Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia.

abstract：:This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for init...

journal_title：Endocrine journal

authors： Kawanabe S,Nagai Y,Nakamura Y,Nishine A,Nakagawa T,Tanaka Y

更新日期：2019-01-28 00:00:00

abstract：:Although gonadal estrogens are known to facilitate the development of skeletal lesion in SHOX haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly...

journal_title：Endocrine journal

authors： Fukami M,Nishi Y,Hasegawa Y,Miyoshi Y,Okabe T,Haga N,Nagai T,Tanaka T,Ogata T

更新日期：2004-04-01 00:00:00

abstract：:Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism and anosmia, for which three modes of transmission have been described: X-linked, autosomal recessive and autosomal dominant. The KAL1 gene, responsible for the X-linked form of the disease, has been isolated and its intron-exon organizat...

journal_title：Endocrine journal

authors： Izumi Y,Tatsumi K,Okamoto S,Hosokawa A,Ueno S,Fukui H,Amino N

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients. MATERIAL AND METHODS:Thirty type 2 di...

journal_title：Endocrine journal

authors： Akalin A,Temiz G,Akcar N,Sensoy B

更新日期：2008-10-01 00:00:00

abstract：:The cytologic localization and cellular levels of insulin-like growth factor binding protein-4 (IGFBP-4) in follicular and stromal compartments of normal and polycystic ovary syndrome (PCOS) ovaries during follicular growth and regression were investigated by the avidin/biotin immunoperoxidase method with a polyclonal...

journal_title：Endocrine journal

authors： Peng X,Maruo T,Samoto T,Mochizuki M

更新日期：1996-06-01 00:00:00

abstract：:In order to investigate the immunological aspects of silent thyroiditis, T lymphocyte subsets were analyzed by two-color flow cytometry in 10 patients with silent thyroiditis in the thyrotoxic phase, 12 patients with silent thyroiditis in the recovery phase, and 11 healthy volunteers as a control. The percentages of C...

journal_title：Endocrine journal

authors： Kushima K,Ban Y,Taniyama M,Itoh K

更新日期：1994-12-01 00:00:00

abstract：:The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

journal_title：Endocrine journal

authors： Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

更新日期：2005-10-01 00:00:00

abstract：:Central diabetes insipidus (CDI) is characterized by polyuria and polydipsia caused by impairment of arginine vasopressin (AVP) secretion. In this study, we evaluated plasma AVP concentrations during a hypertonic saline infusion test using a new AVP radioimmunoassay (RIA) which is now available in Japan. Thirteen cont...

journal_title：Endocrine journal

authors： Takagi H,Hagiwara D,Handa T,Sugiyama M,Onoue T,Tsunekawa T,Ito Y,Iwama S,Goto M,Suga H,Banno R,Takahashi K,Matsui S,Arima H

更新日期：2020-03-28 00:00:00

abstract：:The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, ...

journal_title：Endocrine journal

authors： Ogawa M,Moriya N,Ikeda H,Tanae A,Tanaka T,Ohyama K,Mori O,Yazawa T,Fujita K,Seino Y,Kubo T,Tanaka H,Nishi Y,Yoshimoto M

更新日期：2004-02-01 00:00:00

abstract：:Steroidogenic factor-1 [(SF-1/Ad4BP) (MIM184757)] is a nuclear receptor that regulates multiple genes involved in adrenal and gonadal development, steroidogenesis, reproduction, and other metabolic functions. Initially, mutations of SF-1/Ad4BP gene (NR5A1) in humans were identified in two 46, XY female patients with a...

journal_title：Endocrine journal

authors： Tajima T,Fujiwara F,Fujieda K

更新日期：2009-01-01 00:00:00

abstract：:In contrast to minimally invasive follicular thyroid carcinoma (FTC), widely invasive FTC is aggressive and is associated with a dire prognosis. However, prognostic factors of widely invasive FTC have not been intensively investigated. In this study, we investigated this issue in a series of 79 widely invasive FTC pat...

journal_title：Endocrine journal

authors： Ito Y,Hirokawa M,Masuoka H,Yabuta T,Fukushima M,Kihara M,Higashiyama T,Takamura Y,Kobayashi K,Miya A,Miyauchi A

更新日期：2013-01-01 00:00:00

abstract：:Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension. The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium...

journal_title：Endocrine journal

authors： Ohtsuka H,Komiya I,Aizawa T,Yamada T

更新日期：1995-12-01 00:00:00

abstract：:An early thirties man diagnosed with Erdheim-Chester disease (ECD) was simultaneously disclosed to have hypogonadotropic hypogonadism, central adrenal insufficiency, and GH deficiency in addition to central diabetes insipidus (CDI). Pituitary magnetic resonance imaging (MRI) showed swelling in the stalk, enlargement o...

journal_title：Endocrine journal

authors： Manaka K,Makita N,Iiri T

更新日期：2014-01-01 00:00:00

abstract：:The syndrome of inappropriate secretion of thyrotropin (SITSH) is defined as the inappropriate non-suppression of serum TSH in the presence of elevated free thyroid hormone; TSH-secreting pituitary adenomas and the syndrome of resistance to thyroid hormone are the main etiologies of SITSH. In addition, erroneous thyro...

journal_title：Endocrine journal

authors： Ohba K,Noh JY,Unno T,Satoh T,Iwahara K,Matsushita A,Sasaki S,Oki Y,Nakamura H

更新日期：2012-01-01 00:00:00

abstract：:We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (N...

journal_title：Endocrine journal

authors： Watanabe K,Iwatani Y,Hidaka Y,Watanabe M,Amino N

更新日期：1995-10-01 00:00:00

abstract：:A fasting triglyceridemia >10 mmol/L is associated with chylomicronemia (CM) and an increased recurrent acute pancreatitis (RAP) risk. The number of pancreatitis episodes varies significantly between patients with CM. The objective of this study was to investigate gene expression profiles of RAP in patients with CM. A...

journal_title：Endocrine journal

authors： Tremblay K,Brisson D,Gaudet D

更新日期：2020-11-28 00:00:00

abstract：:Progression to overt hypothyroidism and the associated adverse effects on lipid metabolism and the cardiovascular system are major concerns for patients diagnosed with subclinical hypothyroidism (SCH). No consensus regarding the clinical parameters associated with prognosis for this mild thyroid dysfunction has yet be...

journal_title：Endocrine journal

authors： Shin DY,Kim EK,Lee EJ

更新日期：2010-01-01 00:00:00

abstract：:Sera from 30 Japanese insulin-dependent diabetes mellitus (IDDM) patients of short duration were examined to determine whether they had antibodies to proteolytic fragments of islet antigen, the molecular weights of which were 37,000 and/or 40,000 Mr (37KAb). The median age and disease duration of the patients were 13 ...

journal_title：Endocrine journal

authors： Ozawa Y,Kasuga A,Maruyama T,Kitamura Y,Amemiya S,Ishihara T,Suzuki R,Saruta T

更新日期：1996-12-01 00:00:00

abstract：:The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary thyroid carcinoma (PTC) is significantly lower in Asian countries than Western countries; however, the difference remains unexplained. This study aimed to evaluate the incidence of NIFTP in tumors diagnos...

journal_title：Endocrine journal

authors： Hirokawa M,Higuchi M,Suzuki A,Hayashi T,Kuma S,Miyauchi A

更新日期：2020-10-28 00:00:00

abstract：:The aim of this study is to investigate glucose metabolism longitudinally during pregnancy to explore mechanisms underlying gestational diabetes mellitus (GDM). We reviewed a total of 62 pregnant Japanese women who underwent a 75g oral glucose tolerance test (OGTT) twice during pregnancy (median: early, 13; late, 28 w...

journal_title：Endocrine journal

authors： Saisho Y,Miyakoshi K,Ikenoue S,Kasuga Y,Matsumoto T,Minegishi K,Yoshimura Y,Itoh H

更新日期：2013-01-01 00:00:00

abstract：:The synthesis of nitric oxide (NO) has been demonstrated in the vascular endothelial cells and other tissues including in rat and bovine adrenal gland. To determine whether NO mediates aldosterone production in the adrenals, we evaluated the basal production of aldosterone, and the ACTH or angiotensin II (A II)-stimul...

journal_title：Endocrine journal

authors： Nakayama T,Izumi Y,Soma M,Kanmatsuse K

更新日期：1996-04-01 00:00:00

abstract：:We measured serum levels of the carboxy-terminal propeptide of type 1 procollagen (P1CP) as a marker of bone formation and the carboxy-terminal telopeptide of type 1 collagen (1CTP) as a marker of bone resorption by RIA in sera from 40 Graves' disease patients and 14 Hashimoto's disease patients before and during trea...

journal_title：Endocrine journal

authors： Miyakawa M,Tsushima T,Demura H

更新日期：1996-12-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH)-stimulated thyroid stimulating hormone (TSH) response in normal subjects is suppressed by oral glucose administration. Pharmacologic studies indicate that this suppressive action of glucose is mediated by an increase in hypothalamic somatostatin (SRIH) tone. Since activation of the ...

journal_title：Endocrine journal

authors： Park C,Kim E,Sohn S,Yang I,Koh G,Oh S,Woo J,Kim S,Kim J,Kim Y,Oh K,Park S,Park S

更新日期：2005-02-01 00:00:00

abstract：:The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These fact...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kobayashi K,Kihara M,Miya A

更新日期：2014-01-01 00:00:00

abstract：:Late-night salivary cortisol (NSC) has been recognized as a sensitive and easy-to-perform screening test for the diagnosis of overt Cushing's syndrome (CS). However, there have been few reports on the diagnostic utility of salivary cortisol (SC) measurement in the diagnosis of subclinical Cushing's syndrome (SCS). T...

journal_title：Endocrine journal

authors： Tateishi Y,Kouyama R,Mihara M,Doi M,Yoshimoto T,Hirata Y

更新日期：2012-01-01 00:00:00

abstract：:Sixteen sporadic pheochromocytomas, 3 pheochromocytomas in neurofibromatosis 1, and 4 pheochromocytomas in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations at codon 768 of the RET proto-oncogene by AluI digestion of polymerase chain reaction PCR products and mutations in exon 13 by PCR-single st...

journal_title：Endocrine journal

authors： Yoshimoto K,Kimura T,Tanaka C,Moritani M,Iwahana H,Itakura M

更新日期：1996-02-01 00:00:00

abstract：:The effect of luteinizing hormone releasing hormone (LHRH) on the neuronal activity of CA1 and CA3 regions of the hippocampus was studied by means of extracellular recordings in the castrated male, intact male, castrated female, and castrated female injected s.c. with 20 micrograms estradiol benzoate (EB) for 3 days. ...

journal_title：Endocrine journal

authors： Osada T,Kimura F

更新日期：1995-04-01 00:00:00

abstract：:Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HP...

journal_title：Endocrine journal

authors： Satoh M,Aso K,Nakayama T,Saji T

更新日期：2017-12-28 00:00:00

abstract：:Obesity consists of hypertrophy and hyperplasia of adipocytes. Although the number of adipocytes is influenced by anatomical location, nutritional environment, hormone and genetic variation, it has been thought to be determined by the proliferation of precursor cells and subsequent differentiation. However, our recent...

journal_title：Endocrine journal

authors： Hanamoto T,Kajita K,Mori I,Ikeda T,Fujioka K,Yamauchi M,Okada H,Usui T,Takahashi N,Kitada Y,Taguchi K,Kajita T,Uno Y,Morita H,Ishizuka T

更新日期：2013-01-01 00:00:00

abstract：:Components of cyclinD1/cyclin-dependent kinase 4 (CDK4)/p16INK4a/pRb pathway are the frequent target of many tumor types. We examined the role of retinoblastoma susceptibility gene (RB1) and the CDK4 gene in human pituitary tumorigenesis. For the RB1 gene, pRb expression and loss of heterozygosity (LOH) on 13q in pitu...

journal_title：Endocrine journal

authors： Honda S,Tanaka-Kosugi C,Yamada S,Sano T,Matsumoto T,Itakura M,Yoshimoto K

更新日期：2003-06-01 00:00:00