Bistramide A-induced irreversible arrest of cell proliferation in a non-small-cell bronchopulmonary carcinoma is similar to induction of terminal maturation.

Abstract:

:Bistramide A, a new toxin isolated from a New Caledonian Urochordata, shows an antiproliferative effect on a non-small-cell lung carcinoma line in vitro and G1-blockade. In this work, the growth arrest induced by bistramide A was shown to be irreversible as assessed by growth kinetics of pretreated cells. Furthermore, the drug caused an underexpression of the nuclear antigen Ki67. These events are similar to a G1-differentiation cell cycle step blockage and a terminal maturation induction.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Riou D,Roussakis C,Robillard N,Biard JF,Verbist JF

doi

10.1016/s0248-4900(05)80196-0

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

261-4

issue

3

eissn

0248-4900

issn

1768-322X

journal_volume

77

pub_type

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