A somatotropin-producing pituitary adenoma with an isolated adrenocorticotropin-producing pituitary adenoma in a female patient with acromegaly, subclinical Cushing's disease and a left adrenal tumor.

abstract：:The neurohypophysial hormone, oxytocin, is involved in the regulation of energy metabolism. Adiponectin (APN) is an adipose tissue-specific serum protein that inversely associates with metabolic syndrome (MetS). High-molecular-weight adiponectin (HMW APN) is considered the active form. In the present study, we aimed t...

journal_title：Endocrine journal

authors： Yuan G,Qian W,Pan R,Jia J,Jiang D,Yang Q,Wang S,Liu Y,Yu S,Hu H,Sun W,Ye J,Mao C,Zhuang R,Zhou L

更新日期：2016-07-30 00:00:00

abstract：:Our previous studies have revealed that protein malnutrition enhances insulin signaling in rat liver and muscle in response to a bolus insulin injection. However, it has not been established whether protein malnutrition up-regulates insulin signaling under physiological conditions, such as feeding. Here, we studied th...

journal_title：Endocrine journal

authors： Toyoshima Y,Tokita R,Taguchi Y,Akiyama-Akanishi N,Takenaka A,Kato H,Chida K,Hakuno F,Minami S,Takahashi S

更新日期：2014-01-01 00:00:00

abstract：:Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-rel...

journal_title：Endocrine journal

authors： Irie J,Inagaki E,Fujita M,Nakaya H,Mitsuishi M,Yamaguchi S,Yamashita K,Shigaki S,Ono T,Yukioka H,Okano H,Nabeshima YI,Imai SI,Yasui M,Tsubota K,Itoh H

更新日期：2020-02-28 00:00:00

abstract：:The present study used intermittently scanned continuous glucose monitoring (isCGM) in 10 patients with type 1 diabetes mellitus (T1DM) to evaluate the efficacy and safety of 7-day outpatient treatment with the combination of intensive insulin therapy and sodium-glucose transporter 2 inhibitor (SGLT2-I). All participa...

journal_title：Endocrine journal

authors： Kurozumi A,Okada Y,Tanaka Y

更新日期：2020-11-18 00:00:00

abstract：:Methylenetetrahydrofolate reductase plays an important role in folate metabolism. Individuals who are type 2 diabetes mellitus have greatest risk for the development of vascular complications. The results of studies which assessed the association between MTHFR C677T polymorphism and T2DM with vascular complications we...

journal_title：Endocrine journal

authors： Zhang D,Zhou Y,Han L,Ji H,Li J

更新日期：2014-01-01 00:00:00

abstract：:Decreased circulating levels of adiponectin, a novel adipose-derived adipocytokine, in obesity possibly contribute to the development of insulin resistance which is a major factor in the pathogenesis of type 2 diabetes. The present study was conducted to examine whether circulating and adipose tissue adiponectin level...

journal_title：Endocrine journal

authors： Fujita H,Fujishima H,Koshimura J,Hosoba M,Yoshioka N,Shimotomai T,Morii T,Narita T,Kakei M,Ito S

更新日期：2005-08-01 00:00:00

abstract：:Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

journal_title：Endocrine journal

authors： Luo J,Yang X,Liang J,Li W

更新日期：2015-01-01 00:00:00

abstract：:Hypertension and norepinephrine hypersecretion in a 59-year-old woman suffering from malignant pheochromocytoma with multiple metastases were appropriately controlled with alpha- and beta- blockers, and alpha-methyltyrosine (alpha-MT), a catecholamine-synthesis inhibitor. Metastasized vertebrae were treated with exter...

journal_title：Endocrine journal

authors： Teno S,Tanabe A,Nomura K,Demura H

更新日期：1996-10-01 00:00:00

abstract：:Adult growth hormone deficiency (GHD) is a well defined clinical condition, which is characterized by abnormal body composition, impaired physical activity and decreased quality of life. In addition, in recent years, growing interest has been shown towards cardiovascular risks in adult patients affected by GHD. In thi...

journal_title：Endocrine journal

authors： Giovannini L,Tirabassi G,Muscogiuri G,Di Somma C,Colao A,Balercia G

更新日期：2015-01-01 00:00:00

abstract：:The amounts of immunoreactive proinsulin (IRP), immunoreactive insulin (IRI), and C-peptidelike immunoreactivity (CPR) in six insulinomas and one nesidioblastosis lesion were determined together with those in the surrounding pancreatic tissue. Four non-insulinoma and nondiabetic human pancreases were used as the contr...

journal_title：Endocrine journal

authors： Tasaka Y,Nakaya F,Matsumoto H,Odagiri R,Ohgawara H,Omori Y

更新日期：1993-04-01 00:00:00

abstract：:von Hippel-Lindau (VHL) disease (VHLD) is a hereditary autosomal dominant syndrome that causes various benign and malignant tumors. VHLD is caused by mutations in the VHL tumor suppressor gene. Here, we report a mutation in the VHL gene in a Japanese family with VHLD type 2A, characterized by pheochromocytoma (PHE), a...

journal_title：Endocrine journal

authors： Imanaka M,Iida K,Takahashi K,Tsuji K,Nishizawa H,Fukuoka H,Takeno R,Takahashi Y,Okimura Y,Kaji H,Chihara K

更新日期：2006-12-01 00:00:00

abstract：:The identification of unique point mutations in patients with pseudohypoparathyroidism (PHP) with Albright's hereditary osteodystrophy (AHO) in different ethnic backgrounds has proved that defects within the Gs alpha gene account for Gs alpha deficiency in those patients. To search a mutation hot spot of the Gs alpha ...

journal_title：Endocrine journal

authors： Takeda K,Yokoyama M,Hashimoto K,Hiromatsu Y,Yamanaka H,Shimizu T,Sasaki M

更新日期：1997-08-01 00:00:00

abstract：:In an attempt to define the hypothalamic-pituitary-adrenal (HPA) axis in non-insulin dependent diabetic rats (WBN/Kob), we measured plasma corticotropin releasing factor (CRF), as well as arginine vasopressin (AVP), ACTH, and corticosterone (B), CRF concentrations in the median eminence (ME), the remainder of the hypo...

journal_title：Endocrine journal

authors： Tojo C,Takao T,Nishioka T,Numata Y,Suemaru S,Hashimoto K

更新日期：1996-04-01 00:00:00

abstract：:In recent times, the role of fibroblast growth factor 21 (FGF21) in patients with gestational diabetes mellitus (GDM) has been increasingly investigated. However, to our knowledge, no systematic analysis has been conducted yet to evaluate the relationship between FGF21 levels and GDM. Confirmed studies related to circ...

journal_title：Endocrine journal

authors： Jia J,Wei W,Yu F,Liu R,Shen Y,Zhang R,Yuan G,Zhou H

更新日期：2020-11-06 00:00:00

abstract：:It has been reported that there is an inverse relationship between serum sodium (Na) and potassium (K) levels in patients with diabetic coma. The present study was undertaken to determine whether such an inverse relation depends upon plasma glucose levels in diabetic patients for their glycemic control. We examined tw...

journal_title：Endocrine journal

authors： Saito T,Ishikawa S,Higashiyama M,Nakamura T,Rokkaku K,Hayashi H,Kusaka I,Nagasaka S,Saito T

更新日期：1999-02-01 00:00:00

abstract：:We examined 13 patients with euthyroid Graves' disease suspected ophthalmologically, by comparing them with 20 patients with untreated Graves' disease and by following them up for 5 to 10 years. They had Graves' ophthalmopathy (NOSPECS class II-IV) without other ocular diseases, normal levels of serum thyroid hormones...

journal_title：Endocrine journal

authors： Kashiwai T,Tada H,Asahi K,Hidaka Y,Tamaki H,Iwatani Y,Amino N

更新日期：1995-06-01 00:00:00

abstract：:In this study, we investigated the value of thyroxine administration to prevent recurrence after bilateral subtotal thyroidectomy for multinodular goiter. Patients that had benign multinodular goiter were operated on with the same surgical principles: ligation of both superior and inferior thyroid arteries on both sid...

journal_title：Endocrine journal

authors： Kulaçoglu H,Dener C,Ziraman I,Kama NA

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:Surgical removal of growth hormone-producing pituitary adenomas (GHomas) becomes difficult when they invade the cavernous sinus (CS). We investigated the relation among tumor proliferative potential, tumor volume and invasion of GHomas to CS. MATERIALS & METHODS:15 patients with GHoma aged 20-59 years were enr...

journal_title：Endocrine journal

authors： Iuchi S,Saeki N,Uchino Y,Higuchi Y,Tatsuno I,Nakamura S,Yasuda T,Yamaura A

更新日期：2000-03-01 00:00:00

abstract：:Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells are necessary to comprehend its range of diverse and contradictory effects. In this study, we examined the anti-obesity effects of resveratrol on high-fat diet (HFD)-induced obese mice at dosages ranging from 1 to 30 mg/kg treatme...

journal_title：Endocrine journal

authors： Chang CC,Lin KY,Peng KY,Day YJ,Hung LM

更新日期：2016-01-01 00:00:00

abstract：:In hope of understanding possible roles of estrogen during early embryogenesis, we examined the expression of both estrogen receptor alpha (ER alpha) and ER beta, a recently cloned novel subtype, in mouse oocytes and preimplantation embryos by means of reverse transcription polymerase chain reaction (RT-PCR). To inves...

journal_title：Endocrine journal

authors： Hiroi H,Momoeda M,Inoue S,Tsuchiya F,Matsumi H,Tsutsumi O,Muramatsu M,Taketani Y

更新日期：1999-02-01 00:00:00

abstract：:It has been indicated that some subsets of clinically nonfunctioning pituitary adenoma exhibit immunohistochemical and ultrastructural features of somatotroph or corticotroph cells, which are described as silent somatotroph and corticotroph adenomas, respectively. We here describe a 70-year-old woman with nonfunctioni...

journal_title：Endocrine journal

authors： Sakaguchi H,Koshiyama H,Sano T,Inoue D,Hashimoto N,Aoki N,Nakao K

更新日期：1997-04-01 00:00:00

abstract：:A 19-year-old girl presented at our emergency room with hypokalemic periodic paralysis. She had a thyrotoxic goiter and had experienced three paralytic attacks during the previous 2 years on occasions when she stopped taking antithyroid drugs. In addition to thyrotoxic periodic paralysis (TPP), she had metabolic acido...

journal_title：Endocrine journal

authors： Im EJ,Lee JM,Kim JH,Chang SA,Moon SD,Ahn YB,Son HS,Cha BY,Lee KW,Son HY

更新日期：2010-01-01 00:00:00

abstract：:Adult patients with hypopituitarism are treated by the replacement of deficient hormones, although GH has not been substituted until March 2006 in Japan except for clinical trial. This study examines which hormonal status influences the prevalence of vascular risk disorders in hypopituitary adults. A sample of 263 adu...

journal_title：Endocrine journal

authors： Kaji H,Iida K,Takahashi Y,Okimura Y,Chihara K

更新日期：2007-04-01 00:00:00

abstract：:Ghrelin is a peptide hormone with a unique structure comprising a medium chain fatty acid modification. Ghrelin cells are known to be abundantly localized in the gastric mucosa and are released into the blood stream to exert their multifunctional physiological effects. To elucidate the regulatory mechanisms of ghrelin...

journal_title：Endocrine journal

authors： Sakata I,Gong Z,Ikenoya C,Takemi S,Sakai T

更新日期：2017-01-01 00:00:00

abstract：:The tissue-specific circulating markers of thyroid hormone action on cardiac function have not been established. Although the relationship between thyroid function and plasma brain natriuretic peptide (BNP) levels has been evaluated in patients with thyroid disorders, the relationship between these parameters in the g...

journal_title：Endocrine journal

authors： Ohba K,Okada E,Goto Y,Suzuki S,Machii M,Nonaka D,Matsushita A,Sasaki S,Suda T,Oki Y,Takase H

更新日期：2020-04-28 00:00:00

abstract：:Musk is a secreted external hormone or information compound that is stored in musk scent glands of the males of species within the family Moschidae, such as Moschus berezovskii. The secretion of musk changes periodically during the courtship and reproduction periods, with the early stage of secretion occurring from Ma...

journal_title：Endocrine journal

authors： Fan M,Zhang M,Shi M,Zhang T,Qi L,Yu J,Li X,Lin S,Huang Z,Yang S,Zhou J,Li Y,Sun X,Cha M,Xu S,Liu Y,Guo X,Hu D,Liu S

更新日期：2018-11-29 00:00:00

abstract：:Age is an important prognostic factor in papillary thyroid carcinoma (PTC). In this study, we investigated the difference in prognosis of 7 subsets of PTC patients without distant metastasis at presentation or a history of radiation exposure (20 years or younger, 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kihara M,Takamura Y,Kobayashi K,Miya A

更新日期：2012-01-01 00:00:00

abstract：:The relative concentrations of total insulin receptor (IR) mRNA were measured in the epididymal adipose tissue and liver of intact untreated rats, dexamethasone-treated rats, adrenalectomized rats and adrenalectomized rats treated with dexamethasone, using RNA blot assays and a specific IR cDNA probe. Northern blot as...

journal_title：Endocrine journal

authors： Leal MA,Aller P,Mas A,Carranza MC,Calle C

更新日期：1994-12-01 00:00:00

abstract：:Metabolic syndrome is a common disorder in Taiwan. For this study 431 subjects were randomly selected from visitors to the Department of Health Management. Blood pressure, blood glucose, lipid, uric acid levels and anthropometric measurements with immunoreactive insulin (IRI) and leptin levels were all correlated. We ...

journal_title：Endocrine journal

authors： Chiou WK,Lin JD,Weng HF,Ou YC,Liu TH,Fang JT

更新日期：2005-02-01 00:00:00

abstract：:We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide po...

journal_title：Endocrine journal

authors： Zheng J,Chen LL,Xiao F,Hu X,Deng X,Li H

更新日期：2012-01-01 00:00:00