Protective effects of sodium thiosulfate for cisplatin-mediated ototoxicity in patients with head and neck cancer.

Abstract:

CONCLUSIONS:Intra-arterial high-dose cisplatin chemoradiation (CRT-IA) with sodium thiosulfate (STS) causes relatively less severe cisplatin ototoxicity than intravenous cisplatin chemoradiation without STS (CRT-IV). The results of this study also suggest that early detection of ototoxicity is possible by testing the hearing loss at ultra-high frequencies. OBJECTIVES:To investigate protective effects of STS against cisplatin ototoxicity. METHODS:Between 2011 and 2013, 18 patients with head and neck carcinomas were treated with intra-arterial infusions of high-dose cisplatin (range 100-180 mg/body, mean 111 mg/body; range 2-5 courses, mean 3.6 courses) and systemic administration of cisplatin (range 66-185 mg/body, mean 130 mg/body; range 1-3 courses, mean 2.6 courses) and concurrent radiation therapy (range 60-70 Gy, mean 69 Gy). Cisplatin was neutralized by STS in CRT-IA but not in CRT-IV. RESULTS:Intra-arterial infusion in the high-dose cisplatin group caused significant hearing loss at ultra-high frequencies of 10 and 12 kHz (p = 0.028, 0.039, respectively), whereas the group receiving systemic administration of cisplatin had significant hearing loss at high frequencies of 8 and 10 kHz (p = 0.016, 0.027, respectively).

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Ishikawa E,Sugimoto H,Hatano M,Nakanishi Y,Tsuji A,Endo K,Kondo S,Wakisaka N,Murono S,Ito M,Yoshizaki T

doi

10.3109/00016489.2015.1035797

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

919-24

issue

9

eissn

0001-6489

issn

1651-2251

journal_volume

135

pub_type

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