A comparison between nitric oxide output in the nose and sinuses: A pilot study in one volunteer.

Abstract:

:From a study of nitric oxide (NO) output in the nose and sinuses it seems that: (i) the results obtained regarding the regulation of NO output in the nose do not necessarily apply to the sinuses; (ii) the results obtained for one group of sinuses may not apply to another; and (iii) NO output in the sinuses does not behave as one would expect if it serves to protect against infection.A pilot study was undertaken in one subject to determine whether the control of NO output in the nose differs from that in the sinuses.NO output was measured by aspirating different gaseous concentrations of oxygen (and/or carbon dioxide) through the nasal airways or punctured maxillary and frontal sinuses before and after i.v. administration of L-arginine (20 mg/kg). In the absence of gaseous oxygen in the nose or maxillary antrum, the effect of L-arginine on NO output was the same as that in the presence of oxygen. In the frontal sinus, the effect of L-arginine on NO output was blocked by the absence of gaseous oxygen. NO output in the nose and frontal sinus showed similar changes after either i.v. administration of L-arginine or removal of oxygen from the air. NO output in the maxillary antrum was virtually unaffected by either procedure. NO output in the nose was largely unaffected by the gaseous carbon dioxide content but that in the frontal and maxillary sinuses was profoundly inhibited by it. In both sinuses, suppression of NO output by carbon dioxide was countered by oxygen. Alterations in the oxygen or carbon dioxide content of the maxillary antrum did not alter NO output in the frontal sinus, or vice versa. After i.v. infusion of L-arginine, nasal NO output remained elevated for >1 h.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Qian W,Mäkitie AA,Witterick I,Haight JS

doi

10.1080/00016480510031524

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

1080-5

issue

10

eissn

0001-6489

issn

1651-2251

pii

RHDYQK1JW7PCVA1E

journal_volume

125

pub_type

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