Abstract:
CONCLUSIONS:Surgery for oral or oropharyngeal cancer with free-flap reconstruction is associated with moderate but persistent functional and quality of life (QoL) problems. Patient age, tumor stage, tumor site, and radiotherapy were the main predictors of functional outcome. OBJECTIVES:To evaluate long-term functional outcomes and QoL, and to determine their predictive factors in patients with oral or oropharyngeal cancer after oncologic surgery and free-flap reconstruction. METHODS:Patients who underwent surgery with free-flap reconstruction for oral or oropharyngeal cancer between 2000 and 2009 who were alive at least 1 year after therapy were included in this study. Patients completed the Voice Handicap Index (VHI-10) questionnaire and the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaires QLQ-C30 and H&N35. Swallowing was evaluated using the Dysphagia Outcome and Severity Scale (DOSS) and by flexible fiberoptic laryngoscopy. RESULTS:Sixty-four patients were included in the study. VHI-10 mean score was 11.2 ± 9 and its predictive factors were T stage (p = 0.005) and tumor involvement of the tongue base (p = 0.01). The mean DOSS score was 4 ± 0.8. Age (p = 0.008), gender (p = 0.04), and radiotherapy (p = 0.001) were the main predictive factors of the DOSS score.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Pierre CS,Dassonville O,Chamorey E,Poissonnet G,Riss JC,Ettaiche M,Peyrade F,Benezery K,Chand ME,Leyssalle A,Sudaka A,Haudebourg J,Santini J,Bozec Adoi
10.3109/00016489.2014.913809subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1086-93issue
10eissn
0001-6489issn
1651-2251journal_volume
134pub_type
杂志文章abstract:CONCLUSION:MCT is a useful tool to pre-operatively determine whether internal nasal valve (INV) narrowing affects a nasal obstruction. Functional rhinoplasty seemed to produce better results than septoplasty in Asian patients with a nasal obstruction, due to INV narrowing. OBJECTIVE:This study compared pre-operative m...
journal_title:Acta oto-laryngologica
pub_type: 评论,杂志文章
doi:10.3109/00016489.2015.1108523
更新日期:2016-01-01 00:00:00
abstract:CONCLUSIONS:A large series confirmation may suggest elective neck dissection in cN0 MASPIN-negative oral squamous cell carcinomas (SCCs). Re-activated nuclear MASPIN in association with anti-angiogenic or cytotoxic drugs may be extremely effective in the treatment of laryngeal SCC. OBJECTIVES:MASPIN is a serpin showin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.1080/00016480802256079
更新日期:2009-05-01 00:00:00
abstract:CONCLUSION:The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosom...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701813822
更新日期:2008-09-01 00:00:00
abstract::Negative membrane potentials from the stria vascularis of the guinea pig have been recorded in vivo. Stable negative membrane potentials from the stria cells have also been recorded for as long as 2 minutes in vitro. They varied from -20 mV to -49 mV, irrespective of whether the stria vascularis was immersed in Ring...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909137159
更新日期:1979-01-01 00:00:00
abstract::Experimental animals (cats) were exposed to tones of 125, 1000, 2000, and 4000 Hz at sound pressure levels in the range 120 to 157.5 dB, and for durations of one hour (1000, 2000, 4000 Hz) or four hours (125 Hz). Pure tone audiograms were obtained for each animal before and after exposure. Post-exposure tests were con...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121336
更新日期:1975-11-01 00:00:00
abstract::The facial nerve of the albino rat was compressed by inserting a thin nylon thread in the facial canal. After a survival period of 1-60 days, the animal was perfused with Ringer's solution followed by a 2% periodate-lysine-paraformaldehyde fixative. Frozen sections from the brain stem containing the facial motor nucle...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126055
更新日期:1994-05-01 00:00:00
abstract::Dynamic range (DR) of cochlear implant electrodes and speech recognition scores (SRS) were chronologically studied in 23 post-lingually deaf subjects over a period of one year. DR significantly increased over one year (ANOVA, p = 0.03). When DR was compared among three groups of electrodes which were located in the in...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137829
更新日期:1996-03-01 00:00:00
abstract:CONCLUSIONS:Analysis of the complete mtDNA genome and X-linkage of this five-generation Chinese family revealed that the 1555A > G mutation may lead to deafness. OBJECTIVES:Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. However, the variable clinical phenotype ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.575794
更新日期:2011-09-01 00:00:00
abstract::The correlation between allergen-induced specific and non-specific (histamine) nasal reactions was studied, especially as regards topical glucocorticosteroid effects on the non-specific reactions. Thirteen patients with strictly seasonal allergic rhinitis participated. A nasal challenge with histamine and three increa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488909127508
更新日期:1989-03-01 00:00:00
abstract::Several studies have reported variations in shape and size of stereociliary bundles and in a limited number of observations have associated them to type I and type II hair cells. A systematic study has been undertaken for which a technique was developed in order to identify both cell types and their corresponding hair...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137453
更新日期:1992-01-01 00:00:00
abstract::The results of myringoplasty on 172 ears examined after an average follow-up time of 1.5 years are reported. The fascial underlay technique with swing-door plasty was employed in 78% of the cases. The graft take was successful in 150 ears (87%), three of which (2%) later revealed adhesive changes in the middle ear. Th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209130902
更新日期:1982-05-01 00:00:00
abstract::Human papillomavirus (HPV) has a well-established association with benign and malignant cervical tumours as well as with laryngeal papillomas, while its association with laryngeal carcinomas is still controversial. We have examined 39 squamous cell carcinomas of the larynx for HPV using PCR with three consensus primer...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137949
更新日期:1996-11-01 00:00:00
abstract::The input from fore- and hindlimbs to the vestibular nuclear complex (VNC) was investigated in awake cats. Electrical stimulus was given to the sciatic, radial and vestibular nerves bilaterally and single unit responses were recorded in the VNC with extracellular technique. The position of the microelectrode was histo...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487909126395
更新日期:1979-01-01 00:00:00
abstract::Based on the experimental results of thyroplasty, thyroplasty type I which aims at medical shifting the vocal cord was performed on 8 patients with dysphonia, 6 with vocal cord paralysis and 2 with vocal cord atrophy. The surgery was conducted on either in- or out-patient basis and local anesthesia was used. Usually, ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487509121353
更新日期:1975-11-01 00:00:00
abstract::Normal quantum type bone remodeling was studied in temporal bones of young domestic pigs by means of combined microradiography, osteofluorochrome labelling and osteoid staining. Evolving secondary osteons were morphologically normal although much less in the otic capsule than in the surrounding compacta of the tempora...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009122540
更新日期:1990-09-01 00:00:00
abstract:CONCLUSION:This study demonstrated differential gene expression profiles in salicylate ototoxicity with oligonucleotide microarray. This study may also provide basic information on candidate genes associated with hearing loss and/or tinnitus or recovery after salicylate-induced cochlear dysfunction. OBJECTIVES:Salicyl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600801365
更新日期:2007-05-01 00:00:00
abstract::In a retrospective study of 475 patients suffering from Meniere's disease, the hearing loss, both in the low and high frequencies, and the loss of vestibular function were studied over time. There were large variations of hearing loss from case to case but, overall, the low were more affected than the high frequencies...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137819
更新日期:1996-03-01 00:00:00
abstract::Explants of stria vascularis and spiral ligament of guinea pig cochlea were kept in primary culture. On the explant, proliferating marginal cells advanced by 15 microns/day, suggesting that in vivo defects of the strial epithelium can be covered by new marginal cells. The marginal cells growing in the cell culture dis...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489209137471
更新日期:1992-09-01 00:00:00
abstract:INTRODUCTION:Bilateral cochlear implants are seen to improve hearing capabilities. OBJECTIVE:To assess the auditory outcome of paediatric bilateral cochlear implant in Universiti Kebangsaan Malaysia. MATERIALS AND METHODS:This was a cross-sectional and descriptive study single centre analysis. Categories of Auditory ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1775887
更新日期:2020-10-01 00:00:00
abstract:CONCLUSION:The existence of patients with positive non-sentinel node indicates a risk of misdiagnosis of metastasis in oropharyngeal and oral cancer. OBJECTIVES:We attempted to confirm the usefulness of sentinel lymph node biopsy (SLNB) in oropharyngeal and oral cavity cancer to detect clinically occult metastases. P...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480801891710
更新日期:2008-10-01 00:00:00
abstract:CONCLUSIONS:The expression of phosphorylcholine (ChoP) in the surface of nontypeable Haemophilus influenzae (NTHi) is an important factor in the pathogenesis of persistent otitis media with effusion (OME) in humans. OBJECTIVES:Lipooligosaccharide (LOS) in NTHi undergoes phase variation in expression of the ChoP epitop...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802468195
更新日期:2009-08-01 00:00:00
abstract::The purpose of this study was to establish whether lactoferrin (hLf) attached to Streptococcus pyogenes, one causative agent of acute pharyngotonsillitis (AT), during the course of the disease. Bacterial samples were obtained from the tonsillar surfaces of 7 patients (6 females, 1 male; median age 26 years; range 16-5...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract::Nerves displaying vasoactive intestinal peptide (VIP) immunoreactivity were detected in the upper respiratory tract of guinea pigs, rabbits and cats. VIP nerves were numerous in the cat, less numerous in the rabbit and rare in the guinea pig. In the nasal mucosa, fine varicose VIP nerves were found to surround nasal g...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809107524
更新日期:1978-11-01 00:00:00
abstract:CONCLUSION:Alterations within a novel putative Exon 1a within the gap junction beta 2 (GJB2) gene may play a role in the development of genetic hearing impairment in Austria. OBJECTIVES:Mutations in the GJB2 gene are the most common cause of hereditary sensorineural deafness. Genome-wide screening for alternative tran...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1249946
更新日期:2017-04-01 00:00:00
abstract:CONCLUSION:The Finnish Matrix Test is the first sentence test in noise for the Finnish language. It was developed according to the HearCom standards and provides reliable speech intelligibility measurements with highly comparable results with the other international matrix tests. OBJECTIVES:The aim of the study was to...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.3109/00016489.2014.898185
更新日期:2014-07-01 00:00:00
abstract:CONCLUSIONS:Concurrent chemoradiotherapy with carboplatin and uracil-f tegafur (UFT) seems to be a promising and appropriate regimen for patients with poor performance status (PS) with locally advanced squamous cell carcinoma of the head and neck (SCCHN). OBJECTIVE:We designed a regimen based on divided low-dose admin...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016480701200251
更新日期:2007-10-01 00:00:00
abstract::Volumetric changes of the scala media were histologically investigated in normal guinea pigs to see whether glycerol-induced volumetric change of the scala media followed a biphasic course similar to the auditory threshold in the glycerol test. Glycerol was administered orally in a 12 ml/kg dose. The volume of the sca...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489950181369
更新日期:1999-01-01 00:00:00
abstract:CONCLUSIONS:Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines in vitro. These cytokines induced the migration of eosinophils and neutrophils. Protease-activated receptors (PARs) might also play a role in the process of epithelial cell activation. OBJECTIVE:The...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480500395179
更新日期:2006-12-01 00:00:00
abstract::A thorough examination of hearing and hearing loss among workers in the saw- and papermill industries in northern Sweden showed that even a serious hearing loss does not give the expected social handicap. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487609119960
更新日期:1976-03-01 00:00:00
abstract::The feasibility of furosemide test for the detection of endolymphatic hydrops has previously been discussed (Authors, 1973, 1975). The glycerol test also has been reported as being effective for the same purpose but only in Meniere patients with fluctuating hearing loss (Klockhoff & Lindblom, 1966). In 48 patients wit...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487709128845
更新日期:1977-03-01 00:00:00