Abstract：
CONCLUSION:Ear, nose and throat (ENT) involvement is common in Churg-Strauss syndrome (CSS), usually manifesting as allergic rhinitis and chronic rhinosinusitis with or without polyps. Otolaryngologists may play a pivotal role in making an early diagnosis of this disease. OBJECTIVES:CSS is a systemic vasculitic disorder that affects small to medium-sized blood vessels. Although the cause of CSS remains unknown, tissue damage seems more likely to be mediated by activated eosinophils. Patients affected by CSS frequently have ENT manifestations, which are often present at the time of disease onset and may represent relevant clues for the diagnosis. Thus, our objective was to present the ENT manifestations at the onset, at the diagnosis and at some point during the course of the disease in a series of patients with CSS collected at a single center. MATERIALS AND METHODS:Twenty-eight patients with CSS, as defined according to the 1990 American College of Rheumatology classification criteria, were identified. Twenty-one (75%) of these patients had ENT involvement. We evaluated the clinical course, laboratory data, histologic findings, treatment and outcomes. RESULTS:Of the 21 patients, 13 (61.9%) had ENT involvement at asthma onset and 8 (38%) at diagnosis or during follow-up. The most common ENT manifestations were allergic rhinitis in 9 (42.8%) patients and nasal polyposis in 16 (76.1%). Three (14.2%) patients developed chronic rhinosinusitis without polyps, three (14.2%) had nasal crusting, one (4.7%) serous otitis media, one (4.7%) purulent otitis media, two (9.5%) progressive sensorineural hearing loss, and one (4.7%) unilateral facial palsy. Corticosteroid therapy associated with immunosuppressive drugs usually yielded improvement or stabilization.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Bacciu A,Bacciu S,Mercante G,Ingegnoli F,Grasselli C,Vaglio A,Pasanisi E,Vincenti V,Garini G,Ronda N,Ferri T,Corradi D,Buzio Cdoi
10.1080/00016480500437435subject
Has Abstractpub_date
2006-05-01 00:00:00pages
503-9issue
5eissn
0001-6489issn
1651-2251pii
M811P4X41368470Mjournal_volume
126pub_type
杂志文章abstract：:To elucidate the effects of CO2 in the middle ear upon the cochlea, measurements were made of the cochlear potentials (compound action potential and endocochlear potential) and of the pH of the inner ear fluids and the organ of Corti. Gas containing CO2 did not affect the AP threshold, except for a slight decrease in ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488909107397
更新日期：1989-07-01 00:00:00
abstract：:Detection of immune complexes (ICs) of IgG, IgM, or IgA isotypes in middle ear effusions (MEEs) by the solid-phase anti-C3 ELISA and cytologic analyses of MEEs were done in 245 patients with otitis media with effusion (OME). In 320 ears, the clinical classification was acute, 10.3%; subacute, 16.6%; chronic, 73.1%. In...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488709128278
更新日期：1987-11-01 00:00:00
abstract：:Rhinomanometric observations of nasal airway patency were obtained for each nasal passage every 10 min throughout an uninterrupted 8-h session. The 49 airflow observations for each nasal passage were subjected to autocorrelation analysis, a statistical technique for quantifying periodicities in a temporal sequence of ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488709109065
更新日期：1987-07-01 00:00:00
abstract：OBJECTIVE:In order to facilitate surgery for spasmodic dysphonia, i.e. type 2 thyroplasty, a device was designed to fix the incised edges of the thyroid cartilage firmly. MATERIAL AND METHODS:Various types and sizes of titanium bridge were developed for clinical use. RESULTS:The results of surgery for spasmodic dysph...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480410016261
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:To identify the difference of surgical margin and recurrence status of early stage tongue carcinoma via wide excision in a single institution with and without free flap reconstruction. OBJECTIVE:Survey whether the reconstruction methods for early tongue cancer affects disease control, survival outcomes. ME...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016489.2018.1490030
更新日期：2018-10-01 00:00:00
abstract：:We studied three-dimensional arrangement of collagen fibers and elastic fibers in the human vocal fold by scanning electron microscopy after digesting cellular elements and collagen fibers with formic acid treatment and cellular elements and elastic fibers with 10% sodium hydroxide. The superficial layer consisted of ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489609137924
更新日期：1996-09-01 00:00:00
abstract：:Although doxorubicin [adriamycin (ADM)] ototoxicity has not been detected to date, it has been reported that neurotoxicity in the central nervous system was induced by chemotherapy with ADM in patients receiving chronic cyclosporin A (CsA) treatment. ADM ototoxicity may be induced by combination therapy with CsA becau...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480152602212
更新日期：2001-10-01 00:00:00
abstract：CONCLUSION:The increased AQP5 expression associated with ageing in glands, which mainly secreted a serous solution, suggests a compensation for the decreased amount of saliva secretion associated with age progression. OBJECTIVE:To investigate the change in aquaporin-1 (AQP1) and aquaporin-5 (AQP5) expression in the sa...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489.2016.1165353
更新日期：2016-09-01 00:00:00
abstract：:Head and neck surgeons hesitate to resect the carotid artery because of the postoperative risk of neurologic sequelae. However, there is no curative therapeutic option for head and neck neoplasms involving the carotid artery, with the exception of complete tumor removal. To evaluate the benefits and risks of carotid r...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480260092417
更新日期：2002-07-01 00:00:00
abstract：:Test-retest variability of values for directional asymmetry in primary and secondary horizontal optokinetic after-nystagmus (OKAN I and OKAN II, respectively) was studied in 16 apparently healthy subjects. OKAN was induced by 60 s of whole-field optokinetic stimulation at speeds of 60 degrees/s and 90 degrees/s in eit...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489209100776
更新日期：1992-01-01 00:00:00
abstract：:Background: A set of Chinese Mandarin monosyllable test lists has been widely used in clinical diagnosis, while the performance of the Mandarin-speaking patients with auditory neuropathy (AN) in the monosyllable tests was still unknown.Objectives: To analyze the characteristics of monosyllable recognition in Mandarin-...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016489.2020.1726459
更新日期：2020-06-01 00:00:00
abstract：:In 6 pigs a bronchoscopical resection of the tracheal mucosa was performed using CO2-laser on one side, and an electric high-frequency cutting loop (ECL) on the other. The pigs were sacrificed 3 months later. On macroscopic examination the tracheal mucosa appeared almost normal on the laser-resected side, while severe...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488909127514
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:To develop a large animal model for studies of laryngeal abductor reinnervation. MATERIAL AND METHODS:Six minipigs underwent unilateral anastomosis of the phrenic nerve-abductor branch of the recurrent laryngeal nerve (RLN). Polyhydroxybutyrate (PHB) conduits were used for repair. At each of 30, 60 and 120 d...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480410022507
更新日期：2004-09-01 00:00:00
abstract：PURPOSE:To analyze the outcomes following re-irradiation for local recurrence of rare head and neck tumors. MATERIAL AND METHODS:We retrospectively analyzed 11 patients who had received intensity-modulated radiation therapy (IMRT) for recurrent tumors in the head and neck except for laryngopharynx. RESULTS:Primary tu...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016489.2018.1438662
更新日期：2018-08-01 00:00:00
abstract：:During the course of a chronic intracochlear electrical stimulation study using charge balanced biphasic current pulses, one animal inadvertently received a short period of direct current (DC) stimulation at a level of approximately 1 microA. Subsequent, the animal was chronically stimulated using a poorly charge bala...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489109138421
更新日期：1991-01-01 00:00:00
abstract：:The efflux of Na-24 was investigated in isolated labyrinths from a membrane section containing stria vascularis and spiral ligament in artificial endolymph medium. The efflux curves were calculated and compartmental analyses were made. The theoretical possibility of a exchange of sodium between compartments connected ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016487509121308
更新日期：1975-07-01 00:00:00
abstract：CONCLUSIONS:The present study revealed that miR-21 promotes the proliferation and invasion of cholesteatoma keratinocytes. These results provide a partial explanation for the more aggressive clinical behavior observed in cholesteatoma. OBJECTIVE:This study aims to investigate the post-transcriptional regulatory effect...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016489.2016.1202447
更新日期：2016-12-01 00:00:00
abstract：CONCLUSION:Selected patients with Meniere's disease (MD) show an improvement of disability from vertigo after transtympanic ventilation tube insertion, although an effect on vestibular function is not seen if ipsilateral middle ear pressure lower than -50 daPa is used as a selection criterion. OBJECTIVES:Transtympanic...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016480902791678
更新日期：2009-12-01 00:00:00
abstract：:Outer hair cells (OHCs) are the source of otoacoustic emissions, following a tropomyosin-miosin-dependent contraction, which are regulated by the olivocochlear bundle via the release of acetylcholine (ACh). ACh acts on ACh receptors (AChR) located on the OHC post-synaptic membrane. In myasthenia gravis (M.G.) neuromus...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/000164801300043127
更新日期：2001-01-01 00:00:00
abstract：:Lymphangioscopical and ultrastructural studies of the larynx reveal a lymphatic capillary and a collecting vessel system. Collecting vessels show luminal valves and elastic structural components within the wall. Lymphangioscopy reveals that a strict compartmentation of different laryngeal areas is unjustifiable with t...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488009127137
更新日期：1980-03-01 00:00:00
abstract：:In a previous paper we demonstrated physiologically a sensitive period for acoustic trauma in the rat pup cochlea, with a maximum at 22 days of age. Seven or 60 days after noise exposure these 22-day exposed rats were used for light and electron microscopy. At 7 days, surface preparation revealed restricted damage to ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016488009127143
更新日期：1980-03-01 00:00:00
abstract：CONCLUSIONS:The vestibular function can be assessed by ice-water caloric test, rotational chair test and VEMP recording in severely hearing impaired infants and young children, and 85% of these patients showed abnormal responses in these tests. OBJECTIVES:To evaluate the vestibular function of infants and young childr...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480601002039
更新日期：2007-07-01 00:00:00
abstract：:Myelin basic protein (MBP) in the cerebrospinal fluid (CSF) was quantified from 28 patients with acute facial palsy. The mean value of MBP in CSF in the study group was 3.4 +/- 0.22 micrograms/l (mean +/- SEM), which was significantly higher than the found in 37 healthy subjects (2.4 +/- 0.13 micrograms/l). Using a 95...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：CONCLUSION:The circling mouse (cir/cir) has phenotypes which follow the pattern of neuroepithelial defects of deafness from 10 days after birth. The cir mouse is defective in Tmie gene, the function of which should be further elucidated. OBJECTIVES:We previously reported a recessive mutation of deafness called circlin...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016480600827071
更新日期：2007-03-01 00:00:00
abstract：:Changes in ambient pressure can elicit the vertigo and bodily disequilibrium known clinically as alternobaric vertigo. Our previous studies showed that changes in middle ear pressure altered the activity of the primary vestibular neuron, and the finding suggests that the pressure-induced vestibular response causes alt...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.1080/00016489850183232
更新日期：1998-09-01 00:00:00
abstract：CONCLUSION:This study provides evidence that histamine induced MUC5AC mRNA expression through the activation of the core region of its promoter. It may also help in approaching new therapeutic strategies in airway mucins hypersecretory diseases. OBJECTIVE:Mucin hypersecretion characterizes several respiratory diseases...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489.2015.1017890
更新日期：2015-07-01 00:00:00
abstract：CONCLUSIONS:Intra-arterial high-dose cisplatin chemoradiation (CRT-IA) with sodium thiosulfate (STS) causes relatively less severe cisplatin ototoxicity than intravenous cisplatin chemoradiation without STS (CRT-IV). The results of this study also suggest that early detection of ototoxicity is possible by testing the h...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489.2015.1035797
更新日期：2015-09-01 00:00:00
abstract：CONCLUSION:Because nystagmus induced by ampullopetal inhibition of the posterior semicircular canal (PSCC) rotates around the axis perpendicular to the plane of the anterior semicircular canal (ASCC) of the other side, when free-floating debris is initially located at the distal portion of the PSCC, a patient showing p...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489.2012.763180
更新日期：2013-06-01 00:00:00
abstract：:A comparison was made between polysomnographic recordings and recordings of airflow pressures in the pharynx and respiratory pressures in the esophagus of 10 adult sleeping subjects with differing degrees of apnea. Pressure measurements were obtained by microsensors mounted on a 7F gauge flexible catheter which sited ...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489509139346
更新日期：1995-05-01 00:00:00
abstract：:An oral dose of 400 mg enoxacin was given to each of 19 patients with long-standing secretory otitis media (SOM). A total of 27 samples of middle ear effusion (MEE) and blood were collected at different intervals during a 6-h period after administration of the drug. The concentration of enoxacin in MEE and serum was d...
journal_title：Acta oto-laryngologica
pub_type： 杂志文章
doi：10.3109/00016489009125166
更新日期：1990-05-01 00:00:00
