Abstract:
CONCLUSION:An 18-mer peptide derived from the neurotrophic region of prosaposin (PS-pep) prevents hearing loss and cochlear damage due to transient cochlear ischaemia by activating an anti-apoptotic pathway. PS-pep is a potent candidate molecule for alleviating ischaemia-induced hearing loss. OBJECTIVE:PS-pep was investigated for its protective effects against ischaemia-induced hearing loss and cochlear damage. METHODS:Ischaemia was induced in both cochleae in Mongolian gerbils by pulling the ligatures around both vertebral arteries in an anterior direction using 5 g weights for 15 min. PS-pep was synthesized artificially and administered subcutaneously four times after the induction of transient cochlear ischaemia. RESULTS:An increase in the auditory brainstem response threshold was alleviated in animals treated with 2.0 mg/kg PS-pep. Histological examinations conducted on day 7 showed that the loss of inner hair cells (IHCs) was more prominent than that of outer hair cells. Higher doses of PS-pep significantly alleviated IHC loss. An increase in the anti-apoptotic factor bcl-2 was also noted in the IHCs treated with PS-pep.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Terashita T,Saito S,Nabeka H,Hato N,Wakisaka H,Shimokawa T,Kobayashi N,Gyo K,Matsuda Sdoi
10.3109/00016489.2012.750430subject
Has Abstractpub_date
2013-05-01 00:00:00pages
462-8issue
5eissn
0001-6489issn
1651-2251journal_volume
133pub_type
杂志文章abstract:CONCLUSION:Concomitant antiemetic therapy comprising fosaprepitant, palonosetron, and dexamethasone is effective for head and neck carcinoma. OBJECTIVE:A patient diary was constructed to determine the effectiveness of concomitant antiemetic therapy with a neurokinin-1 receptor antagonist (fosaprepitant), 5-hydroxytryp...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.3109/00016489.2014.913314
更新日期:2014-11-01 00:00:00
abstract:CONCLUSION:The endoscopic approaches developed for the treatment of the chordomas according to the different clival location provide the possibility for more complete tumor resection with maximal preservation of anatomic structures and reduction of the overall incidence of complications. OBJECTIVE:The endoscope has re...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480801995404
更新日期:2009-01-01 00:00:00
abstract::Background: Frequency-specific hearing studies are important for predicting hearing results and the prognosis after stapes surgery, to prepare for the rehabilitation of frequency-specific hearing in patients with otosclerosis.Objectives: To evaluate outcomes of stapes surgery of Chinese otosclerosis patients with diff...
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pub_type: 杂志文章
doi:10.1080/00016489.2020.1724331
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Differential diagnosis of persistent vertigo/dizziness in patients with a past history of vestibular neuritis (VN) and sudden deafness with vertigo (SDV) could sometimes be difficult for physicians due to variable vertiginous symptoms from rotatory to floating sensation. OBJECTIVES:The main purpose of the p...
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pub_type: 杂志文章
doi:10.1080/00016489.2020.1813327
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abstract:CONCLUSION:The prognosis of the clinically positive neck in temporal bone squamous cell carcinoma is bad and failures never occur in the neck but at the site of the primary. A clinically positive neck at presentation is a sign of aggressiveness of the primary and, in such cases, therapeutic neck dissection is to be per...
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更新日期:2010-08-01 00:00:00
abstract::The author presents a study of the personality structure, youth development and the role of interhuman conflicts in the work situation and the family, in the causation and course of Menière's disease, the somatopsychic reactions of the patients to the illness, and the principles of a form of psychotherapy which was co...
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pub_type: 杂志文章
doi:10.3109/00016488309139423
更新日期:1983-05-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/00016489.2011.552920
更新日期:2011-07-01 00:00:00
abstract::Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possib...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
abstract:CONCLUSION:Moxifloxacin was generally well tolerated and highly effective in the treatment of acute bacterial rhinosinusitis (ABS). The incidence of adverse events (AEs) and adverse drug reactions (ADRs) was low. The effectiveness, safety, and tolerability information collected in this study confirm the clinical safety...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2010-09-01 00:00:00
abstract:CONCLUSION:Idiopathic otolithic vertigo (IOV) with relatively long duration of attacks might be caused by endolymphatic hydrops in the otolith organ. OBJECTIVES:To clarify the pathophysiology underlying IOV, episodic tilting or translational sensation attacks by unknown causes, especially the possibility of endolympha...
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abstract::In rabbits the nasal vestibule was surgically occluded on one side. The rabbits were observed for varying periods, maximum 90 days. The mucosa of the septum was removed from both sides, stained by the PAS-alcian blue whole-mount method, and the goblet cells were counted. The difference in goblet-cell density between t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
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更新日期:1978-09-01 00:00:00
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doi:
更新日期:2001-07-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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更新日期:2006-05-01 00:00:00
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journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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更新日期:2020-11-05 00:00:00
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doi:10.3109/00016480903510742
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更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. METHODS:Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese mu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
abstract::The occurrence of symptoms from the upper airways in the furniture industry was studied by means of a questionnaire which was answered by 676 wood furniture workers from 50 different factories. Twenty per cent reported nasal hypersecretion and 40% nasal obstruction. A randomized sample of 61 workers was investigated f...
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doi:10.3109/00016488409107596
更新日期:1984-11-01 00:00:00
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doi:10.3109/00016489709113445
更新日期:1997-07-01 00:00:00
abstract::The results of myringoplasty on 172 ears examined after an average follow-up time of 1.5 years are reported. The fascial underlay technique with swing-door plasty was employed in 78% of the cases. The graft take was successful in 150 ears (87%), three of which (2%) later revealed adhesive changes in the middle ear. Th...
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更新日期:1982-05-01 00:00:00
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journal_title:Acta oto-laryngologica
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abstract:CONCLUSION:Cochlear implantation (CI) for Japanese single-sided deafness patients resulted in improved speech perception, increased sound localization accuracy, and reduced tinnitus handicap. OBJECTIVES:This study reports results for five adult SSD cases with CI, focusing on the benefits they obtained in terms of spee...
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pub_type: 杂志文章,多中心研究
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更新日期:2016-01-01 00:00:00
abstract::The spiral ganglion from white cats with hereditary deafness has been studied with the transmission electron microscope, and comparisons made with hearing animals at different ages. Ganglion cell loss occurs secondary to destruction of the organ of Corti, but only after the lapse of several months. Prior to neuronal l...
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更新日期:1980-11-01 00:00:00
abstract:CONCLUSION:This study shows that, in cochlear implantation (CI) surgery, pre-operative caloric test results are not correlated with post-operative outcomes of dizziness or speech perception. OBJECTIVES:To determine the role of pre-operative caloric tests in CI. METHODS:The records of 95 patients who underwent unilate...
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更新日期:2016-09-01 00:00:00
abstract::To elucidate the effects of CO2 in the middle ear upon the cochlea, measurements were made of the cochlear potentials (compound action potential and endocochlear potential) and of the pH of the inner ear fluids and the organ of Corti. Gas containing CO2 did not affect the AP threshold, except for a slight decrease in ...
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更新日期:1989-07-01 00:00:00