Supracricoid laryngectomies: long-term oncological and functional results.


CONCLUSIONS:Our results confirm that supracricoid laryngectomies (SL) are reliable techniques for glottosupraglottic tumors, even for selected T3 and T4 cases, if the indications are correct. These surgical techniques allow a good quality of life with the preservation of the larynx. OBJECTIVE:SL with cricohyoidoepiglottopexy (CHEP) and cricohyoidopexy (CHP) have been popular over the last 20 years for the treatment of the glottic and/or supraglottic squamous cell carcinoma due to demonstrated good oncological and functional results. We report our experience with these techniques, with special focus on long-term oncological and functional results. PATIENTS AND METHODS:We retrospectively reviewed 206 patients who had undergone SL with CHEP or CHP technique between 1987 and 1998 for glottosupraglottic squamous cell carcinoma in our department. The long-term results for 206 patients with T1-T4 laryngeal carcinomas treated with SL are reported: 90.8% CHEP and 9.2% CHP. The mean follow-up was 62 months. RESULTS:Oncological results: the 5-year actuarial disease-free survival was 85%; the 5-year determinate actuarial survival was 88.3%. Functional results: organ preservation rate was 97%. Phonation was assessed according to the GRBAS scale.


Acta Otolaryngol


Acta oto-laryngologica


Laudadio P,Presutti L,Dall'olio D,Cunsolo E,Consalici R,Amorosa L,Cancellieri A,Bocciolini C




Has Abstract


2006-06-01 00:00:00














  • The contribution of vestibulo-spinal mechanisms to the maintenance of human upright posture.

    abstract::The maintenance of upright stance in humans requires the integrative evaluation of vestibular, visual, and proprioceptive information. Recent experiments prove the existence of fast vestibulo-spinal reactions in humans. Their physiological significance for the compensation of sudden external displacements of the body ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Dichgans J,Diener HC

    更新日期:1989-05-01 00:00:00

  • Artifacts in eighth cranial nerve biopsy.

    abstract::The occurrence of artifactual morphological changes was investigated in human eighth nerve biopsies and corresponding changes were brought about in biopsies from rats by mechanical handling before fixation. At the very site of compression by a pair of forceps the biopsy stained lighter than in its immediate surroundin...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Collan Y,Ylikoski J,Palva T,Selamaa R

    更新日期:1980-01-01 00:00:00

  • Role of margin status in recurrence after CO2 laser endoscopic resection of early glottic cancer.

    abstract:CONCLUSION:In patients with early glottic squamous cell carcinoma (SCC) submitted to CO2 laser endoscopic resection, local disease recurrence was significantly correlated with the presence of positive additional surgical margins on permanent sections. OBJECTIVES:To evaluate the rate of cancer recurrence in patients wi...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Crespo AN,Chone CT,Gripp FM,Spina AL,Altemani A

    更新日期:2006-03-01 00:00:00

  • Hearing impairment, cochlear morphology, and peroxynitrite (ONOO(-)) formation in adult and aging NOS II knockout mice.

    abstract:CONCLUSION:Nitric oxide synthase (NOS) II induction is a protective mechanism against age-related degeneration of the cochlea. OBJECTIVES:An induction of NOS II has been described in different inner ear pathologies. The objective was to examine the role of NOS II in age-related degeneration of the cochlea. METHODS:Th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Labbé D,Bloch W,Schick B,Michel O

    更新日期:2016-10-01 00:00:00

  • Freeze-fracture study of the cell junctions in the utricle and saccule.

    abstract::The maculae sacculi and utriculi of the chinchilla vestibular labyrinth have been studied by freeze-fracture method. In the replicas extensive zonulae occludentes have been found between sensory and supporting cells at the endolymphatic surface. Gap junctions are located between the supporting cells. Some intramembran...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Laciano L,Franke K,Iurato S,Reale E

    更新日期:1977-01-01 00:00:00

  • Combination of head-up sleep and vertical recognition training may cure intractable motion-evoked dizziness with unknown origin.

    abstract::Background: It has been reported that head-up sleep (HUS) prevents free-floating otoliths from entering canals and that vertical recognition training (VRT) promotes vestibular compensation.Aims/objectives: We would like to assess HUS and VRT for intractable motion-evoked dizziness, including possible benign paroxysmal...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Kitahara T,Horinaka A,Shiozaki T,Ito T,Wada Y,Yamanaka T,Nario K

    更新日期:2020-06-01 00:00:00

  • Clinical trial on tinnitus patients with normal to mild hearing loss: broad band noise and mixed pure tones sound therapy.

    abstract:BACKGROUND:Tinnitus treatments present a quandary for clinicians, but no thoroughly satisfactory medical treatments are offered to tinnitus patients. OBJECTIVE:We compared sound therapy effects of the broad band noise (BBN) and the mixed pure tones on tinnitus patients with normal to mild hearing loss, and the possibl...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,随机对照试验


    authors: Li Y,Feng G,Wu H,Gao Z

    更新日期:2019-03-01 00:00:00

  • The olfactory and respiratory epithelium in rhesus and squirrel monkeys studied with freeze-fracture technique.

    abstract::Olfactory and respiratory epithelia was prepared for thin-section and freeze-fracture replicas, and were investigated using electron microscopy. Three cell types were identified in the olfactory epithelium: olfactory receptor neurons (ORN), sustentacular cells (SC) and basal cells (BC); and respiratory epithelial cell...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Engström B,Ekblom A,Hansson P

    更新日期:1989-09-01 00:00:00

  • Cuff pressure and microvascular occlusion in the tracheal mucosa. An intravital microscopic study in the rabbit.

    abstract::A method is described for the intravital microscopic observations of rabbit tracheal mucosa microcirculation during compression with a thin, transparent high volume cuff. The cuff pressure (CP) required to cause complete ischemia in the mucosa over the cartilages was measured and a correlation was found to the mean ar...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Stenqvist O,Bagge U

    更新日期:1979-01-01 00:00:00

  • In vitro cholesteatoma growth and secretion of cytokines.

    abstract:CONCLUSION:Our results show a significant difference between skin and cholesteatoma biology in vitro. OBJECTIVES:Cholesteatoma disease is a process of destruction characterized by uncontrolled growth of squamous epithelial cells in the middle ear or temporal bone. The pathophysiology behind the cholesteatoma developme...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Helgaland T,Engelen B,Olsnes C,Aarstad HJ,Vassbotn FS

    更新日期:2010-07-01 00:00:00

  • Evoked potentials from the auditory nerve following sinusoidal electrical stimulation of the cochlea: new possibilities for preoperative testing in cochlear-implant candidates?

    abstract::To predict the possible benefit of a cochlear implant to a patient, the clinician requires a reliable objective method to monitor the presence of surviving fibres in the 8th nerve. The subjective promontory test and the evaluation of electrically evoked brainstem potentials are not adequate. An electrical stimulus art...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Hartmann R,Pfennigdorff T,Klinke R

    更新日期:1994-09-01 00:00:00

  • Plaster of Paris: thermal properties and biocompatibility. A study on an alternative implant material for ear surgery.

    abstract::There is no single technique for reconstruction of the canal wall following radical mastoidectomy. Autograft tissues may be unsuitable because of resorption and limited availability. An ideal foreign implant material should be bone-like in quality, non-ototoxic, readily available and malleable. Plaster of Paris, a deg...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Högset O,Bredberg G

    更新日期:1986-05-01 00:00:00

  • Auditory potentials in profoundly deaf subjects.

    abstract::In 12 healthy volunteers, and 5 prelingually and 5 postlingually profoundly deaf subjects, a 500 Hz filtered click stimulus was applied to the mastoid via the bone conductor. In all the healthy volunteers, middle latency response (MLR) was recorded. Among all profoundly deaf subjects, MLR was recorded only in 2 with p...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Ribarić K,Padovan I,Prevec TS

    更新日期:1985-03-01 00:00:00

  • Leiomyosarcoma of the thyroid gland.

    abstract::The existence of primary thyroid sarcomas represents a contentious issue. Some authors believe that thyroid sarcomas are, in fact, anaplastic carcinomas with sarcomatous (spindle cell) features. From the standpoint of treatment and prognosis, the histogenesis of thyroid 'sarcomas' is academic, because these tumors, ir...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Mansouri H,Gaye M,Errihani H,Kettani F,Gueddari BE

    更新日期:2008-03-01 00:00:00

  • Allergen-induced specific and non-specific nasal reactions. Reciprocal relationship and inhibition by topical glucocorticosteroids.

    abstract::The correlation between allergen-induced specific and non-specific (histamine) nasal reactions was studied, especially as regards topical glucocorticosteroid effects on the non-specific reactions. Thirteen patients with strictly seasonal allergic rhinitis participated. A nasal challenge with histamine and three increa...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Andersson M,Andersson P,Pipkorn U

    更新日期:1989-03-01 00:00:00

  • MASPIN tumour-suppressing activity in head and neck squamous cell carcinoma: emerging evidence and therapeutic perspectives.

    abstract:CONCLUSIONS:A large series confirmation may suggest elective neck dissection in cN0 MASPIN-negative oral squamous cell carcinomas (SCCs). Re-activated nuclear MASPIN in association with anti-angiogenic or cytotoxic drugs may be extremely effective in the treatment of laryngeal SCC. OBJECTIVES:MASPIN is a serpin showin...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审


    authors: Marioni G,Staffieri C,Staffieri A,De Filippis C,Blandamura S

    更新日期:2009-05-01 00:00:00

  • Posturographic limits of stability can predict the increased risk of falls in elderly patients with instability?

    abstract:CONCLUSIONS:There was a difference in average score of the sensory organization test (SOT) of the case group (elderly instability) compared to the control group (healthy subjects). Cases had worse scores on the limits of stability (LOS) than controls, but were only able to confirm statistically significant differences ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Faraldo-García A,Santos-Pérez S,Rossi-Izquierdo M,Lirola-Delgado A,Vaamonde-Sánchez-Andrade I,Del-Río-Valeiras M,Soto-Varela A

    更新日期:2016-11-01 00:00:00

  • Quantitative analysis of EMG interference pattern in patients with laryngeal paresis.

    abstract::Conventional (visual) analysis of EMG was compared to a computerized quantitative method (turns/amplitude). Ten patients with a clinical history of peripheral nerve lesion were examined in order to investigate whether quantitative analysis of EMG increased the diagnostic sensitivity of peripheral nerve lesions to the ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Lindestad PA,Persson A

    更新日期:1994-01-01 00:00:00

  • Experimental intravenous inoculation of Klebsiella rhinoscleromatis bacilli in albino rats: a histopathological and bacteriological study.

    abstract::Scleroma, chronic specific granuloma of the nose and upper respiratory tract, is endemic in Egypt and many other countries. The exact pathogenesis of the disease as regards the aetiological role of Klebsiella rhinoscleromatis is contradictory. This work investigated the effect of experimental intravenous injection of ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Gaafar HA,Bassiouny M,El Mofty M,Badour NM,Nour YA

    更新日期:2000-03-01 00:00:00

  • Eustachian tube function in young children without a history of otitis media evaluated using a pressure chamber protocol.

    abstract:CONCLUSIONS:Protocol limitations were identified and accounted for in the analysis. Percent gradient equilibrated (PGE) was affected by driving gradient direction in a similar manner to other efficiency measures. A finer resolution of possible age-related changes in eustachian tube opening efficiency is expected with t...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Swarts JD,Casselbrant ML,Teixeira MS,Mandel EM,Richert BC,Banks JM,El-Wagaa J,Doyle WJ

    更新日期:2014-06-01 00:00:00

  • Sensitive period to acoustic trauma in the rat pup cochlea. Histological findings.

    abstract::In a previous paper we demonstrated physiologically a sensitive period for acoustic trauma in the rat pup cochlea, with a maximum at 22 days of age. Seven or 60 days after noise exposure these 22-day exposed rats were used for light and electron microscopy. At 7 days, surface preparation revealed restricted damage to ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Lenoir M,Pujol R

    更新日期:1980-03-01 00:00:00

  • Laryngeal abductor muscle reinnervation in a pig model.

    abstract:OBJECTIVE:To develop a large animal model for studies of laryngeal abductor reinnervation. MATERIAL AND METHODS:Six minipigs underwent unilateral anastomosis of the phrenic nerve-abductor branch of the recurrent laryngeal nerve (RLN). Polyhydroxybutyrate (PHB) conduits were used for repair. At each of 30, 60 and 120 d...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Birchall M,Idowu B,Murison P,Jones A,Burt R,Ayling S,Stokes C,Pope L,Terenghi G

    更新日期:2004-09-01 00:00:00

  • A contribution to the structural pattern differences between the apical and basal spiral ganglions in mammals.

    abstract::The purpose of this paper was to establish a mammalian comparative study between the neuronal spaces of the upper versus the basal cochlear turns. We studied with light microscopy i) Webster albino rat embryos at various gestational days (GD), and a postnatal (PN) series; ii) kittens 3 weeks old; iii) pigmented guinea...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Sánchez-Fernández JM,Sánchez-del Rey A,Santaolalla-Montoya F,Martinez Ibarguen A

    更新日期:1997-03-01 00:00:00

  • Substance P nerve fibres in the canine larynx by PAP immunohistochemistry.

    abstract::The distribution of the Substance P (SP) immunoreactive nerve fibres in the canine larynx and laryngeal nerves was studied by PAP immunohistochemistry. Many individual SP immunoreactive nerve fibres with varicosities were observed within the epithelial layer and in the connective tissue below the epithelium of the lar...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Hisa Y,Sato F,Fukui K,Ibata Y,Mizukoshi O

    更新日期:1985-07-01 00:00:00

  • Effect of acute endolymphatic hydrops overload on the endolymphatic sac.

    abstract:CONCLUSIONS:Homeostasis of endolymph volume is a complex mechanism, in which the endolymphatic sac (ES) may play an important role. OBJECTIVES:To elucidate the effect of acute endolymphatic hydrops (EH) on the ES and to gain further information about the volume and pressure regulative function of the ES. MATERIALS AN...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Akagi N,Takumida M,Anniko M

    更新日期:2008-03-01 00:00:00

  • Protective effects of sodium thiosulfate for cisplatin-mediated ototoxicity in patients with head and neck cancer.

    abstract:CONCLUSIONS:Intra-arterial high-dose cisplatin chemoradiation (CRT-IA) with sodium thiosulfate (STS) causes relatively less severe cisplatin ototoxicity than intravenous cisplatin chemoradiation without STS (CRT-IV). The results of this study also suggest that early detection of ototoxicity is possible by testing the h...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Ishikawa E,Sugimoto H,Hatano M,Nakanishi Y,Tsuji A,Endo K,Kondo S,Wakisaka N,Murono S,Ito M,Yoshizaki T

    更新日期:2015-09-01 00:00:00

  • Meniere's disease and middle ear pressure: vestibular function after transtympanic tube placement.

    abstract:CONCLUSION:Selected patients with Meniere's disease (MD) show an improvement of disability from vertigo after transtympanic ventilation tube insertion, although an effect on vestibular function is not seen if ipsilateral middle ear pressure lower than -50 daPa is used as a selection criterion. OBJECTIVES:Transtympanic...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Park JJ,Chen YS,Westhofen M

    更新日期:2009-12-01 00:00:00

  • Tinnitus and bilateral sensorineural hearing loss: ankylosing spondylitis or a side-effect of sulphasalazine treatment?

    abstract::We report the case of a young male patient with ankylosing spondylitis treated with sulphasalazine who developed bilateral sensorineural hearing loss with tinnitus. Discontinuation of sulphasalazine led to complete resolution of tinnitus and an improvement in hearing loss. We discuss the features of this case and also...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审


    authors: Savastano M,Marioni G,Bernini G,Punzi L

    更新日期:2005-06-01 00:00:00

  • On the Limited Transfer of Information with Noise-induced Hearing Loss.

    abstract::Assessment of hearing handicap is frequently based on hearing loss in the frequency region from 0.5 to 2.0 kHz. The region above 2 kHz, however, is important for hearing, particularly when one considers speech perception in conditions with ambient noise. The present study, based on 200 individuals (400 ears) with nois...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Smoorenburg GF

    更新日期:1990-01-01 00:00:00

  • Amplification of int-2 and bcl-1 genes in squamous cell carcinoma of the larynx.

    abstract::We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases, the int-2 gene was amplified (42.9%) and in 4 cases. the bcl-1 gene was amplified (25.0%). Co-amplification of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other am...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Miyahara H,Naito H,Ueda K,Yane K,Matsunaga T,Okaichi K,Ohnishi T

    更新日期:1998-09-01 00:00:00