Purine sensing by riboswitches.

Abstract:

:Structured mRNA elements called riboswitches control gene expression by binding to small metabolites. Over a dozen riboswitch classes have been characterized that target a broad range of molecules and vary widely in size and secondary structure. Four of the known riboswitch classes recognize purines or modified purines. Three of these classes are closely related in conserved sequence and secondary structure, but members of these classes selectively recognize guanine, adenine or 2'-deoxyguanosine. Members of the fourth riboswitch class adopt a distinct structure to form a selective binding pocket for the guanine analogue preQ(1) (7-aminomethyl-7-deazaguanine). All four classes of purine-sensing riboswitches are most likely to recognize their respective metabolites by utilizing a riboswitch residue to make a canonical Watson-Crick base-pair with the ligand. This review will provide a summary of the purine-sensing riboswitches, as well as discuss the complex functions and applications of these RNAs.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Kim JN,Breaker RR

doi

10.1042/BC20070088

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

1-11

issue

1

eissn

0248-4900

issn

1768-322X

pii

BC20070088

journal_volume

100

pub_type

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