Abstract:
CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL. OBJECTIVES:The present study investigated the prevalence of congenital CMV infection diagnosed retrospectively by detection of CMV DNA in dried umbilical cord specimens from children with unilateral or bilateral SNHL up to the age of 12 years. METHODS:Preserved dried umbilical cords were collected from 134 children with bilateral (46 children) or unilateral (88 children) SNHL. DNA was extracted from the dried umbilical cords and CMV DNA was detected by quantitative PCR. Genetic deafness tests based on the invader assay were performed in children with bilateral SNHL. RESULTS:CMV DNA from the dried umbilical cords was detected in 8.7% of the bilateral SNHL and 9.1% of unilateral SNHL. Deafness gene mutations were identified in 21.7% (10/46) of children with bilateral SNHL.
journal_name
Acta Otolaryngoljournal_title
Acta oto-laryngologicaauthors
Furutate S,Iwasaki S,Nishio SY,Moteki H,Usami Sdoi
10.3109/00016489.2011.583268subject
Has Abstractpub_date
2011-09-01 00:00:00pages
976-82issue
9eissn
0001-6489issn
1651-2251journal_volume
131pub_type
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