Long-term functional outcomes and quality of life after oncologic surgery and microvascular reconstruction in patients with oral or oropharyngeal cancer.

Abstract:

CONCLUSIONS:Surgery for oral or oropharyngeal cancer with free-flap reconstruction is associated with moderate but persistent functional and quality of life (QoL) problems. Patient age, tumor stage, tumor site, and radiotherapy were the main predictors of functional outcome. OBJECTIVES:To evaluate long-term functional outcomes and QoL, and to determine their predictive factors in patients with oral or oropharyngeal cancer after oncologic surgery and free-flap reconstruction. METHODS:Patients who underwent surgery with free-flap reconstruction for oral or oropharyngeal cancer between 2000 and 2009 who were alive at least 1 year after therapy were included in this study. Patients completed the Voice Handicap Index (VHI-10) questionnaire and the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaires QLQ-C30 and H&N35. Swallowing was evaluated using the Dysphagia Outcome and Severity Scale (DOSS) and by flexible fiberoptic laryngoscopy. RESULTS:Sixty-four patients were included in the study. VHI-10 mean score was 11.2 ± 9 and its predictive factors were T stage (p = 0.005) and tumor involvement of the tongue base (p = 0.01). The mean DOSS score was 4 ± 0.8. Age (p = 0.008), gender (p = 0.04), and radiotherapy (p = 0.001) were the main predictive factors of the DOSS score.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Pierre CS,Dassonville O,Chamorey E,Poissonnet G,Riss JC,Ettaiche M,Peyrade F,Benezery K,Chand ME,Leyssalle A,Sudaka A,Haudebourg J,Santini J,Bozec A

doi

10.3109/00016489.2014.913809

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1086-93

issue

10

eissn

0001-6489

issn

1651-2251

journal_volume

134

pub_type

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