Relapse of Graves' disease in a patient with pheochromocytoma.

Abstract:

:We describe a patient with right adrenal tumor detected incidentally. The tumor was diagnosed as pheochromocytoma by endocrinological and radiological studies, and was removed surgically. Graves' disease, which had been in remission for more than two decades after discontinuation of antithyroid drug treatment, relapsed during preoperative evaluation of pheochromocytoma when the patient was treated with alpha- and beta1-adrenergic antagonists. Administration of methimazole resulted in a rapid improvement of thyroid function and the patient remained euthyroid on small doses of methimazole. This case may suggest possible involvement of excessive catecholamine secretion and beta2-adrenergic receptor activation by pheochromocytoma in the relapse of Graves' disease.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Abe M,Mori K,Nagai K,Ito S

doi

10.1507/endocrj.50.767

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

767-70

issue

6

eissn

0918-8959

issn

1348-4540

journal_volume

50

pub_type

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