Abstract:
CONCLUSION:The circling mouse (cir/cir) has phenotypes which follow the pattern of neuroepithelial defects of deafness from 10 days after birth. The cir mouse is defective in Tmie gene, the function of which should be further elucidated. OBJECTIVES:We previously reported a recessive mutation of deafness called circling mice (cir/cir). The present study focused on investigating phenotypes and histological findings of the cochlea in circling mice with respect to age. MATERIALS AND METHODS:In order to analyze cochlear pathology over time, five different age groups of circling mice were examined (10, 18, 21, 35, and 90 days old). The organs of Corti and spiral ganglion neurons in basal and middle turns were evaluated. RESULTS:The pathology of the organ of Corti followed the pattern of neuroepithelial defects. Hair cells in organs of Corti had degenerated in circling mice at 10 days old, in a time-dependent manner. Scanning electron microscopy (SEM) showed that stereociliary bundles were irregular in size and had shortened at 10 days, and that this degeneration was complete at 21 days. The number of spiral ganglion neurons significantly reduced with age. RT-PCR analysis indicated that the transmembrane inner ear gene (Tmie) was absent in various organs in circling mice.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Chung WH,Kim KR,Cho YS,Cho DY,Woo JH,Ryoo ZY,Cho KI,Hong SHdoi
10.1080/00016480600827071subject
Has Abstractpub_date
2007-03-01 00:00:00pages
244-51issue
3eissn
0001-6489issn
1651-2251pii
771163654journal_volume
127pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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