Abstract:
:The objective of this study was to determine whether methylcobalamin inhibits the ototoxic action of gentamicin. Fourteen pigmented guinea pigs were randomly divided into experimental and control groups. Each animal in the experimental group was given a large single dose of gentamicin (125 mg/kg i.m.), followed by immediate administration of methylcobalamin (1 mg kg i.m.). In the control group, the animals received gentamicin only, at the same dose as the experimental group. The compound action potentials (CAPs) in the right ears of animals were measured using a signal processor before and 15, 30, 45, 60 and 75 min after injection of the drugs. The sound stimulus was presented by means of clicks and tone pips at 2, 4 and 8 kHz. Following the electro-physiological tests, the animal was sacrificed and prepared for scanning electron microscopic observation. There was prolongation of latency and diminution of amplitude of CAPs N1 and N2 15 min after injection of gentamicin. Although the N1-N2 intervals increased as the time after injection of gentamicin increased, the variations were still within normal ranges. In contrast, there was no prolongation of N1 latencies or N1-N2 intervals 30 min after injection in the experimental group. There were no marked changes in N1 or N2 amplitudes, compared with the results before injection, in the experimental group. The firing mechanism of the inner ear may be affected by a single dose of gentamicin. This suggests that the transient ototoxic action of gentamicin hardly affected the conductive function of the nerve fibres, even though the firing function of the inner ear was influenced. Methylcobalamin may inhibit the ototoxic side effects of gentamicin.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Jin X,Jin X,Sheng Xdoi
10.1080/000164801300102752subject
Has Abstractpub_date
2001-04-01 00:00:00pages
351-4issue
3eissn
0001-6489issn
1651-2251journal_volume
121pub_type
杂志文章abstract::Cell proliferation in the endolymphatic sac (ES) after immunostimulation was assessed immunohistochemically. Guinea pigs were employed as experimental animals and keyhole limpet hemocyanin was used as the antigen. After i.p. injection of 5-bromo-2'-deoxyuridine (BrdUrd), the BrdUrd+ cells were counted to assess the nu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139336
更新日期:1995-05-01 00:00:00
abstract:CONCLUSION:MCT is a useful tool to pre-operatively determine whether internal nasal valve (INV) narrowing affects a nasal obstruction. Functional rhinoplasty seemed to produce better results than septoplasty in Asian patients with a nasal obstruction, due to INV narrowing. OBJECTIVE:This study compared pre-operative m...
journal_title:Acta oto-laryngologica
pub_type: 评论,杂志文章
doi:10.3109/00016489.2015.1108523
更新日期:2016-01-01 00:00:00
abstract:CONCLUSION:The results support that chronic electromagnetic field exposure may cause damage by leading to neuronal degeneration of the auditory system. OBJECTIVES:Numerous researches have been done about the risks of exposure to the electromagnetic fields that occur during the use of these devices, especially the effe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1032434
更新日期:2015-08-01 00:00:00
abstract::The object of this study was to assess the contributions of various cranial nerve nuclei to the short latency vestibular evoked potentials (VsEPs) in cat. The following nuclei were investigated: vestibular nuclei, and 3rd, 6th and 10th cranial nerve nuclei. In unilateral labyrinthectomized cats, suboccipital craniecto...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139277
更新日期:1995-03-01 00:00:00
abstract::Several reports indicate that disturbances of the vestibulo-oculomotor ability are a manifestation of the toxic action on the central nervous system exerted by some industrial solvents. The aim of the present investigation was to examine the vestibulo-oculomotor system during exposure to styrene, which is extensively ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128939
更新日期:1982-11-01 00:00:00
abstract:CONCLUSION:Compared with normal-weight individuals, obese young adults exhibited a significantly higher taste threshold for salty taste. Smoking also affected taste functions in this population. OBJECTIVE:The aim of this study was to investigate the differences in taste detection thresholds between normal-weight and o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.975370
更新日期:2015-05-01 00:00:00
abstract:CONCLUSION:Vibrant Soundbridge (VSB) application to the middle ear windows yields better functional outcomes than conventional hearing aids. However, speech discrimination scores obtained with VSB and conventional hearing aids are similar. OBJECTIVE:To assess audiological outcomes of round and oval window applications...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.702353
更新日期:2012-12-01 00:00:00
abstract::In precollicular decerebrate cats, activation of limb extensors during side-down roll tilt of the animal depends on both an increased discharge of excitatory vestibulospinal neurons and a reduced discharge of inhibitory medullary reticulospinal (mRS) neurons. These inhibitory neurons are tonically excited by a choline...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract:CONCLUSION:Our results indicate that siRNA E6 and/or E7 may have potential as a gene-specific therapy for human papillomavirus (HPV) type 16 (HPV16)-related squamous cell carcinoma of the head and neck (HNSCC). OBJECTIVES:To evaluate the effectiveness of siRNA targeting E6 and/or E7 on the in vitro and in vivo growth ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.773405
更新日期:2013-07-01 00:00:00
abstract::Thorotrast(R) containing thorium dioxide particles with diameters of around 100 Å was introduced in perilymph or endolymph using various methods and concentrations. The location of the tracer particles in the cochleas was determined using the transmission electron microscope. Injection of tracer into the cerebrospinal...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/16512251.1974.11675750
更新日期:1974-01-01 00:00:00
abstract::Changes in ambient pressure can elicit the vertigo and bodily disequilibrium known clinically as alternobaric vertigo. Our previous studies showed that changes in middle ear pressure altered the activity of the primary vestibular neuron, and the finding suggests that the pressure-induced vestibular response causes alt...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850183232
更新日期:1998-09-01 00:00:00
abstract:CONCLUSION:The developed software (HITCal) may be a useful tool in the analysis and measurement of the saccadic video head impulse test (vHIT) responses and with the experience obtained during its use the authors suggest that HITCal is an excellent method for enhanced exploration of vHIT outputs. OBJECTIVE:To develop ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1035401
更新日期:2015-09-01 00:00:00
abstract:CONCLUSIONS:Protocol limitations were identified and accounted for in the analysis. Percent gradient equilibrated (PGE) was affected by driving gradient direction in a similar manner to other efficiency measures. A finer resolution of possible age-related changes in eustachian tube opening efficiency is expected with t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.882017
更新日期:2014-06-01 00:00:00
abstract::The purpose of this study was to show the early stages of polyp formation, as part of our studies on the pathogenesis of nasal polyps. Two and 4 weeks after experimental tubal occlusion in 18 Wistar rats, 13 showed signs of bacterial infection, respective acute otitis media. In the majority of these rats polypouslike ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489109138432
更新日期:1991-01-01 00:00:00
abstract::This study aimed to investigate whether unilateral vestibular neuritis (VN) causes the same deficits of ocular counter-roll during static head roll (OCR(S)) and dynamic vestibulo-ocular reflex gains during head impulses (VOR(HI)) as unilateral vestibular deafferentation (VD). Ten patients with acute and 14 patients wi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950180379
更新日期:1999-01-01 00:00:00
abstract::Background: Neutrophil-to-lymphocyte ratio (NLR) has emerged as a marker for degree of inflammation. Inflammation has been regarded as one of the causes of idiopathic sudden sensorineural hearing loss.Objectives: This study investigated the potential association between neutrophil-to-lymphocyte ratio (NLR) and prognos...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1705998
更新日期:2020-04-01 00:00:00
abstract::This work describes the different patterns of expression of integrins and extracellular matrix proteins in normal and transformed mucosa in laryngeal and oropharyngeal carcinomas. Samples from each tumor group were sectioned and examined by immunohistochemistry using monoclonal antibodies raised against integrin chain...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480252814298
更新日期:2002-03-01 00:00:00
abstract::Human papillomavirus (HPV) has a well-established association with benign and malignant cervical tumours as well as with laryngeal papillomas, while its association with laryngeal carcinomas is still controversial. We have examined 39 squamous cell carcinomas of the larynx for HPV using PCR with three consensus primer...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137949
更新日期:1996-11-01 00:00:00
abstract::Luetic hydrops can occur in both congenital and acquired lues and otologic manifestations may be indistinguishable from Meniere's disease. Eight endolymphatic sac decompression procedures were performed on 6 patients with refractory luetic vertigo. Of those, 3 had congenital and 3 acquired lues. All cases had received...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009127172
更新日期:1980-05-01 00:00:00
abstract::[3H]Dihydrostreptomycin was given intramuscularly to young pigmented guinea pigs and rats. Whole-body autoradiography, combined with densitometric measurement of the blackening of the autoradiograms, and liquid scintillation counting were used to determine the levels of radioactivity in the inner ear in relation to bl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609132834
更新日期:1986-03-01 00:00:00
abstract:CONCLUSION:An 18-mer peptide derived from the neurotrophic region of prosaposin (PS-pep) prevents hearing loss and cochlear damage due to transient cochlear ischaemia by activating an anti-apoptotic pathway. PS-pep is a potent candidate molecule for alleviating ischaemia-induced hearing loss. OBJECTIVE:PS-pep was inve...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.750430
更新日期:2013-05-01 00:00:00
abstract::Efforts to evaluate findings in the nystagmogram were made in a material of 338 vertiginous and dizzy patients. A spontaneous nystagmus, a positional nystagmus as well as a difference in caloric reactivity are as solitary findings of lettle value for revealing peripheral disorders. On the other hand, central disturban...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809124728
更新日期:1978-07-01 00:00:00
abstract:CONCLUSIONS:We describe a Japanese family with high-frequency sensorineural hearing loss (SNHL) harboring a c.211delC mutation in the KCNQ4 gene. Families showing progressive high-frequency SNHL should be investigated for mutations in the KCNQ4 gene. OBJECTIVE:To determine the responsible deafness gene in a Japanese f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.890740
更新日期:2014-06-01 00:00:00
abstract::The efflux of Na-24 was investigated in isolated labyrinths from a membrane section containing stria vascularis and spiral ligament in artificial endolymph medium. The efflux curves were calculated and compartmental analyses were made. The theoretical possibility of a exchange of sodium between compartments connected ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121308
更新日期:1975-07-01 00:00:00
abstract:CONCLUSION:Vasomotor symptoms (VMS) and especially hot flushes are negatively associated with recovery from menopause-related dizziness. A further study is justified to determine whether hormone replacement therapy (HRT) can shorten this recovery time. OBJECTIVES:This study aimed to compare the rate of recovery from d...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2013.841991
更新日期:2014-02-01 00:00:00
abstract::The properties of the vestibulo-ocular reflex (VOR) were examined during sinusoidal passive head rotation in the dark at 1/6 Hz, in 9 normal subjects and 14 unilateral vestibular patients. Rotation speeds ranged from 90 to 180 degrees/s. The bias (offset of slow-phase velocity from zero) and gain in the VOR were estim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139351
更新日期:1995-07-01 00:00:00
abstract::We investigated the effect of prolonged hypergravity on the otoconial layer of the maculae utriculi and the maculae sacculi in hamsters. The animals were placed in a centrifuge under conditions of 2.5 G, and remained there for 6 months. We then determined the calcium contents of the otoconia with energy dispersive X-r...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489509139297
更新日期:1995-03-01 00:00:00
abstract::Four groups of guinea pigs received different doses of cis-platinum. SEM and TEM showed a direct relation between the dose and the damage. The first row of OHC is the first one to be damaged. The IHC are more resistant than the OHC. The pattern of destruction is similar to the one produced by the aminoglucoside antibi...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488509108921
更新日期:1985-03-01 00:00:00
abstract:CONCLUSION:After conventional curette adenoidectomy, a significant mass of residual adenoid tissue is observed in about 50% of the cases. The combined approach of conventional curette and endoscopic adenoidectomy with microdebrider assures a complete and accurate removal of the mass. It is an effective and safe method ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802294377
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Temperature-controlled radiofrequency volumetric tissue reduction (RFVTR) is a minimally invasive technique used in the treatment of the tongue base, soft palate and turbinates. Complications seem to be rare, but the scope of previous studies was often limited by the small number of patients included. The aim...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310001385
更新日期:2003-05-01 00:00:00