CCL2 level is elevated with metabolic syndrome and CXCL10 level is correlated with visceral fat area in obese children.

abstract：:The aim of this study was to assess the changes in insulin secretion and insulin sensitivity in relation to fasting and 2-hour plasma glucose (PG) levels and to assess the independent contributions of their impairments to non-diabetic hyperglycemia. A total of 2157 Japanese workers (mean age 52.6±7.3 years and mean B...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Sakurai M,Nakamura K,Moriuchi T,Miyamoto S,Nohara A,Kawashiri MA,Takeda Y,Yamagishi M

更新日期：2012-01-01 00:00:00

abstract：:A 67-year-old female with hypertension and impaired glucose tolerance was admitted to our hospital because of a typical acromegalic appearance, including large, thickened bulky hands and feet, and a large prominent forehead and tongue. She did not have a Cushingoid appearance, such as a moon-face, buffalo hump, purple...

journal_title：Endocrine journal

authors： Kobayashi Y,Takei M,Ohkubo Y,Kakizawa Y,Matoba H,Kumagai M,Takeda T,Suzuki S,Komatsu M

更新日期：2014-01-01 00:00:00

abstract：:Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis. Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes. We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected...

journal_title：Endocrine journal

authors： Ito Y,Higashiyama T,Hirokawa M,Fukushima M,Inoue H,Yabuta T,Tomoda C,Uruno T,Kihara M,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi A

更新日期：2008-12-01 00:00:00

abstract：:Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma (EFV-PTC) are indistinguishable preoperatively. CD26 expression in follicular tumor-uncertain malignant potential (FT-UMP) is reported to be clearly higher t...

journal_title：Endocrine journal

authors： Takagi S,Hirokawa M,Nagashima K,Higuchi M,Kadota K,Ishikawa R,Sato M,Miyauchi A,Miyake Y,Haba R

更新日期：2020-12-28 00:00:00

abstract：:Sera from 30 Japanese insulin-dependent diabetes mellitus (IDDM) patients of short duration were examined to determine whether they had antibodies to proteolytic fragments of islet antigen, the molecular weights of which were 37,000 and/or 40,000 Mr (37KAb). The median age and disease duration of the patients were 13 ...

journal_title：Endocrine journal

authors： Ozawa Y,Kasuga A,Maruyama T,Kitamura Y,Amemiya S,Ishihara T,Suzuki R,Saruta T

更新日期：1996-12-01 00:00:00

abstract：:Breast cancer in young women younger than 35 years old is rare, aggressive and associated with a poor prognosis. Endocrine therapy is a preferred treatment modality in hormone receptor-positive early stage and advanced breast cancer, combined therapy of goserelin and letrozole presents an option for premenopausal wome...

journal_title：Endocrine journal

authors： Liu X,Qu H,Cao W,Wang Y,Ma Z,Li F,Wang H

更新日期：2013-01-01 00:00:00

abstract：:21-hydroxylase deficiency (21-OHD) is the most common type of congenital adrenal hyperplasia. In addition to the clinical problems caused by adrenal insufficiency and androgen excess, a risk for obesity and metabolic syndrome during young adulthood is a major ramification of the disease. Although glucocorticoid therap...

journal_title：Endocrine journal

authors： Takishima S,Nakajima K,Nomura R,Tsuji-Hosokawa A,Matsuda N,Matsubara Y,Ono M,Miyai K,Takasawa K,Morio T,Hasegawa Y,Kashimada K

更新日期：2016-11-30 00:00:00

abstract：:An open-label prospective cross-over trial was performed to compare the efficacy and adverse effects of nateglinide with those of voglibose on Japanese early type 2 diabetes (who were oral hypoglycemic agent naïve and whose HbA(1C) levels were between 7.0 and 7.9% before treatment). Fourteen patients received 270 mg/d...

journal_title：Endocrine journal

authors： Kurebayashi S,Watada H,Tanaka Y,Kawasumi M,Kawamori R,Hirose T

更新日期：2006-04-01 00:00:00

abstract：:Isolated hypoaldosteronism is a rare and occasionally life-threatening cause of salt wasting in infancy. A 2-month-old Japanese boy of unrelated parents was examined for failure to thrive and poor weight gain. Laboratory findings were hyponatremia, hyperkalemia, high plasma renin and low aldosterone levels. Spot ur...

journal_title：Endocrine journal

authors： Kondo E,Nakamura A,Homma K,Hasegawa T,Yamaguchi T,Narugami M,Hattori T,Aoyagi H,Ishizu K,Tajima T

更新日期：2013-01-01 00:00:00

abstract：:KRN568 is a calcimimetic compound which acts on the calcium sensing receptors (CaR) on the parathyroid gland to suppress secretion of PTH. A recent report has demonstrated that CaRs are expressed on cultured human antral gastrin cells and that gastrin secretion is stimulated by an increase in extracellular calcium lev...

journal_title：Endocrine journal

authors： Igarashi T,Ogata E,Maruyama K,Fukuda T

更新日期：2000-10-01 00:00:00

abstract：:X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

journal_title：Endocrine journal

authors： Miyamoto J,Koto S,Hasegawa Y

更新日期：2000-04-01 00:00:00

abstract：:We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (N...

journal_title：Endocrine journal

authors： Watanabe K,Iwatani Y,Hidaka Y,Watanabe M,Amino N

更新日期：1995-10-01 00:00:00

abstract：:We describe a patient with right adrenal tumor detected incidentally. The tumor was diagnosed as pheochromocytoma by endocrinological and radiological studies, and was removed surgically. Graves' disease, which had been in remission for more than two decades after discontinuation of antithyroid drug treatment, relapse...

journal_title：Endocrine journal

authors： Abe M,Mori K,Nagai K,Ito S

更新日期：2003-12-01 00:00:00

abstract：:Ghrelin is a peptide hormone with a unique structure comprising a medium chain fatty acid modification. Ghrelin cells are known to be abundantly localized in the gastric mucosa and are released into the blood stream to exert their multifunctional physiological effects. To elucidate the regulatory mechanisms of ghrelin...

journal_title：Endocrine journal

authors： Sakata I,Gong Z,Ikenoya C,Takemi S,Sakai T

更新日期：2017-01-01 00:00:00

abstract：:Exercise is a fundamental component of diabetes management. However, choosing inappropriate type or timing of exercise is associated with mild or severe hypoglycemia either during exercise or several hours after exercise. Several studies have shown that impaired counterregulatory responses triggers hypoglycemia. There...

journal_title：Endocrine journal

authors： Mao Y,Wen S,Zhou M,Zhu S,Zhou L

更新日期：2019-09-28 00:00:00

abstract：:This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for init...

journal_title：Endocrine journal

authors： Kawanabe S,Nagai Y,Nakamura Y,Nishine A,Nakagawa T,Tanaka Y

更新日期：2019-01-28 00:00:00

abstract：:The relation between thyroid ultrasonography and laboratory, and the relationship of thyroid volume with clinical and anthropometric parameters, are not well clarified. Aim of the study was to investigate normal and hypoechoic-inhomogeneous not nodular thyroid gland in predicting thyroid tests, and to assess the corre...

journal_title：Endocrine journal

authors： Trimboli P,Rossi F,Thorel F,Condorelli E,Laurenti O,Ventura C,Nigri G,Romanelli F,Guarino M,Valabrega S

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study is to explore beta cell dysfunction and its clinical significance in gestational diabetes mellitus (GDM). We assessed insulin sensitivity and insulin secretion in a total of 277 Japanese women between 24 and 27 weeks of pregnancy who underwent a 2 h, 75 g oral glucose tolerance test (OGTT) becaus...

journal_title：Endocrine journal

authors： Saisho Y,Miyakoshi K,Tanaka M,Shimada A,Ikenoue S,Kadohira I,Yoshimura Y,Itoh H

更新日期：2010-01-01 00:00:00

abstract：:Thyrotoxic periodic paralysis (TPP) is mainly associated with Graves' disease but rarely with autonomously functioning thyroid nodule (AFTN). We herein report a case of AFTN associated with TPP in which the latter resolved after (131) I therapy for the former. We analyzed the genes encoding thyrotropin receptor (TSHR)...

journal_title：Endocrine journal

authors： Ozaki H,Mori K,Nakagawa Y,Hoshikawa S,Ito S,Yoshida K

更新日期：2008-03-01 00:00:00

abstract：:Diarrhea is a non-specific symptom which may be associated with Addison's disease and several causes had been demonstrated in the aetiology. We describe a patient with Addison's disease who was suffering from chronic diarrhea for three months. She was diagnosed as having collagenous colitis and successfully treated wi...

journal_title：Endocrine journal

authors： Unlühizarci K,Bayram F,Ozbakir O,Kirgin A,Patiroglu T,Yücesoy M,Keleştimur F

更新日期：1998-08-01 00:00:00

abstract：:The aim of the study was to explore the relationship between daily glycemic variability (GV) and visit-to-visit glycemic variability (VVV) in patients with type 2 diabetes (T2DM). A total of 156 outpatients with T2DM who had undergone continuous glucose monitoring (CGM) for 5 days were included in this study. Indices ...

journal_title：Endocrine journal

authors： Tsuchiya T,Saisho Y,Murakami R,Watanabe Y,Inaishi J,Itoh H

更新日期：2020-08-28 00:00:00

abstract：:Cushing's disease rarely appears as a consequence of hereditary disease. However, familial diseases with diminished glucocorticoid feedback are associated with secondary hypercorticotropinism and have been shown to give rise to pituitary adenomas. We here describe the rare case of a 30-year old female patient with con...

journal_title：Endocrine journal

authors： Haase M,Schott M,Kaminsky E,Lüdecke DK,Saeger W,Fritzen R,Schinner S,Scherbaum WA,Willenberg HS

更新日期：2011-01-01 00:00:00

abstract：:It has been reported that there is an inverse relationship between serum sodium (Na) and potassium (K) levels in patients with diabetic coma. The present study was undertaken to determine whether such an inverse relation depends upon plasma glucose levels in diabetic patients for their glycemic control. We examined tw...

journal_title：Endocrine journal

authors： Saito T,Ishikawa S,Higashiyama M,Nakamura T,Rokkaku K,Hayashi H,Kusaka I,Nagasaka S,Saito T

更新日期：1999-02-01 00:00:00

abstract：:Primary granulomatous hypophysitis (PGH) is a rarely occurred inflammatory disease of unknown etiology. We retrospective review a case of PGH treated by microsurgical transsphenoidal approach and review the appropriately documented cases of PGH collected from the literatures. The patient was a 56-year-old female who p...

journal_title：Endocrine journal

authors： Su SB,Zhang DJ,Yue SY,Zhang JN

更新日期：2011-01-01 00:00:00

abstract：:The extent of thyroidectomy in Graves' disease remains controversial. In our institution, long-term euthyroidism without thyroxin replacement therapy has been the aim, and it has long been the standard surgical procedure used to treat Graves' disease in many institutions, including our hospital. Based our several clin...

journal_title：Endocrine journal

authors： Sugino K,Nagahama M,Kitagawa W,Ohkuwa K,Uruno T,Matsuzu K,Suzuki A,Tomoda C,Y Hames K,Akaishi J,Masaki C,Ogimi Y,Yabuta T,Ito K

更新日期：2019-02-28 00:00:00

abstract：:The inflammatory biomarkers that fully characterize the metabolically unhealthy (MU) state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggest follistatin-like protein 1 (FSTL1) could be used as a biomarker for inflammation and CVD, however there is little information on FSTL...

journal_title：Endocrine journal

authors： Lee SY,Kim DY,Kyung Kwak M,Hee Ahn S,Kim H,Kim BJ,Koh JM,Rhee Y,Hwa Kim C,Hyun Baek K,Min YK,Hun Lee S,Kang MI

更新日期：2019-03-28 00:00:00

abstract：:The antidiabetic effects of Lactobacillus casei (LC) on a non-insulin-dependent diabetes mellitus (NIDDM) model, KK-Ay mice, were investigated. The oral administration of LC to male 4-week-old KK-Ay mice, or raising the mice on a 0.05% LC-containing diet significantly decreased the plasma glucose at 8 to 10 weeks of a...

journal_title：Endocrine journal

authors： Matsuzaki T,Yamazaki R,Hashimoto S,Yokokura T

更新日期：1997-06-01 00:00:00

abstract：:The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established. Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT). Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with t...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Hayashi K,Kawashiri MA,Yamagishi M,Yamada M,Fumisawa Y,Yamauchi K,Aizawa T

更新日期：2014-01-01 00:00:00

abstract：:The presence of human progesterone receptor (PR) mRNA variants has been demonstrated in uterine endometrium and breast tissues as well as in cancer cells of these tissues. While exon deletions by the alternative splicing in these variants have been reported, there are few reports available on the PR mRNA variants with...

journal_title：Endocrine journal

authors： Yamanaka T,Hirata S,Shoda T,Hoshi K

更新日期：2002-08-01 00:00:00

abstract：:The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, ...

journal_title：Endocrine journal

authors： Ogawa M,Moriya N,Ikeda H,Tanae A,Tanaka T,Ohyama K,Mori O,Yazawa T,Fujita K,Seino Y,Kubo T,Tanaka H,Nishi Y,Yoshimoto M

更新日期：2004-02-01 00:00:00