Abstract:
:Erdheim-Chester disease (ECD) is a form of non-Langerhans histiocytosis. In this report, we show a case of ECD presenting diabetes insipidus and multiple xanthogranulomas received glucocorticoid treatment over a year. During this period, xanthogranulomas improved in response to the glucocorticoid therapy. Furthermore, the expression of osteopontin in xanthogranulomatous tissues significantly decreased following the treatment. Our data show the expression of osteopontin in xanthogranulomatous tissues of ECD. Furthermore, the osteopontin mRNA decreased following glucocorticoid therapy with xanthogranuloma regression, suggesting that the expression level of osteopontin could be a marker of the disease activity of ECD.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Taguchi T,Iwasaki Y,Asaba K,Yoshida T,Takao T,Ikeno F,Nakajima H,Kodama H,Hashimoto Kdoi
10.1507/endocrj.k07e-044subject
Has Abstractpub_date
2008-03-01 00:00:00pages
217-23issue
1eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K07E-044journal_volume
55pub_type
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