Abstract:
:We provide the details of the successful management of a patient with active Cushing's disease complicated with coronavirus disease 2019 (COVID-19) pneumonia. The patient was a 27-year-old Japanese female healthcare worker who was scheduled to undergo pituitary surgery for Cushing's disease. She had been in close contact with an undiagnosed patient infected with COVID-19 and then developed COVID-19 pneumonia. Despite a lack of known risk factors associated with severe COVID-19 infection, the patient's dyspnea worsened and her respiratory condition deteriorated, as indicated by the need for 7 L/min oxygen supply by mask to maintain her oxygen saturation at >90%. Medical treatment was initiated to control hypercortisolism by the 'block and replace' regimen using steroidogenesis inhibitors and hydrocortisone. The COVID-19 pneumonia improved with multi-modal treatment including antiviral therapy. One month later, after a negative severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) test result and with appropriate protection against virus transmission to medical staff in the operating room and daily medical care nurses, trans-sphenoidal surgery was performed by our highly experienced pituitary surgeon. One month after the surgery, the patient's basal ACTH and cortisol levels and urinary free cortisol were all under the detection limit. Surgical remission was expected. Since hypercortisolism due to active Cushing's disease may worsen a COVID-19 infection, multi-disciplinary management that includes appropriate and prompt treatment strategies is mandatory in such cases.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Yuno A,Kenmotsu Y,Takahashi Y,Nomoto H,Kameda H,Cho KY,Nakamura A,Yamashita Y,Nakamura J,Nakakubo S,Kamada K,Suzuki M,Sugino H,Inoshita N,Konno S,Miyoshi H,Atsumi T,Sawamura Y,Shimatsu Adoi
10.1507/endocrj.EJ20-0613subject
Has Abstractpub_date
2020-12-24 00:00:00eissn
0918-8959issn
1348-4540pub_type
杂志文章abstract::This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...
journal_title:Endocrine journal
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pub_type: 临床试验,杂志文章
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更新日期:1993-02-01 00:00:00
abstract::Immunoreactive activin A (ir-activin A) release from cultured rat anterior pituitary cells was examined by measuring ir-activin A in culture medium by a specific radioimmunoassay. Ir-activin A release into the medium increased over 1-18 days, and reached a maximal level at 12-15 days. The basal levels of ir-activin A ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.39
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journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究
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更新日期:1998-06-01 00:00:00
abstract::The present study set forth the reference values for penile size and determined the prevalence of buried penis in Japanese full-term newborns. The stretched penile length was measured and the presence of buried penis was assessed at 1-7 days of age in 547 Japanese full-term newborn infants born between 2008 and 2012 i...
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journal_title:Endocrine journal
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abstract::Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. It has recently been reported that this syndrome is caused by mutations in the AAAS gene. In the present study, we analyzed the AAAS gene in a Japanese patient with...
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journal_title:Endocrine journal
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
abstract::Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism and anosmia, for which three modes of transmission have been described: X-linked, autosomal recessive and autosomal dominant. The KAL1 gene, responsible for the X-linked form of the disease, has been isolated and its intron-exon organizat...
journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
abstract::The relation between thyroid ultrasonography and laboratory, and the relationship of thyroid volume with clinical and anthropometric parameters, are not well clarified. Aim of the study was to investigate normal and hypoechoic-inhomogeneous not nodular thyroid gland in predicting thyroid tests, and to assess the corre...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej11-0129
更新日期:2012-01-01 00:00:00
abstract::Growth hormone (GH) is known to accelerate spermatogenesis and maintain gonadal function. In this study, we evaluated the effect of GH on recovery from testicular damage induced by cyclophosphamide (CP). Eleven- to fourteen-week-old GH-deficient Lewis rats (dw/dw) were divided into 4 groups (n = 10 each), with one gro...
journal_title:Endocrine journal
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更新日期:2002-12-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.723
更新日期:1999-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ19-0502
更新日期:2020-05-28 00:00:00
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更新日期:2014-01-01 00:00:00
abstract::The objective of this study was to assess the potential predictive factors for follicle growth, ovulation, and pregnancy rate in patients with primary ovarian insufficiency/premature ovarian failure (POI/POF). We enrolled 25 POI patients with desired fertility who were treated and monitored for a minimum of 7 months b...
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pub_type: 杂志文章
doi:10.1507/endocrj.EJ14-0189
更新日期:2015-01-01 00:00:00
abstract::The presence of human progesterone receptor (PR) mRNA variants has been demonstrated in uterine endometrium and breast tissues as well as in cancer cells of these tissues. While exon deletions by the alternative splicing in these variants have been reported, there are few reports available on the PR mRNA variants with...
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pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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abstract::It is known that endoplasmic reticulum (ER) stress is provoked under diabetic conditions and is possibly involved in the development of insulin resistance. In this study, using ER stress-activated indicator (ERAI) transgenic mice which express green fluorescent protein under ER stress conditions, we directly evaluated...
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abstract::This is a case report of an 18-year-old man with central diabetes incipidus (DI). An MRI done three months after the onset of the DI did not disclose a responsible lesion. Four months later, a second MRI showed the location of the tumor origin at the upper pituitary stalk and median eminence. Eight months later, the t...
journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
abstract::Pregnancy in acromegalic patients is a rare event, but is usually uneventful, with stable GH and IGF-I levels and no tumor enlargement. Medical treatment can usually be withdrawn without problems and although no major adverse event has been reported, the suspension of drug treatments is generally recommended. No cas...
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abstract::Although gonadal estrogens are known to facilitate the development of skeletal lesion in SHOX haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly...
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abstract::An early thirties man diagnosed with Erdheim-Chester disease (ECD) was simultaneously disclosed to have hypogonadotropic hypogonadism, central adrenal insufficiency, and GH deficiency in addition to central diabetes insipidus (CDI). Pituitary magnetic resonance imaging (MRI) showed swelling in the stalk, enlargement o...
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更新日期:2014-01-01 00:00:00