Supracricoid laryngectomies: long-term oncological and functional results.


CONCLUSIONS:Our results confirm that supracricoid laryngectomies (SL) are reliable techniques for glottosupraglottic tumors, even for selected T3 and T4 cases, if the indications are correct. These surgical techniques allow a good quality of life with the preservation of the larynx. OBJECTIVE:SL with cricohyoidoepiglottopexy (CHEP) and cricohyoidopexy (CHP) have been popular over the last 20 years for the treatment of the glottic and/or supraglottic squamous cell carcinoma due to demonstrated good oncological and functional results. We report our experience with these techniques, with special focus on long-term oncological and functional results. PATIENTS AND METHODS:We retrospectively reviewed 206 patients who had undergone SL with CHEP or CHP technique between 1987 and 1998 for glottosupraglottic squamous cell carcinoma in our department. The long-term results for 206 patients with T1-T4 laryngeal carcinomas treated with SL are reported: 90.8% CHEP and 9.2% CHP. The mean follow-up was 62 months. RESULTS:Oncological results: the 5-year actuarial disease-free survival was 85%; the 5-year determinate actuarial survival was 88.3%. Functional results: organ preservation rate was 97%. Phonation was assessed according to the GRBAS scale.


Acta Otolaryngol


Acta oto-laryngologica


Laudadio P,Presutti L,Dall'olio D,Cunsolo E,Consalici R,Amorosa L,Cancellieri A,Bocciolini C




Has Abstract


2006-06-01 00:00:00














  • Effects of age, sex and stimulus parameters upon vestibulo-ocular responses to sinusoidal rotation.

    abstract::We evaluated the vestibulo-ocular reflex (VOR) in 50 normal human subjects, uniformly distributed in age 20-59 years, and evenly distributed in sex by decade, using sinusoidal rotation over the frequency range of 0.005 to 1.0 Hz and three peak amplitudes of 25, 50, and 100 deg/sec. Age variations. The gain magnitude o...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Wall C 3rd,Black FO,Hunt AE

    更新日期:1984-09-01 00:00:00

  • Clinical and laboratory findings in patients with acute tonsillitis.

    abstract::In 82 patients with acute tonsillitis studied, beta-hemolytic group A streptococci were isolated from 30 (37%), and group C or G streptococci from 12 (15%). In the 40 patients with non-streptococcal tonsillitis there was a significantly higher isolation rate of pneumococci, H. influenzae and/or B. catarrhalis, as comp...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Stjernquist-Desatnik A,Prellner K,Christensen P

    更新日期:1987-09-01 00:00:00

  • The nasopharyngeal microflora of otitis-prone children, with emphasis on H. influenzae.

    abstract::The nasopharyngeal microflora was monitored during a prospective study of 52 otitis-prone children and 33 age-matched controls up to the age of 30 months. The relation between nasopharyngeal culture results and corresponding otoscopic findings was investigated. In contrast to pneumococci, the rate of H. influenzae iso...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Freijd A,Bygdeman S,Rynnel-Dagöö B

    更新日期:1984-01-01 00:00:00

  • Quantification of hearing loss in patients with posterior semicircular canal dehiscence.

    abstract:CONCLUSION:Patients with posterior semicircular canal dehiscence (PSCD) have low frequency conductive hearing loss similar to patients with superior semicircular canal dehiscence (SSCD) secondary to a pathologic third window. OBJECTIVES:PSCD can result in conductive hearing loss, but the magnitude of this hearing loss...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审


    authors: Bear ZW,McEvoy TP,Mikulec AA

    更新日期:2015-01-01 00:00:00

  • Evoked potentials from the auditory nerve following sinusoidal electrical stimulation of the cochlea: new possibilities for preoperative testing in cochlear-implant candidates?

    abstract::To predict the possible benefit of a cochlear implant to a patient, the clinician requires a reliable objective method to monitor the presence of surviving fibres in the 8th nerve. The subjective promontory test and the evaluation of electrically evoked brainstem potentials are not adequate. An electrical stimulus art...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Hartmann R,Pfennigdorff T,Klinke R

    更新日期:1994-09-01 00:00:00

  • Cognitive tinnitus sensitization: behavioral and neurophysiological aspects of tinnitus centralization.

    abstract:OBJECTIVE:Acquired centralized tinnitus (ACT) is the most frequent type of chronic tinnitus. We introduce a cognitive neurophysiological ACT hypothesis based on centralized cognitive sensitization processes. MATERIAL AND METHODS:Published cognitive sensitization processes were reviewed using PubMed. Furthermore, a Coc...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Zenner HP,Zalaman IM

    更新日期:2004-05-01 00:00:00

  • Residual dizziness after successful treatment of idiopathic benign paroxysmal positional vertigo originates from persistent utricular dysfunction.

    abstract:OBJECTIVE:We used ocular vestibular evoked myogenic potentials to investigate the relationship between residual dizziness and utricular function following the canalith repositioning procedure for benign paroxysmal positional vertigo. METHODS:Ocular vestibular evoked myogenic potentials were measured in 44 patients (40...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Seo T,Shiraishi K,Kobayashi T,Mutsukazu K,Fujita T,Saito K,Watanabe H,Doi K

    更新日期:2017-11-01 00:00:00

  • Vestibular malformation in mice lacking Na-K-2Cl cotransporter 1 and expression of Na-K-2Cl cotransporter 1 in human vestibular end organs.

    abstract:CONCLUSION:The Na-K-2Cl cotransporter-1 (NKCCl) may be essential for the maintenance and functioning of the vestibular morphology in mice and it is strongly expressed in human vestibular end organs. OBJECTIVE:NKCCl is a member of the cation-coupled chloride transporter which participates in salt transport and cell vol...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Young Choi J,Ho Jung S,Namkung W,Lee JH,Jin Son E,Wook Shin J,Park HY,Sang Lee W,Kim HN

    更新日期:2005-12-01 00:00:00

  • Abducent nerve paralysis: first clinical sign of clivus metastasis from tonsillar carcinoma.

    abstract::It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone. Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature. We describe the rare occurrence of clival metastasis from tonsillar ca...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Marchese-Ragona R,Maria Ferraro S,Marioni G,Staffieri C,Manara R,Restivo DA,Staffieri A

    更新日期:2008-06-01 00:00:00

  • Protease-dependent activation of nasal polyp epithelial cells by airborne fungi leads to migration of eosinophils and neutrophils.

    abstract:CONCLUSIONS:Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines in vitro. These cytokines induced the migration of eosinophils and neutrophils. Protease-activated receptors (PARs) might also play a role in the process of epithelial cell activation. OBJECTIVE:The...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Shin SH,Lee YH,Jeon CH

    更新日期:2006-12-01 00:00:00

  • Characterization of AMC-HN-9, a cell line established from an undifferentiated carcinoma of the parotid gland: expression of alpha6beta4 with the absence of BP180 and 230.

    abstract::We recently reported the development of a cell line, AMC-HN-9, established from an undifferentiated carcinoma (UDC) of the parotid gland. AMC-HN-9 consists mostly of spindle-shaped cells, has poor in vitro adhesiveness and an in vitro appearance that is different from that of other epithelial cell lines. To test the h...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Kim SH,Carey TE,Liebert M,Yoo SJ,Kwon HJ,Kim SY

    更新日期:2000-08-01 00:00:00

  • Investigation of the ototoxicity of gadoteridol (ProHance) and gadodiamide (Omniscan) in mice.

    abstract:CONCLUSION:In the mouse, when a tympanic perforation is present, gadoteridol does not seem to cause ototoxicity. Gadodiamide may cause mild ototoxicity other than toxicity to the outer hair cells of the cochlea. OBJECTIVES:Endolymphatic hydrops have been visualized through intra-tympanic injection of gadolinium-based ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Nonoyama H,Tanigawa T,Shibata R,Tanaka H,Katahira N,Horibe Y,Takemura K,Murotani K,Ozeki N,Ueda H

    更新日期:2016-11-01 00:00:00

  • Antibodies against Streptococcus pneumoniae, Haemophilus influenzae and Branhamella catarrhalis in middle ear effusion during early phase of acute otitis media.

    abstract::Serum type (IgG, IgM and IgA-class) and secretory type antibodies specific to Streptococcus pneumoniae (Pn), Haemophilus influenzae (Hi) and Branhamella catarrhalis (Br) were measured by enzyme-linked immunosorbent assay (ELISA) in 46 serum and 114 middle ear effusion (MEE) samples from 85 children with acute otitis m...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Karjalainen H,Koskela M,Luotonen J,Herva E,Sipilä P

    更新日期:1990-01-01 00:00:00

  • The effect of vasopressin upon the cochlear potentials in the guinea pig.

    abstract::The change in the EP, CM, SP and AP during perilymphatic perfusion of vasopressin (antidiuretic hormone) was examined in the guinea pig. The EP was recorded with a microelectrode through the spiral ligament of the second turn. The CM, SP and AP were measured with the differential electrodes in the basal turn. The perf...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Mori N,Ohta K,Matsunaga T

    更新日期:1986-03-01 00:00:00

  • Auditory brainstem evoked responses in the clinical evaluation and follow-up of insulin-dependent diabetic subjects.

    abstract::In the last few years the use of ABR in the dysmetabolic encephalopathies has aroused considerable interest. Even though brainstem involvement in these syndromes is not yet entirely understood, ABR techniques have provided new and important insights. We studied 60 insulin-dependent diabetic subjects, 29 females and 31...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Martini A,Comacchio F,Fedele D,Crepaldi G,Sala O

    更新日期:1987-05-01 00:00:00

  • Strial circulation impairment due to acoustic trauma.

    abstract::Blood circulation in the cochlear lateral wall after exposure to a non-physiological level of sound (120-125 dB SPL, 3 h) was investigated immunohistologically. Kanamycin (KM), which was expected to function as a tracer of blood flow, was administered to guinea pigs 5 min to 21 h after sound termination. At 5-30 min, ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Yamane H,Nakai Y,Konishi K,Sakamoto H,Matsuda Y,Iguchi H

    更新日期:1991-01-01 00:00:00

  • Blood-perilymph barrier and ototoxicity: an in vivo study in the rat.

    abstract::Cisplatin and gentamicin are two ototoxicants that are supposed to be transported by the paracellar route, i.e. via cellular junctions, to the perilymphatic compartment. This study was initiated to test the hypothesis that susceptive variation of individuals to ototoxic drugs may be explained by variability in transpo...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Laurell G,Viberg A,Teixeira M,Sterkers O,Ferrary E

    更新日期:2000-10-01 00:00:00

  • Experimental cholesteatoma. Epidermal ingrowth through tympanic membrane following middle ear application of propylene glycol.

    abstract::This study was designed to investigate morphological changes in the tympanic membrane (TM) associated with cholesteatoma formation in experimental animals following application of propylene glycol to the middle ear. A 50% solution of propylene glycol was applied bilaterally to the middle ear cavities of 30 young-adult...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Masaki M,Wright CG,Lee DH,Meyerhoff WL

    更新日期:1989-07-01 00:00:00

  • Epiglottitis and necrotizing fasciitis: a life-threatening complication of infectious mononucleosis.

    abstract::Life-threatening cervical complications associated with infectious mononucleosis are rare. The combination of acute epiglottitis and subsequent necrotizing fasciitis of the head and neck in a patient with infectious mononucleosis has not been reported to date.A 47-year-old female with infectious mononucleosis and epig...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Caballero M,Sabater F,Traserra J,Alòs L,Bernal-Sprekelsen M

    更新日期:2005-10-01 00:00:00

  • A contribution to the structural pattern differences between the apical and basal spiral ganglions in mammals.

    abstract::The purpose of this paper was to establish a mammalian comparative study between the neuronal spaces of the upper versus the basal cochlear turns. We studied with light microscopy i) Webster albino rat embryos at various gestational days (GD), and a postnatal (PN) series; ii) kittens 3 weeks old; iii) pigmented guinea...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Sánchez-Fernández JM,Sánchez-del Rey A,Santaolalla-Montoya F,Martinez Ibarguen A

    更新日期:1997-03-01 00:00:00

  • Plaster of Paris: thermal properties and biocompatibility. A study on an alternative implant material for ear surgery.

    abstract::There is no single technique for reconstruction of the canal wall following radical mastoidectomy. Autograft tissues may be unsuitable because of resorption and limited availability. An ideal foreign implant material should be bone-like in quality, non-ototoxic, readily available and malleable. Plaster of Paris, a deg...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Högset O,Bredberg G

    更新日期:1986-05-01 00:00:00

  • Expression of transient receptor potential channel melastin (TRPM) 1-8 and TRPA1 (ankyrin) in mouse inner ear.

    abstract:CONCLUSIONS:It has been shown that TRPMs may play a functional role in sensory cell physiology, fluid homeostasis, sensory cell death, and thermosensation in the inner ear, while TRPA1 plays an important role in sensory transduction. OBJECTIVE:To study expression of TRPM1-8 and TRPA1 in the mouse inner ear. MATERIALS...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Takumida M,Ishibashi T,Hamamoto T,Hirakawa K,Anniko M

    更新日期:2009-10-01 00:00:00

  • Comparison of hearing thresholds obtained using pure-tone behavioral audiometry, the Cantonese Hearing in Noise Test (CHINT) and cortical evoked response audiometry.

    abstract:CONCLUSION:Speech thresholds measured using Cantonese Hearing in Noise Test (CHINT) and cortical evoked response audiometry (CERA) thresholds were highly correlated with pure-tone behavioral results. Both tests are considered to provide good estimates of hearing thresholds and can be employed to confirm the degree of h...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Wong LL,Cheung C,Wong EC

    更新日期:2008-06-01 00:00:00

  • Prospective multi-center study on expansion sphincter pharyngoplasty.

    abstract:BACKGROUND AND OBJECTIVE:The aim of this study was to demonstrate the long-term effectiveness of Expansion Sphincter Pharyngoplasty (ESP) as a standalone surgical treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients through a prospective multi-center study. MATERIAL AND METHODS:A prospective non-com...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,多中心研究


    authors: Plaza G,Baptista P,O'Connor-Reina C,Bosco G,Pérez-Martín N,Pang KP

    更新日期:2019-02-01 00:00:00

  • Conductive deafness with normal eardrum: absence of the long process of the incus.

    abstract:CONCLUSIONS:The most likely cause of lesions with an absence of the long process of the incus was congenital origin because many cases were associated with the stapedial anomaly. However, the possibility of a potential inflammation of this lesion could not be completely excluded, especially in cases with only an absenc...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Park K,Choung YH,Shin YR,Hong SP

    更新日期:2007-08-01 00:00:00

  • Assessment of diagnostic approaches to idiopathic sudden sensorineural hearing loss and their influence on treatment and outcome.

    abstract:CONCLUSION:Results from a database for sudden sensorineural hearing loss (SSNHL) demonstrate no correlation between laboratory findings, treatment, and outcome in 400 patients. The patients with pathological test results were not treated differently from those with normal test results. The value of laboratory findings ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Nosrati-Zarenoe R,Hansson M,Hultcrantz E

    更新日期:2010-03-01 00:00:00

  • Basilar papilla explants: a model to study hair cell regeneration-repair and protection.

    abstract::Explants of basilar papillae from 6-7 days posthatch chicks were cultured in growth medium for a period of 1-8 days. Hair cells were counted following staining of stereocilia bundles with FITC-phalloidin, and the percentage of hair cell survival was determined by comparison to control (i.e. uncultured) specimens. Hair...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Frenz DA,Yoo H,Liu W

    更新日期:1998-09-01 00:00:00

  • Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats.

    abstract:CONCLUSION:Systemic application of human mesenchymal stem cells (hMSCs) may be another effective tool for stem cell supply to the inner ear. OBJECTIVES:Most researchers have used local application to provide the inner ear with stem cells. In spite of their efficacy, these methods can potentially cause irreversible dam...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Choi BY,Song JJ,Chang SO,Kim SU,Oh SH

    更新日期:2012-06-01 00:00:00

  • Changes in ribbon synapses and rough endoplasmic reticulum of rat utricular macular hair cells in weightlessness.

    abstract::This study combined ultrastructural and statistical methods to learn the effects of weightlessness on rat utricular maculae. A principle aim was to determine whether weightlessness chiefly affects ribbon synapses of type II cells, since the cells communicate predominantly with branches of primary vestibular afferent e...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Ross MD

    更新日期:2000-06-01 00:00:00

  • Ultrastructural features of vocal fold nodules and polyps.

    abstract::Earlier investigation did not show any clear distinctive pathological features that differentiate vocal polyps from vocal nodules. The light microscopic distinctive features between the two lesions point in the direction of a more pronounced epithelial reaction and a more fibrous stromal change in vocal nodules. In th...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章


    authors: Kotby MN,Nassar AM,Seif EI,Helal EH,Saleh MM

    更新日期:1988-05-01 00:00:00