Abstract:
:Tumour growth of vestibular schwannomas is still difficult to predict. The aim of our study was to determine whether any defined histopathological feature was correlated with the clinical course. We did a retrospective study with 69 paraffin-embedded tumours to establish whether the number of vessels, blood cells extravasation or degree of inflammation, all semi-quantitatively assessed, could be indicative of potential of growth. An immunohistochemical study was also performed with an endothelial marker CD34, the leukocyte common antigen CD45 and the estrogen and progesterone hormone receptors. All these parameters were correlated with patient's age, duration of symptoms (d), with a clinical growth index (CLI = tumour size/d). No clinical parameters proved to be predictive of tumour growth. Tumour size was significantly (p = 0.01) related to the number of vessels and we found a significant relationship between the clinical growth index (CLI) and total number of vessels, especially when duration of symptoms lasted less than 1 year (p < 0.001). However, we found no relationship between duration of symptoms or CLI and CD34 index. The degree of inflammation was significantly correlated (p = 0.007) with duration of symptoms when it lasted more than 1 year. The CD45 index and the semi-quantitative evaluation of the inflammation were well correlated (p = 0.001). No estrogen receptors antigenic site was detected and only seven tumours expressed progesterone receptor in a few cells without any significant clinical value. These results suggest that vessel density is determinant for sporadic acoustic neuroma growth especially for a short clinical course.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Labit-Bouvier C,Crebassa B,Bouvier C,Andrac-Meyer L,Magnan J,Charpin Cdoi
10.1080/00016480050218681subject
Has Abstractpub_date
2000-10-01 00:00:00pages
950-4issue
8eissn
0001-6489issn
1651-2251journal_volume
120pub_type
杂志文章abstract:BACKGROUND:Although endoscopic endonasal approach (EEA) for skull base tumors showed a good prognosis in sinonasal quality of life (QOL), what factors have influence on QOL is still in question. Aim/Objectives: To investigate the recovery of sinonasal QOL after EEA for anterior skull base tumors and find its prognostic...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2019.1574982
更新日期:2019-05-01 00:00:00
abstract::Merkel cell carcinoma (MCC) is an uncommon cutaneous neoplasm which arises in adults with a peak incidence in the sixth and seventh decades. MCC most often arises in the head and neck area and extremities. Among head and neck primary sites, auricular MCC has proven to be rare and only 20 cases have been reported in th...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.1080/00016480410017503-1
更新日期:2005-02-01 00:00:00
abstract:CONCLUSIONS:Codeine shows a similar association with profound deafness to other opiates. Good cochlear implant outcomes suggest a sensory disorder. Although macrocytosis could be due to confounding factors, the lack of other consistent findings may signify a vascular pathology. OBJECTIVES:To describe a series of patie...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802579082
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:The aim of this prospective study was to assess the usefulness of nasal smear eosinophilia compared with a skin sensitivity test for the diagnosis of allergic rhinitis and to determine the degree of correlation between the tests. MATERIAL AND METHODS:Fifty patients with a clinical history suggestive of nasa...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310002159
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the safety and effectiveness of a new cochlear implant (CI) system developed in China, the Nurotron Venus device. MATERIAL AND METHODS:Fifteen post-lingually deafened patients received Nurotron Venus CIs in our hospital. The safety and effectiveness of the devices were ev...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.894250
更新日期:2014-06-01 00:00:00
abstract:CONCLUSION:The external neck brace (ENB) is a new concept in the improvement of peristomal fixation of an automatic stoma valve (ASV), which was evaluated with a new imaging method. The addition of the ENB to the Flexiderm (FLD) and Xtrabase (XB) adhesives significantly reduced absolute mean differences between the spe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016480903426600
更新日期:2010-07-01 00:00:00
abstract:CONCLUSION:Delayed facial palsy after tympanoplasty had no predisposition for gender or side. It seemed that prednisolone alone without antiviral drugs was enough for the treatment of delayed facial palsy after tympanoplasty. OBJECTIVE:To analyze the clinical characteristics and prognosis of delayed facial palsy after...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.971464
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:To investigate the outcome of pediatric tracheostomy and identify predictive factors for successful decannulation. METHODS:We performed a retrospective chart review of a series of 42 consecutive patients of less than 24 months of age who underwent a tracheostomy between 2012 and 2015. RESULTS:Successful de...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2017.1326064
更新日期:2017-10-01 00:00:00
abstract::We established new cell lines from head and neck cancer patients for studies of adhesion molecules and cellular behavior in nine patients with primary or metastatic cancer treated at the Asan Medical Center. Explant cultures of fresh tumor tissue were used to develop new permanent tumor cell lines. Lines were tested f...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489709113477
更新日期:1997-09-01 00:00:00
abstract::This paper presents the results of an investigation into the possibility that gangliosides (brain cortex glycosphingolipids) are capable of being functionally incorporated into cell membranes and of interfering with enzymatic activity of the ATPase system on the stria vascularis and spiral ligament in the guinea pig. ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488109133282
更新日期:1981-11-01 00:00:00
abstract::Five out of eight consecutive cases with initial symptoms of a 'midline granuloma' were identified as malignant histiocytosis (histiocytic sarcoma) which within 5 months to 4 years led to generalization and death. The three remaining cases also fulfilled the morphological criteria of this type of neoplasia, though the...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488609108616
更新日期:1986-01-01 00:00:00
abstract::Eight patients with dystrophia myotonica (Steinert) were studied. They all had myotonia and pathological EMG and in some cases other signs of the disease. The 50% relaxation times of the stapedius reflex were significantly prolonged compared with a control group of 40 healthy, young subjects with normal hearing and no...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488209128937
更新日期:1982-11-01 00:00:00
abstract::The diagnosis and management of spontaneous otogenic pneumocephalus with literature review is described. A young sportsman experienced headache and fluctuating mass in his occiput during increased physical activity. A large extradural intracranial pneumocephalus with corresponding emphysema was imaged on a CT scan. Tr...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章,评审
doi:10.3109/00016489.2010.541941
更新日期:2011-06-01 00:00:00
abstract::Nerves displaying vasoactive intestinal peptide (VIP) immunoreactivity were detected in the upper respiratory tract of guinea pigs, rabbits and cats. VIP nerves were numerous in the cat, less numerous in the rabbit and rare in the guinea pig. In the nasal mucosa, fine varicose VIP nerves were found to surround nasal g...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016487809107524
更新日期:1978-11-01 00:00:00
abstract::The early diagnosis of the Mondini dysplasia by means of electrocochleography and temporal bone polytomography, and the prevention of further hearing loss through the endolymphatic subarachnoid shunt operation, brought new data on the follow-up of patients with this malformation. They were found to present specific me...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488309139454
更新日期:1983-05-01 00:00:00
abstract::Endoscopy is needed for reliable evaluation of the treatment of nasal polyposis. In this study, we compared the reproducibility of various score systems for staging nasal polyposis and the inter-individual variations between investigators. The mass of the polyps was assessed by five methods, three new techniques (numb...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164800760370873
更新日期:2000-01-01 00:00:00
abstract::Angioneurotic edema is a non-pitting edema which is usually limited to the skin and the mucous membranes of the face and upper aerodigestive tract. The risk of acute upper airway obstruction makes angioneurotic edema a concern for emergency room physicians, internists and otolaryngologists because prompt recognition o...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480310005129
更新日期:2003-10-01 00:00:00
abstract::In 82 patients with acute tonsillitis studied, beta-hemolytic group A streptococci were isolated from 30 (37%), and group C or G streptococci from 12 (15%). In the 40 patients with non-streptococcal tonsillitis there was a significantly higher isolation rate of pneumococci, H. influenzae and/or B. catarrhalis, as comp...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016488709107339
更新日期:1987-09-01 00:00:00
abstract:CONCLUSION:Glucocorticoid (GC) administration enhanced apoptotic changes in mature olfactory receptor neurons (ORNs). GC administration may enhance regeneration of olfactory epithelium (OE). OBJECTIVES:The mechanism underlying olfactory epithelial cells turnover involves apoptosis replaced by new ORNs. On regeneration...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480802530663
更新日期:2009-09-01 00:00:00
abstract:CONCLUSION:The results of this study give support to the theory that opening the middle ear (ME) to the atmosphere leads to a deterioration in its pressure regulation capacity. However, this is probably not the reason why a perforation of the tympanic membrane becomes chronic. OBJECTIVE:Direct, continuous measurement ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480510029374
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:Although community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections have recently become an increasing problem in various fields of medicine, they have rarely been studied in the ear. The purpose of this study was to determine the prevalence of community-acquired MRSA infections in disc...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/0036554021000028076
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Smell and taste disorders occur in COVID-19 with a high prevalence, but little is known about the duration of the symptoms. In particular, studies using validated olfactory tests are very rare to date. AIMS/OBJECTIVES:The aim of this study was to determine the olfactory function of COVID-19 recoveries by a ...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489.2020.1811999
更新日期:2020-12-01 00:00:00
abstract::Thirty-two patients affected by idiopathic benign paroxysmal positional vertigo (BPPV) of the posterior semicircular canal were studied before, 3 days and I month after a resolutive Semont manoeuvre by means of dynamic posturography. The overall postural control in BPPV patients was shown to be impaired, as demonstrat...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016489850183340
更新日期:1998-06-01 00:00:00
abstract:CONCLUSION:Neck dissection (ND) may not be warranted for those patients with complete response in the neck. Human papillomavirus (HPV)-positive or -negative tumour does not affect this recommendation. OBJECTIVES:Treatment of tonsillar cancer varies considerably worldwide, although non-surgical treatment, e.g. radiothe...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2014.920516
更新日期:2014-10-01 00:00:00
abstract::An oral dose of 400 mg enoxacin was given to each of 19 patients with long-standing secretory otitis media (SOM). A total of 27 samples of middle ear effusion (MEE) and blood were collected at different intervals during a 6-h period after administration of the drug. The concentration of enoxacin in MEE and serum was d...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489009125166
更新日期:1990-05-01 00:00:00
abstract:CONCLUSION:This study demonstrated differential gene expression profiles in salicylate ototoxicity with oligonucleotide microarray. This study may also provide basic information on candidate genes associated with hearing loss and/or tinnitus or recovery after salicylate-induced cochlear dysfunction. OBJECTIVES:Salicyl...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480600801365
更新日期:2007-05-01 00:00:00
abstract::This work describes the different patterns of expression of integrins and extracellular matrix proteins in normal and transformed mucosa in laryngeal and oropharyngeal carcinomas. Samples from each tumor group were sectioned and examined by immunohistochemistry using monoclonal antibodies raised against integrin chain...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/00016480252814298
更新日期:2002-03-01 00:00:00
abstract::The aim of this study was to investigate the influence of weather conditions on the frequency of acute laryngitis in adults. The medical records of 825 patients with a diagnosis of acute laryngitis obtained over a 5-year period were reviewed. Meteorological data reviewed included the daily values of 13 parameters. The...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.1080/000164802320396358
更新日期:2002-09-01 00:00:00
abstract:CONCLUSION:The results suggest that the beneficial effect of astragaloside IV on impulse noise-induced hearing loss may be due to its ability to inhibit reactive oxygen species (ROS) and prevent apoptosis. OBJECTIVE:Astragaloside IV is the major active constituent of Astragalus membranaceus, which has been widely used...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489.2011.643457
更新日期:2012-05-01 00:00:00
abstract::The Pathologic changes in the inner ears of 5 patients with Cogan's syndrome were studied by a combined application of MR imaging and CT scanning. We used T1- and T2-weighted MR imaging sequences and a special three-dimensional MR imaging technique which allows a very detailed imaging of the inner ear structures. By t...
journal_title:Acta oto-laryngologica
pub_type: 杂志文章
doi:10.3109/00016489309135875
更新日期:1993-09-01 00:00:00