Analysis of the KAL1 gene in 19 Japanese patients with Kallmann syndrome.

abstract：:Expression of activin A in fetal rat pancreas was studied immunohistochemically by using anti-activin A antibody. On embryonic day 12 (E12), cells in cap-like pancreatic anlage were stained with anti-activin A antibody. In these sections, no immunoreactive insulin or glucagon was observed. On E13.5, cells containing i...

journal_title：Endocrine journal

authors： Furukawa M,Eto Y,Kojima I

更新日期：1995-02-01 00:00:00

abstract：:The gene responsible for multiple endocrine neoplasia type 1 (MEN1) has recently been cloned, and its germline mutations were identified in patients with this syndrome. The majority of the mutations, frameshift or nonsense mutations, are expected to result in a loss of function of the gene product menin. Since the con...

journal_title：Endocrine journal

authors： Miyauchi A,Sato M,Matsubara S,Ohye H,Kihara M,Matsusaka K,Nishitani A,Takahara J

更新日期：1998-12-01 00:00:00

abstract：:A 70-year-old man with abdominal aortic aneurysm underwent surgical repair with Hemashield vascular graft. Postoperatively, he was found to have very low plasma cortisol levels, which failed to increase after stimulation with ACTH. A tentative diagnosis of adrenal insufficiency was made despite the lack of its clinica...

journal_title：Endocrine journal

authors： Sakai H,Matsumoto K,Sugiyama M,Yoshimoto T,Doi M,Izumiyama H,Hirata Y

更新日期：2006-06-01 00:00:00

abstract：:The physiology of insulin signaling under normal and disease conditions is well studied in classical insulin target tissues, but not in podocytes. To examine insulin stimulation of podocyte GLUT4 translocation, we established a protocol involving treatment with the PPARα agonist fenofibrate to induce E11 podocyte diff...

journal_title：Endocrine journal

authors： Saito T,Yamada E,Okada S,Shimoda Y,Tagaya Y,Hashimoto K,Satoh T,Mori M,Okada J,Pessin JE,Yamada M

更新日期：2014-01-01 00:00:00

abstract：:Growth hormone (GH) is known to accelerate spermatogenesis and maintain gonadal function. In this study, we evaluated the effect of GH on recovery from testicular damage induced by cyclophosphamide (CP). Eleven- to fourteen-week-old GH-deficient Lewis rats (dw/dw) were divided into 4 groups (n = 10 each), with one gro...

journal_title：Endocrine journal

authors： Satoh K,Ohyama K,Nakagomi Y,Ohta M,Shimura Y,Sano T,Ishikawa H,Amemiya S,Nakazawa S

更新日期：2002-12-01 00:00:00

abstract：:There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control d...

journal_title：Endocrine journal

authors： Abbas JM,Chakraborty J,Akanji AO,Doi SA

更新日期：2008-05-01 00:00:00

abstract：:We report herein the case of a 1-year-old boy with McCune-Albright syndrome (MAS) who presented with infantile-onset Cushing' s syndrome caused by ACTH independent macronodular adrenal hyperplasia (AIMAH). Abdominal CT, MRI, and adrenal scintigraphy with (131)I-adosterol identified bilateral adrenal involvement with t...

journal_title：Endocrine journal

authors： Hamajima T,Maruwaka K,Homma K,Matsuo K,Fujieda K,Hasegawa T

更新日期：2010-01-01 00:00:00

abstract：:Our previous studies have revealed that protein malnutrition enhances insulin signaling in rat liver and muscle in response to a bolus insulin injection. However, it has not been established whether protein malnutrition up-regulates insulin signaling under physiological conditions, such as feeding. Here, we studied th...

journal_title：Endocrine journal

authors： Toyoshima Y,Tokita R,Taguchi Y,Akiyama-Akanishi N,Takenaka A,Kato H,Chida K,Hakuno F,Minami S,Takahashi S

更新日期：2014-01-01 00:00:00

abstract：:Previously, we reported that short-term continuous glucose monitoring (CGM) with the professional iPro2© CGM device is a good clinical indicator of glycated hemoglobin (HbA1c) levels. However, there was no significant correlation between CGM and HbA1c levels when HbA1c levels were >8.0%. To further investigate this is...

journal_title：Endocrine journal

authors： Yamada M,Okada S,Oda H,Nakajima Y,C Bastie C,Kasai Y,Osaki A,Shimoda Y,Shibusawa R,Uehara R,Saito T,Ozawa A,Yamada E

更新日期：2020-05-28 00:00:00

abstract：:Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism and anosmia, for which three modes of transmission have been described: X-linked, autosomal recessive and autosomal dominant. The KAL1 gene, responsible for the X-linked form of the disease, has been isolated and its intron-exon organizat...

journal_title：Endocrine journal

authors： Izumi Y,Tatsumi K,Okamoto S,Hosokawa A,Ueno S,Fukui H,Amino N

更新日期：1999-10-01 00:00:00

abstract：:The renin-angiotensin system (RAS) has been unequivocally implicated as a mediator of diabetic complications. The present study was designed to evaluate the RAS in non-insulin dependent diabetic patients with diabetic nephropathy. Plasma renin activity, plasma angiotensin II and serum angiotensin-converting enzyme (AC...

journal_title：Endocrine journal

authors： Nicola W,Sidhom G,El Khyat Z,Ibrahim S,Salah A,El Sayed A

更新日期：2001-02-01 00:00:00

abstract：:We here describe two patients with empty sella syndrome who had variable and abnormal ACTH and cortisol secretory profiles. The patients are a 58-year old male and a 41-year old female, both of whom were neurotic. In both cases, low-dose dexamethasone suppression tests (1 mg, p.o., overnight) caused variable responses...

journal_title：Endocrine journal

authors： Sakaguchi H,Inoue D,Kataoka K,Koshiyama H,Aoki N,Nakao K

更新日期：1996-08-01 00:00:00

abstract：:We report on two siblings with classic simple virilizing 21-hydroxylase deficiency whose neonatal screening for serum 17alpha-hydroxyprogesterone (17-OHP) gave normal results. The proband, a girl with clitoromegaly whose screening 17-OHP value had been 9.2 ng/ml, was diagnosed at the age of 6 months, and her elder bro...

journal_title：Endocrine journal

authors： Shinohara O,Ishiguro H,Shinagawa T,Kubota C

更新日期：1998-06-01 00:00:00

abstract：:We provide the details of the successful management of a patient with active Cushing's disease complicated with coronavirus disease 2019 (COVID-19) pneumonia. The patient was a 27-year-old Japanese female healthcare worker who was scheduled to undergo pituitary surgery for Cushing's disease. She had been in close cont...

journal_title：Endocrine journal

authors： Yuno A,Kenmotsu Y,Takahashi Y,Nomoto H,Kameda H,Cho KY,Nakamura A,Yamashita Y,Nakamura J,Nakakubo S,Kamada K,Suzuki M,Sugino H,Inoshita N,Konno S,Miyoshi H,Atsumi T,Sawamura Y,Shimatsu A

更新日期：2020-12-24 00:00:00

abstract：:The octanoylation of Ser3 is essential for the biological function of ghrelin. We examined the concentrations of the n-octanoylated active-form ghrelin in cord and neonatal blood using an RIA system that specifically recognized n-octanoylated ghrelin, as well as a system that measured the total ghrelin concentration. ...

journal_title：Endocrine journal

authors： Yokota I,Kitamura S,Hosoda H,Kotani Y,Kangawa K

更新日期：2005-04-01 00:00:00

abstract：:Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance. The aim of the present study was to determine the relationship between serum irisin concentration and ...

journal_title：Endocrine journal

authors： Adamska A,Karczewska-Kupczewska M,Lebkowska A,Milewski R,Górska M,Otziomek E,Nikolajuk A,Wolczynski S,Kowalska I

更新日期：2016-12-30 00:00:00

abstract：:A series of chimeric TSH-LH/CG receptors were constructed by substituting homologous segments of the extracellular domain of the rat TSH receptor with corresponding segments of rat LH/CG receptor: C1 (amino acids 37-123 substituted), C2 (91-112), C3 (173-234), C4 (233-266), C5 (268-304), C6 (112-305) and C7 (36-404). ...

journal_title：Endocrine journal

authors： Akamizu T,Inoue D,Kosugi S,Ban T,Kohn LD,Imura H,Mori T

更新日期：1993-06-01 00:00:00

abstract：:Ghrelin is a peptide hormone with a unique structure comprising a medium chain fatty acid modification. Ghrelin cells are known to be abundantly localized in the gastric mucosa and are released into the blood stream to exert their multifunctional physiological effects. To elucidate the regulatory mechanisms of ghrelin...

journal_title：Endocrine journal

authors： Sakata I,Gong Z,Ikenoya C,Takemi S,Sakai T

更新日期：2017-01-01 00:00:00

abstract：:We present a rare case of a 66-year-old woman with the syndrome of inappropriate antidiuresis (SIAD) accompanied by an empty sella whose symptoms were seen twice in the eight years after the administration of non-steroidal anti-inflammatory drugs (NSAID) or prochlorperazine. No diuresis or suppression of the plasma le...

journal_title：Endocrine journal

authors： Shimada T,Higashi K,Kimura K,Shido T,Tomita K

更新日期：1995-04-01 00:00:00

abstract：:Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity...

journal_title：Endocrine journal

authors： Iwasaki T,Nakajima A,Yoneda M,Terauchi Y

更新日期：2006-06-01 00:00:00

abstract：:Obesity consists of hypertrophy and hyperplasia of adipocytes. Although the number of adipocytes is influenced by anatomical location, nutritional environment, hormone and genetic variation, it has been thought to be determined by the proliferation of precursor cells and subsequent differentiation. However, our recent...

journal_title：Endocrine journal

authors： Hanamoto T,Kajita K,Mori I,Ikeda T,Fujioka K,Yamauchi M,Okada H,Usui T,Takahashi N,Kitada Y,Taguchi K,Kajita T,Uno Y,Morita H,Ishizuka T

更新日期：2013-01-01 00:00:00

abstract：:Seven patients with growth hormone (GH)-secreting pituitary adenoma were treated preoperatively with octreotide (Sandostatin or SMS 201-995; a somatostatin analogue), and were compared with 18 non-treated patients in their clinical courses and adenoma analyses. Octreotide treatment improved the endocrinological data i...

journal_title：Endocrine journal

authors： Tsukamoto N,Nagaya T,Kuwayama A,Takano K,Shizume K,Sugita K,Seo H

更新日期：1994-08-01 00:00:00

abstract：:Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case of a 52-year-old female doctor suffering from breast cancer having metastasized to the lung...

journal_title：Endocrine journal

authors： Okahata S,Sakamoto K,Mitsumatsu T,Kondo Y,Noso S,Ikegami H,Shiba T

更新日期：2019-04-25 00:00:00

abstract：:The antidiabetic effects of Lactobacillus casei (LC) on a non-insulin-dependent diabetes mellitus (NIDDM) model, KK-Ay mice, were investigated. The oral administration of LC to male 4-week-old KK-Ay mice, or raising the mice on a 0.05% LC-containing diet significantly decreased the plasma glucose at 8 to 10 weeks of a...

journal_title：Endocrine journal

authors： Matsuzaki T,Yamazaki R,Hashimoto S,Yokokura T

更新日期：1997-06-01 00:00:00

abstract：:The proteins found in cow milk have been reported to cause systemic inflammation. Endoplasmic reticulum (ER) stress is known to be involved in the development of several metabolic disorders including insulin resistance and non-alcoholic fatty liver disease. However, the effect of thiazolidinediones (TZDs) on ER stress...

journal_title：Endocrine journal

authors： Kang SB,Kim HM,Kim HJ,Seok H,Huh JH,Lee BW,Kang ES,Lee HC,Cha BS

更新日期：2013-01-01 00:00:00

abstract：:The common phenotype of nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene mutations in 46,XY is gonadal dysgenesis without adrenal deficiency. Though the phenotype of gonadal dysgenesis is variable, ranging from complete female to normal male genitalia, an asymptomatic 46,XY male is rare. Preserved fertil...

journal_title：Endocrine journal

authors： Yagi H,Takagi M,Kon M,Igarashi M,Fukami M,Hasegawa Y

更新日期：2015-01-01 00:00:00

abstract：:In the last ten years a liquid formulation of liothyronine (L-T3) became available. To date, no studies on its systematic use have been reported. This study is aimed at assessing the reliability of liquid L-T3 in achieving target TSH in patients with differentiated thyroid cancers (DTC). Twenty-one high risk DTC patie...

journal_title：Endocrine journal

authors： Trimboli P,Centanni M,Virili C

更新日期：2016-06-30 00:00:00

abstract：:Recent evidence indicates that urinary gonadotropins may be an alternative method for detecting pubertal disorders. The aim of this study was to evaluate the associations of first morning voided (FMV) and random urinary gonadotropins with the pubertal response to a gonadotropin-releasing hormone (GnRH) stimulation tes...

journal_title：Endocrine journal

authors： Shim YS,An SH,Lee HJ,Kang MJ,Yang S,Hwang IT

更新日期：2019-10-28 00:00:00

abstract：:The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary thyroid carcinoma (PTC) is significantly lower in Asian countries than Western countries; however, the difference remains unexplained. This study aimed to evaluate the incidence of NIFTP in tumors diagnos...

journal_title：Endocrine journal

authors： Hirokawa M,Higuchi M,Suzuki A,Hayashi T,Kuma S,Miyauchi A

更新日期：2020-10-28 00:00:00

abstract：:The neurohypophysial hormone, oxytocin, is involved in the regulation of energy metabolism. Adiponectin (APN) is an adipose tissue-specific serum protein that inversely associates with metabolic syndrome (MetS). High-molecular-weight adiponectin (HMW APN) is considered the active form. In the present study, we aimed t...

journal_title：Endocrine journal

authors： Yuan G,Qian W,Pan R,Jia J,Jiang D,Yang Q,Wang S,Liu Y,Yu S,Hu H,Sun W,Ye J,Mao C,Zhuang R,Zhou L

更新日期：2016-07-30 00:00:00