Abstract:
CONCLUSIONS:Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines in vitro. These cytokines induced the migration of eosinophils and neutrophils. Protease-activated receptors (PARs) might also play a role in the process of epithelial cell activation. OBJECTIVE:The nasal epithelium is the first barrier encountered by airborne allergens and an active participant in airway inflammation. Fungi have been increasingly recognized as important pathogens in sinusitis and consist of several allergenic proteins. MATERIALS AND METHODS:Nasal polyp epithelial cells were obtained from patients and stimulated with Alternaria, Aspergillus, and Cladosporium. Interleukin-8 (IL-8), granulocyte-macrophage colony stimulating factor (GM-CSF), and regulated on activation normal T expressed and secreted (RANTES) were measured to determine the activation of epithelial cells. Reverse transcriptase-polymerase chain reaction test (RT-PCR) for PAR mRNA expression in nasal epithelial cells was performed. Eosinophil and neutrophil migration was induced with nasal polyp epithelial cells conditioned media (HPECM). RESULTS:Fungi enhanced the production of chemical mediators from nasal epithelial cells. When nasal epithelial cells were activated with fungi, PAR2 and PAR3 mRNAs were more strongly expressed than in nonactivated cells. Eosinophil migration was induced by RANTES and eotaxin, and neutrophil migration was induced by IL-8 in HPECM.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Shin SH,Lee YH,Jeon CHdoi
10.1080/00016480500395179subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1286-94issue
12eissn
0001-6489issn
1651-2251pii
K6X171882875R4L2journal_volume
126pub_type
杂志文章abstract::In a previous paper we demonstrated physiologically a sensitive period for acoustic trauma in the rat pup cochlea, with a maximum at 22 days of age. Seven or 60 days after noise exposure these 22-day exposed rats were used for light and electron microscopy. At 7 days, surface preparation revealed restricted damage to ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488009127143
更新日期:1980-03-01 00:00:00
abstract::The DBA/2 strain of mice have genetically induced vestibular dysfunction that presents grossly at an early age as circling behavior and abnormal righting reflexes. The vestibular morphology of this strain has not previously been examined. DBA/2 mice of different ages that showed circling behavior were sacrificed and t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489409126075
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Traumatic tympanic membrane perforation (TTMP) is usually managed conservatively because most close spontaneously within a few months. Nevertheless, spontaneous closure of TTMP during long-term observation has not been well described in the literature. OBJECTIVES:The present study investigated factors assoc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1592225
更新日期:2019-06-01 00:00:00
abstract::Localization of elements at the cellular and sub-cellular levels was performed with the energy dispersive X-ray microanalysis technique, using shock-frozen, freeze-dried and araldite-embedded mouse (CBA/CBA) cochleae sectioned dry. Anatomical identification occurred in the STEM (scanning transmission electron microsco...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488409107585
更新日期:1984-11-01 00:00:00
abstract:CONCLUSION:Intra-tympanic dexamethasone injection (ITD) could serve as a first-line intra-tympanic (IT) treatment for Meniere's disease (MD), regardless of hearing level. Even if the response to initial ITD course was unsatisfactory, a repeated course may be beneficial with some patients. OBJECTIVES:This study examine...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2016.1224920
更新日期:2017-02-01 00:00:00
abstract::The embryonic development of the crista ampullaris of the CBA/CBA mouse was followed both in organ culture of explanted inner ears of the 16th gestational day and in vivo from the 16th gestational day until the 21st day, an age corresponding to birth. Cytodifferentiation of the sensory epithelium of the crista ampulla...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309132868
更新日期:1983-07-01 00:00:00
abstract:CONCLUSIONS:We conclude that the capsaicin inhalation test is useful to directly assess cough reflex and sensation around the larynx, while it indirectly reflects central nervous system function. OBJECTIVES:To understand the state of the cough reflex before patients with dysphagia start eating. METHODS:We studied the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2010.516013
更新日期:2011-01-01 00:00:00
abstract:CONCLUSION:Chronic subjective dizziness (CSD) is frequent and affects twice as many women as men. Anxiety is a strong predisposing factor. The pathophysiologic concept of this disorder assumes that balance function and emotion share common neurologic pathways, which might explain that the balance disorder can provoke f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480701805455
更新日期:2008-10-01 00:00:00
abstract:CONCLUSION:The addition of transoral robotic surgery (TORS) in the diagnostic management of patients classified with head and neck squamous cell carcinoma of unknown primary (SCCUP) is promising and appears to improve detection rates of the primary tumour. The approach presented in this first Scandinavian study could p...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1052983
更新日期:2015-01-01 00:00:00
abstract:CONCLUSIONS:These findings are in line with previous data on the horizontal vestibulo-ocular reflex (VOR) from this laboratory and suggest that eye position signals do not modulate natural vestibular responses. Hence, the Alexander's law (AL) phenomenon cannot be interpreted simply as a consequence of vestibular or ocu...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2012.682120
更新日期:2012-10-01 00:00:00
abstract::Life-threatening cervical complications associated with infectious mononucleosis are rare. The combination of acute epiglottitis and subsequent necrotizing fasciitis of the head and neck in a patient with infectious mononucleosis has not been reported to date.A 47-year-old female with infectious mononucleosis and epig...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510027475
更新日期:2005-10-01 00:00:00
abstract:CONCLUSION:A man-made bone tunnel of 1.5 turns around the modiolus can be created in cases of total cochlear ossification. Patients with ossified cochlea types I and II achieved satisfactory hearing results after cochlear implantation (CI). Patients with ossified cochlea type III, in which the modiolus is damaged by th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.947656
更新日期:2014-12-01 00:00:00
abstract:CONCLUSION:The present study demonstrated the robustness of VEMP testing with toneburst stimuli, since it is hardly affected by head position, i.e. base or tonic excitation levels of the saccule and inferior vestibular nerve. However, the small but highly significant difference found in latency should not be neglected:...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600740597
更新日期:2007-01-01 00:00:00
abstract::Five temporal bones and three surgical cochlear nerve specimens from patients who previously underwent labyrinthectomy were studied by light and electron microscopy. All cochleas had nearly total loss of sensory cells, extensive or total loss of both cochlear nerve fibers in the osseous spiral lamina, and spiral gangl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109138495
更新日期:1981-03-01 00:00:00
abstract:HYPOTHESIS:To examine the cellular events following induced superficial lesions of the human tympanic membrane (TM). Such information could lead to enhanced appreciation of repair mechanisms and novel strategies to restore TM perforations. BACKGROUND:Persistent perforation of the TM in chronic otitis media is a major ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1321139
更新日期:2017-09-01 00:00:00
abstract::Nitric oxide synthase (NOS) isoforms I and III were localized in the guinea pig cochlea by indirect immunohistochemistry using frozen sections and paraffin sections. NOS I staining was observed in the cytoplasm of outer hair cells, in nerve cell somata and fibers of the spiral ganglion, and in axonal profiles of the s...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489609137914
更新日期:1996-09-01 00:00:00
abstract::Central origin of the vidian nerve in the dog was investigated using the retrograde tracing technique of horseradish peroxidase (HRP). After HRP was applied to the vidian nerve, labelled neurons were found in the medulla oblongata and the geniculate ganglion but could not be found in the trigeminal ganglion. Labelled ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309132883
更新日期:1983-07-01 00:00:00
abstract::Background: Betahistine is used worldwide to treat patients with Menière's disease. However, despite it being used for decades, diverging opinions on the effect of betahistine on Menière's symptomatology still exist.Aims: The objective of this systematic review was to provide an overview and rate the certainty of the ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1777326
更新日期:2020-10-01 00:00:00
abstract::EMG recordings of the neck muscles (biventer cervicis, complexus, splenius, longus capitis) of decerebrate cats were obtained during pitch and roll stimulations (sinusoidal stimulation: 30 degrees p-p amplitude, 0.2 Hz frequency). Most of the EMG responses to pitch showed activation peaks leading the position stimuli ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135800
更新日期:1993-05-01 00:00:00
abstract::The electromagnetic interference of the recently introduced bone-anchored hearing aid (BAHA) model "BAHA Compact" by digital cellular phones is investigated and compared with that of the older "BAHA Classic 300" model. Measurements with two different digital cellular phones in a laboratory setting indicated that the n...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480260092318
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:The graviceptive otolith function can be measured using subjective visual horizontal (SVH) testing. Nevertheless, more research efforts are required to understand the essential variables affecting SVH. OBJECTIVE:The aim of the present study was to determine the effects of type of visual image and gender on ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1817552
更新日期:2021-01-01 00:00:00
abstract:CONCLUSION:Cochlear implantation (CI) for Japanese single-sided deafness patients resulted in improved speech perception, increased sound localization accuracy, and reduced tinnitus handicap. OBJECTIVES:This study reports results for five adult SSD cases with CI, focusing on the benefits they obtained in terms of spee...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,多中心研究
doi:10.3109/00016489.2015.1116046
更新日期:2016-01-01 00:00:00
abstract:CONCLUSION:The results show that the DUET2 offers users speech perception that is equivalent to or better than the DUET. Moreover, the DUET2 offers subjective benefits above those provided by the DUET. BACKGROUND:The DUET is a combination of hearing aid and CI in one device for electric acoustic stimulation. Since its...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2015.1050605
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To investigate the outcome of pediatric tracheostomy and identify predictive factors for successful decannulation. METHODS:We performed a retrospective chart review of a series of 42 consecutive patients of less than 24 months of age who underwent a tracheostomy between 2012 and 2015. RESULTS:Successful de...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1326064
更新日期:2017-10-01 00:00:00
abstract::Vestibular microphonics in response to acoustical stimulation were recorded in cochlea-deprived pigeons. Endolymph flow in the semicircular canals alters this response. A caloric stimulus was applied to the horizontal canal or the posterior vertical canal close to the ampulla. To minimize the influence of gravity, the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488809097016
更新日期:1988-03-01 00:00:00
abstract:INTRODUCTION:Bilateral cochlear implants are seen to improve hearing capabilities. OBJECTIVE:To assess the auditory outcome of paediatric bilateral cochlear implant in Universiti Kebangsaan Malaysia. MATERIALS AND METHODS:This was a cross-sectional and descriptive study single centre analysis. Categories of Auditory ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1775887
更新日期:2020-10-01 00:00:00
abstract::While cigarette smoking and alcohol consumption are recognized covariates for head and neck squamous cell carcinoma (SCC), the role of genetic factors in determining individual susceptibility is unknown. The human tumour necrosis factor (TNF) region on chromosome 6p21 within the major histocompatibility complex (MHC) ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850155035
更新日期:1998-03-01 00:00:00
abstract::Tumour growth of vestibular schwannomas is still difficult to predict. The aim of our study was to determine whether any defined histopathological feature was correlated with the clinical course. We did a retrospective study with 69 paraffin-embedded tumours to establish whether the number of vessels, blood cells extr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480050218681
更新日期:2000-10-01 00:00:00
abstract::Background: Intratympanic and intravenous gadolinium administration is used to visualise endolymphatic hydrops. Aims/objectives: The goal of this study was to compare the image quality between intratympanic (IT-method) and intravenous (IV-method) gadolinium administration using three-dimensional inversion recovery wit...
journal_title:Acta oto-laryngologica
pub_type: 临床试验,杂志文章
doi:10.1080/00016489.2019.1600719
更新日期:2019-08-01 00:00:00
abstract:CONCLUSION:Results from a database for sudden sensorineural hearing loss (SSNHL) demonstrate no correlation between laboratory findings, treatment, and outcome in 400 patients. The patients with pathological test results were not treated differently from those with normal test results. The value of laboratory findings ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480903161541
更新日期:2010-03-01 00:00:00