Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise.

Abstract:

CONCLUSION:The results suggest that the beneficial effect of astragaloside IV on impulse noise-induced hearing loss may be due to its ability to inhibit reactive oxygen species (ROS) and prevent apoptosis. OBJECTIVE:Astragaloside IV is the major active constituent of Astragalus membranaceus, which has been widely used for the treatment of diseases in China for its antioxidant properties. ROS and apoptosis are involved in damage induced by impulse noise trauma. We aimed to investigate if the beneficial effects of astragaloside IV on cochlea exposed to impulse noise are associated with the inhibition of ROS and the decrease in apoptosis. METHODS:4-Hydroxynonenal (HNE) was used as the marker of ROS. Active-caspase-3 (cas-3) served as a marker for apoptosis. 4HNE and cas-3 were determined immunohistochemically. Guinea pigs in the experimental group were administered astragaloside IV intragastrically. Auditory thresholds were assessed by sound-evoked auditory brainstem response (ABR) 72 h before and after exposure to impulse noise. RESULTS:The results showed that astragaloside IV significantly reduced ABR deficits, and decreased the expression of ROS and cas-3.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Xiong M,He Q,Lai H,Wang J

doi

10.3109/00016489.2011.643457

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

467-74

issue

5

eissn

0001-6489

issn

1651-2251

journal_volume

132

pub_type

杂志文章
  • The rebound phenomenon of glycerol-induced changes in the endolymphatic space.

    abstract::Volumetric changes of the scala media were histologically investigated in normal guinea pigs to see whether glycerol-induced volumetric change of the scala media followed a biphasic course similar to the auditory threshold in the glycerol test. Glycerol was administered orally in a 12 ml/kg dose. The volume of the sca...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489950181369

    authors: Takeda T,Takeda S,Saito H,Hamada M,Sawada S

    更新日期:1999-01-01 00:00:00

  • Racial considerations in acoustic neuroma removal with hearing preservation via the retrosigmoid approach.

    abstract::Racial differences in the size, shape and structure of the cranium exist. This paper evaluates the importance of race in influencing the required sizes of craniotomies for gaining access to the lateral end of the internal auditory meatus without breaching the labyrinth via the retrosigmoid approach. Fine-cut CT scans ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489509139402

    authors: Low WK,Fenton JE,Fagan PA,Gibson WP

    更新日期:1995-11-01 00:00:00

  • Failure of gaze stabilization under high-frequency head oscillation.

    abstract::Gaze functions under high-frequency head oscillations with large amplitudes were investigated in 12 normal subjects. Oscillation amplitude decreased as the frequency increased (31 degrees at 2 Hz to 11 degrees at 5 Hz on average). Maximum head velocity and acceleration were 170-200 degrees/s and 2,500-5,000 degrees/s2...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488909127495

    authors: Takahashi M,Akiyama I,Tsujita N

    更新日期:1989-03-01 00:00:00

  • Diagnostic criteria of barotraumatic perilymph fistula based on clinical manifestations.

    abstract:CONCLUSIONS:Patients with sudden hearing loss and dizziness after barotrauma should be suspected of barotraumatic perilymph fistula (PLF). Early surgical repair of PLF showed better hearing outcomes. Therefore, diagnostic criteria should help surgical indications of barotraumatic PLF. OBJECTIVES:The aim of this study ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2016.1213419

    authors: Choi JE,Moon IJ,Kim H,Lee K,Cho YS,Chung WH

    更新日期:2017-01-01 00:00:00

  • Acute rhinosinusitis - are we forgetting the possibility of a dental origin? A retrospective study of 385 patients.

    abstract::Background: Odontogenic sinusitis (OS) is a common but underdiagnosed form of acute rhinosinusitis (ARS). OS carries no specific characteristics, but unilateral symptoms and certain microbiological as well as radiological findings indicate odontogenic origin. Aims/objectives: We studied the proportion of OS in ARS pat...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2019.1634837

    authors: Wuokko-Landén A,Blomgren K,Välimaa H

    更新日期:2019-09-01 00:00:00

  • One-third of vertiginous episodes during the follow-up period are caused by benign paroxysmal positional vertigo in patients with Meniere's disease.

    abstract:CONCLUSION:In the present study, about one-third of patients with Meniere's disease developed benign paroxysmal positional vertigo (BPPV)-like attacks. Additionally, more than one-third of all vertigo attacks were BPPV-like attacks. Thus, vertigo attacks in patients with Meniere's disease must be carefully treated beca...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2014.936624

    authors: Taura A,Funabiki K,Ohgita H,Ogino E,Torii H,Matsunaga M,Ito J

    更新日期:2014-11-01 00:00:00

  • Interaction and immunological effect of very late antigen-4, 5, and fibronectin in tonsillar lymphocytes and their relation to age.

    abstract::We examined the expressions of alpha-subunits of very late antigen (VLA)-4 (alpha4) and VLA-5 (alpha5) on tonsillar lymphocytes and the interaction between these integrin receptors and their ligand, fibronectin (FN). Immunohistological and flow cytometric analyses showed that alpha4 and alpha5 were expressed in the ly...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489609137722

    authors: Ohguro S,Tsubota H,Harabuchi Y

    更新日期:1996-01-01 00:00:00

  • Impaired membrane targeting and aberrant cellular localization of human Cx26 mutants associated with inherited recessive hearing loss.

    abstract:CONCLUSION:This study demonstrated that five Cx26 mutations (R32H, S199F, 572delT, 631-632delGT, and Y155X) affect gap junction (GJ) functions by causing impaired membrane targeting and aberrant cellular localization, and one mutation (R165W) leads to a constriction of the channel pore with no dye coupling. OBJECTIVE:...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2010.506885

    authors: Xiao Z,Yang Z,Liu X,Xie D

    更新日期:2011-01-01 00:00:00

  • Suppressive action of picrotoxin, a GABA antagonist, on labyrinthine spontaneous nystagmus and vertigo in man.

    abstract::There is evidence that GABA acts as the excitatory neurotransmitter at synapses between vestibular hair cells and the afferent fibres in the mammalian labyrinth. The question arose as to whether certain vestibular dysfunctions such as labyrinthine vertigo could be treated in patients by influencing the peripheral GABA...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488209130882

    authors: Ehrenberger K,Benkoe E,Felix D

    更新日期:1982-01-01 00:00:00

  • Principles of cranial base ossification in humans and rats.

    abstract:CONCLUSIONS:1. The principle of bilateral symmetry depends on the chordal cartilage that is the keystone in cranial base ossification in rats and humans, due to its anatomical situation and for the production of the chordin protein that regulates the bone morphogenetic protein BMP-7. 2. In humans and in rats, foramen l...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.642814

    authors: Santaolalla-Montoya F,Martinez-Ibargüen A,Sánchez-Fernández JM,Sánchez-del-Rey A

    更新日期:2012-04-01 00:00:00

  • High-resolution cone-beam computed tomography: a potential tool to improve atraumatic electrode design and position.

    abstract:CONCLUSIONS:Flat-panel cone-beam computed tomography (CBCT) is able to assess the trajectory of the implanted cochlear implant (CI) array. This is essential to determine specific effects of electrode design and surgical innovations on outcomes in cochlear implantation. CBCT is a non-invasive approach yielding similar d...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.644805

    authors: Cushing SL,Daly MJ,Treaba CG,Chan H,Irish JC,Blaser S,Gordon KA,Papsin BC

    更新日期:2012-04-01 00:00:00

  • Prospective multi-center study on expansion sphincter pharyngoplasty.

    abstract:BACKGROUND AND OBJECTIVE:The aim of this study was to demonstrate the long-term effectiveness of Expansion Sphincter Pharyngoplasty (ESP) as a standalone surgical treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients through a prospective multi-center study. MATERIAL AND METHODS:A prospective non-com...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00016489.2018.1533992

    authors: Plaza G,Baptista P,O'Connor-Reina C,Bosco G,Pérez-Martín N,Pang KP

    更新日期:2019-02-01 00:00:00

  • The effects of fatal hemorrhage on the cochlear vasculature.

    abstract::The condition of the cochlear vasculature was evaluated in 7 normal guinea pigs subsequent to fatal aortic hemorrhage. The cochleas were prepared for histological analysis using a soft surface preparation technique. The data analysis revealed two statistically significant differences: an increase in the number of aggr...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409130986

    authors: Jones-Mumby C,Axelsson A

    更新日期:1984-03-01 00:00:00

  • Vestibular nuclear neuron activity in chronically hemilabyrinthectomized cats.

    abstract::The activity of central vestibular neurons (Vn) of the horizontal canal system was recorded in chronically hemilabyrinthectomized cats and compared with that of labyrinth intact animals. In both groups the cerebellar vermis was removed in order to assess the efficacy of the vestibular brainstem commissure alone by mea...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488409107529

    authors: Ried S,Maioli C,Precht W

    更新日期:1984-07-01 00:00:00

  • Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application.

    abstract::Basic scientific research has demonstrated that epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor-AA (PDGF-AA) and transforming growth factor-alpha (TGF-alpha) are induced by acute tympanic membrane (TM) perforation. The expression of these growth factors peaks during...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章,评审

    doi:10.1080/000164802320396259

    authors: Ma Y,Zhao H,Zhou X

    更新日期:2002-09-01 00:00:00

  • The developing electrolytes concentrations of inner ear fluids in guinea pigs.

    abstract::Cochlear endolymph, scala tympani perilymph, and scala vestibuli perilymph were collected from fetal, neonatal, and mature guinea pigs. The concentrations of Na and K in these fluids were then assessed using a microflame photometer. The electrolyte composition in the endolymph was already characterized by a high conce...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488509182256

    authors: Kanoh N,Ohmura M,Fukazawa T,Hirono Y,Makimoto K

    更新日期:1985-05-01 00:00:00

  • A device for measuring mucociliary activity in the human bronchi during fibre-optic bronchoscopy.

    abstract::An in vivo method for the study of mucociliary activity in the human trachea and bronchi is presented. The method is based on a two-way fibre-optic system whereby reflections of light emitted by one glass-fibre and reflected by the cilia are picked up by a second glass fibre and transmitted to a recording unit. The gl...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489309135885

    authors: Huberman D

    更新日期:1993-09-01 00:00:00

  • Is horizontal semicircular canal ocular reflex influenced by otolith organs input?

    abstract:CONCLUSION:Otolith organs input influences the axis of horizontal semicircular canal ocular reflex; therefore, the plane of compensatory eye movements induced by the horizontal canal stimulation is not always parallel to the canal. OBJECTIVE:To clarify whether horizontal canal ocular reflex is influenced by otolith or...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.656286

    authors: Ichijo H

    更新日期:2012-07-01 00:00:00

  • Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats.

    abstract:CONCLUSION:Systemic application of human mesenchymal stem cells (hMSCs) may be another effective tool for stem cell supply to the inner ear. OBJECTIVES:Most researchers have used local application to provide the inner ear with stem cells. In spite of their efficacy, these methods can potentially cause irreversible dam...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2012.660731

    authors: Choi BY,Song JJ,Chang SO,Kim SU,Oh SH

    更新日期:2012-06-01 00:00:00

  • Clinical profile of hearing loss in children with congenital cytomegalovirus (CMV) infection: CMV DNA diagnosis using preserved umbilical cord.

    abstract:CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489.2011.583268

    authors: Furutate S,Iwasaki S,Nishio SY,Moteki H,Usami S

    更新日期:2011-09-01 00:00:00

  • Histological study of chronic electrode implantation through the round window of the guinea pig.

    abstract::A platinum-iridium electrode with a Teflon cover tube was chronically implanted through the round window into the scala tympani of the guinea pig. Animals were sacrificed at 30 to 40 weeks after electrode implantation, and the cochleae were observed by scanning electron microscopy or with light microscopy. The results...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488809097005

    authors: Gyo K

    更新日期:1988-03-01 00:00:00

  • Col11a1 and Col11a2 mRNA expression in the developing mouse cochlea: implications for the correlation of hearing loss phenotype with mutant type XI collagen genotype.

    abstract:OBJECTIVE:Mutations in the fibrillar collagen genes COL11A1 and COL11A2 can cause sensorineural hearing loss associated with Stickler syndrome. There is a correlation of hearing loss severity, onset, progression and affected frequencies with the underlying mutated collagen gene. We sought to determine whether differenc...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480410016162

    authors: Shpargel KB,Makishima T,Griffith AJ

    更新日期:2004-04-01 00:00:00

  • Free flap reconstruction for early stage tongue squamous cell carcinoma: surgical margin and recurrence.

    abstract:BACKGROUND:To identify the difference of surgical margin and recurrence status of early stage tongue carcinoma via wide excision in a single institution with and without free flap reconstruction. OBJECTIVE:Survey whether the reconstruction methods for early tongue cancer affects disease control, survival outcomes. ME...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489.2018.1490030

    authors: Lu CC,Tsou YA,Hua CH,Tsai MH

    更新日期:2018-10-01 00:00:00

  • A contribution to the structural pattern differences between the apical and basal spiral ganglions in mammals.

    abstract::The purpose of this paper was to establish a mammalian comparative study between the neuronal spaces of the upper versus the basal cochlear turns. We studied with light microscopy i) Webster albino rat embryos at various gestational days (GD), and a postnatal (PN) series; ii) kittens 3 weeks old; iii) pigmented guinea...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489709117781

    authors: Sánchez-Fernández JM,Sánchez-del Rey A,Santaolalla-Montoya F,Martinez Ibarguen A

    更新日期:1997-03-01 00:00:00

  • Differences in hair bundles associated with type I and type II vestibular hair cells of the guinea pig saccule.

    abstract::Several studies have reported variations in shape and size of stereociliary bundles and in a limited number of observations have associated them to type I and type II hair cells. A systematic study has been undertaken for which a technique was developed in order to identify both cell types and their corresponding hair...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016489209137453

    authors: Lapeyre P,Guilhaume A,Cazals Y

    更新日期:1992-01-01 00:00:00

  • The estimated incidence of symptomatic nasal polyps.

    abstract::The objective of the present study was to establish the estimated incidence of symptomatic nasal polyps within a defined geographic area. Over a 6-year period all polyp patients diagnosed for the first time (n = 252; 174 males, 78 females) were prospectively registered at the study clinic. An estimated background popu...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480252814199

    authors: Larsen K,Tos M

    更新日期:2002-03-01 00:00:00

  • Tonsillectomy: an appraisal of indications in developing countries.

    abstract::The records of 627 patients with inflammatory disease of the tonsils and 310 patients undergoing dissection tonsillectomy are analysed. The majority of the tonsil population in our study group are adults, and there is a high incidence of rheumatic fever and rheumatic heart disease. The study population is apt to recei...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488309132739

    authors: Okafor BC

    更新日期:1983-11-01 00:00:00

  • Protease-dependent activation of nasal polyp epithelial cells by airborne fungi leads to migration of eosinophils and neutrophils.

    abstract:CONCLUSIONS:Proteases in fungi interact with nasal epithelial cells and enhance the production of inflammatory cytokines in vitro. These cytokines induced the migration of eosinophils and neutrophils. Protease-activated receptors (PARs) might also play a role in the process of epithelial cell activation. OBJECTIVE:The...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500395179

    authors: Shin SH,Lee YH,Jeon CH

    更新日期:2006-12-01 00:00:00

  • Validity of a new feedback method for the VEMP test.

    abstract:CONCLUSIONS:We used a feedback method, based on a blood pressure manometer with inflatable cuff, to control the sternocleidomastoid muscle (SCM) contraction. To obtain comparable left-right VEMP responses, it is necessary (1) to determine which cuff pressures on both sides yield identical mean rectified voltage (MRV) v...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480500527227

    authors: Vanspauwen R,Wuyts FL,Van De Heyning PH

    更新日期:2006-08-01 00:00:00

  • Lexical tone identification and consonant recognition in acoustic simulations of cochlear implants.

    abstract:CONCLUSION:Cochlear implant (CI) recipients' performance of lexical tone identification and consonant recognition can be enhanced by providing greater spectral details. OBJECTIVE:To evaluate the effects of increasing the number of total spectral channels on the lexical tone identification and consonant recognition by ...

    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016480802032793

    authors: Lin YS,Lu HP,Hung SC,Chang CP

    更新日期:2009-06-01 00:00:00