Relationship between metabolic syndrome categorized by newly recommended by International Diabetes Federation criteria with plasma homocysteine concentration.

Abstract:

:Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and increased tHcy levels have been reported to be a novel risk factor of atherosclerotic disease. The aim of this study was to assess the association of the metabolic syndrome components with plasma (tHcy) level. Total 722 participants (284 men, 438 women) from the medical checkup program were enrolled in this study. The clinical characteristics and biochemical parameters of the subjects were assessed and the tHcy levels were compared according to the components of metabolic syndrome diagnosed by Adult Treatment Panel (ATP) III guideline and International Diabetes Federation (IDF) criteria. Among the components, groups with larger waist circumference and higher fasting blood glucose levels showed significantly higher tHcy level than the counterparts. Although statistically insignificant, mean concentrations of tHcy was higher in subjects with metabolic syndrome defined by both criteria. In multiple regression analysis, age, sex and systolic blood pressure were the independent determinants of tHcy level. In conclusion, tHcy level was not associated with metabolic syndrome defined by either criteria in Korean subjects.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Rhee EJ,Hwang ST,Lee WY,Yoon JH,Kim BJ,Kim BS,Kang JH,Lee MH,Park JR,Sung KC

doi

10.1507/endocrj.k07e-018

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

995-1002

issue

6

eissn

0918-8959

issn

1348-4540

pii

JST.JSTAGE/endocrj/K07E-018

journal_volume

54

pub_type

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