

authors： Hayashi A,Takano K,Kawai S,Shichiri M

更新日期：2016-01-01 00:00:00

abstract：:Effects of prolactin and bromocriptine on neutral and phospholipids of liver, adipose tissue and serum were studied in mature male bonnet monkeys. Hyperprolactinemia (ovine prolactin, 250 micrograms/kg body weight/day, i.p. for 30 days) elevated hepatic total lipids and phospholipids and decreased total and free chole...

journal_title：Endocrine journal

authors： Aruldhas MM,Thampi LT,Kumari TM,Govindarajulu P

更新日期：1994-04-01 00:00:00

abstract：:Maternal Graves' disease (GD) during pregnancy may influence thyroid function in fetuses. Neonates born to mothers with high serum TSH receptor antibody (TRAb) levels have been reported to develop 'neonatal GD'. Therefore, evaluations of serum thyroid hormone and TRAb levels in neonates upon birth are crucial for a pr...

journal_title：Endocrine journal

authors： Wada M,Kita M,Kawasaki K,Kusakabe T,Tagami T,Satoh-Asahara N,Shimatsu A,Hashimoto K

更新日期：2018-05-28 00:00:00

abstract：:Steroidogenic factor-1 [(SF-1/Ad4BP) (MIM184757)] is a nuclear receptor that regulates multiple genes involved in adrenal and gonadal development, steroidogenesis, reproduction, and other metabolic functions. Initially, mutations of SF-1/Ad4BP gene (NR5A1) in humans were identified in two 46, XY female patients with a...

journal_title：Endocrine journal

authors： Tajima T,Fujiwara F,Fujieda K

更新日期：2009-01-01 00:00:00

abstract：:A 77-year-old man was diagnosed as having hypothyroidism. An electrocardiogram obtained at the time of the first examination revealed Brugada electrocardiographic waveforms in leads V1 to V3. When pilsicainide hydrochloride loading changed the waveforms of the electrocardiographic ST segment, this result suggested an ...

journal_title：Endocrine journal

authors： Kitahara A,Hirai R,Matsui Y,Ikeda Y,Nakamura H

更新日期：2008-07-01 00:00:00

abstract：:Aerobic (sub lactate threshold; sub-LT) exercise training facilitates oxidative phosphorylation and glycolysis of skeletal muscle. Thyroid hormone (TH) also facilitates such metabolic events. Thus, we studied whether TH signaling pathway is activated by treadmill training. Male adult rats received 30 min/day treadmill...

journal_title：Endocrine journal

authors： Lesmana R,Iwasaki T,Iizuka Y,Amano I,Shimokawa N,Koibuchi N

更新日期：2016-08-31 00:00:00

abstract：:X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

journal_title：Endocrine journal

authors： Miyamoto J,Koto S,Hasegawa Y

更新日期：2000-04-01 00:00:00

abstract：:Musk is a secreted external hormone or information compound that is stored in musk scent glands of the males of species within the family Moschidae, such as Moschus berezovskii. The secretion of musk changes periodically during the courtship and reproduction periods, with the early stage of secretion occurring from Ma...

journal_title：Endocrine journal

authors： Fan M,Zhang M,Shi M,Zhang T,Qi L,Yu J,Li X,Lin S,Huang Z,Yang S,Zhou J,Li Y,Sun X,Cha M,Xu S,Liu Y,Guo X,Hu D,Liu S

更新日期：2018-11-29 00:00:00

abstract：:We propose a new classification of thyroid follicular cell tumors which is correlated with patient's prognosis. It is unique as to two new categories: borderline malignancy between benign and malignant, and moderately differentiated adenocarcinoma (MDA) as a differentiation classification to stratify tumor aggressive...

journal_title：Endocrine journal

authors： Kakudo K,Bai Y,Liu Z,Li Y,Ito Y,Ozaki T

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this prospective study was to characterize the changes in serum levels of two proteins produced during the synthesis and degradation of type I collagen, i.e., the carboxyterminal propeptide of type I procollagen (PICP) and the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICT...

journal_title：Endocrine journal

authors： Yasumizu T,Fukada Y,Hoshi K

更新日期：1999-04-01 00:00:00

abstract：:We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...

journal_title：Endocrine journal

authors： Oita M,Miyoshi H,Ono K,Nakamura A,Cho KY,Nomoto H,Yamamoto K,Omori K,Manda N,Kurihara Y,Aoki S,Atsumi T

更新日期：2018-02-26 00:00:00

abstract：:The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

journal_title：Endocrine journal

authors： Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

更新日期：2005-10-01 00:00:00

abstract：:In an attempt to define the hypothalamic-pituitary-adrenal (HPA) axis in non-insulin dependent diabetic rats (WBN/Kob), we measured plasma corticotropin releasing factor (CRF), as well as arginine vasopressin (AVP), ACTH, and corticosterone (B), CRF concentrations in the median eminence (ME), the remainder of the hypo...

journal_title：Endocrine journal

authors： Tojo C,Takao T,Nishioka T,Numata Y,Suemaru S,Hashimoto K

更新日期：1996-04-01 00:00:00

abstract：:Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally. This implies how difficult it is to diagnosis this type of cancer at the pre-operative or intra-operative stage of treatment. Fine needle aspiration cytology has been sh...

journal_title：Endocrine journal

authors： Lin JD,Chao TC

更新日期：2006-08-01 00:00:00

abstract：:Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether t...

journal_title：Endocrine journal

authors： Botelho IMB,Moura Neto A,Silva CA,Tambascia MA,Alegre SM,Zantut-Wittmann DE

更新日期：2018-10-29 00:00:00

abstract：:The mechanisms of paradoxical TRH response in human somatotroph adenoma cells were investigated using intracellular calcium measurement and static incubation assay. Intracellular calcium measurement revealed that TRH induces a biphasic response: a transient increase followed by a sustained plateau. The transient phase...

journal_title：Endocrine journal

authors： Okinaga H,Takano K,Hayashi S,Yasufuku-Takano J,Teramoto A,Fujita T

更新日期：2005-12-01 00:00:00

abstract：:Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation....

journal_title：Endocrine journal

authors： Yamamuro T,Inoue K,Nagai Y,Azuma D,Yamamoto A,Hara K,Kohara M,Iwata T,Nakatsuka S,Morii E,Yamamoto T

更新日期：2018-12-28 00:00:00

abstract：:We investigated the regulation of each intracellular signal transduction system including cyclic AMP (cAMP)-dependent and calcium (Ca2+) messenger systems in bovine adrenal fasciculo-reticularis cells to clarify the exact mode of action of ACTH. Pretreatment with primaquine and quinacrine, which are phospholipase A2 i...

journal_title：Endocrine journal

authors： Omura M,Suematsu S,Nishikawa T

更新日期：2007-08-01 00:00:00

abstract：:Clinical studies have shown that hyperhomocysteinemia is associated with bone fragility. Homocysteine (Hcy) induces apoptosis of osteoblastic cell lineage by increasing oxidative stress, which may contribute to Hcy-induced bone fragility. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ameliorate ...

journal_title：Endocrine journal

authors： Takeno A,Kanazawa I,Tanaka K,Notsu M,Yokomoto-Umakoshi M,Sugimoto T

更新日期：2016-04-25 00:00:00