The long-term effect of bilateral inferior colliculus ablation on auditory brainstem response in awake cats.

Abstract:

:In this study auditory brainstem responses (ABRs) were recorded repeatedly in three awake cats before and after bilateral aspiration of the inferior colliculi (ICs). All surgical procedures were performed under anaesthesia with Nembutal. Postoperative recordings were obtained 1 week, 3 months, 8 months and 13 months after bilateral aspiration of the ICs in order to study the long-term changes in ABRs. The P5 amplitude was markedly reduced only at 1 week after aspiration. P1 and P2 amplitudes were affected slightly at 3 months and 1 year, but those of P3 and P4 decreased significantly. After perfusion of these cats, histological examination of the brainstem revealed complete ablation of both ICs, neuronal loss in the nucleus of the lateral lemniscus and the superior olivary complex and preservation of the cochlear nucleus. Our results suggest that retrograde degeneration of neuronal cells of the brainstem, which project to the IC from the nucleus of the lateral lemniscus and superior olivary complex except the cochlear nucleus, affect the peak amplitudes of the ABR over the long-term.

journal_name

Acta Otolaryngol

journal_title

Acta oto-laryngologica

authors

Kaga K,Yamada K,Tsuzuku T,Uno A

doi

10.1080/00016489950181503

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

128-31

issue

2

eissn

0001-6489

issn

1651-2251

journal_volume

119

pub_type

杂志文章
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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.3109/00016488209130856

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  • Sinonasal cancer and exposure to softwood.

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  • Radical scavengers for elderly patients with age-related hearing loss.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Ultrastructural features of the interferon-treated adult laryngeal papilloma.

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  • Congenital unilateral lower lip palsy.

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  • Vestibulo-ocular reflex (VOR) biases in normal subjects and patients with compensated vestibular loss.

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  • Photographic studies of the larynx in central laryngeal paresis and paralysis.

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    pub_type: 杂志文章

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  • Postnatal development of vestibular receptor surfaces in the rat.

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    pub_type: 杂志文章

    doi:10.3109/00016488609108602

    authors: Dechesne C,Mbiene JP,Sans A

    更新日期:1986-01-01 00:00:00

  • The relevance of migraine in patients with Meńière's disease.

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    pub_type: 杂志文章

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    journal_title:Acta oto-laryngologica

    pub_type: 杂志文章

    doi:10.1080/00016489850154937

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    更新日期:1998-03-01 00:00:00

  • Effects of age, sex and stimulus parameters upon vestibulo-ocular responses to sinusoidal rotation.

    abstract::We evaluated the vestibulo-ocular reflex (VOR) in 50 normal human subjects, uniformly distributed in age 20-59 years, and evenly distributed in sex by decade, using sinusoidal rotation over the frequency range of 0.005 to 1.0 Hz and three peak amplitudes of 25, 50, and 100 deg/sec. Age variations. The gain magnitude o...

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    pub_type: 杂志文章

    doi:10.3109/00016488409107563

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  • Analysis of the performance of post-lingually deafened patients with Nurotron(®) Venus™ cochlear implants.

    abstract:OBJECTIVE:The aim of this study was to analyze the safety and effectiveness of a new cochlear implant (CI) system developed in China, the Nurotron Venus device. MATERIAL AND METHODS:Fifteen post-lingually deafened patients received Nurotron Venus CIs in our hospital. The safety and effectiveness of the devices were ev...

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  • Methylcobalamin as antagonist to transient ototoxic action of gentamicin.

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    pub_type: 杂志文章

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  • A daily nasal spray with saline prevents symptoms of rhinitis.

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