Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma.

abstract：:We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA1c level < 7.5% for at least one year without fluctuation by more than 0.5%. We also followed the changes of GA and HbA1c in 18 type 2 diabetic patients for 16 weeks as they progressed from untreated severe h...

journal_title：Endocrine journal

authors： Takahashi S,Uchino H,Shimizu T,Kanazawa A,Tamura Y,Sakai K,Watada H,Hirose T,Kawamori R,Tanaka Y

更新日期：2007-02-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) is a form of non-Langerhans histiocytosis. In this report, we show a case of ECD presenting diabetes insipidus and multiple xanthogranulomas received glucocorticoid treatment over a year. During this period, xanthogranulomas improved in response to the glucocorticoid therapy. Furthermore,...

journal_title：Endocrine journal

authors： Taguchi T,Iwasaki Y,Asaba K,Yoshida T,Takao T,Ikeno F,Nakajima H,Kodama H,Hashimoto K

更新日期：2008-03-01 00:00:00

abstract：:The effect of luteinizing hormone releasing hormone (LHRH) on the neuronal activity of CA1 and CA3 regions of the hippocampus was studied by means of extracellular recordings in the castrated male, intact male, castrated female, and castrated female injected s.c. with 20 micrograms estradiol benzoate (EB) for 3 days. ...

journal_title：Endocrine journal

authors： Osada T,Kimura F

更新日期：1995-04-01 00:00:00

abstract：:Progression to overt hypothyroidism and the associated adverse effects on lipid metabolism and the cardiovascular system are major concerns for patients diagnosed with subclinical hypothyroidism (SCH). No consensus regarding the clinical parameters associated with prognosis for this mild thyroid dysfunction has yet be...

journal_title：Endocrine journal

authors： Shin DY,Kim EK,Lee EJ

更新日期：2010-01-01 00:00:00

abstract：:Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes. And tumor necrosis factor alpha (TNF-α) is one of the ...

journal_title：Endocrine journal

authors： Wu S,Dong K,Wang J,Bi Y

更新日期：2018-06-27 00:00:00

abstract：:Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amyl...

journal_title：Endocrine journal

authors： Miyagawa J,Hanafusa O,Sasada R,Yamamoto K,Igarashi K,Yamamori K,Seno M,Tada H,Nammo T,Li M,Yamagata K,Nakajima H,Namba M,Kuwajima M,Matsuzawa Y

更新日期：1999-12-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH)-stimulated thyroid stimulating hormone (TSH) response in normal subjects is suppressed by oral glucose administration. Pharmacologic studies indicate that this suppressive action of glucose is mediated by an increase in hypothalamic somatostatin (SRIH) tone. Since activation of the ...

journal_title：Endocrine journal

authors： Park C,Kim E,Sohn S,Yang I,Koh G,Oh S,Woo J,Kim S,Kim J,Kim Y,Oh K,Park S,Park S

更新日期：2005-02-01 00:00:00

abstract：:Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-rel...

journal_title：Endocrine journal

authors： Irie J,Inagaki E,Fujita M,Nakaya H,Mitsuishi M,Yamaguchi S,Yamashita K,Shigaki S,Ono T,Yukioka H,Okano H,Nabeshima YI,Imai SI,Yasui M,Tsubota K,Itoh H

更新日期：2020-02-28 00:00:00

abstract：:A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and still showed impaired water diuresis during glucocorticoid replacement therapy is reported. A 45-year-old woman was initially admitted for nausea, vomiting, and general malaise. Her serum sodium and plasma osmolality, ACTH and cort...

journal_title：Endocrine journal

authors： Kageyama Y

更新日期：2000-12-01 00:00:00

abstract：:Pituitary adrenocorticotropic hormone (ACTH)-secreting tumor presents with a variety of clinical features. We outlined the features of ACTH release and characteristics of corticotroph adenoma cells. We especially focused on the corticotroph adenomas in patients with no clinical features of Cushing's disease. Subclinic...

journal_title：Endocrine journal

authors： Kageyama K,Oki Y,Nigawara T,Suda T,Daimon M

更新日期：2014-01-01 00:00:00

abstract：:Diarrhea is a non-specific symptom which may be associated with Addison's disease and several causes had been demonstrated in the aetiology. We describe a patient with Addison's disease who was suffering from chronic diarrhea for three months. She was diagnosed as having collagenous colitis and successfully treated wi...

journal_title：Endocrine journal

authors： Unlühizarci K,Bayram F,Ozbakir O,Kirgin A,Patiroglu T,Yücesoy M,Keleştimur F

更新日期：1998-08-01 00:00:00

abstract：:We present a rare case of a 66-year-old woman with the syndrome of inappropriate antidiuresis (SIAD) accompanied by an empty sella whose symptoms were seen twice in the eight years after the administration of non-steroidal anti-inflammatory drugs (NSAID) or prochlorperazine. No diuresis or suppression of the plasma le...

journal_title：Endocrine journal

authors： Shimada T,Higashi K,Kimura K,Shido T,Tomita K

更新日期：1995-04-01 00:00:00

abstract：:It has been demonstrated the involvement of branched-chain amino acids (BCAA) on obesity and related metabolic disorder. We investigated the effects of branched-chain amino acids (BCAA) on obesity and on glucose/fat homeostasis in mice fed on a high-fat (45%) diet. BCAA was dissolved in 0.5% methylcellulose and added ...

journal_title：Endocrine journal

authors： Arakawa M,Masaki T,Nishimura J,Seike M,Yoshimatsu H

更新日期：2011-01-01 00:00:00

abstract：:Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completel...

journal_title：Endocrine journal

authors： Fukumoto S,Ozono K,Michigami T,Minagawa M,Okazaki R,Sugimoto T,Takeuchi Y,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells are necessary to comprehend its range of diverse and contradictory effects. In this study, we examined the anti-obesity effects of resveratrol on high-fat diet (HFD)-induced obese mice at dosages ranging from 1 to 30 mg/kg treatme...

journal_title：Endocrine journal

authors： Chang CC,Lin KY,Peng KY,Day YJ,Hung LM

更新日期：2016-01-01 00:00:00

abstract：:We had a patient with asymptomatic hyper-immunoreactive glucagonemia and with no evidence of pancreatic tumor detected by radiological examinations. The glucagon level was not decreased by the administration of glucose or somatosatin analogue (SMS 201-995). Gel filtration studies revealed that most glucagon immunoreac...

journal_title：Endocrine journal

authors： Hattori N,Saiki Y,Kajikawa M,Ishihara T,Moridera K,Hino M,Ikekubo K,Kurahachi H

更新日期：1995-08-01 00:00:00

abstract：:The identification of unique point mutations in patients with pseudohypoparathyroidism (PHP) with Albright's hereditary osteodystrophy (AHO) in different ethnic backgrounds has proved that defects within the Gs alpha gene account for Gs alpha deficiency in those patients. To search a mutation hot spot of the Gs alpha ...

journal_title：Endocrine journal

authors： Takeda K,Yokoyama M,Hashimoto K,Hiromatsu Y,Yamanaka H,Shimizu T,Sasaki M

更新日期：1997-08-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) may mimic mixed medullary and follicular thyroid carcinoma (MMFTC). MTC originates from para-follicular cells, while MMFTC is an uncommon tumor characterized by coexistence of follicular and para-follicular cell-derived tumor populations. A 35-year-old woman was diagnosed with MTC but...

journal_title：Endocrine journal

authors： Takeshima K,Ariyasu H,Uraki S,Morita S,Furukawa Y,Inaba H,Iwakura H,Doi A,Warigaya K,Murata SI,Enomoto K,Hotomi M,Akamizu T

更新日期：2020-10-28 00:00:00

abstract：:Adult patients with hypopituitarism are treated by the replacement of deficient hormones, although GH has not been substituted until March 2006 in Japan except for clinical trial. This study examines which hormonal status influences the prevalence of vascular risk disorders in hypopituitary adults. A sample of 263 adu...

journal_title：Endocrine journal

authors： Kaji H,Iida K,Takahashi Y,Okimura Y,Chihara K

更新日期：2007-04-01 00:00:00

abstract：:There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control d...

journal_title：Endocrine journal

authors： Abbas JM,Chakraborty J,Akanji AO,Doi SA

更新日期：2008-05-01 00:00:00

abstract：:The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These fact...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kobayashi K,Kihara M,Miya A

更新日期：2014-01-01 00:00:00

abstract：:The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established. Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT). Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with t...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Hayashi K,Kawashiri MA,Yamagishi M,Yamada M,Fumisawa Y,Yamauchi K,Aizawa T

更新日期：2014-01-01 00:00:00

abstract：:The present study was undertaken to determine pathophysiology of body water control in hypernatremic subjects with hypothalamic space-occupying lesions. Eight subjects with hypothalamic space-occupying lesions were divided into two groups of hypernatremia in the presence or absence of body water deficit. In 5 dehydrat...

journal_title：Endocrine journal

authors： Hayashi T,Murata M,Saito T,Ikoma A,Tamemoto H,Kawakami M,Ishikawa SE

更新日期：2008-08-01 00:00:00

abstract：:Defects in insulin receptor function have been associated with insulin resistant states such as obesity and type 2 diabetes mellitus. Several types of mutations in the insulin receptor gene have been identified in patients with genetic syndromes of extreme insulin resistance. We have studied a 10-year-old Japanese gir...

journal_title：Endocrine journal

authors： Hashiramoto M,Osawa H,Ando M,Murakami A,Nishimiya T,Nakano M,Nishida W,Onuma H,Makino H

更新日期：2005-08-01 00:00:00

abstract：:Effects of prolactin and bromocriptine on neutral and phospholipids of liver, adipose tissue and serum were studied in mature male bonnet monkeys. Hyperprolactinemia (ovine prolactin, 250 micrograms/kg body weight/day, i.p. for 30 days) elevated hepatic total lipids and phospholipids and decreased total and free chole...

journal_title：Endocrine journal

authors： Aruldhas MM,Thampi LT,Kumari TM,Govindarajulu P

更新日期：1994-04-01 00:00:00

abstract：:Although curcumin was widely applied as a functional food for different diseases, it was found to reduce serum testosterone level and fertility in male animals by unknown molecular mechanisms. Here in our study, we investigated the possible mechanisms of curcumin-suppressed testosterone production in Leydig cells. Our...

journal_title：Endocrine journal

authors： Lin YC,Chiu CH,Liu HC,Wang JY

更新日期：2018-08-27 00:00:00

abstract：:Triptolide, a major active component of Tripterygium wilfordii Hook F (TWHF), is known to have multiple pharmacological activities. However, studies have also shown that triptolide is highly toxic to the reproductive system by disrupting normal androgen and estrogen signaling. In the present study, we investigated the...

journal_title：Endocrine journal

authors： Zhang J,Liu L,Mu X,Jiang Z,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:Impaired secretion of glucagon-like peptide 1 (GLP-1) has been suggested to contribute to the deficient incretin effect in patients with type 2 diabetes mellitus (T2DM). Recent studies, however, have not always supported this notion. Since Japanese patients with T2DM usually have severe impairment in the earlyphase of...

journal_title：Endocrine journal

authors： Lee S,Yabe D,Nohtomi K,Takada M,Morita R,Seino Y,Hirano T

更新日期：2010-01-01 00:00:00

abstract：:Thyroid nodules (TN) are common in the general population, and the clinical importance of diagnosing thyroid nodules is based on excluding the possibility of thyroid cancer, which occurs in 7-15% of cases. The thyroid gland, owing to its superficial location, is easily accessible via thermography, a noninvasive method...

journal_title：Endocrine journal

authors： Damião CP,Montero JRG,Moran MBH,de Oliveira Marçal E Silva Carvalho ME,de Farias CG,Brito IB,Saad MAN,Fontes CAP,Fainstein C,Rodrigues MFO,Palombo A,Conci A,da Cruz Filho RA,Lima GAB

更新日期：2021-01-21 00:00:00

abstract：:Recent evidence indicates that urinary gonadotropins may be an alternative method for detecting pubertal disorders. The aim of this study was to evaluate the associations of first morning voided (FMV) and random urinary gonadotropins with the pubertal response to a gonadotropin-releasing hormone (GnRH) stimulation tes...

journal_title：Endocrine journal

authors： Shim YS,An SH,Lee HJ,Kang MJ,Yang S,Hwang IT

更新日期：2019-10-28 00:00:00